scholarly journals Multi-Time Scale Perspective in Analyzing Cardiovascular Data

2014 ◽  
pp. 439-456 ◽  
Author(s):  
H. K. LACKNER ◽  
J. J. BATZEL ◽  
A. RÖSSLER ◽  
H. HINGHOFER-SZALKAY ◽  
I. PAPOUSEK
Keyword(s):  
Transient Behavior ◽  
System Response ◽  
Fine Grained ◽  
Hemodynamic Variables ◽  
Physiological Processes ◽  
Specific Effects ◽  
Social Observation ◽  
Transient Variations ◽  
Time Frames ◽  
The Impact

Cardiovascular dynamic and variability data are commonly used in experimental protocols involving cognitive challenge. Usually, the analysis is based on a sometimes more and sometimes less well motivated single specific time resolution ranging from a few seconds to several minutes. The present paper aimed at investigating in detail the impact of different time resolutions of the cardiovascular data on the interpretation of effects. We compared three template tasks involving varying types of challenge, in order to provide a case study of specific effects and combinations of effects over different time frames and using different time resolutions. Averaged values of hemodynamic variables across an entire protocol confirmed typical findings regarding the effects of mental challenge and social observation. However, the hemodynamic response also incorporates transient variations in variables reflecting important features of the control system response. The fine-grained analysis of the transient behavior of hemodynamic variables demonstrates that information that is important for interpreting effects may be lost when only average values over the entire protocol are used as a representative of the system response. The study provides useful indications of how cardiovascular measures may be fruitfully used in experiments involving cognitive demands, allowing inferences on the physiological processes underlying the responses.

A Theory of Post-Stall Transients in Axial Compression Systems: Part II—Application

1986 ◽  
Vol 108 (2) ◽  
pp. 231-239 ◽  
Author(s):  
E. M. Greitzer ◽  
F. K. Moore
Keyword(s):  
Axial Compression ◽  
Parametric Study ◽  
Pressure Rise ◽  
Transient Behavior ◽  
Rotating Stall ◽  
Future Research ◽  
System Response ◽  
System Behavior ◽  
Flow Pressure ◽  
The Impact

Using the theory developed in Part I, calculations have been carried out to show the evolution of the mass flow, pressure rise, and rotating-stall cell amplitude during compression system post-stall transients. In particular, it is shown that the unsteady growth or decay of the stall cell can have a significant effect on the instantaneous compressor pumping characteristic and hence on the overall system behavior. A limited parametric study is carried out to illustrate the impact of different system features on transient behavior. It is shown, for example, that the ultimate mode of system response, surge or stable rotating stall, depends not only on the B parameter, but also on the compressor length-to-radius ratio. Small values of the latter quantity tend to favor the occurrence of surge, as do large values of B. Based on the analytical and numerical results, some specific topics are suggested for future research on post-stall transients.

Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology

2011 ◽  
Vol 301 (6) ◽  
pp. C1307-C1315 ◽  
Author(s):  
Mohamed Kodiha ◽  
Dennis Ho-Wo-Cheong ◽  
Ursula Stochaj
Keyword(s):  
De Novo ◽  
Cell Physiology ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Α Subunit ◽  
Physiological Processes ◽  
Specific Effects ◽  
The Impact ◽  
Nuclear Processes

5′-AMP-activated kinase (AMPK) regulates numerous biological events and is an essential target for the treatment of type 2 diabetes. The objectives of the present study were first to determine the compartment-specific effects of three established AMPK activators on Thr172 phosphorylation of the α-subunit, an indicator of AMPK activation. Second, we examined how cytoplasmic and nuclear processes are modulated by pharmacological AMPK activators. Specifically, the impact of phenformin, resveratrol, and 5-aminoimidazole-4-carboxamide riboside (AICAR) on Thr172 phosphorylation in the cytoplasm and nucleus was quantified by different methods. To analyze how these activators change cell physiology, we measured the inactivation of acetyl-CoA-carboxylase 1, a predominantly cytoplasmic enzyme that is crucial for lipid metabolism. As a criterion for activities associated with the nucleus, de novo RNA synthesis in nucleoli was quantified. Our studies demonstrate that pharmacological activators of AMPK can alter the balance between nuclear and cytoplasmic AMPK pools. Thus, phenformin and resveratrol caused a strong activation of AMPK in the cytoplasm, whereas the effect was less pronounced in nuclei. By contrast, AICAR elicited a comparable rise in Thr172 phosphorylation in both compartments. Notably, these activators differed drastically in their effects on physiological processes that are located in distinct subcellular compartments. All compounds led to a substantial inactivation of acetyl-CoA-carboxylase 1 in the cytoplasm, with only minor changes to the nuclear enzyme. In the nucleolus, transcription was strongly inhibited by resveratrol, while a moderate inhibition was observed with phenformin and AICAR. Taken together, the compartment-specific phosphorylation of AMPK and downstream events are determined by the activator.

The Impact of Visual Stereotypes on Judgments about Rape

2016 ◽  
Vol 75 (3) ◽  
pp. 133-140
Author(s):  
Robert Busching ◽  
Johannes Lutz
Keyword(s):  
Mental Representations ◽  
Irrelevant Information ◽  
Clear Distinction ◽  
Rape Myth ◽  
Facial Features ◽  
Reverse Correlation ◽  
Correlation Technique ◽  
Specific Effects ◽  
Legal Judgments ◽  
The Impact

Abstract. Legally irrelevant information like facial features is used to form judgments about rape cases. Using a reverse-correlation technique, it is possible to visualize criminal stereotypes and test whether these representations influence judgments. In the first step, images of the stereotypical faces of a rapist, a thief, and a lifesaver were generated. These images showed a clear distinction between the lifesaver and the two criminal representations, but the criminal representations were rather similar. In the next step, the images were presented together with rape scenarios, and participants (N = 153) indicated the defendant’s level of liability. Participants with high rape myth acceptance scores attributed a lower level of liability to a defendant who resembled a stereotypical lifesaver. However, no specific effects of the image of the stereotypical rapist compared to the stereotypical thief were found. We discuss the findings with respect to the influence of visual stereotypes on legal judgments and the nature of these mental representations.

1033 REDUCING NITROGEN FERTILIZER APPLICATIONS BY BALANCING THE NITROGEN SULFUR RATIO

HortScience ◽  
1994 ◽  
Vol 29 (5) ◽  
pp. 576d-576
Author(s):  
Ellen T. Paparozzi
Keyword(s):  
Groundwater Contamination ◽  
Nitrogen Fertilizer ◽  
Nutrient Balance ◽  
Ornamental Plants ◽  
Consumer Perceptions ◽  
Consumer Acceptance ◽  
Statistical Techniques ◽  
Physiological Processes ◽  
The Impact ◽  
Future Plans

Fertilizer particularly nitrogen is part of the concern about groundwater contamination. Many floricultural and ornamental plants do not need the high rates of nitrogen that are typically recommended. However, whenever one alters the quantity of a given nutrient the overall nutrient balance, as well as other physiological processes, changes. A brief overview of our research on poinsettias, roses, and chrysanthemums will be presented. Suggested ratios, critical S levels and nutrient problems associated with incorrect balances will be shared. Limitations due to statistical methods and the impact nutrient balance has on certain plant processes such as flowering and coloring and thus, consumer acceptance will be summarized. Future plans in this area may focus on the need for new statistical techniques, nutrient acquisition by roots and consumer perceptions of plant quality.

scholarly journals Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side Chain

2020 ◽  
Vol 22 (1) ◽  
pp. 155
Author(s):  
Mikhail V. Diachkov ◽  
Karoll Ferrer ◽  
Jana Oklestkova ◽  
Lucie Rarova ◽  
Vaclav Bazgier ◽  
...  
Keyword(s):  
Biological Activity ◽  
Functional Groups ◽  
Side Chain ◽  
Biotic And Abiotic Stresses ◽  
Short Side ◽  
Arabidopsis Root ◽  
Physiological Processes ◽  
Growth Promoting ◽  
The Impact ◽  
Brassinosteroid Analogues

Brassinosteroids are a class of plant hormones that regulate a broad range of physiological processes such as plant growth, development and immunity, including the suppression of biotic and abiotic stresses. In this paper, we report the synthesis of new brassinosteroid analogues with a nitrogen-containing side chain and their biological activity on Arabidopis thaliana. Based on molecular docking experiments, two groups of brassinosteroid analogues were prepared with short and long side chains in order to study the impact of side chain length on plants. The derivatives with a short side chain were prepared with amide, amine and ammonium functional groups. The derivatives with a long side chain were synthesized using amide and ammonium functional groups. A total of 25 new brassinosteroid analogues were prepared. All 25 compounds were tested in an Arabidopsis root sensitivity bioassay and cytotoxicity screening. The synthesized substances showed no significant inhibitory activity compared to natural 24-epibrassinolide. In contrast, in low concentration, several compounds (8a, 8b, 8e, 16e, 22a and 22e) showed interesting growth-promoting activity. The cytotoxicity assay showed no toxicity of the prepared compounds on cancer and normal cell lines.

scholarly journals Vibro-Acoustical Sensitivities of Stiffened Aircraft Structures Due to Attached Mass-Spring-Dampers with Uncertain Parameters

Aerospace ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 174
Author(s):  
Johannes Seidel ◽  
Stephan Lippert ◽  
Otto von Estorff
Keyword(s):  
System Response ◽  
Fuzzy Arithmetic ◽  
Parameter Uncertainties ◽  
Excitation Spectra ◽  
Radiated Noise ◽  
Linking Elements ◽  
Manufacturing Tolerances ◽  
Suitable Framework ◽  
Mass Spring ◽  
The Impact

The slightest manufacturing tolerances and variances of material properties can indeed have a significant impact on structural modes. An unintentional shift of eigenfrequencies towards dominant excitation frequencies may lead to increased vibration amplitudes of the structure resulting in radiated noise, e.g., reducing passenger comfort inside an aircraft’s cabin. This paper focuses on so-called non-structural masses of an aircraft, also known as the secondary structure that are attached to the primary structure via clips, brackets, and shock mounts and constitute a significant part of the overall mass of an aircraft’s structure. Using the example of a simplified fuselage panel, the vibro-acoustical consequences of parameter uncertainties in linking elements are studied. Here, the fuzzy arithmetic provides a suitable framework to describe uncertainties, create combination matrices, and evaluate the simulation results regarding target quantities and the impact of each parameter on the overall system response. To assess the vibrations of the fuzzy structure and by taking into account the excitation spectra of engine noise, modal and frequency response analyses are conducted.

scholarly journals Potential Impacts of Future Climate Change Scenarios on Ground Subsidence

Water ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 219 ◽  
Author(s):  
Antonio-Juan Collados-Lara ◽  
David Pulido-Velazquez ◽  
Rosa María Mateos ◽  
Pablo Ezquerro
Keyword(s):  
Climate Change ◽  
Land Subsidence ◽  
Ground Subsidence ◽  
Lower Percentage ◽  
Future Climate Change ◽  
Climate Change Scenarios ◽  
Fine Grained ◽  
Fine Grained Material ◽  
The Impact

In this work, we developed a new method to assess the impact of climate change (CC) scenarios on land subsidence related to groundwater level depletion in detrital aquifers. The main goal of this work was to propose a parsimonious approach that could be applied for any case study. We also evaluated the methodology in a case study, the Vega de Granada aquifer (southern Spain). Historical subsidence rates were estimated using remote sensing techniques (differential interferometric synthetic aperture radar, DInSAR). Local CC scenarios were generated by applying a bias correction approach. An equifeasible ensemble of the generated projections from different climatic models was also proposed. A simple water balance approach was applied to assess CC impacts on lumped global drawdowns due to future potential rainfall recharge and pumping. CC impacts were propagated to drawdowns within piezometers by applying the global delta change observed with the lumped assessment. Regression models were employed to estimate the impacts of these drawdowns in terms of land subsidence, as well as to analyze the influence of the fine-grained material in the aquifer. The results showed that a more linear behavior was observed for the cases with lower percentage of fine-grained material. The mean increase of the maximum subsidence rates in the considered wells for the future horizon (2016–2045) and the Representative Concentration Pathway (RCP) scenario 8.5 was 54%. The main advantage of the proposed method is its applicability in cases with limited information. It is also appropriate for the study of wide areas to identify potential hot spots where more exhaustive analyses should be performed. The method will allow sustainable adaptation strategies in vulnerable areas during drought-critical periods to be assessed.

scholarly journals A Study of the Impact of Graphite on the Kinetics of SPS in Nano- and Submicron WC-10%Co Powder Compositions

Ceramics ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 331-363
Author(s):  
Eugeniy Lantcev ◽  
Aleksey Nokhrin ◽  
Nataliya Malekhonova ◽  
Maksim Boldin ◽  
Vladimir Chuvil'deev ◽  
...  
Keyword(s):  
Activation Energy ◽  
Solid Phase ◽  
Continuous Heating ◽  
Diffusion Creep ◽  
Hard Alloys ◽  
Fine Grained ◽  
Plasma Sintering ◽  
Spark Plasma ◽  
The Impact ◽  
Kinetics Of

This study investigates the impact of carbon on the kinetics of the spark plasma sintering (SPS) of nano- and submicron powders WC-10wt.%Co. Carbon, in the form of graphite, was introduced into powders by mixing. The activation energy of solid-phase sintering was determined for the conditions of isothermal and continuous heating. It has been demonstrated that increasing the carbon content leads to a decrease in the fraction of η-phase particles and a shift of the shrinkage curve towards lower heating temperatures. It has been established that increasing the graphite content in nano- and submicron powders has no significant effect on the SPS activation energy for “mid-range” heating temperatures, QS(I). The value of QS(I) is close to the activation energy of grain-boundary diffusion in cobalt. It has been demonstrated that increasing the content of graphite leads to a significant decrease in the SPS activation energy, QS(II), for “higher-range” heating temperatures due to lower concentration of tungsten atoms in cobalt-based γ-phase. It has been established that the sintering kinetics of fine-grained WC-Co hard alloys is limited by the intensity of diffusion creep of cobalt (Coble creep).

scholarly journals Childhood adversity and psychosis: generalised or specific effects?

2015 ◽  
Vol 25 (4) ◽  
pp. 349-359 ◽  
Author(s):  
E. Longden ◽  
M. Sampson ◽  
J. Read
Keyword(s):  
Sexual Abuse ◽  
Physical Abuse ◽  
Negative Symptoms ◽  
Childhood Adversity ◽  
Clinical Intervention ◽  
Current Data ◽  
Psychotic Symptoms ◽  
Multiple Exposures ◽  
Specific Effects ◽  
The Impact

Background.This study examines relationships between childhood adversity and the presence of characteristic symptoms of schizophrenia. It was hypothesised that total adversity exposures would be significantly higher in individuals exhibiting these symptoms relative to patients without. Recent proposals that differential associations exist between specific psychotic symptoms and specific adversities was also tested, namely: sexual abuse and hallucinations, physical abuse and delusions, and fostering/adoption and delusions.Method.Data were collected through auditing 251 randomly selected medical records, drawn from adult patients in New Zealand community mental health centres. Information was extracted on presence and subtype of psychotic symptoms and exposure to ten types of childhood adversity, including five types of abuse and neglect.Results.Adversity exposure was significantly higher in patients experiencing hallucinations in general, voice hearing, command hallucinations, visions, delusions in general, paranoid delusions and negative symptoms than in patients without these symptoms. There was no difference in adversity exposure in patients with and without tactile/olfactory hallucinations, grandiose delusions or thought disorder. Indication of a dose–response relationship was detected, in that total number of adversities significantly predicted total number of psychotic symptoms. Although fostering/adoption was associated with paranoid delusions, the hypothesised specificity between sexual abuse and hallucinations, and physical abuse and delusions, was not found. The two adversities showing the largest number of associations with psychotic symptoms were poverty and being fostered/adopted.Conclusions.The current data are consistent with a model of global and cumulative adversity, in which multiple exposures may intensify psychosis risk beyond the impact of single events. Implications for clinical intervention are discussed.

scholarly journals Optimising pasture and grazing management decisions on the Cicerone Project farmlets over variable time horizons

2013 ◽  
Vol 53 (8) ◽  
pp. 796 ◽  
Author(s):  
Karl Behrendt ◽  
Oscar Cacho ◽  
James M. Scott ◽  
Randall Jones
Keyword(s):  
Simulation Model ◽  
Strategic Decision ◽  
Stochastic Dynamic ◽  
Economic Returns ◽  
Strategic Decisions ◽  
Trade Offs ◽  
Using Data ◽  
Time Frames ◽  
The Impact ◽  
Stocking Rates

This study addresses the problem of balancing the trade-offs between the need for animal production, profit, and the goal of achieving persistence of desirable species within grazing systems. The bioeconomic framework applied in this study takes into account the impact of climate risk and the management of pastures and grazing rules on the botanical composition of the pasture resource, a factor that impacts on livestock production and economic returns over time. The framework establishes the links between inputs, the state of the pasture resource and outputs, to identify optimal pasture development strategies. The analysis is based on the application of a dynamic pasture resource development simulation model within a seasonal stochastic dynamic programming framework. This enables the derivation of optimum decisions within complex grazing enterprises, over both short-term tactical (such as grazing rest) and long-term strategic (such as pasture renovation) time frames and under climatic uncertainty. The simulation model is parameterised using data and systems from the Cicerone Project farmlet experiment. Results indicate that the strategic decision of pasture renovation should only be considered when pastures are in a severely degraded state, whereas the tactical use of grazing rest or low stocking rates should be considered as the most profitable means of maintaining adequate proportions of desirable species within a pasture sward. The optimal stocking rates identified reflected a pattern which may best be described as a seasonal saving and consumption cycle. The optimal tactical and strategic decisions at different pasture states, based on biomass and species composition, varies both between seasons and in response to the imposed soil fertility regime. Implications of these findings at the whole-farm level are discussed in the context of the Cicerone Project farmlets.

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