Adaptación y validación del Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities (CAMDEX-DS) en población española con discapacidad intelectual

2013 ◽  
Vol 57 (08) ◽  
pp. 337 ◽  
Author(s):  
Susanna Esteba Castillo ◽  
Albert Dalmau Bueno ◽  
Núria Ribas Vidal ◽  
Marta Vilà Alsina ◽  
Ramon Novell Alsina ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Older People ◽  
Intellectual Disabilities ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Discapacidad Intelectual

scholarly journals Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

BJPsych Open ◽  
2021 ◽  
Vol 7 (3) ◽  
Author(s):  
Jessica A. Beresford-Webb ◽  
Elijah Mak ◽  
Monika Grigorova ◽  
Samuel J. Daffern ◽  
Anthony J. Holland ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Mental Disorders ◽  
Older People ◽  
Intellectual Disabilities ◽  
Down’S Syndrome ◽  
Healthy Adults ◽  
Prodromal Alzheimer’S Disease ◽  
Alzheimer’S Disease Dementia

Background Diagnosis of prodromal Alzheimer's disease and Alzheimer's disease dementia in people with Down syndrome is a major challenge. The Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS) has been validated for diagnosing prodromal Alzheimer's disease and Alzheimer's disease dementia, but the diagnostic process lacks guidance. Aims To derive CAMDEX-DS informant interview threshold scores to enable accurate diagnosis of prodromal Alzheimer's disease and Alzheimer's disease dementia in adults with Down syndrome. Method Psychiatrists classified participants with Down syndrome into no dementia, prodromal Alzheimer's disease and Alzheimer's disease dementia groups. Receiver operating characteristic analyses assessed the diagnostic accuracy of CAMDEX-DS informant interview-derived scores. Spearman partial correlations investigated associations between CAMDEX-DS scores, regional Aβ binding (positron emission tomography) and regional cortical thickness (magnetic resonance imaging). Results Diagnostic performance of CAMDEX-DS total scores were high for Alzheimer's disease dementia (area under the curve (AUC), 0.998; 95% CI 0.953–0.999) and prodromal Alzheimer's disease (AUC = 0.954; 95% CI 0.887–0.982) when compared with healthy adults with Down syndrome. When compared with those with mental health conditions but no Alzheimer's disease, CAMDEX-DS Section B scores, denoting memory and orientation ability, accurately diagnosed Alzheimer's disease dementia (AUC = 0.958; 95% CI 0.892–0.984), but were unable to diagnose prodromal Alzheimer's disease. CAMDEX-DS total scores exhibited moderate correlations with cortical Aβ (r ~ 0.4 to 0.6, P ≤ 0.05) and thickness (r ~ −0.4 to −0.44, P ≤ 0.05) in specific regions. Conclusions CAMDEX-DS total score accurately diagnoses Alzheimer's disease dementia and prodromal Alzheimer's disease in healthy adults with Down syndrome.

Differential Rates of Psychiatric Disorders in Adults with Down's Syndrome Compared with Other Mentally Handicapped Adults

1992 ◽  
Vol 161 (5) ◽  
pp. 671-674 ◽  
Author(s):  
Richard A. Collacott ◽  
Sally-Ann Cooper ◽  
Catherine McGrother
Keyword(s):  
Personality Disorder ◽  
Mental Disorders ◽  
Conduct Disorder ◽  
Psychiatric Disorders ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mentally Handicapped ◽  
Mental Handicap

The total number of adults with Down's syndrome living in Leicestershire, ascertained by widespread enquiry, was found to be 378. Of these, 371 were matched with adults with mental handicap due to other pathologies, on the basis of age, sex, and type of residence. Those with Down's syndrome were found to have a different spectrum of mental disorders from those without the syndrome. In particular, Down's syndrome patients were more likely to have been diagnosed as having depression and dementia; the controls were more likely to have been diagnosed as suffering from conduct disorder, personality disorder, or schizophrenia/paranoid state. The same proportion of each group had been given a diagnosis of autism.

The influence of intellectual disability on longitudinal arching and symmetry of lateral and medial load of the foot

2019 ◽  
Vol 6 (1) ◽  
pp. 29-34
Author(s):  
Marta Bibro ◽  
Agnieszka Jankowicz-Szymańska ◽  
Katarzyna Wódka ◽  
Małgorzata Łaczek-Wójtowicz
Keyword(s):  
Intellectual Disability ◽  
Intellectual Disabilities ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Control Group ◽  
Functional Efficiency ◽  
Flat Feet ◽  
People With Intellectual Disabilities ◽  
The Right ◽  
The Impact

Background: In the population of people with intellectual disabilities (ID) there is a frequent occurrence of bone deformities and orthopedic problems affecting the feet as well. They are associated with a change of the loading of the feet. It affects the deterioration of the functional efficiency of the feet, often contributes to discomfort, pain and predisposes to the development of adverse changes in the upper body segments. The aim of the study was to assess the impact of intellectual disability in participants with aetiology other than Down’s syndrome on longitudinal arching and symmetry of lateral and medial load of the foot. Materials and methods: There were 38 participants with mild and moderate intellectual disability, with an average age of 23 years and 44 young non-disabled people with an average age of 20.8 under research. The main measurement tool used to assess the arching and loading the foot zones was the BTS P-WALK platform. The measurement included analysis in terms of statics and lasted 30s. Results: The comparison of both groups showed no significant differentiation in the medial and lateral load of the forefoot and rearfoot. Among people with ID correct arches of the feet were observed in 52.6% of participants in the right foot and 57.9% of the left foot, while in the control group in 56.9% in both the right and left foot. People with intellectual disabilities were characterized by a higher rate of flatfoot in relation to the control group. The hollow foot was more frequently observed in control group than in people with ID. Conclusions: In people with intellectual disabilities with aetiology other than Down’s syndrome, flat feet are diagnosed more often than in healthy peers who do not differ in body weight and BMI. Intellectual disability is associated with a greater loading of the medial part of the forefoot.

scholarly journals Dementia Screening Questionnaire for Individuals with Intellectual Disabilities

2007 ◽  
Vol 190 (5) ◽  
pp. 440-444 ◽  
Author(s):  
Shoumitro Deb ◽  
Monika Hare ◽  
Lindsay Prior ◽  
Sabyasachi Bhaumik
Keyword(s):  
Intellectual Disabilities ◽  
Psychometric Properties ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Good Test ◽  
Screening Questionnaire ◽  
Dementia Screening ◽  
Adults With Intellectual Disabilities ◽  
User Friendly ◽  
Individuals With Intellectual Disabilities

BackgroundMany adults with Down's syndrome develop Alzheimer's dementia relatively early in their lives, but accurate clinical diagnosis remains difficult.AimsTo develop a user-friendly observer-rated dementia screening questionnaire with strong psychometric properties for adults with intellectual disabilities.MethodWe used qualitative methods to gather information from carers of people with Down's syndrome about the symptoms of dementia. This provided the items for the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID), which we then tested for its psychometric properties.ResultsThe DSQIID was administered to carers of 193 adults with Down's syndrome, 117 of whom were examined by clinicians who confirmed a diagnosis of dementia for 49 according to modified ICD–10 criteria. We established that a total score of 20 provides maximum sensitivity (0.92) and optimum specificity (0.97) for screening. The DSQIID has sound internal consistency (α = 0.91) for all its 53 items, and good test–retest and interrater reliability. We established a good construct validity by dividing the items into four factors.ConclusionsThe DSQIID is a valid, reliable and user-friendly observer-rated questionnaire for screening for dementia among adults with Down's syndrome.

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