Aloe vera plant products as antimicrobial agents

2019 ◽  
Vol 2 (2) ◽  
Keyword(s):  
Antimicrobial Agents ◽  
Aloe Vera ◽  
Plant Products

scholarly journals Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Biomimetics ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 45 ◽  
Author(s):  
Zehra Edis ◽  
Samir Haj Bloukh
Keyword(s):  
Antimicrobial Agents ◽  
Microstructural Analysis ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
Surgical Site Infections ◽  
Halogen Bonding ◽  
Polyglycolic Acid ◽  
Antimicrobial Activities ◽  
One Pot

Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly Aloe Vera Barbadensis Miller (AV)-iodine biomaterials as a new generation of antimicrobial agents. In a facile, one-pot synthesis, we encapsulated fresh AV gel with polyvinylpyrrolidone (PVP) as a stabilizing agent and incorporated iodine moieties in the form of iodine (I2) and sodium iodide (NaI) into the polymer matrix. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) verified the composition of AV-PVP-I2, AV-PVP-I2-NaI. AV, AV-PVP, AV-PVP-I2, AV-PVP-I2-NaI, and AV-PVP-NaI were tested in-vitro by disc diffusion assay and dip-coated on polyglycolic acid (PGA) sutures against ten microbial reference strains. All the tested pathogens were more susceptible towards AV-PVP-I2 due to the inclusion of “smart” triiodides with halogen bonding in vitro and on dip-coated sutures. The biocomplexes AV-PVP-I2, AV-PVP-I2-NaI showed remarkable antimicrobial properties. “Smart” biohybrids with triiodide inclusions have excellent antifungal and promising antimicrobial activities, with potential use against surgical site infections (SSI) and as disinfecting agents.

scholarly journals Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

2021 ◽  
Vol 9 (A) ◽  
pp. 946-954
Author(s):  
Paul Akinduti ◽  
Yemisi D. Obafemi ◽  
Patrick O. Isibor ◽  
Rapheal Ishola ◽  
Frank E. Ahuekwe ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Alternative Therapy ◽  
Aloe Vera ◽  
Antibacterial Activities ◽  
Viable Count ◽  
Resistant Bacteria ◽  
Aloe Barbadensis ◽  
Drug Candidates ◽  
Time Kill ◽  
Promising Avenue

Uncontrolled use of antibiotics has resulted in the emergence of resistant bacteria. It has necessitated the evaluation of antibacterial activities and phylo-diversity of Aloe vera (also called Aloe barbadensis) plants as antimicrobial agent in Nigeria. Biotyped enteric bacilli of 251 strains obtained from fecal samples of patients with various gastro-intestinal complications are profiled for antibiogram. Resistant biotypes were assayed for susceptibility to Aloe vera latex and further evaluated for time-kill kinetics and phylo-diversity. More than 30% of enteric bacilli, including Citrobacter freundii, Escherichia coli and Proteus mirabilis were resistant to cotrimoxazole, ciprofloxacin, and tetracycline respectively at MIC >16 µg/ml (p=0.004). Aloe vera latex significantly inhibited 39.5% resistant enteric biotypes with a significant average reduction of the viable count at 1xMIC and 2xMIC to less than 3.0 Log10CFU/mL after 24 hours. Flavonoids, alkaloids, terpenoids and anthraquinine in anti-enteric sap significantly correlated and regressed with antibacterial activity (p<0.05), while two of the antimicrobial Aloe vera plants showed phylogenetic relatedness with other homologous. Anti-bacteria efficacy of some Nigerian Aloe vera latex could provide alternative therapy, while its phylo-diversity and genomic profiling would offer a promising avenue for identification and development of antimicrobial agents as drug candidates for natural antibiotics.

Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced Dermatitis: First Review on the Clinical Studies

2021 ◽  
Vol 21 ◽  
Author(s):  
Faizan Kalekhan ◽  
Avinash K. Kudva ◽  
Shamprasad V. Raghu ◽  
Suresh Rao ◽  
Sanath K. Hegde ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Aloe Vera ◽  
Acute Radiation ◽  
Radiation Dermatitis ◽  
Protective Effects ◽  
Matricaria Chamomilla ◽  
Calendula Officinalis ◽  
Plant Products ◽  
Beneficial Effects ◽  
Curative Radiotherapy

: In the treatment of cancer, the use of ionizing radiation is an important modality. However, on the downside, radiation, when used for curative purposes, causes acute dermatitis or radiodermatitis at the site of radiation in most individuals. From a clinical viewpoint, severe dermatitis causes a burning and itching sensation is very painful, and severely affects the quality of life of the individual undergoing treatment. In worse situations, acute radiation dermatitis can cause gaps or breaks in the planned treatment and this can adversely affect the treatment objective and outcome. Background: In various traditional and folk systems of medicine, plants and plant products have been used since time immemorial for treating various skin ailments. Further, many cosmeceutical creams formulated based on knowledge from ethnomedicinal use are marketed and used to treat various ailments. In the current review, an attempt is made at summarizing the beneficial effects of some plants and plant products in mitigating acute radiation dermatitis in humans undergoing curative radiotherapy. Additionally, the emphasis is also placed on the mechanism/s responsible for the beneficial effects. Objective: The objective of this review is to summarize the clinical observations on the prevention of radiodermatitis by plant products. In this review, the protective effects of Adlay (Coix lachryma-jobi L.) bran extract, Aloe vera, Calendula officinalis, Cucumis sativus, green tea constituent the epigallocatechin-3-gallate, honey, Achillea millefolium, Matricaria chamomilla, olive oil and some polyherbal creams are addressed by also addressing on the mechanism of action for the beneficial effects. Methods: Two authors’ data mined for information in Google Scholar, PubMed, Embase and the Cochrane Library for publications in the field from 1901 up to July 2020. The focus was on acute radiation dermatitis, ionizing radiation, curative radiotherapy, human cancer. The articles were collected and analyzed. Results: For the first time, this review addresses the usefulness of natural products like adlay bran, Aloe vera, Calendula officinalis, Cucumis sativus, green tea constituent the epigallocatechin-3-gallate, honey, Achillea millefolium, Matricaria chamomilla, olive oil and some experimentally constituted and commercially available polyherbal creams as skincare agents against the deleterious effects of ionizing radiation on the skin. The protective effects are possibly due to the free radical scavenging, antioxidant, anti-inflammatory, wound healing and skin protective effects. Conclusion: The authors suggest that these plants have been used since antiquity as medicinal agents and require in-depth investigation with both clinical and preclinical validated models of study. The results of these studies will be extremely useful to cancer patients requiring curative radiotherapy, the dermatology fraternity, agro-based and pharmaceutical sectors at large.

scholarly journals Antibacterial Effects of Palm Wine (Elaeis guineensis) on Salmonella typhi Isolated from Different Sources

2019 ◽  
pp. 1-12
Author(s):  
O. C. Ojo ◽  
S. A. Agboola
Keyword(s):  
Antimicrobial Agents ◽  
Elaeis Guineensis ◽  
Salmonella Typhi ◽  
Antibacterial Effects ◽  
Natural Fermentation ◽  
Palm Wine ◽  
Plant Products ◽  
Palm Trees ◽  
Zones Of Inhibition ◽  
Different Sources

Background: Palm wine is a traditional alcoholic beverage produce by natural fermentation of the sap of palm trees. Palm wine is normally use traditionally for the extraction of active ingredients from leaves, barks and stems of some medicinal search for new antimicrobial agents. The discovery of new antimicrobial agents from different sources such as microorganisms, animals, plants and plant products has been the major challenge of researchers. Aims: This research work is to investigate the antibacterial effects of palm wine (Elaeis guineensis) on Salmonella typhi isolated from different sources. Study Design: The samples were collected overnight from palm trees (E. guineensis). And it was assayed for antibacterial activity on S. typhi isolated from different sources using Agar well diffusion method. The effect of dilution and fermentation duration of the palm wines on isolated S. typhi was also determined. Palm wine (E. guineensis) inhibited S. typhi isolated, with diameter zones of inhibition ranging from 6.33±0.67 to 39.33±0.33 mm respectively. Palm wine from both palm trees was found to be more active against S. typhi than the conventional antibiotics (Chloramphenicol, Amoxycillin, Gentamycin and Ciprofloxacin) used, with diameter zones of inhibition ranging from 1.00± 0.33 to 20.67±0.57. The greatest inhibitory effect was on S. typhi isolated from well water (6.67± 0.31 to 44.67± 0.67 mm), while the least effect was on S. typhi isolated from an apparently healthy individual with inhibition ranging from 7.33±0.33 to 29.67± 0.33 mm. Also, the growth inhibitory effects of both palm wines on all S. typhi isolates used increased with increase in period of fermentation with diameter zones of inhibition ranging from 15.67±0.67 to 44.33 ± 0.33 mm for palm wine from R. vinifera and 6.33±0.33to 39.33±0.33 mm for palm wine from E. guineensis. Conclusion: The discovery of new antimicrobial agents from different sources such as microorganisms, animals, plants and plant products has been the major challenge of researchers. It is conceivable therefore that palm wine subjected to natural fermentation could be used to treat infections caused by S. typhi that is typhoid fever.

scholarly journals Postharvest Application of Aloe vera Gel-Based Edible Coating to Improve the Quality and Storage Stability of Fresh-Cut Papaya

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Vittorio Farina ◽  
Roberta Passafiume ◽  
Ilenia Tinebra ◽  
Dario Scuderi ◽  
Filippo Saletta ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Antimicrobial Agents ◽  
Aloe Vera ◽  
Titratable Acidity ◽  
Solid Content ◽  
Soluble Solid Content ◽  
Aloe Vera Gel ◽  
Soluble Solid ◽  
Fresh Cut ◽  
Ripening Rate

Ready-to-eat products are damaged by various factors, including exposure to O2 and CO2, extreme temperatures, and rapid decay, due to trauma during processing. The use of natural antimicrobial agents and antioxidants might extend the shelf-life of the fruits. The aim of this work is to investigate the effects of four different antibrowning and gelling agents added into the Aloe vera gel-based edible coatings and applied to fresh-cut papaya. EC1 treatment consists of Aloe vera gel (30% v/v), EC2 contains CaCl2 (5% v/v), EC3 contains K carrageenan (0.5% v/v), and EC4 contains sodium alginate (1.5% v/v) and K carrageenan (0.5% v/v). The fruits treated with EC2 showed the best results while maintaining high values in terms of firmness (that differ from the control of 42.5%), soluble solid content (that differ from the control of 14.6%), and titratable acidity (that differ from the control of 49%). Hence, the addition of CaCl2 also reduces the ripening rate and loss of color without altering the product’s sensory qualities. EC3 and EC4 treatments have provided an oxygen barrier and reduced respiratory rate, increasing the firmness retention and keeping a high C∗ value thanks to K carrageenan and sodium alginate.

scholarly journals Effects of Extracts of Feed Additives Including Rosemary (Rosmarinus officinalis) and Aloe Vera (Aloe barbadensis) on the Growth Performance and Feed Utility of Nile Tilapia (Oreochromis niloticus)

2019 ◽  
Vol 7 (6) ◽  
pp. 866 ◽  
Author(s):  
Ebru Yılmaz ◽  
Deniz Çoban ◽  
Birsen Kırım ◽  
Mehmet Güler
Keyword(s):  
Growth Performance ◽  
Oreochromis Niloticus ◽  
Antimicrobial Agents ◽  
Aloe Vera ◽  
Rosmarinus Officinalis ◽  
Feed Additives ◽  
Rosemary Extract ◽  
Hepatosomatic Index ◽  
Experimental Diet ◽  
Aloe Barbadensis

This study was performed to determine the effects of the extracts of two alternative antimicrobial agents that do not harm the ecosystem (rosemary, Rosmarinus officinalis and aloe vera, Aloe barbadensis) when added to the feed of tilapia (Oreochromis niloticus) on the growth performance, proximate composition, and biometric characteristics. Rosemary extract was added to the experimental diet in ratios of 0.1%, 0.25%, and 0.5% while aloe vera extract was added to the experimental diet in ratios of 0.5%, 1%, and 2.5%. After 90 days of the feeding trial, no change was seen in the weight increase, specific growth rate, feed conversion ratio, condition factor, hepatosomatic index, or viscerosomatic index of the tilapia. The fact that proximate analyses did not differ between groups showed that the plant extracts did not adversely affect the health status of tilapia in the ratios used in this study. As a result, the addition of 0.1%, 0.25%, and 0.5% rosemary extract and the addition of 0.5%, 1%, and 2.5% aloe vera extract to tilapia feeds did not cause changes in the growth performance, biometric indexes, or chemical composition findings of the fish meat.

In vitro evaluation of antibacterial effect of combination of honey and Aloe vera extract against Enterococcus faecalis and Escherichia coli

2021 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Paria Motahari ◽  
Hossein Samadi Kafil ◽  
Zahra Taheri Bonab
Keyword(s):  
Escherichia Coli ◽  
Enterococcus Faecalis ◽  
Antimicrobial Agents ◽  
Antibacterial Effect ◽  
Aloe Vera ◽  
Inhibitory Effect ◽  
New Drugs ◽  
Colony Count ◽  
Significant Difference

Antimicrobial agents are used as intra-canal drugs or canal cleaners for complete dental root canal cleaning. This new study attempts to compare the antibacterial effect of 2% chlorhexidine and combination of honey and Aloe vera extract (H-Av mixture) against Enterococcus faecalis (E.faecalis) and Escherichia coli (E.coli) which are the most important pathogens isolated from infectious root canals. Enterococcus faecalis (ATCC® 29212™) and Escherichia coli (ATCC® 25922™) were cultured in the tryptic soy broth medium. Dilution of H-Av mixture by the method of macrodilution to determine Minimum Inhibitory Concentration was investigated. In this paper agar well diffusion and colony count methods were also used to ensure the accuracy of the results. The results were statistically analyzed by student’s t-test. The significant level established at 5% (P<0.05). The results of the methods of macrodilution, colony count and Agar well diffusion confirm the inhibitory effect of H-Av mixture on E.coli and E. fecalis. Statistically, there was no significant difference between the antibacterial effect of 2% chlorhexidine and 25% H-Av mixture (P>0.05) Increasing drug resistance to antimicrobial compounds needs to study of new drugs against pathogens. H-Av mixture with benefits such as availability, good taste and easier use than chlorhexidine, and fewer side effects can be a good option for intracanal irrigation after clinical trials.

scholarly journals Aloe Vera (Aloe barbadensis Miller) Extract as a Natural Antimicrobial Agent in Hand-Washing Liquid Soap

2019 ◽  
Vol 1 ◽  
pp. 96-107
Author(s):  
A T Tyowua ◽  
T B Vitalis ◽  
M M Terhemen ◽  
E M Mbaawuaga
Keyword(s):  
Antimicrobial Agent ◽  
Antimicrobial Agents ◽  
Soap Solution ◽  
Skin Irritation ◽  
Aloe Vera ◽  
Coconut Oil ◽  
Hand Washing ◽  
Liquid Soap ◽  
Aloe Barbadensis

Synthetic antimicrobial agents, like triclosan, used in many cosmetics are now associated with serious health problems, beginning with skin irritation to cancer. This calls for alternative antimicrobial agents. Many plant extracts have the potential to inhibit the growth of microorganisms and perhaps kill them and thus can serve as alternative antimicrobial agents in cosmetic formulations. To demonstrate this, a hand-washing liquid soap was prepared in the presence of varying concentrations of aloe vera extract and tested in-vitro against common skin microbes. First, a liquid soap paste was prepared by saponifying a vegetable oil blend containing olive oil (80.0 %w/w), coconut oil (14.3 %w/w) and castor oil (5.7 %w/w) with aqueous KOH solution (22.5 %w/w) at a relatively high temperature (200 °C). Second, the soap paste was diluted with distilled water in the presence of varying concentrations (0 to 66.67 %w/w) of aloe vera extract to obtain hand-washing liquid soap samples, with the extract acting as an antimicrobial agent. Third, the liquid soap solutions were characterised in terms of foaming, wetting and cleansing abilities and the ability to inhibit the growth of Staphylococcus aureus, Pseudomonas aeruginosa and the fungus Aspergillus flavus. These were compared with those of a commercial (Astonish) hand-washing liquid soap sample containing triclosan (0.1 %w/w) as an antimicrobial agent. The liquid soap solutions exhibited excellent foaming, wetting and cleansing abilities, similar to the commercial liquid soap solution. In addition, the liquid soap solutions gave an average zone of inhibition between 9.0±0.3 mm and 11.0±0.2 mm for S. aureus, 7.0±0.1 mm and 10.0±0.2 mmfor P. aeruginosa and also inhibited the growth of the fungus A. flavus. These results compare favourably ( p= 0.05)with the commercial liquid soap solution, which gave an average inhibition zone of 9.00±1 mmfor both bacteria and also inhibited the growth of the fungus. This indicates that aloe vera extract can be used as an antimicrobial agent in the formulation of antimicrobial hand-washing liquid soap and other related products, rather than synthetic agents which are inherently harmful.

scholarly journals Topical treatment of Klebsiella pneumoniae B5055 induced burn wound infection in mice using natural products

2010 ◽  
Vol 4 (06) ◽  
pp. 367-377 ◽  
Author(s):  
Seema Kumari ◽  
Kusum Harjai ◽  
Sanjay Chhibber
Keyword(s):  
Klebsiella Pneumoniae ◽  
Wound Infection ◽  
Antimicrobial Agents ◽  
Aloe Vera ◽  
Burn Wound ◽  
Additional Advantage ◽  
Specific Phage ◽  
Aloe Vera Gel ◽  
Therapeutic Value ◽  
Daily Application

Background: Burn wound infection remains the principal cause of death in burn patients. Efficacy of honey and aloe vera gel was evaluated in the treatment of burn wound infection induced with Klebsiella pneumoniae B5055 and their efficacy was compared with an isolated and well-characterized Klebsiella specific phage Kpn5. Methodology: A full thickness burn wound was induced in mice and infected with K. pneumoniae B5055 via topical route. The efficacy of natural antimicrobial agents (honey and aloe vera gel) topically applied daily was compared with the efficacy of phage Kpn5 suspended in hydrogel applied topically a single time on the burn wound. Efficacy of these antimicrobial agents was assessed on the basis of the percentage of infected mice that survived following treatment. Results: In comparison to untreated control mice, those treated with a single dose of phage Kpn5 at MOI of 200 showed significant reduction in mortality (P < 0.001). Daily application of honey and aloe vera gel provided significant protection (P < 0.001), but in combination with phage, no additional advantage was observed (P > 0.05) compared to the use of honey and aloe vera gel alone. Conclusions: The results of this study strongly suggest that phage Kpn5 has therapeutic value in treating burn wound infection in mice as a single topical application of this phage was able to rescue mice from infection caused by K. pneumoniae B5055 in comparison to multiple applications of honey and aloe vera gel.

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