scholarly journals Erratum of the article: KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DANN Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in Adult T-Cell Leukemia-Lymphoma Cells

2019 ◽  
Vol 52 (6) ◽  
pp. 1588-1588
Keyword(s):  
T Cell ◽  
Homologous Recombination ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
End Joining ◽  
Lymphoma Cells ◽  
Adult T Cell Leukemia ◽  
Damage Repair ◽  
Non Homologous End Joining

scholarly journals KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in Adult T-Cell Leukemia-Lymphoma Cells

2018 ◽  
Vol 49 (6) ◽  
pp. 2111-2123 ◽  
Author(s):  
Wenlei Yu ◽  
Liang Li ◽  
Guangming Wang ◽  
Wenjun Zhang ◽  
Jun Xu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Homologous Recombination ◽  
Jurkat Cells ◽  
Cell Leukemia ◽  
End Joining ◽  
Adult T Cell Leukemia ◽  
Damage Repair ◽  
Repair Efficiency ◽  
Promising Target ◽  
Non Homologous End Joining

Background/Aims: Adult T-cell leukemia-lymphoma (ATL) is an aggressive disease which is highly resistant to chemotherapy. Studies show that enhanced ability of DNA damage repair (DDR) in cancer cells plays a key role in chemotherapy resistance. Here, we suggest that defect in DDR related genes might be a promising target to destroy the genome stability of tumor cells. Methods: Since KU70 is highly expressed in Jurkat cells, one of the most representative cell lines of ATL, we knocked down KU70 by shRNA and analyzed the impact of KU70 deficiency in Jurkat cells as well as in NOD-SCID animal models by western blot, immunofluorescence, flow cytometry and measuring DNA repair efficiency. Results: It is observed that silencing of KU70 resulted in accumulated DNA damage and impaired DDR in Jurkat cells, resulting in more apoptosis, decreased cell proliferation and cell cycle arrest. DNA damage leads to DNA double-strand breaks (DSBs), which are processed by either non-homologous end joining(NHEJ) or homologous recombination(HR). In our study, both NHEJ and HR are impaired because of KU70 defect, accompanied with increased protein level of SHP-1, a dephosphorylation enzyme. In turn, SHP-1 led to dephosphorylation of SIRT1, which further impaired HR repair efficiency. Moreover, KU70 deficiency prolonged survival of Jurkat-xenografted mice. Conclusion: These findings suggest that targeting KU70 is a promising target for ATL and might overcome the existing difficulties in chemotherapy.

scholarly journals Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells

2016 ◽  
Vol 22 (23) ◽  
pp. 5915-5928 ◽  
Author(s):  
Kazumi Nakano ◽  
Kaoru Uchimaru ◽  
Atae Utsunomiya ◽  
Kazunari Yamaguchi ◽  
Toshiki Watanabe
Keyword(s):  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Lymphoma Cells ◽  
Aberrant Expression ◽  
Adult T Cell Leukemia

scholarly journals Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells

2005 ◽  
Vol 96 (8) ◽  
pp. 527-533 ◽  
Author(s):  
Tomoko Kohno ◽  
Yasuaki Yamada ◽  
Norihiko Akamatsu ◽  
Simeru Kamihira ◽  
Yoshitaka Imaizumi ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Virus Type ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Lymphoma Cells ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia

scholarly journals SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair

2015 ◽  
Vol 34 (6) ◽  
pp. 2935-2942 ◽  
Author(s):  
LIANG LI ◽  
SHIGUANG YE ◽  
MENG YANG ◽  
WENLEI YU ◽  
ZHUOYI FAN ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Lymphoma Cells ◽  
Adult T Cell Leukemia

Regulatory T-cell function of adult T-cell leukemia/lymphoma cells

2007 ◽  
Vol 120 (9) ◽  
pp. 2052-2057 ◽  
Author(s):  
Hiroki Yano ◽  
Takashi Ishida ◽  
Atsushi Inagaki ◽  
Toshihiko Ishii ◽  
Shigeru Kusumoto ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Cell Function ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Lymphoma Cells ◽  
Adult T Cell Leukemia ◽  
T Cell Function

scholarly journals Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells

2011 ◽  
Vol 52 (6) ◽  
pp. 1108-1117 ◽  
Author(s):  
Hiroo Hasegawa ◽  
Minori Komoda ◽  
Yasuaki Yamada ◽  
Suguru Yonezawa ◽  
Hideaki Tsutsumida ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Progression ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Lymphoma Cells ◽  
Adult T Cell Leukemia
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