scholarly journals The Deletion of TRPC6 Channels Perturbs Iron and Zinc Homeostasis and Pregnancy Outcome in Mice

2019 ◽  
Vol 52 (3) ◽  
pp. 455-467 ◽  
Keyword(s):  
Pregnancy Outcome ◽  
Zinc Homeostasis ◽  
Iron And Zinc

scholarly journals Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption?

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1885 ◽  
Author(s):  
Palsa Kondaiah ◽  
Puneeta Singh Yaduvanshi ◽  
Paul A Sharp ◽  
Raghu Pullakhandam
Keyword(s):  
Iron Absorption ◽  
Iron Status ◽  
The Body ◽  
Zinc Homeostasis ◽  
Iron Accumulation ◽  
Intestinal Cell ◽  
Deficiency Anemia ◽  
Intestinal Iron Absorption ◽  
Tissue Iron ◽  
Iron And Zinc

Iron and zinc are essential micronutrients required for growth and health. Deficiencies of these nutrients are highly prevalent among populations, but can be alleviated by supplementation and food fortification. Cross-sectional studies in humans showed positive association of serum zinc levels with hemoglobin and markers of iron status. Dietary restriction of zinc or intestinal specific conditional knock out of ZIP4 (SLC39A4), an intestinal zinc transporter, in experimental animals demonstrated iron deficiency anemia and tissue iron accumulation. Similarly, increased iron accumulation has been observed in cultured cells exposed to zinc deficient media. These results together suggest a potential role of zinc in modulating intestinal iron absorption and mobilization from tissues. Studies in intestinal cell culture models demonstrate that zinc induces iron uptake and transcellular transport via induction of divalent metal iron transporter-1 (DMT1) and ferroportin (FPN1) expression, respectively. It is interesting to note that intestinal cells are exposed to very high levels of zinc through pancreatic secretions, which is a major route of zinc excretion from the body. Therefore, zinc appears to be modulating the iron metabolism possibly via regulating the DMT1 and FPN1 levels. Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.

scholarly journals Dissection of Molecular Processes and Genetic Architecture Underlying Iron and Zinc Homeostasis for Biofortification: From Model Plants to Common Wheat

2020 ◽  
Vol 21 (23) ◽  
pp. 9280
Author(s):  
Jingyang Tong ◽  
Mengjing Sun ◽  
Yue Wang ◽  
Yong Zhang ◽  
Awais Rasheed ◽  
...  
Keyword(s):  
Wheat Genome ◽  
Zinc Homeostasis ◽  
Molecular Processes ◽  
Physiological Mechanisms ◽  
Sequencing Technologies ◽  
Zn Homeostasis ◽  
Iron And Zinc ◽  
Trait Locus ◽  
Edible Parts ◽  
Generation Sequencing

The micronutrients iron (Fe) and zinc (Zn) are not only essential for plant survival and proliferation but are crucial for human health. Increasing Fe and Zn levels in edible parts of plants, known as biofortification, is seen a sustainable approach to alleviate micronutrient deficiency in humans. Wheat, as one of the leading staple foods worldwide, is recognized as a prioritized choice for Fe and Zn biofortification. However, to date, limited molecular and physiological mechanisms have been elucidated for Fe and Zn homeostasis in wheat. The expanding molecular understanding of Fe and Zn homeostasis in model plants is providing invaluable resources to biofortify wheat. Recent advancements in NGS (next generation sequencing) technologies coupled with improved wheat genome assembly and high-throughput genotyping platforms have initiated a revolution in resources and approaches for wheat genetic investigations and breeding. Here, we summarize molecular processes and genes involved in Fe and Zn homeostasis in the model plants Arabidopsis and rice, identify their orthologs in the wheat genome, and relate them to known wheat Fe/Zn QTL (quantitative trait locus/loci) based on physical positions. The current study provides the first inventory of the genes regulating grain Fe and Zn homeostasis in wheat, which will benefit gene discovery and breeding, and thereby accelerate the release of Fe- and Zn-enriched wheats.

scholarly journals The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e78351 ◽  
Author(s):  
Agnese Serafini ◽  
Davide Pisu ◽  
Giorgio Palù ◽  
G. Marcela Rodriguez ◽  
Riccardo Manganelli
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Secretion System ◽  
Zinc Homeostasis ◽  
Iron And Zinc

scholarly journals Correction: The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Agnese Serafini ◽  
Davide Pisu ◽  
Giorgio Palù ◽  
G. Marcela Rodriguez ◽  
Riccardo Manganelli
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Secretion System ◽  
Zinc Homeostasis ◽  
Iron And Zinc

An Omics Study of Iron and Zinc Homeostasis in Finger Millet: Biofortified Foods for Micronutrient Deficiency in an Era of Climate Change?

2020 ◽  
Vol 24 (12) ◽  
pp. 688-705
Author(s):  
Ajay Kumar Chandra ◽  
Dinesh Pandey ◽  
Apoorv Tiwari ◽  
Divya Sharma ◽  
Aparna Agarwal ◽  
...  
Keyword(s):  
Climate Change ◽  
Finger Millet ◽  
Micronutrient Deficiency ◽  
Zinc Homeostasis ◽  
Iron And Zinc

A FIT-binding protein is involved in modulating iron and zinc homeostasis in Arabidopsis

2018 ◽  
Vol 41 (7) ◽  
pp. 1698-1714 ◽  
Author(s):  
Chun-Lin Chen ◽  
Yan Cui ◽  
Man Cui ◽  
Wen-Juan Zhou ◽  
Hui-Lan Wu ◽  
...  
Keyword(s):  
Binding Protein ◽  
Zinc Homeostasis ◽  
Iron And Zinc
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