scholarly journals Common Carotid Wall Shear Stress and Carotid Atherosclerosis in End-Stage Renal Disease Patients

2012 ◽  
pp. 355-361 ◽  
Author(s):  
J. MALÍK ◽  
J. KUDLIČKA ◽  
V. TUKA ◽  
E. CHYTILOVÁ ◽  
J. ADAMEC ◽  
...  
Keyword(s):  
Shear Stress ◽  
Shear Rate ◽  
Wall Shear Stress ◽  
Carotid Bifurcation ◽  
Wall Shear Rate ◽  
Carotid Wall ◽  
Wall Shear ◽  
End Stage ◽  
Common Carotid Arteries ◽  
Esrd Patients

Decrease of arterial wall shear stress (WSS) is associated with higher probability of atherosclerotic plaque development in many disease conditions. End-stage renal diseases (ESRD) patients suffer from vascular disease frequently, but its nature differs from general population. This study was aimed at proving an association between common carotid wall shear stress and the presence of carotid bifurcation plaques in a group of ESRD patients. ESRD subjects, planned for the creation of a dialysis access and therapy were included. Wall shear rate (WSR) was used as a surrogate of WSS and was analyzed in the common carotid arteries by duplex ultrasonography. Intima media thickness (IMT) was measured at the same site. The presence/absence of carotid bifurcation plaques was recorded. The endothelial function was estimated by the levels of von Willebrand factor (vWf). 35 ESRD patients were included (19 females, 17 diabetics). Atherosclerotic plaque was present in 53 % of bifurcations. Wall shear rate was lower in arteries with plaques (349±148 vs. 506±206 s-1, p=0.005) and was directly related to the height of IMT and inversely to the activity of vWf (r= –0.65, p=0.016). Lower wall shear rate in the common carotid arteries is linked to the endothelial dysfunction and to the presence of atherosclerotic plaques in carotid bifurcations in ESRD subjects. Faster arterial dilatation may facilitate this process in ESRD subjects.

Analysis of Flow Disturbance in a Stenosed Carotid Artery Bifurcation Using Two-Equation Transitional and Turbulence Models

2008 ◽  
Vol 130 (6) ◽  
Author(s):  
F. P. P. Tan ◽  
G. Soloperto ◽  
S. Bashford ◽  
N. B. Wood ◽  
S. Thom ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Laminar Flow ◽  
Wall Shear Stress ◽  
Turbulence Models ◽  
Carotid Bifurcation ◽  
Patient Specific ◽  
Shear Stresses ◽  
Zone Length ◽  
Wall Shear

In this study, newly developed two-equation turbulence models and transitional variants are employed for the prediction of blood flow patterns in a diseased carotid artery where the growth, progression, and structure of the plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, the laminar-turbulent transition in the poststenotic zone can alter the separation zone length, wall shear stress, and pressure distribution over the plaque, with potential implications for stresses within the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based transitional version of Menter’s hybrid k‐ϵ∕k‐ω shear stress transport (SST) model and its “scale adaptive simulation” (SAS) variant were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress, and turbulence intensity were conducted. In general, the transitional version of SST and its SAS variant are shown to give a better overall agreement than their standard counterparts with experimental data for pulsatile flow in an axisymmetric stenosed tube. For the patient-specific case reported, the wall shear stress analysis showed discernable differences between the laminar flow and SST transitional models but virtually no difference between the SST transitional model and its SAS variant.

scholarly journals Periodontal Treatment Elevates Carotid Wall Shear Stress in the Medium Term

Medicine ◽  
2015 ◽  
Vol 94 (42) ◽  
pp. e1724 ◽  
Author(s):  
Claudio Carallo ◽  
Maria Serena De Franceschi ◽  
Cesare Tripolino ◽  
Claudio Iovane ◽  
Serena Catalano ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Periodontal Treatment ◽  
Medium Term ◽  
Carotid Wall ◽  
Wall Shear

A Numerical Multiscale Study of the Haemodynamics in an Image-Based Model of Human Carotid Artery Bifurcation

2009 ◽  
Author(s):  
Diego Gallo ◽  
Raffaele Ponzini ◽  
Filippo Consolo ◽  
Diana Massai ◽  
Luca Antiga ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Blood Flow ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Cardiovascular System ◽  
Vessel Wall ◽  
3D Model ◽  
Carotid Bifurcation ◽  
Wall Shear ◽  
Flow Division

The initiation and progression of vessel wall pathologies have been linked to disturbances of blood flow and altered wall shear stress. The development of computational techniques in fluid dynamics, together with the increasing performances of hardware and software allow to routinely solve problems on a virtual environment, helping to understand the role of biomechanics factors in the healthy and diseased cardiovascular system and to reveal the interplay of biology and local fluid dynamics nearly intractable in the past, opening to detailed investigation of parameters affecting disease progression. One of the major difficulties encountered when wishing to model accurately the cardiovascular system is that the flow dynamics of the blood in a specific vascular district is strictly related to the global systemic dynamics. The multiscale modelling approach for the description of blood flow into vessels consists in coupling a detailed model of the district of interest in the framework of a synthetic description of the surrounding areas of the vascular net [1]. In the present work, we aim at evaluating the effect of boundary conditions on wall shear stress (WSS) related vessel wall indexes and on bulk flow topology inside a carotid bifurcation. To do it, we coupled an image-based 3D model of carotid bifurcation (local computational domain), with a lumped parameters (0D) model (global domain) which allows for physiological mimicking of the haemodynamics at the boundaries of the 3D carotid bifurcation model here investigated. Two WSS based blood-vessel wall interaction descriptors, the Time Averaged WSS (TAWSS), and the Oscillating Shear Index (OSI) were considered. A specific Lagrangian-based “bulk” blood flow descriptor, the Helical Flow Index (HFI) [2], was calculated in order to get a “measure” of the helical structure in the blood flow. In a first analysis the effects of the coupled 0D models on the 3D model are evaluated. The results obtained from the multiscale simulation are compared with the results of simulations performed using the same 3D model, but imposing a flow rate at internal carotid (ICA) outlet section equal to the maximum (60%) and the minimum (50%) flow division obtained out from ICA in the multiscale model simulation (the presence of the coupled 0D model gives variable internal/external flow division ratio during the cardiac cycle), and a stress free condition on the external carotid (ECA).

Compaction and flow of potato starch and potato granules Compactación y flujo de almidón de patata y gránulos de patata

1997 ◽  
Vol 3 (5) ◽  
pp. 333-342 ◽  
Author(s):  
P.J. Halliday ◽  
A.C. Smith
Keyword(s):  
Shear Stress ◽  
Shear Rate ◽  
Wall Shear Stress ◽  
Water Content ◽  
Capillary Flow ◽  
Potato Starch ◽  
Slip Flow ◽  
Shear Stresses ◽  
Wall Shear ◽  
Water Contents

Potato starch and potato granules are materials that are often used in extrusion processes. It is important to quantify their rheology for modelling and prediction of process performance. The compaction behaviour of potato starch was examined at water contents of 4-18% wwb (wet weight basis) for pressures between 1 and 85 MPa. The Heckel deformation stress decreased as the water content increased up to 12% but became inaccurate at 18%. This decrease agreed qualitatively with other observations of the decrease in stiffness of starchy materials over this water content range. Potato granules were examined at water contents of 25-45% wwb and aspects of their rheo logical behaviour characterized using different approaches. A first approximation used the shear viscosity-shear rate power law which produced a law exponent for the resulting pastes (0.1-0.2). The classical Benbow equation was used to estimate yield and wall shear stresses in capillary flow. The latter indicates the presence of slip which was examined more fully as a function of wall shear stress. The Mooney technique was used together with a variation of the method where the shear rate for each die was subtracted from that for a non-slip flow, which was approximated using rough dies. A critical wall shear stress for slip was found to be 0.05-0.1 MPa, making it consistent with published results for other materials.

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