scholarly journals Identification of the Molecular Basis of Anti-fibrotic Effects of Soluble Guanylate Cyclase Activator Using the Human Lung Fibroblast

2020 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Guanylate Cyclase ◽  
Molecular Basis ◽  
Human Lung ◽  
Soluble Guanylate Cyclase ◽  
Lung Fibroblast ◽  
Human Lung Fibroblast ◽  
Guanylate Cyclase Activator ◽  
Cyclase Activator

scholarly journals Identification of the Molecular Basis of Anti-fibrotic Effects of Soluble Guanylate Cyclase Activator Using the Human Lung Fibroblast Phosphoproteome

2020 ◽  
Author(s):  
Sunhwa Kim ◽  
Ashmita Saigal ◽  
Weilong Zhao ◽  
Peyvand Amini ◽  
Alex M. Tamburino ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Guanylate Cyclase ◽  
Molecular Basis ◽  
Transforming Growth Factor ◽  
Human Lung ◽  
Soluble Guanylate Cyclase ◽  
Guanosine Monophosphate ◽  
Lung Fibroblasts ◽  
Human Lung Fibroblast ◽  
Clinical Benefits

AbstractIdiopathic pulmonary fibrosis (IPF) is an irreversible and progressive fibrotic lung disease. Advanced IPF patients often demonstrate pulmonary hypertension, which severely impairs patients’ quality of life. The critical physiological roles of soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway have been well characterized in vasodilation and the corresponding therapies and pathway agonists have shown clinical benefits in treating hypertension. In recent years, many preclinical studies have demonstrated anti-fibrotic efficacy of sGC-cGMP activation in various experimental fibrosis models but the molecular basis of the efficacy in these models are not well understood. Also, sGC pathway agonism has demonstrated encouraging clinical benefits in advanced IPF patients (NCT00517933). Here, we have revealed the novel phosphorylation events downstream of sGC activation in human lung fibroblasts using phosphoproteomics. sGCact A, a potent and selective sGC activator, significantly attenuated more than 2,000 phosphorylation sites. About 20% of phosphorylation events, attenuated by transforming growth factor β (TGFβ), a master regulator of fibrosis, were further dysregulated in the sGCact A co-treated lung fibroblasts. The overall magnitude and diversity of the sGCact A phosphoproteome was extensive. Further investigation would be required to understand how these newly identified changes facilitate human pulmonary fibrosis.

scholarly journals Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)

2021 ◽  
Author(s):  
Michael G. Hahn ◽  
Thomas Lampe ◽  
Sherif El Sheikh ◽  
Nils Griebenow ◽  
Elisabeth Woltering ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Guanylate Cyclase Activator ◽  
Cyclase Activator

A Convenient Route to the Soluble Guanylate Cyclase Activator YC-1 and Its N2 Regioisomer

Heterocycles ◽  
2001 ◽  
Vol 55 (9) ◽  
pp. 1813 ◽  
Author(s):  
David L. Selwood ◽  
Patricia A. Fernandez ◽  
Tom Bellamy ◽  
Marcel Kling ◽  
David J. Madge
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Guanylate Cyclase Activator ◽  
Convenient Route ◽  
Cyclase Activator

Pharmacological characterisation of the relaxation induced by the soluble guanylate cyclase activator, BAY 60-2770 in rabbit corpus cavernosum

2015 ◽  
Vol 116 (4) ◽  
pp. 657-664 ◽  
Author(s):  
Camila S. Estancial ◽  
Renata L. Rodrigues ◽  
Gilberto De Nucci ◽  
Edson Antunes ◽  
Fabiola Z. Mónica
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Corpus Cavernosum ◽  
Rabbit Corpus Cavernosum ◽  
Guanylate Cyclase Activator ◽  
Cyclase Activator

scholarly journals Pharmacological activation of soluble guanylate cyclase activator protects the heart against isoproterenol-induced myocardial ischemia in rats

2009 ◽  
Vol 9 (S1) ◽  
Author(s):  
Sevil Korkmaz ◽  
Tamás Radovits ◽  
Enikő Barnucz ◽  
Kristóf Hirschberg ◽  
Philipp Neugebauer ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Guanylate Cyclase Activator ◽  
Cyclase Activator

scholarly journals Antiplatelet effects of aspirin are not affected by the soluble guanylate cyclase activator cinaciguat (BAY 58-2667)

2011 ◽  
Vol 11 (S1) ◽  
Author(s):  
Reiner Frey ◽  
Wolfgang Mueck ◽  
Michael Becka ◽  
Joern Kraetzschmar ◽  
Georg Wensing
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Guanylate Cyclase Activator ◽  
Cyclase Activator
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