Vascular risk factors, brain changes and cognitive functioning in mid and late life

10.33540/1074 ◽  
2021 ◽  
Author(s):  
◽  
Kim Blom
Keyword(s):  
Risk Factors ◽  
Cognitive Functioning ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Brain Changes

Mid-life and late-life vascular risk factors and dementia in Korean men and women

2011 ◽  
Vol 52 (3) ◽  
pp. e117-e122 ◽  
Author(s):  
H. Kimm ◽  
P.H. Lee ◽  
Y.J. Shin ◽  
K.S. Park ◽  
J. Jo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Men And Women

Cognitive decline precedes late-life longitudinal changes in vascular risk factors

2010 ◽  
Vol 81 (9) ◽  
pp. 1028-1032 ◽  
Author(s):  
P. van Vliet ◽  
R. G. J. Westendorp ◽  
D. van Heemst ◽  
A. J. M. de Craen ◽  
A. M. Oleksik
Keyword(s):  
Risk Factors ◽  
Cognitive Decline ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Longitudinal Changes

O2-09-02: Midlife and Late Life Vascular Risk Factors and Microstructural Integrity Assessed Using Diffusion Tensor Imaging: The Aric-NCS Study

2016 ◽  
Vol 12 ◽  
pp. P247-P248
Author(s):  
Melinda C. Power ◽  
Jonathan V. Tingle ◽  
Robert I. Reid ◽  
Juebin Huang ◽  
A Richey Sharrett ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Microstructural Integrity

scholarly journals The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life

2015 ◽  
Vol 29 (4) ◽  
pp. 287-293 ◽  
Author(s):  
Anand Viswanathan ◽  
Eric A. Macklin ◽  
Rebecca Betensky ◽  
Bradley Hyman ◽  
Eric E. Smith ◽  
...  
Keyword(s):  
Risk Factors ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk

Changes in Vascular Risk Factors from Midlife to Late Life and White Matter Lesions: A 20-Year Follow-Up Study

2011 ◽  
Vol 31 (2) ◽  
pp. 119-125 ◽  
Author(s):  
Miika Vuorinen ◽  
Alina Solomon ◽  
Suvi Rovio ◽  
Lasse Nieminen ◽  
Ingemar Kåreholt ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Lesions ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Follow Up Study

Is apathy in late-life depressive illness related to age-at-onset, cognitive function or vascular risk?

2004 ◽  
Vol 16 (4) ◽  
pp. 481-486 ◽  
Author(s):  
Indrag K. Lampe ◽  
Thea J. Heeren
Keyword(s):  
Risk Factors ◽  
Cognitive Function ◽  
Rating Scale ◽  
Late Onset ◽  
Late Life ◽  
Depressive Illness ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Onset Type ◽  
Depressed Patients

Background: Apathy has been shown to be an important feature of degenerative, vascular or traumatic brain disorder. Its presence is associated with high depression scores, higher age, low performance on frontal tasks, and more severe deep white matter hyperintensities. In late-life depression, lack of interest or motivation are often more prominent than depressed mood, especially in the late-onset type. It was hypothesized that in a heterogeneous sample of elderly depressed patients, apathy is associated with late-onset type of depression, cognitive dysfunction or vascular risk factors.Method: The Apathy Evaluation Scale (AES) was administered to twenty-nine elderly (≥60 years) inpatients with a DSM-IV major depression or dysthymic disorder. The severity of the depression was measured with the Montgomery-Åsberg Depression Rating Scale (MADRS) and cognitive function with the Mini-mental State Examination (MMSE). The presence of vascular risk factors was traced in the patient's medical records.Results: Apathy was found in 86% of the patients. The AES-score was correlated with the negative symptom score, but not with total MADRS or MMSE-score. No difference in AES-score between early-onset depressed (n = 16) and late-onset depressed (n = 13) patients was found, and between patients with or without vascular risk.Conclusion: Apathy is a main feature of moderate to severe depressive illness in elderly patients and related to the negative symptoms of the disorder. Further studies should include less severely depressed patients and investigate the relation between depression severity and apathy.

scholarly journals Late-onset depressive disorders: a preventable variant of cerebrovascular disease?

1998 ◽  
Vol 28 (5) ◽  
pp. 1007-1013 ◽  
Author(s):  
IAN HICKIE ◽  
ELIZABETH SCOTT
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Depressive Disorders ◽  
Late Onset ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Late Life Depression ◽  
Age Related ◽  
Medical Morbidity

The severe depressive disorders of late life are associated with high rates of medical morbidity and mortality, cognitive impairment, suicide, disability, complex treatment regimens, institutionalization and high costs to the community (Murphy, 1983; Murphy et al. 1988; Bruce & Leaf, 1989; NIH Consensus Development Panel, 1992; Alexopoulos et al. 1993a, b; Brodaty et al. 1993; Bruce et al. 1994; Forsell et al. 1994; Hickie et al. 1995; Blazer, 1996). Those disorders that are accompanied by cognitive impairment and/or concurrent medical morbidity have a particularly poor outcome (Bruce & Leaf, 1989; Alexopoulos et al. 1993b; Hickie et al. 1995, 1997a). Although psychosocial models of late-life depression place considerable importance on age-related psychological and social risk factors, those who survive into later life may actually be characterized by psychological resilience (Henderson, 1994; Blazer, 1997).Current aetiological research in late-life depression, therefore, places particular emphasis on the potential role of biological risk factors. The potential importance of vascular risk factors is receiving renewed attention and may provide opportunities for specific prevention and intervention strategies in high-risk populations. This emphasis on possible vascular risk factors, and the wider importance of vascular pathologies in late-life neuropsychiatric disorders, mirrors the emphasis of much earlier clinico-pathological studies (Binswanger, 1894; Alzheimer, 1895). The specific focus on the importance of small progressive changes within the subcortical white matter, as distinct from more discrete cortical infarcts (Olszewski, 1962), is now supported by the emerging neuroimaging literature and theoretical constructs in late-life depression (Krishnan, 1991, 1993; Hickie et al. 1996, 1997b; Krishnan et al. 1997).

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