scholarly journals Toxics source reduction and sewage upgrades eliminated winter flounder liver neoplasia (1984-2017) from Boston Harbor, MA, USA

2018 ◽  
Vol 131 (3) ◽  
pp. 239-243 ◽  
Author(s):  
M Moore ◽  
A Pembroke ◽  
E Nestler ◽  
M Hall ◽  
L Lefkovitz ◽  
...  
Keyword(s):  
Winter Flounder ◽  
Boston Harbor ◽  
Source Reduction ◽  
Liver Neoplasia

c-K-ras Oncogenes: Prevalence in Livers of Winter Flounder from Boston Harbor

2018 ◽  
pp. 229-236
Author(s):  
L. Gerald McMahon ◽  
Julie Huber ◽  
Michael J. Moore ◽  
John J. Stegeman ◽  
Gerald N. Wogan
Keyword(s):  
Winter Flounder ◽  
Boston Harbor ◽  
Ras Oncogenes

Induced Cytochrome P4501A in Winter Flounder, Pleuronectes americanus, from Offshore and Coastal Sites

1994 ◽  
Vol 51 (4) ◽  
pp. 933-941 ◽  
Author(s):  
Emily Monosson ◽  
John J. Stegeman
Keyword(s):  
East Coast ◽  
Dry Weight ◽  
Winter Flounder ◽  
Boston Harbor ◽  
Pleuronectes Americanus ◽  
Georges Bank ◽  
Urban Centers ◽  
Cytochrome P4501a ◽  
Passamaquoddy Bay ◽  
Specific Activities

Cytochrome P4501A (CYP1A), Aroclor 1254 (A1254), and 3,3′,4,4′-tetrachlorobiphenyl (TCB) were measured in liver of winter flounder, Pleuronectes americanus, from Boston Harbor, Mass., Hempsted Harbor, N.Y., Niantic, Conn., and an offshore site, Georges Bank. We also measured CYP1A content and activity in flounder from Passamaquoddy Bay, N.B. Concentrations of A1254 and TCB were the least in fish from Georges Bank (0.46 and 0.002 μg∙g dry weight−1, respectively); concentrations in fish from Boston, Niantic, and Hempsted ranged from 7.6 to 11.3 μg∙g−1 and from 0.013 to 0.024 μg∙g−1. Immunodetected microsomal CYP1A contents (expressed as scup P450E equivalents) were 0.17 and 0.19 nmol∙mg−1 in fish from Georges Bank and Passamaquoddy and 0.25–0.41 nmol∙mg−1 in fish from Boston, Niantic, and Hempsted. Ethoxyresorufin-O-deethylase specific activities likewise were greater in fish from Boston, Niantic, and Hempsted (1.7–2.4 nmol∙min−1∙mg−1) than in fish from Georges Bank or Passamaquoddy (0.83 and 0.61 nmol∙min−1∙mg−1). CYP1A content and activity were correlated with hepatic concentrations of A1254 and TCB. These data, together with data reported in previous studies, indicate that strong induction of CYP1A protein occurs in winter flounder populations along most of the industrialized east coast and that induction of CYP1A is common, but less strong, at sites distant from the urban centers of the Northeast.

Vitellogenin in Winter Flounder (Pleuronectes americanus) from Long Island Sound and Boston Harbor

Estuaries ◽  
1992 ◽  
Vol 15 (3) ◽  
pp. 289 ◽  
Author(s):  
J. J. Pereira ◽  
J. Ziskowski ◽  
R. Mercaldo-Allen ◽  
C. Kuropat ◽  
D. Luedke ◽  
...  
Keyword(s):  
Long Island ◽  
Long Island Sound ◽  
Winter Flounder ◽  
Boston Harbor ◽  
Pleuronectes Americanus ◽  
Island Sound

scholarly journals Mutations in c-Ki-ras oncogenes in diseased livers of winter flounder from Boston Harbor.

1990 ◽  
Vol 87 (2) ◽  
pp. 841-845 ◽  
Author(s):  
G. McMahon ◽  
L. J. Huber ◽  
M. J. Moore ◽  
J. J. Stegeman ◽  
G. N. Wogan
Keyword(s):  
Winter Flounder ◽  
Boston Harbor ◽  
Ras Oncogenes

Ultrastructure of vacuolated cells in the liver of rock sole and winter flounder living in contaminated environments

1990 ◽  
Vol 48 (3) ◽  
pp. 522-523
Author(s):  
Carla Stehr
Keyword(s):  
Electron Microscopy ◽  
Light Microscopy ◽  
Puget Sound ◽  
Light And Electron Microscopy ◽  
Similar Type ◽  
Winter Flounder ◽  
Boston Harbor ◽  
Liver Lesions ◽  
Pseudopleuronectes Americanus ◽  
Vacuolated Cells

Focal and diffuse areas of nonneoplastic vacuolated cells in the liver have been observed with light microscopy in up to 12% of the demersal rock sole (Lepidopsetta bilineata) inhabiting Eagle Harbor, which is a contaminated bay in Puget Sound. A similar type of liver vacuolation has also been observed at higher prevalences in winter flounder (Pseudopleuronectes americanus) inhabiting contaminated areas of Boston Harbor. This paper compares the ultrastructure of vacuolated liver lesions in feral rock sole with that of winter flounder from contaminated areas of Puget Sound and Boston Harbor, respectively.Rock sole from Eagle Harbor, Puget Sound, and winter flounder from Boston Harbor, were collected by bottom trawl from NOAA research vessels. Fish were killed and immediately necropsied. Adjacent pieces of tissue were collected for light and electron microscopy from grossly visible liver lesions or from the center of the liver. Samples collected for histology were fixed in Dietrich's solution, embedded in paraffin and stained with H&E.

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