scholarly journals Characterization of genetic variation and basis of inflammatory bowel disease in the Toll-like receptor 5 gene of the red wolf and the maned wolf

2017 ◽  
Vol 32 ◽  
pp. 135-144 ◽  
Author(s):  
LH Henson ◽  
N Songsasen ◽  
W Waddell ◽  
KN Wolf ◽  
L Emmons ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Genetic Variation ◽  
Bowel Disease ◽  
Toll Like Receptor ◽  
Red Wolf ◽  
Maned Wolf ◽  
Inflammatory Bowel ◽  
Toll Like Receptor 5

scholarly journals Toll-Like Receptor 5 is Significantly Associated With Canine Inflammatory Bowel Disease: Genetical and Functional Analysis

2011 ◽  
Vol 140 (5) ◽  
pp. S-846
Author(s):  
Aarti Kathrani ◽  
Angela Holder ◽  
Brian Catchpole ◽  
Dirk Werling ◽  
Karin Allenspach
Keyword(s):  
Inflammatory Bowel Disease ◽  
Functional Analysis ◽  
Bowel Disease ◽  
Toll Like Receptor ◽  
Inflammatory Bowel ◽  
Toll Like Receptor 5

Breed-independent toll-like receptor 5 polymorphisms show association with canine inflammatory bowel disease

2011 ◽  
Vol 78 (2) ◽  
pp. 94-101 ◽  
Author(s):  
A. Kathrani ◽  
A. House ◽  
B. Catchpole ◽  
A. Murphy ◽  
D. Werling ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Toll Like Receptor ◽  
Inflammatory Bowel ◽  
Toll Like Receptor 5

S1194 Functional Toll-Like Receptor 5 Gene Variants Are Not Associated with Susceptibility to Inflammatory Bowel Disease in the German Population

2009 ◽  
Vol 136 (5) ◽  
pp. A-210-A-211
Author(s):  
Julia Seiderer ◽  
Jürgen Glas ◽  
Helga-Paula Török ◽  
Burkhard Göke ◽  
Thomas Ochsenkühn ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
German Population ◽  
Gene Variants ◽  
Toll Like Receptor ◽  
Inflammatory Bowel ◽  
Toll Like Receptor 5

Characterization of Helicobacter-induced inflammatory bowel disease in IL-10 -/- and T cell deficient mice

2001 ◽  
Vol 120 (5) ◽  
pp. A523-A523
Author(s):  
A BURICH ◽  
R HERSHBERG ◽  
K WAGGIE ◽  
W ZENG ◽  
J VINEY ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Deficient Mice

scholarly journals Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model

2020 ◽  
Vol 22 (1) ◽  
pp. 364
Author(s):  
Qiyuan Han ◽  
Thomas J. Y. Kono ◽  
Charles G. Knutson ◽  
Nicola M. Parry ◽  
Christopher L. Seiler ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gastrointestinal Disease ◽  
Tumor Development ◽  
Proximal Colon ◽  
Helicobacter Hepaticus ◽  
Reduced Representation ◽  
Reduced Representation Bisulfite Sequencing ◽  
Inflammatory Bowel

Epigenetic dysregulation is hypothesized to play a role in the observed association between inflammatory bowel disease (IBD) and colon tumor development. In the present work, DNA methylome, hydroxymethylome, and transcriptome analyses were conducted in proximal colon tissues harvested from the Helicobacter hepaticus (H. hepaticus)-infected murine model of IBD. Reduced representation bisulfite sequencing (RRBS) and oxidative RRBS (oxRRBS) analyses identified 1606 differentially methylated regions (DMR) and 3011 differentially hydroxymethylated regions (DhMR). These DMR/DhMR overlapped with genes that are associated with gastrointestinal disease, inflammatory disease, and cancer. RNA-seq revealed pronounced expression changes of a number of genes associated with inflammation and cancer. Several genes including Duox2, Tgm2, Cdhr5, and Hk2 exhibited changes in both DNA methylation/hydroxymethylation and gene expression levels. Overall, our results suggest that chronic inflammation triggers changes in methylation and hydroxymethylation patterns in the genome, altering the expression of key tumorigenesis genes and potentially contributing to the initiation of colorectal cancer.

Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease

1994 ◽  
Vol 39 (9) ◽  
pp. 1893-1899 ◽  
Author(s):  
Jeffrey S. Hyams ◽  
John E. Fitzgerald ◽  
Nancy Wyzga ◽  
William R. Treem ◽  
Christopher J. Justinich ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Receptor Antagonist ◽  
Bowel Disease ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Inflammatory Bowel

Characterization of Anti-Lymphocyte Antibodies in Inflammatory Bowel Disease

1976 ◽  
Vol 5 (6-7) ◽  
pp. 837-844 ◽  
Author(s):  
C. A. HENDERSON ◽  
L. GREENLEE ◽  
R. C. WILLIAMS ◽  
R.G. STRICKLAND
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel
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