Reversible Time as Habitation in the Recent Poetry of Mei-mei Berssenbrugge

2018 ◽  
Vol 59 (4) ◽  
pp. 413-446
Author(s):  
EDWARD ALEXANDER
Keyword(s):  
Reversible Time

Krankenkarriere und Existenzbelastung

1976 ◽  
Vol 5 (3) ◽  
Author(s):  
Uta Gerhardt
Keyword(s):  
San Francisco ◽  
Family Relations ◽  
Theory Approach ◽  
Financial Cost ◽  
Financial Status ◽  
Time Perspectives ◽  
Impact On Family ◽  
Reversible Time ◽  
Analytical Category ◽  
Grounded Theory Approach

AbstractA sociological notion of illness is introduced which focuses on extra-medical aspects of the illness processes. As a central analytical category of the sociological notion of illness, the stress upon the individual’s social- financial status has three aspects, namely financial cost, loss or change of job, and impact on family relations. Illness forms a multidimensional career structuring a process of vague and reversible time perspectives. An exploratory study of patient careers (University of California,San Francisco Medical Centre) is described with two aims: first, to clarify the theoretical notions, and, second, to develop a method of dynamic data analysis which owes much to the „Grounded-Theory“ approach.

scholarly journals Energy drift in reversible time integration

2004 ◽  
Vol 37 (45) ◽  
pp. L593-L598 ◽  
Author(s):  
R I McLachlan ◽  
M Perlmutter
Keyword(s):  
Time Integration ◽  
Reversible Time

Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells

1994 ◽  
Vol 266 (1) ◽  
pp. C254-C268 ◽  
Author(s):  
A. P. Morris ◽  
S. A. Cunningham ◽  
A. Tousson ◽  
D. J. Benos ◽  
R. A. Frizzell
Keyword(s):  
Epithelial Cells ◽  
Apical Membrane ◽  
Brefeldin A ◽  
Microtubule Organizing Center ◽  
Cl Secretion ◽  
Organizing Center ◽  
Reversible Time ◽  
Golgi Network ◽  
Ht 29 ◽  
Cl Conductance

The relationship between adenosine 3',5'-cyclic monophosphate (cAMP)-mediated Cl- secretion and the cellular location of the cystic fibrosis transmembrane conductance regulator (CFTR) was determined in both polarized (Cl.19A) and unpolarized (parental) HT-29 colonocytes expressing similar levels of CFTR mRNA and protein. CFTR immunolocalized to the apical membrane domain of polarized colonocytes exhibiting cAMP-responsive Cl- secretion. In contrast, CFTR staining was perinuclear in unpolarized colonocytes, which gave little or no cAMP-stimulated Cl- conductance responses. Thus cAMP-stimulated Cl- secretion coincided with an apical localization of CFTR. Brefeldin A (BFA) was used to perturb glycoprotein targeting in these cells. In polarized colonocytes, BFA caused a reversible, time-dependent decrease in the Cl-conductance response to cAMP but not Ca2+. Apical CFTR redistributed into large coalesced intracellular vesicles, located within the same plane as the microtubule organizing center, a marker for the trans-Golgi network (TGN). In preconfluent monolayers or unpolarized HT-29 cells, BFA had no effect on CFTR staining, which remained perinuclear. Mature, Golgi-processed CFTR protein was isolated from both polarized and unpolarized colonocytes. Thus the mechanism for polarization-dependent apical membrane CFTR targeting and the acquisition of cAMP-dependent Cl- secretion lies at or beyond the late Golgi-TGN in epithelial cells.

scholarly journals Reversible time travel with freedom of choice

2019 ◽  
Vol 36 (22) ◽  
pp. 224002
Author(s):  
Ämin Baumeler ◽  
Fabio Costa ◽  
Timothy C Ralph ◽  
Stefan Wolf ◽  
Magdalena Zych
Keyword(s):  
Time Travel ◽  
Freedom Of Choice ◽  
Reversible Time

Characterization of cholecystokinin binding sites in goldfish brain and pituitary

1996 ◽  
Vol 271 (1) ◽  
pp. R137-R143 ◽  
Author(s):  
B. A. Himick ◽  
S. R. Vigna ◽  
R. E. Peter
Keyword(s):  
Binding Sites ◽  
Hormone Secretion ◽  
Pituitary Hormone ◽  
Tissue Sections ◽  
High Affinity ◽  
Hypothalamic Nuclei ◽  
High Affinity Binding Site ◽  
Vagal Lobe ◽  
Feeding Center ◽  
Reversible Time

The characterization and distribution of cholecystokinin (CCK)/gastrin binding sites were determined in the goldfish central nervous system (CNS). Binding of 125I-sulfated CCK octapeptide (125I-CCK-8s) in tissue sections was found to be saturable, reversible, time dependent, and displaceable by CCK/gastrin-like peptides. Analysis of saturable equilibrium binding revealed a high-affinity binding site (dissociation constant of 0.706 +/- 0.188 nM), which also displayed high affinity for gastrin-17s and caerulein. Lower affinities were observed for the nonsulfated forms of CCK-8 and gastrin-17. These findings suggest that a single primitive CCK/gastrin receptor exists in the goldfish CNS. The distribution of CCK/gastrin binding sites in the goldfish brain and pituitary revealed high densities within the telencephalon and preoptic hypothalamus, as well as within hypothalamic nuclei associated with the brain feeding center. High densities of binding sites were also localized within the midbrain tegmentum and optic tectum of the midbrain, the facial lobe and vagal lobe of the hindbrain, and within the pituitary pars distalis. Overall, these findings support previous studies that indicate that CCK/gastrin-like peptides play a role in the central regulation of feeding behavior and pituitary hormone secretion in fish.

On the Nonlocality of Reversible-Time Particle Tracking Methods

2003 ◽  
Vol 4 (3) ◽  
pp. 215-225 ◽  
Author(s):  
Amvrossios C. Bagtzoglou
Keyword(s):  
Particle Tracking ◽  
Reversible Time

scholarly journals Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+.

1984 ◽  
Vol 98 (3) ◽  
pp. 1082-1089 ◽  
Author(s):  
C P Burns ◽  
E Rozengurt
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Dna Synthesis ◽  
Cellular Proliferation ◽  
Weak Acid ◽  
Mechanisms Of Action ◽  
Epidermal Growth ◽  
Reversible Time ◽  
Stimulation Of

Initiation of DNA synthesis in confluent quiescent 3T3 cell cultures stimulated by epidermal growth factor (EGF), vasopressin, and insulin was abolished by removing extracellular Na+. The inhibition was reversible, time- and Na+-concentration-dependent, and not due to an effect on binding or internalization of 125I-EGF. Stimulation by combinations of other growth factors with different mechanisms of action was also affected by decreasing extracellular Na+, but with different half-maximal Na+ concentrations. When choline was used as an osmotic substitute for Na+, the decrease in DNA synthesis was correlated with the decrease in intracellular K+. In contrast, when sucrose was used there was stimulation of the Na+-K+ pump and maintenance of intracellular K+ that resulted in a somewhat higher rate of DNA synthesis at lowered extracellular Na+ compared to choline. Mitogenesis induced by epidermal growth factor, vasopressin, and insulin led to cytoplasmic alkalinization as determined by an increase in uptake of the weak acid 5,5-dimethyloxazolidine-2,4-dione. Experimental decrease in extracellular Na+ blocked this cellular alkalinization. Therefore, under some conditions the supply of extracellular Na+ may limit cellular proliferation because of a reduction in the provision of Na+ to the Na+/H+ antiport and resultant failure of alkalinization. We conclude that Na+ flux and its effect on intracellular K and pH has a major role in the complex system that regulates proliferation.

Graphical representation of survival curves associated with a binary non-reversible time dependent covariate

1992 ◽  
Vol 11 (4) ◽  
pp. 455-474 ◽  
Author(s):  
Eric J. Feuer ◽  
Benjamin F. Hankey ◽  
Jeffrey J. Gaynor ◽  
Margaret N. Wesley ◽  
Stuart G. Baker ◽  
...  
Keyword(s):  
Graphical Representation ◽  
Time Dependent ◽  
Survival Curves ◽  
Reversible Time
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