scholarly journals Valsartan prevented neointimal hyperplasia and inhibited SRSF1 expression and the TLR4–iNOS–ERK–AT1 receptor pathway in the balloon-injured rat aorta

2021 ◽  
pp. 533-542
Author(s):  
Yonghong Li ◽  
Junjie Guo ◽  
Haichu Yu ◽  
Xin Liu ◽  
Jingwei Zhou ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Protein Expression ◽  
Neointimal Hyperplasia ◽  
Treated Group ◽  
Rat Aorta ◽  
At1 Receptor ◽  
At2 Receptor ◽  
Oxide Synthase

Valsartan has the potential to attenuate neointimal hyperplasia and to suppress the inflammatory response. This study aimed to evaluate the role of valsartan in neointimal hyperplasia and the toll-like receptor 4 (TLR4)-nitric oxide synthase (NOS) pathway in the balloon-injured rat aorta. Forty-eight Wistar rats were randomly allocated to three groups: sham control (control), balloon-injured group (surgery), and balloon-injured+valsartan-treated group (valsartan). Rats were killed at 14 and 28 days after balloon-injury, and then the aortic tissues were collected for morphometric analysis as well as for measurements of the mRNA or protein expression of angiotensin II, angiotensin II type 1 (AT1) receptor, angiotensin II type 2 (AT2) receptor, TLR4, endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), serine/arginine-rich splicing factor 1(SRSF1) and extracellular signal regulated kinase (ERK). Valsartan at a dose of 20 mg/kg/day markedly decreased neointimal hyperplasia in the aorta of balloon-injured rats, and significantly reduced the mRNA or protein expression of TLR4, AT1 receptor, SRSF1 and phosphorylated-ERK (p-ERK) as well as the aortic levels of iNOS (all p<0.05). Moreover, valsartan increased the eNOS level and AT2 receptor mRNA and protein expression levels (all p<0.05). Valsartan prevented neointimal hyperplasia and inhibited SRSF1 expression and the TLR4-iNOS-ERK-AT1 receptor pathway in the balloon-injured rat aorta.

Effects of Angiotensin II Infusion and Inhibition of Nitric Oxide Synthase on the Rat Aorta

Hypertension ◽  
1996 ◽  
Vol 28 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Hiroshi Kato ◽  
Jian Hou ◽  
Aram V. Chobanian ◽  
Peter Brecher
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Rat Aorta ◽  
Oxide Synthase

scholarly journals Angiotensin II is involved in nitric oxide synthase and cyclo-oxygenase inhibition-induced leukocyte-endothelialcell interactions in vivo

2001 ◽  
Vol 132 (3) ◽  
pp. 677-684 ◽  
Author(s):  
Angeles Alvarez ◽  
Laura Piqueras ◽  
Regina Bello ◽  
Amparo Canet ◽  
Lucrecia Moreno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Inflammatory Monocytes Determine Endothelial Nitric-oxide Synthase Uncoupling and Nitro-oxidative Stress Induced by Angiotensin II

2014 ◽  
Vol 289 (40) ◽  
pp. 27540-27550 ◽  
Author(s):  
Sabine Kossmann ◽  
Hanhan Hu ◽  
Sebastian Steven ◽  
Tanja Schönfelder ◽  
Daniela Fraccarollo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Inflammatory Monocytes ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Angiotensin II causes nitric oxide synthase 3 uncoupling in the thick ascending limb

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Katherine Massey ◽  
Jagannath J. Saikumar ◽  
Mark D. Faber ◽  
Jerry J. Yee ◽  
Jeffrey L. Garvin
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Thick Ascending Limb ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

Angiotensin II and nitric oxide in neural control of intrarenal blood flow

2005 ◽  
Vol 289 (3) ◽  
pp. R745-R754 ◽  
Author(s):  
Niwanthi W. Rajapakse ◽  
Amanda K. Sampson ◽  
Gabriela A. Eppel ◽  
Roger G. Evans
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Neural Control ◽  
Renin Angiotensin System ◽  
Renal Medulla ◽  
Renal Nerve ◽  
Intrarenal Blood Flow ◽  
Oxide Synthase

We investigated the roles of the renin-angiotensin system and the significance of interactions between angiotensin II and nitric oxide, in responses of regional kidney perfusion to electrical renal nerve stimulation (RNS) in pentobarbital sodium-anesthetized rabbits. Under control conditions, RNS (0.5–8 Hz) reduced total renal blood flow (RBF; −89 ± 3% at 8 Hz) and cortical perfusion (CBF; −90 ± 2% at 8 Hz) more than medullary perfusion (MBF; −55 ± 5% at 8 Hz). Angiotensin II type 1 (AT1)-receptor antagonism (candesartan) blunted RNS-induced reductions in RBF ( P = 0.03), CBF ( P = 0.007), and MBF ( P = 0.04), particularly at 4 and 8 Hz. Nitric oxide synthase inhibition with NG-nitro-l-arginine (l-NNA) enhanced RBF ( P = 0.003), CBF ( P = 0.001), and MBF ( P = 0.03) responses to RNS, particularly at frequencies of 2 Hz and less. After candesartan pretreatment, l-NNA significantly enhanced RNS-induced reductions in RBF ( P = 0.04) and CBF ( P = 0.007) but not MBF ( P = 0.66). Renal arterial infusion of angiotensin II (5 ng·kg−1·min−1) selectively enhanced responses of MBF to RNS in l-NNA-pretreated but not in vehicle-pretreated rabbits. In contrast, greater doses of angiotensin II (5–15 ng·kg−1·min−1) blunted responses of MBF to RNS in rabbits with intact nitric oxide synthase. These results suggest that endogenous angiotensin II enhances, whereas nitric oxide blunts, neurally mediated vasoconstriction in the renal cortical and medullary circulations. In the renal medulla, but not the cortex, angiotensin II also appears to be able to blunt neurally mediated vasoconstriction.

Upregulation of endothelial nitric oxide synthase in rat aorta after ingestion of fish oil-rich diet

2004 ◽  
Vol 287 (2) ◽  
pp. H567-H572 ◽  
Author(s):  
Diego López ◽  
Xavier Orta ◽  
Kelly Casós ◽  
M. Puy Sáiz ◽  
Pere Puig-Parellada ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Fish Oil ◽  
Endothelial Nitric Oxide Synthase ◽  
Rat Aorta ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Oxygen consumption in the kidney: Effects of nitric oxide synthase isoforms and angiotensin II

2005 ◽  
Vol 68 (2) ◽  
pp. 723-730 ◽  
Author(s):  
Aihua Deng ◽  
Cynthia M. Miracle ◽  
Jorge M. Suarez ◽  
Mark Lortie ◽  
Joseph Satriano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oxygen Consumption ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase
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