scholarly journals Oxide synthase donor gene polymorphisms and cardiac graft coronary artery disease

Cor et Vasa ◽  
2009 ◽  
Vol 51 (3) ◽  
pp. 202-209
Author(s):  
Miroslav Kocík ◽  
Jaroslav Hubáček ◽  
Ivan Málek ◽  
Bronislav Janek ◽  
Michael Želízko ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Artery Disease ◽  
Oxide Synthase ◽  
Donor Gene ◽  
Cardiac Graft

scholarly journals Associations between endothelial nitric oxide synthase gene polymorphisms and the risk of coronary artery disease: A systematic review and meta-analysis of 132 case-control studies

2018 ◽  
Vol 26 (2) ◽  
pp. 160-170 ◽  
Author(s):  
Xiaoqing Li ◽  
Yong Lin ◽  
Ruizhi Zhang
Keyword(s):  
Nitric Oxide ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Coronary Syndrome ◽  
Artery Disease ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

The roles of endothelial nitric oxide synthase gene polymorphisms in coronary artery disease have been intensively analyzed, with inconsistent results. Therefore, we performed this study to better assess the relationship between endothelial nitric oxide synthase genetic variations and the risk of coronary artery disease. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to evaluate associations between endothelial nitric oxide synthase polymorphisms and coronary artery disease. A total of 132 genetic association studies were finally included. Significant associations with the risk of coronary artery disease were detected for the rs891512, rs1799983, rs2070744, rs11771443 and rs869109213 polymorphisms. Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians. When we stratified data based on type of disease, we found that the rs1799983, rs2070744 and rs869109213 polymorphisms were all significantly correlated with the risk of myocardial infarction or acute coronary syndrome in certain genetic models. In conclusion, our findings indicate that the rs891512, rs1799983, rs2070744, rs11771443 and rs869109213 polymorphisms may serve as genetic biomarkers of coronary artery disease.

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