scholarly journals Design and Development of the Telescope-deployment High-vacuum teleOperated Rover (THOR) in an Airless Body Environment

2015 ◽  
Vol 12 (2) ◽  
Author(s):  
Chris Womack ◽  
Miles Crist ◽  
Laura Kruger ◽  
Kelsey DeGeorge ◽  
Karynna Tuan ◽  
...  
Keyword(s):  
Space Exploration ◽  
High Vacuum ◽  
Cost Effective ◽  
Extreme Environment ◽  
Design And Development ◽  
University Of Colorado ◽  
Lunar Environment ◽  
Commercial Off The Shelf ◽  
The University ◽  
Initial Results

The harsh environment on the lunar surface presents unique technological challenges for space exploration. This paper presents research on the design and development of the Telescope-deployment High-vacuum teleOperated Rover (THOR), currently being built and tested in the Lunar and Airless Bodies Simulator (LABS) facility at the University of Colorado Boulder. This rover is fabricated entirely out of cost-effective commercial off-the-shelf (COTS) components and materials. THOR can potentially survive for more than one simulated year in conditions similar to that of the lunar environment, demonstrating the successful initial results of a first phase research study on material and electronic survivability in an extreme environment such as the Moon. KEYWORDS: Telerobotics, Space Exploration, LUNAR, High-vacuum, Electronic Survivability, Robotics, Engineering

The 1-MeV Electron Microscope Installation at the University of Colorado

1973 ◽  
Vol 31 ◽  
pp. 8-9 ◽  
Author(s):  
Mircea Fotino
Keyword(s):  
Electron Microscopy ◽  
Developmental Biology ◽  
Transmission Electron Microscopy ◽  
Electron Microscope ◽  
National Institutes Of Health ◽  
Experimental Program ◽  
University Of Colorado ◽  
Transmission Electron ◽  
The University ◽  
Research Resources

A new 1-MeV transmission electron microscope (Model JEM-1000) was installed at the Department of Molecular, Cellular and Developmental Biology of the University of Colorado in Boulder during the summer and fall of 1972 under the sponsorship of the Division of Research Resources of the National Institutes of Health. The installation was completed in October, 1972. It is installed primarily for the study of biological materials without many of the limitations hitherto unavoidable in standard transmission electron microscopy. Only the technical characteristics of the installation are briefly reviewed here. A more detailed discussion of the experimental program under way is being published elsewhere.

Electrostatic optics and aberration correction in the 1940s and today

1992 ◽  
Vol 50 (1) ◽  
pp. 6-7
Author(s):  
Gertrude F. Rempfer
Keyword(s):  
Electron Microscope ◽  
Focal Point ◽  
Focal Length ◽  
High Vacuum ◽  
Electron Optics ◽  
Applied Physics ◽  
Electrostatic Lenses ◽  
Commercial Instrument ◽  
The University ◽  
Theory And Experiment

I became involved in electron optics in early 1945, when my husband Robert and I were hired by the Farrand Optical Company. My husband had a mathematics Ph.D.; my degree was in physics. My main responsibilities were connected with the development of an electrostatic electron microscope. Fortunately, my thesis research on thermionic and field emission, in the late 1930s under the direction of Professor Joseph E. Henderson at the University of Washington, provided a foundation for dealing with electron beams, high vacuum, and high voltage.At the Farrand Company my co-workers and I used an electron-optical bench to carry out an extensive series of tests on three-electrode electrostatic lenses, as a function of geometrical and voltage parameters. Our studies enabled us to select optimum designs for the lenses in the electron microscope. We early on discovered that, in general, electron lenses are not “thin” lenses, and that aberrations of focal point and aberrations of focal length are not the same. I found electron optics to be an intriguing blend of theory and experiment. A laboratory version of the electron microscope was built and tested, and a report was given at the December 1947 EMSA meeting. The micrograph in fig. 1 is one of several which were presented at the meeting. This micrograph also appeared on the cover of the January 1949 issue of Journal of Applied Physics. These were exciting times in electron microscopy; it seemed that almost everything that happened was new. Our opportunities to publish were limited to patents because Mr. Farrand envisaged a commercial instrument. Regrettably, a commercial version of our laboratory microscope was not produced.

Discourse Mapping

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Joanna BOEHNERT
Keyword(s):  
Environmental Politics ◽  
Technology Policy ◽  
Policy Research ◽  
Mapping Method ◽  
Science And Technology Policy ◽  
Design Practice ◽  
Analysis Method ◽  
Environmental Sciences ◽  
University Of Colorado ◽  
The University

This workshop will create a space for discussion on environmental politics and its impact on design for sustainable transitions. It will help participants identify different sustainability discourses; create a space for reflection on how these discourses influence design practice; and consider the environmental and social implications of different discourses. The workshop will do this work by encouraging knowledge sharing, reflection and interpretative mapping in a participatory space where individuals will create their own discourse maps. This work is informed by my research “Mapping Climate Communication” conducted at the Centre for Science and Technology Policy Research (CSTPR) in the Cooperative Institute for Environmental Sciences (CIRES), the University of Colorado, Boulder. With this research project I developed a discourse mapping method based on the discourse analysis method of political scientists and sustainability scholars. Using my own work as an example, I will facilitate a process that will enable participants to create new discourse maps reflecting their own ideas and agendas.

scholarly journals Assessing Genetic Variants in Matched Biocompartments From Patients With Serous Ovarian Cancer

2021 ◽  
Vol 20 ◽  
pp. 153303382110279
Author(s):  
Brooke E. Sanders ◽  
Lisa Ku ◽  
Paul Walker ◽  
Benjamin G. Bitler
Keyword(s):  
Ovarian Cancer ◽  
Genetic Variants ◽  
Mutant Allele ◽  
Serous Ovarian Cancer ◽  
Brca Testing ◽  
Panel Testing ◽  
University Of Colorado ◽  
Gene Panel Testing ◽  
The University ◽  
Tumor Profiling

The clinical use of molecular tumor profiling (MTP) is expanding and there is an increasing use of MTP data to manage patient care. At the University of Colorado, 18 patients were diagnosed with primary serous ovarian cancer between 9/2015 and 6/2019 and consented for banking and analysis of tumor, ascites and plasma. All 18 patients had tumor and plasma samples that were sent for MTP, and 13 of 18 patients additionally had ascites collected and sent for MTP. 50-gene panel testing and BRCA testing were performed on primary tumor. BRCA genetic variants were more likely to be identified in plasma as compared to ascites or tumor, though not statistically significant ( P = 0.17). Co-occurring genetic variants between plasma and ascites were less common in comparison to co-occurring variants between tumor and plasma or tumor and ascites, though not statistically significant ( P = 0.68). Variants in KDR (VEGFR2) and TP53 were most likely to be conserved across all 3 biocompartments. Mutant allele frequencies (MAF) of individual genetic variants varied across biocompartments, though tended to be highest in the tumor, followed by ascites.

Enhancing the application potential of dissipative controlled rocking connections through detailing and design

2021 ◽  
Author(s):  
Brandon McHaffie ◽  
Peter Routledge ◽  
Alessandro Palermo
Keyword(s):  
Linear Time ◽  
Time History ◽  
Cost Effective ◽  
Real Structure ◽  
Construction Costs ◽  
Alternative Design ◽  
Design Philosophy ◽  
History Analysis ◽  
Application Potential ◽  
The University

<p>Research on low-damage systems has been significant in the past decade. These systems combine post- tensioning, which provides self-centring; and typically use replaceable devices, which give energy dissipation. WSP has used recent research, carried out at the University of Canterbury, on low-damage bridge piers and applied this into a real structure – the Wigram-Magdala Link Bridge. This is believed to be the first bridge in New Zealand and possibly worldwide to adopt such a system. Given this was the first application of the system to a real structure, there were some valuable learnings during design and construction. Firstly, the application of axial dissipaters has some limitations due to available material sizes, construction difficulty and aesthetics. Secondly, there is still some additional cost and complexity associated with using the low-damage system. Given these difficulties, this paper presents an alternative design philosophy which better captures the benefits of the low-damage system, which include cost-effective repair method, controlled damage and additional robustness and resilience. The alternative design philosophy presented is expected to result in reduced construction costs by reducing pier and foundation demands. Peak displacements and forces will be compared to the results from non-linear time history analysis to verify the performance of the low-damage connection using scaled ground motions. Furthermore, the paper will present the possible application of an alternative dissipation device, the lead extrusion damper, which can further improve the performance of low-damage connections.</p>

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