scholarly journals The interaction of genetic and environmental factors in the etiology of hypertension

2009 ◽  
pp. S33-S42 ◽  
Author(s):  
J Kuneš ◽  
J Zicha
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
Environmental Factors ◽  
Research Effort ◽  
Epigenetic Inheritance ◽  
Complex Trait ◽  
Medical Problem ◽  
Regulatory Systems ◽  
Genetic And Environmental Factors

Essential hypertension is a major risk factor for several cardiovascular diseases. It is a complex trait resulting from the interactions of multiple genetic and environmental factors. Moreover, not only genetic but also epigenetic inheritance plays a significant role. One can speculate that hypertension develops as a consequence of “errors” in well-coordinated regulatory systems of blood pressure. Errors in the cascade of molecular, biochemical and genetic processes, which regulate blood pressure, have finally enough potential to result in hypertension. Numerous environmental factors surrounding the organism during its development should influence the expression of genetic information. However, despite the considerable research effort, it is still difficult to identify all genes and/or other genetic determinants leading to essential hypertension and other cardiovascular diseases. This is mainly because these diseases usually become a medical problem in adulthood, although their roots might be traced back to earlier stages of ontogeny. The link between distinct developmental periods (e.g. birth and adulthood) should involve changes in gene expression involving epigenetic phenomena. The purpose of the present paper is to bring a piece of light on gene-environmental interactions potentially implicated in the pathogenesis of hypertension.

scholarly journals A CASE STUDY ON ESSENTIAL HYPERTENSION MANAGING THROUGH AYURVEDA W.S.R. RAKTAGATA VYAN VAISHAMYA

2021 ◽  
Vol p5 (4) ◽  
pp. 2965-2968
Author(s):  
Ruhi Zahir ◽  
Iqbal Khan
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Risk Factor ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
High Blood Pressure ◽  
Direct Reference ◽  
Major Risk Factor ◽  
End Stage

Essential hypertension is high blood pressure that doesn't have any known etiopathology. Most of sufferers (85%) are asymptomatic and as per available reports, in more than 95% cases of hypertension under lying cause is not found. It is estimated that 600 million people are affected worldwide. Hypertension is a major risk factor for the development of cardiovascular diseases (CVD). Its impact is greatest on stroke, MI and end stage is renal failure as it’s known as a Silent Killer. Hence there is no direct reference of hypertension in Ayurvedic classics by name as well as by its path physiological views. Many works have been carried out on hypertension to evaluate the perfect diagnosis and mode of treatment on the basis of Different nomenclatures also have been adopted by Ayurveda experts like Raktagata Vata, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Raktavrita Vata, Siragata Vata etc. Keywords: Essential hypertension, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Cardiovascular diseases, Silent Killer.

THE INFLUENCE OF GENETIC AND ENVIRONMENTAL FACTORS ON BLOOD PRESSURE VARIANCE IN A GENETICALLY ISOLATED POPULATION

2004 ◽  
Vol 22 (Suppl. 2) ◽  
pp. S215
Author(s):  
A. F.C. Schut ◽  
J. Deinum ◽  
Y. S. Aulchenko ◽  
E. A. Croes ◽  
M. C. Zillikens ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Environmental Factors ◽  
Isolated Population ◽  
Genetic And Environmental Factors

scholarly journals Relative roles of genetic and environmental factors in control of blood pressure in normotensive subjects.

Heart ◽  
1969 ◽  
Vol 31 (1) ◽  
pp. 21-25 ◽  
Author(s):  
W W Downie ◽  
J A Boyle ◽  
W R Greig ◽  
W W Buchanan ◽  
F P Alepa
Keyword(s):  
Blood Pressure ◽  
Environmental Factors ◽  
Normotensive Subjects ◽  
Genetic And Environmental Factors

scholarly journals Analysis of gene-gene interactions of polymorphic cytokine genes loci in patients with essential hypertension

2012 ◽  
Vol 18 (5) ◽  
pp. 443-448
Author(s):  
Y. R. Timasheva ◽  
T. R. Nasibullin ◽  
I. A. Tuktarova ◽  
I. M. Karamova ◽  
A. N. Petrin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Essential Hypertension ◽  
Cardiovascular Diseases ◽  
Genetic Markers ◽  
Gene Interactions ◽  
Polymorphic Markers ◽  
Blood Pressure Elevation ◽  
Final Model ◽  
Key Factor

Background. Chronic systemic inflammation is a key factor in the pathogenesis of cardiovascular diseases. The exact mechanisms underlying blood pressure elevation are unclear, but recent findings suggest that inflammatory mediators are involved. The objective of our study was to investigate the influence of gene-gene interactions between IL6, IL1B, IL12B, TNF, LTA and IL10 genes polymorphic markers on susceptibility to essential hypertension. Results. In the ethnic group of Tatars residing in Bashkortostan, Russia, we found an association of IL1B rs16944 and IL10 rs1800872 polymorphic markers with the disease. The analysis of gene-gene interactions showed significant synergy between IL12B rs3212227 and TNF rs1800629 polymorphic markers towards essential hypertension. The final model (logistic regression) included IL10 rs1800872 genetic marker and the combination of IL12B rs3212227 and TNF rs1800629 genetic markers as optimal predictors of essential hypertension. Conclusion. Our data confirm the involvement of cytokine system in the development of essential hypertension.

Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure?

Hypertension ◽  
1991 ◽  
Vol 18 (3_Suppl) ◽  
pp. I29-I29 ◽  
Author(s):  
R. R. Williams ◽  
S. C. Hunt ◽  
S. J. Hasstedt ◽  
P. N. Hopkins ◽  
L. L. Wu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Environmental Factors ◽  
High Blood Pressure ◽  
Genetic And Environmental Factors

scholarly journals Associations Between Obesity Indicators and Blood Pressure in Chinese Adult Twins

2017 ◽  
Vol 20 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Chunxiao Liao ◽  
Wenjing Gao ◽  
Weihua Cao ◽  
Jun Lv ◽  
Canqing Yu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Environmental Factors ◽  
Structural Equation ◽  
Structural Equation Models ◽  
Strong Association ◽  
Linear Regression Models ◽  
General Obesity ◽  
Chinese Adult ◽  
Genetic And Environmental Factors ◽  
Adult Twins

Obesity is associated with blood pressure (BP), but the associations between different obesity indicators and BP have not reached agreement. Besides, both obesity and BP are influenced by genetic and environmental factors. Whether they share the same genetic or environmental etiology has not been fully understood. We therefore analyzed the relationship between different obesity indicators and BP components as well as the genetic and environmental contributions to these relationships in a Chinese adult twin sample. Twins aged 18–79 years (n = 941) were included in this study. Body mass index (BMI) was used as the index of general obesity, whereas waist circumference (WC), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) were used as the indicators of central obesity. BP components included systolic blood pressure (SBP) and diastolic blood pressure (DBP). Linear regression models and bivariate structural equation models were used to examine the relation of various obesity indicators with BP components, and genetic or environmental influences on these associations, respectively. A strong association of BP components with BMI—and a somewhat weaker association with WC, WHtR, and WHR—was found in both sexes, independent of familial factors. Of these phenotypic correlations between obesity indicators and BP components, 60–76% were attributed to genetic factors, whereas 24–40% were attributed to unique environmental factors. General obesity was most strongly associated with high BP in Chinese adult twins. There were common genetic backgrounds for obesity and BP, and unique environmental factors also played a role.

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