Propranolol's Potential to Increase Survival Time in a Disabled Submarine

2012 ◽  
Vol 83 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Seth A. Reini ◽  
David M. Fothergill ◽  
Heath G. Gasier ◽  
Wayne G. Horn
Keyword(s):  
Survival Time ◽  
Increase Survival Time

scholarly journals Can Cytosine Arabinoside With Prednisolone Treatment for Canine Meningoencephalitis of Unknown Origin Increase Survival Time Compared to Prednisolone Treatment Alone?

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Christopher Stefan Francis Kozlowski Hoey ◽  
Christina Maunder
Keyword(s):  
Open Access ◽  
Combination Therapy ◽  
Survival Time ◽  
Median Survival ◽  
Cytosine Arabinoside ◽  
Median Survival Time ◽  
Unknown Origin ◽  
Bottom Line ◽  
Prednisolone Treatment ◽  
Increase Survival Time

<strong>PICO question</strong><br /><p>In treatment of canine patients with meningoencephalitis of unknown origin (MUO), is combination therapy of cytosine arabinoside (CA) with prednisolone more effective than prednisolone as a sole therapy at increasing survival time?</p><strong>Clinical bottom line</strong><br /><p>Based on current available evidence, cytosine arabinoside with prednisolone has greater median survival time than prednisolone as a sole therapy in dogs with meningoencephalitis of unknown origin. The evidence to support this is very weak, as there are currently a low number of published papers with a relatively small number of cases reported in these studies evaluating cytosine arabinoside with prednisolone or prednisolone as a sole therapy for treatment of meningoencephalitis of unknown origin.</p><p> </p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Dietary Supplementation with Fructooligosaccharides Increase Survival Time in a Hamster Model of Clostridium difficile-Colitis

1997 ◽  
Vol 16 (2) ◽  
pp. 59-64 ◽  
Author(s):  
Bryan W. WOLF ◽  
Jonathan A. MEULBROEK ◽  
Kenneth P. JARVIS ◽  
Keith B. WHEELER ◽  
Keith A. GARLEB
Keyword(s):  
Clostridium Difficile ◽  
Survival Time ◽  
Dietary Supplementation ◽  
Hamster Model ◽  
Clostridium Difficile Colitis ◽  
Increase Survival Time

The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis

2011 ◽  
Vol 87 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Y. Li ◽  
J.-P. Tang ◽  
D.-R. Chen ◽  
C.-Y. Fu ◽  
P. Wang ◽  
...  
Keyword(s):  
Survival Time ◽  
Immunoglobulin E ◽  
Foxp3 Expression ◽  
Angiostrongylus Cantonensis ◽  
Neurological Dysfunction ◽  
Eosinophilic Meningitis ◽  
Interleukin 5 ◽  
Worm Recovery ◽  
Time Body Weight ◽  
Increase Survival Time

AbstractAngiostrongylus cantonensis (A. cantonensis) infection causes eosinophilic meningitis in humans. Eosinophilia and a Th2-type immune response are the crucial immune mechanisms for eosinophilic meningitis. CD4+CD25+ regulatory T cells (Treg) are involved in the pathogenesis of A. cantonensis. Diammonium glycyrrhizinate (DG) is a compound related to glycyrrhizin (GL), a triterpene glycoside extracted from liquorice root. We investigated the curative effects and probable mechanisms of therapy involving a combination of albendazole and DG in BALB/c mice infected with A. cantonensis, and compared these with therapy involving albendazole and dexamethasone. We analysed survival time, body weight, signs, eosinophil numbers, immunoglobulin E (IgE), interleukin-5 (IL-5), and eotaxin concentrations, numbers and Foxp3 expression of CD4+CD25+ Treg, worm recovery and histopathology. The present results demonstrated that the combination of albendazole and DG could increase survival time more efficiently and relieve neurological dysfunction; decrease weight loss, eosinophil numbers, concentrations of IgE, IL-5 and eotaxin, the number and expression of Foxp3 of CD4+CD25+ Treg; and improve worm recovery and histopathology changes in treated animals, compared with the combination of albendazole and dexamethasone. The observations presented here suggest that the albendazole and dexamethasone combination could be replaced by the combination of albendazole and DG.

CAROLINA RINSE SOLUTION—A NEW STRATEGY TO INCREASE SURVIVAL TIME AFTER ORTHOTOPIC LIVER TRANSPLANTATION IN THE RAT

1991 ◽  
Vol 52 (3) ◽  
pp. 417-423 ◽  
Author(s):  
WENSHI GAO ◽  
YOSHIYUKI TAKEI ◽  
INGO MARZI ◽  
KELLY A. LINDERT ◽  
JANE C. CALDWELL-KENKEL ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Survival Time ◽  
Orthotopic Liver Transplantation ◽  
New Strategy ◽  
Increase Survival Time

Effect of Intermittent Nitrogen Exposures on Tolerance to Oxygen at High Pressures

1956 ◽  
Vol 186 (1) ◽  
pp. 149-151 ◽  
Author(s):  
Kenneth E. Penrod
Keyword(s):  
Survival Time ◽  
Oxygen Pressure ◽  
Guinea Pigs ◽  
High Pressures ◽  
Oxygen Toxicity ◽  
Apparent Effect ◽  
Large Measure ◽  
Beneficial Effects ◽  
Pulmonary Damage ◽  
Increase Survival Time

If the exposure of guinea pigs to 4 atm. oxygen pressure is interrupted at 30-minute intervals with exposures to air or oxygen-nitrogen mixtures, the total survival time of the guinea pigs is significantly increased. Five-minute exposures to air increase the survival time by 40% with increasing benefits from 10-minute and 20-minute exposures to air. If the oxygen pressure is increased to 5.5 atm. the intermittent air exposures must be 20 minutes in length to significantly increase survival time. In addition to significantly increasing survival time intermittent air exposures have the apparent effect of reducing the frequency of convulsions. An explanation is advanced for the finding of a significant influence on survival at 4 atm. based on the observation that pulmonary damage is the usual cause of mortality at this pressure of oxygen. Since the pulmonary damage has been shown to be in large measure an atelectatic process a theory is proposed that nitrogen inhaled during the intermittent air breathing period is carried by the blood to those areas of the lungs in the process of collapse and the infiltration of nitrogen into the collapsing air sacs has the effect of reinflation, thereby delaying the process. This is not thought to be the sole mechanism responsible for the beneficial effects of intermittent nitrogen breathing on oxygen toxicity as it is not clear how such a mechanism could influence the convulsion frequency.

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