Liposomes for anti-inflammatory drug delivery in ocular diseases: From in vivo models to clinical application

10.33540/526 ◽  
2021 ◽  
Author(s):  
◽  
Chee Wai Wong
Keyword(s):  
Drug Delivery ◽  
Clinical Application ◽  
Ocular Diseases ◽  
In Vivo Models ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Correlation between in vitro and in vivo models in anti-inflammatory drug studies

1971 ◽  
Vol 20 (9) ◽  
pp. 2137-2140 ◽  
Author(s):  
Norman H. Grant ◽  
Harvey E. Alburn ◽  
Arthur C. Singer
Keyword(s):  
In Vivo Models ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Drug Studies

In vivo study of mPEG–PCL as a nanocarriers for anti-inflammatory drug delivery of simvastatin

2019 ◽  
Vol 24 (6) ◽  
pp. 663-670 ◽  
Author(s):  
Mostafa Zamani ◽  
Amin Shirinzadeh ◽  
Mozhgan Aghajanzadeh ◽  
Sina Andalib ◽  
Hossein Danafar
Keyword(s):  
Drug Delivery ◽  
In Vivo Study ◽  
Inflammatory Drug ◽  
Anti Inflammatory

A Review on Opuntia Species and its Chemistry, Pharmacognosy, Pharmacology and Bioapplications

2020 ◽  
Vol 16 (8) ◽  
pp. 1227-1244
Author(s):  
Dharmendra Kumar ◽  
Pramod K. Sharma
Keyword(s):  
Human Consumption ◽  
In Vivo Models ◽  
Sugar Amino Acids ◽  
Opuntia Species ◽  
Therapeutic Uses ◽  
Anti Inflammatory ◽  
Online Library ◽  
Different Parts

Background:: Opuntia species, locally known as prickly pear was used for various purposes as food, medicine, beverage, source of dye and animal food. Many studies have revealed its pharmacology activity from time to time. This review is a collection of chemistry, pharmacognosy, pharmacology and bioapplications of the cactus family. Methods: Many sources were used to collect information about Opuntia species such as Pub med, Google scholar, Agris, science direct, Embase, Merk index, Wiley online library, books and other reliable sources. This review contains studies from 1812 to 2019. Results: The plants from the cactus family offer various pharmacological active compounds including phenolic compounds, carotenoids, betalains, vitamins, steroids, sugar, amino acids, minerals and fibers. These bioactive compounds serve various pharmacological activities such as anticancer, antiviral, anti-diabetic, Neuroprotective, anti-inflammatory, antioxidant, Hepatoprotective, antibacterial, antiulcer and alcohol hangover. According to various studies, Opuntia species offer many bioapplications such as fodder for animal, soil erosion, prevention, human consumption and waste water decontamination. Finally, different parts of plants are used in various formulations that offer many biotechnology applications. Conclusion: Different parts of Opuntia plant (fruits, seeds, flowers and cladodes) are used in various health problems which include wound healing, anti-inflammatory and urinary tract infection from ancient times. Nowadays, researches have extended several pharmacological and therapeutic uses of Opuntia species as discussed in this review. Many in-vitro and in-vivo models are also discussed in this review as the proofs of research findings. Various research gaps have been observed in current studies that require attention in the future.

Company News

2003 ◽  
Vol 07 (10) ◽  
pp. 496-502
Keyword(s):  
Drug Delivery ◽  
Japanese Firm ◽  
Inflammatory Drug ◽  
Synthetic Dna ◽  
Business News ◽  
Medical Standard ◽  
Anti Inflammatory ◽  
Delivery Technology

Prima Subsidiary Breakthrough in Malaria Experiments. Biota Achieves HIV Drug Breakthrough. China Business News. Sino-French Collaboration. US to Export Synthetic DNA to Japanese Firm. Genesis and EvoGenix Collaborates to Discover Anti-Inflammatory Drug. Biomedical Strategy Consultants Marches into Europe. Athelas and MerLion to Work Together on Anti-Infectives. BioPhotoFullerenes to Open HQ in Taiwan. Kiotek to Produce Medical-Standard Chitosan. TaiGen to Buy Microbubble Drug Delivery Technology. Intel Launches Itanium2 Server to Address Bioinformatics Market.

Stimuli Responsive Scaffolds Based on Carboxymethyl Starch and Poly(2‐Dimethylaminoethyl Methacrylate) for Anti‐Inflammatory Drug Delivery

2020 ◽  
Vol 20 (4) ◽  
pp. 1900412 ◽  
Author(s):  
Loredana Elena Nita ◽  
Aurica P. Chiriac ◽  
Alina Gabriela Rusu ◽  
Alina Ghilan ◽  
Raluca P. Dumitriu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Inflammatory Drug ◽  
Carboxymethyl Starch ◽  
Dimethylaminoethyl Methacrylate ◽  
Anti Inflammatory

scholarly journals Reversion of antibiotic resistance in drug-resistant bacteria using non-steroidal anti-inflammatory drug benzydamine

2021 ◽  
Author(s):  
Yuan Liu ◽  
Ziwen Tong ◽  
Jingru Shi ◽  
Tian Deng ◽  
Ruichao Li ◽  
...  
Keyword(s):  
Cost Effective ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Inflammatory Drug ◽  
Development Of Resistance ◽  
Drug Resistant Bacteria ◽  
Metabolic States ◽  
Anti Inflammatory ◽  
Approved Drugs

Antimicrobial resistance has been a growing concern that gradually undermines our tradition treatment regimen. The fact that few antibacterial drugs with new scaffolds or targets have been approved in the past two decades aggravates this crisis. Repurposing previously approved drugs as potent antibiotic adjuvants offers a cost effective strategy to mitigate the development of resistance and tackle the increasing infections by multidrug resistant (MDR) bacteria. Herein, we found that benzydamine, a widely used non-steroidal anti-inflammatory drug in clinic, remarkably potentiated broad spectrum antibiotic tetracyclines activity against a panel of clinical important resistant pathogens, including MRSA, VRE, MCRPEC and tet (X)-positive Gram negative bacteria. Further mechanistically experiments showed that benzydamine dissipated membrane potential (ΔΨ) in both Gram positive and negative bacteria, which in turn upregulated the transmembrane proton gradient (ΔpH) and promoted the uptake of tetracyclines. Additionally, benzydamine exacerbated the oxidative stress by triggering the production of ROS and suppressing GAD system mediated oxidative defensive. This mode of action explains the great bactericidal activity of the doxycycline benzydamine combination against different metabolic states of bacteria including persister cells. As a proof of concept, the in vivo efficacy of this combination therapy was evidenced in multiple animal infection models. These findings revealed that benzydamine is a promising tetracycline antibiotics adjuvant and has the potential to address life threatening infections by MDR bacteria.

scholarly journals Development, Optimisation and Evaluation of Ketoprofen Lipospheres

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1853-1863
Author(s):  
Shubhra Rai ◽  
Gopal Rai ◽  
Ashish Budhrani
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Research Work ◽  
Extended Period ◽  
Entrapment Efficiency ◽  
Inflammatory Activity ◽  
Scanning Calorimetry ◽  
Anti Inflammatory

Lipospheres represent a novel type of fat-based encapsulation system produced for the topical drug delivery of bioactive compounds. The goal of this research work was to develop lipospheres, including ketoprofen applied for topical skin drug delivery. Ketoprofen lipospheres were formulated by melt emulsification method using stearic acid and Phospholipon® 90G. The lipospheres were analysed in terms of particle size and morphology, entrapment efficiency, Differential scanning calorimetry, In-vitro drug release, In-vivo (Anti-inflammatory activity). Outcomes of research revealed that particle size was found to be 9.66 µm and entrapment efficiency 86.21 ± 5.79 %. In-vivo, the study of ketoprofen loaded lipospheres formulation shows a higher plain formulation concentration in plasma (5.61 mg/mL). For dermis, ketoprofen retention was 27.02 ± 5.4 mg/mL for the lipospheres formulation, in contrast to that of the plain formulation group (10.05 ± 2.8 mg/mL). The anti-inflammatory effect of liposphere drug delivery systems was assessed by the xylene induced ear oedema technique and compared with marketed products. Finally, it seems that the liposphere drug delivery system possesses superior anti-inflammatory activity as compared to the marketed product gel consistencies. Liposphere may be capable of entrapping the medicament at very high levels and controlling its release over an extended period. Liposphere furnishes a proper size for topical delivery as well as is based on non-irritating and non-toxic lipids; it’s a better option for application on damaged or inflamed skin.

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