scholarly journals Polymeric Nanogels as Drug Delivery Systems

2018 ◽  
pp. S305-S317 ◽  
Author(s):  
J. KOUSALOVÁ ◽  
T. ETRYCH
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Tissue ◽  
Controlled Drug Delivery ◽  
Biological Evaluation ◽  
Polymer Nanoparticles ◽  
Biologically Active ◽  
Design Synthesis ◽  
Physico Chemical ◽  
Solid Tumor Tissue

The present review focuses on the description of the design, synthesis and physico-chemical and biological evaluation of polymer nanogels. Nanogels are robust swollen cross-linked polymer nanoparticles that can be used as highly efficient and biodegradable carriers for the transport of drugs in controlled drug delivery. In this article, various types of nanogels are described and methods for their preparation discussed. The possibility of using synthesized nanosystems for targeting are reviewed to show the potential of tailored structures to reach either solid tumor tissue or direct tumor cells. Finally, the methods for encapsulation or attachment of biologically active molecules, e.g. drugs, proteins, are described and compared.

Atherosclerosis and Nanomedicine Potential: Current Advances and Future Opportunities

2020 ◽  
Vol 27 (21) ◽  
pp. 3534-3554 ◽  
Author(s):  
Fan Jiang ◽  
Yunqi Zhu ◽  
Changyang Gong ◽  
Xin Wei
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Vascular Wall ◽  
Arterial Disease ◽  
Diagnosis And Treatment ◽  
Antiinflammatory Therapy ◽  
Limited Efficacy ◽  
Conventional Drug ◽  
Diagnostic Modalities

Atherosclerosis is the leading inducement of cardiovascular diseases, which ranks the first cause of global deaths. It is an arterial disease associated with dyslipidemia and changes in the composition of the vascular wall. Besides invasive surgical strategy, the current conservative clinical treatment for atherosclerosis falls into two categories, lipid regulating-based therapy and antiinflammatory therapy. However, the existing strategies based on conventional drug delivery systems have shown limited efficacy against disease development and plenty of side effects. Nanomedicine has great potential in the development of targeted therapy, controlled drug delivery and release, the design of novel specific drugs and diagnostic modalities, and biocompatible scaffolds with multifunctional characteristics, which has led to an evolution in the diagnosis and treatment of atherosclerosis. This paper will focus on the latest nanomedicine strategies for atherosclerosis diagnosis and treatment as well as discussing the potential therapeutic targets during atherosclerosis progress, which could form the basis of development of novel nanoplatform against atherosclerosis.

Dual-pH/Magnetic-Field-Controlled Drug Delivery Systems Based on Fe3 O4 @SiO2 -Incorporated Salecan Graft Copolymer Composite Hydrogels

ChemMedChem ◽  
2017 ◽  
Vol 12 (19) ◽  
pp. 1600-1609 ◽  
Author(s):  
Xinyu Hu ◽  
Yongmei Wang ◽  
Liangliang Zhang ◽  
Man Xu ◽  
Jianfa Zhang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Graft Copolymer ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Composite Hydrogels

Understanding the Diffusion of Dextrans in ‘Click' PNIPAAm Hydrogels

2014 ◽  
Vol 67 (1) ◽  
pp. 85
Author(s):  
Huey Wen Ooi ◽  
Hui Peng ◽  
Kevin S. Jack ◽  
Andrew K. Whittaker
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Mesh Size ◽  
Controlled Drug Delivery ◽  
Molecular Size ◽  
Delivery Systems ◽  
Restricted Diffusion ◽  
Probe Molecules ◽  
Network Studies

Arguably the most important property of a hydrogel is the ability to allow the diffusion of solutes through the crosslinked network. Studies of the diffusion in hydrogels are important for providing information on the rate and extent of the passage of the solute and on the details of the microstructure of the hydrogel. Such knowledge is directly relevant for applications such as controlled drug delivery systems. The structure of novel poly(N-isopropylacrylamide) (PNIPAAm) hydrogels can be revealed by the restricted diffusion of appropriate probe molecules. Dextran molecules, labelled with fluorescent moieties, were incorporated into well-defined PNIPAAm hydrogels to investigate the effects of hydrogel mesh size and dextran molecular size on the diffusivities of solute molecules.

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