scholarly journals The Effect of Environmental Temperature on Immune Response and Metabolism of the Young Chicken. 3. Effect of Environmental Temperature on the Humoral Immune Response Following Injection of Sheep Red Blood Cells

1983 ◽  
Vol 62 (1) ◽  
pp. 51-58 ◽  
Author(s):  
A.M. HENKEN ◽  
A.M.J. GROOTE SCHAARSBERG ◽  
M.G.B. NIEUWLAND
Keyword(s):  
Immune Response ◽  
Red Blood Cells ◽  
Humoral Immune Response ◽  
Blood Cells ◽  
Environmental Temperature ◽  
Humoral Immune ◽  
Sheep Red Blood Cells ◽  
Young Chicken

B.C.L. and Immune Response in Mice

1986 ◽  
Vol 14 (01n02) ◽  
pp. 33-36
Author(s):  
G.M. Sein ◽  
M. Phil
Keyword(s):  
Immune Response ◽  
Herbal Medicine ◽  
Red Blood Cells ◽  
Concanavalin A ◽  
Humoral Immune Response ◽  
Blood Cells ◽  
Parent Compound ◽  
Lymphocyte Transformation ◽  
Immunological Response ◽  
Humoral Immune

The effects of Korean herbal medicine (B.C.L.) on some parametrs of immunological response were studied in mice, B.C.L. pretreatment given either intraperitoneally subcutaneously in a dose of 0.75 mg/mouse did not significantly inhibit lymphocyte transformation induced by concanavalin A. However, B.C.L. pretreatment in a dose of 2.25 mg/mouse was found to reduce significantly both the plaque-forming cells to sheep red blood cells immunisation as well as total splee cell population. Thus, B.C.L. pretreatment with a higher does (2.25 mg/mouse) can selectively depress the humoral immune response. It is unclear, however, whether this action is mediated by the parent compound or its metabolities.

scholarly journals Immunomodulatory Activity of Aqueous Extract of Polyherbal Formulation on Macrophage Function and Humoral Immune Response against SRBCs in Mice

2021 ◽  
pp. 3989-3997
Author(s):  
Hamid K.M. ◽  
Shehu A.A. ◽  
Kalgo M.U. ◽  
Isiyaku A. ◽  
Alkali S. ◽  
...  
Keyword(s):  
Immune Response ◽  
Red Blood Cells ◽  
Antibody Titre ◽  
Aqueous Extract ◽  
Humoral Immune Response ◽  
Blood Cells ◽  
Median Score ◽  
Phagocytic Function ◽  
Humoral Immune ◽  
Polyherbal Formulation

Several herbal formulation were not properly documented due to poor scientific data as well as poor standard regulation in preparation and marketing. The study evaluate the effect of aqueous extract of Polyherbal formulation on Macrophages’ phagocytic function and Humoral immune response in Mice A total of Sixteen 16 Mice was used. Group I received normal saline, Group II-IV received 500 mg, 1000 mg, and 1500 mg of Polyherbal formulation respectively for 21 days each. The animals were sensitized and challenged with Sheep red blood cells at day 14th and 19th of the treatment respectively. On day 21st all the animals were injected with 0.1 ml Indian ink for carbon clearance assay and blood sample was collected at 1 minute and 15 minutes of the injection. The phagocytic function of Macrophages and humoral immune response were determined spectrophotometrically and Hemagglutination assay respectively. The results show that the highest carbonic particle clearances index (K) median score (Median=0.0228), Macrophage phagocytose index (α) median score (Median=3.249), organ weight index (g/100g) mean score (M=0.06633) and Hemagglutination antibody titre median score (Median=32.00) was recorded by Group IV when compared with other groups. The carbonic particle clearance (K) (p=0.02), phagocytic index of Macrophage (α) (p=0.03), and organ weight index (g/100g) (p<0.0001) significantly increase with increase in the Polyherbal formulation concentration. Hemagglutination antibody titre against Sheep red blood cells (p=0.02) also significantly increased. The extract has potential immunostimulatory activity on both Macrophages’ phagocytic function and humoral immune response in mice thus could be useful in improving immune responses.

scholarly journals Bortezomib decreases the magnitude of a primary humoral immune response to transfused red blood cells in a murine model

Transfusion ◽  
2016 ◽  
Vol 57 (1) ◽  
pp. 82-92 ◽  
Author(s):  
Prabitha Natarajan ◽  
Jingchun Liu ◽  
Manjula Santhanakrishnan ◽  
David R. Gibb ◽  
Lewis M. Slater ◽  
...  
Keyword(s):  
Immune Response ◽  
Red Blood Cells ◽  
Murine Model ◽  
Humoral Immune Response ◽  
Blood Cells ◽  
Humoral Immune

scholarly journals CELLS INVOLVED IN THE IMMUNE RESPONSE

1969 ◽  
Vol 129 (4) ◽  
pp. 757-774 ◽  
Author(s):  
Nabih I. Abdou ◽  
Maxwell Richter
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Bone Marrow Cells ◽  
Allogeneic Bone Marrow ◽  
Red Cells ◽  
Allogeneic Bone ◽  
Sheep Red Blood Cells ◽  
Sheep Red Cells

Irradiated rabbits given allogeneic bone marrow cells from normal adult donors responded to an injection of sheep red blood cells by forming circulating antibodies. Their spleen cells were also capable of forming many plaques using the hemolysis in gel technique, and were also capable of undergoing blastogenesis and mitosis and of incorporating tritiated thymidine upon exposure to the specific antigen in vitro. However, irradiated rabbits injected with allogeneic bone marrow obtained from rabbits injected with sheep red blood cells 24 hr prior to sacrifice (primed donors) were incapable of mounting an immune response after stimulation with sheep red cells. This loss of reactivity by the bone marrow from primed donors is specific for the antigen injected, since the immune response of the irradiated recipients to a non-cross-reacting antigen, the horse red blood cell, is unimpaired. Treatment of the bone marrow donors with high-titered specific antiserum to sheep red cells for 24 hr prior to sacrifice did not result in any diminished ability of their bone marrow cells to transfer antibody-forming capacity to sheep red blood cells. The significance of these results, with respect to the origin of the antigen-reactive and antibody-forming cells in the rabbit, is discussed.

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