scholarly journals Response of Human HTB140 Melanoma Cells to Conventional Radiation and Hadrons

2011 ◽  
pp. S129-S135 ◽  
Author(s):  
A. RISTIĆ-FIRA ◽  
D. TODOROVIĆ ◽  
J. ŽAKULA ◽  
O. KETA ◽  
P. CIRRONE ◽  
...  
Keyword(s):  
Bragg Peak ◽  
High Energy ◽  
Melanoma Cells ◽  
Cellular Radio ◽  
Conventional Radiotherapy ◽  
Conventional Radiation ◽  
Γ Rays ◽  
The Common ◽  
Mev Protons ◽  
Spread Out Bragg Peak

Conventional radiotherapy with X- and γ-rays is one of the common and effective treatments of cancer. High energy hadrons, i.e., charged particles like protons and 12C ions, due to their specific physics and radiobiological advantages are increasingly used. In this study, effectiveness of different radiation types is evaluated on the radio-resistant human HTB140 melanoma cells. The cells were irradiated with -rays, the 62 MeV protons at the Bragg peak and in the middle of the spread-out Bragg peak (SOBP), as well as with the 62 MeV/u 12C ions. The doses ranged from 2 to 24 Gy. Cell survival and proliferation were assessed 7 days after irradiation, whereas apoptosis was evaluated after 48 h. The acquired results confirmed the high radio-resistance of cells, showing better effectiveness of protons than γ-rays. The best efficiency was obtained with 12C ions due to higher linear energy transfer. All analyzed radiation qualities reduced cell proliferation. The highest proliferation was detected for 12C ions because of their large killing capacity followed by small induction of reparable lesions. This enabled unharmed cells to preserve proliferative activity. Irradiations with protons and 12C ions revealed similar moderate pro-apoptotic ability that is in agreement with the level of cellular radio-resistance.

DETECTION LIMIT FOR A VERY THIN BACKING FILM

1994 ◽  
Vol 04 (01) ◽  
pp. 1-7 ◽  
Author(s):  
KEIZO ISHII ◽  
HIKONOJO ORIHARA ◽  
YOSHIHIRO IWATA ◽  
KOTARO BESSHO
Keyword(s):  
Thin Film ◽  
Detection Limit ◽  
Spot Size ◽  
High Energy ◽  
High Energy Region ◽  
Beam Spot ◽  
Polyvinyl Formal ◽  
Beam Spot Size ◽  
Γ Rays ◽  
Mev Protons

Detection limit for thin backing films is formulated. A polyvinyl formal film of ~ 0.14µm was bombarded with 3 MeV protons and continuos backgrounds were measured with a Si(Li) detector. A large constant background of a high energy region (≥6 keV ) was interpreted as the Compton tail due to the 440 keV γ-rays from the excited state of 23Na which contaminated the surface of a carbon collimator placed just in front of a target. The detection limits of this thin film, under the condition of the beam spot size 6 mmϕ without collimator, are estimated for the elements of atomic number Z=10~55 and the minimum detection limit is calculated to be 4×10−12 g for Z=28~34.

SPALLATION YIELDS FROM HIGH ENERGY PROTON BOMBARDMENT OF HEAVY ELEMENTS

1957 ◽  
Vol 35 (1) ◽  
pp. 21-37 ◽  
Author(s):  
J. D. Jackson
Keyword(s):  
Cross Sections ◽  
High Energy ◽  
Heavy Elements ◽  
Collective Effects ◽  
Comparison With Experiment ◽  
Energy Proton ◽  
Stringent Test ◽  
Neutron Evaporation ◽  
Nuclear Processes ◽  
Mev Protons

The Monte Carlo calculations of McManus and Sharp (unpublished) for the prompt nuclear processes occurring upon bombardment of heavy elements by 400 Mev. protons are combined with a description of the subsequent neutron evaporation to determine spallation cross sections for comparison with experiment. The model employed is a schematic one which suppresses the detailed characteristics of individual nuclei, but gives the over-all behavior to be expected. Many-particle and collective effects such as alpha particle emission and fission are ignored. The computed cross sections are presented in a variety of different graphical forms which illustrate quantitatively the qualitative picture of high energy reactions first given by Serber (1947). The calculations are in general agreement with existing data when fission is not an important effect, but the agreement does not imply a very stringent test of the various features of the model.

Radiation damage of BGO crystals due to low energy γ rays, high energy protons and fast neutrons

1983 ◽  
Vol 206 (1-2) ◽  
pp. 107-117 ◽  
Author(s):  
Masaaki Kobayashi ◽  
Kenjiro Kondo ◽  
Hiromi Hirabayashi ◽  
Shin-ichi Kurokawa ◽  
Mitsuhiko Taino ◽  
...  
Keyword(s):  
Radiation Damage ◽  
High Energy ◽  
Low Energy ◽  
Fast Neutrons ◽  
Γ Rays

scholarly journals Radiosensitivity of human ovarian carcinoma and melanoma cells to γ-rays and protons

2014 ◽  
Vol 3 ◽  
pp. 578-586 ◽  
Author(s):  
Otilija Keta ◽  
Danijela Todorović ◽  
Nataša Popović ◽  
Lela Korićanac ◽  
Giacomo Cuttone ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Melanoma Cells ◽  
Human Ovarian Carcinoma ◽  
Γ Rays

scholarly journals Measurements of Ion Stopping Around the Bragg Peak in High-Energy-Density Plasmas

2015 ◽  
Vol 115 (20) ◽  
Author(s):  
J. A. Frenje ◽  
P. E. Grabowski ◽  
C. K. Li ◽  
F. H. Séguin ◽  
A. B. Zylstra ◽  
...  
Keyword(s):  
Energy Density ◽  
Bragg Peak ◽  
High Energy ◽  
High Energy Density ◽  
High Energy Density Plasmas
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