scholarly journals Assessment of p53 Protein Expression in Leukoplakia, Oral Submucous Fibrosis and Oral Lichen Planus in Myanmar Patients

2005 ◽  
Vol 10 (1) ◽  
pp. 15-21
Author(s):  
Swe Swe Win ◽  
Mai Nishioka ◽  
Ba Myint ◽  
Minoru Takagi
Keyword(s):  
Protein Expression ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
P53 Protein ◽  
Oral Submucous Fibrosis ◽  
P53 Protein Expression ◽  
Submucous Fibrosis ◽  
Oral Lichen

scholarly journals Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Arpita Kabiraj ◽  
Tanya Khaitan ◽  
Debarati Bhowmick ◽  
Uday Ginjupally ◽  
Aritri Bir ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Submucous Fibrosis ◽  
Class Ii ◽  
Class I ◽  
Exfoliative Cytology ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Oral Lichen

Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening.Materials and Method. A total of 160 subjects with 25–50 years of age were included in the study. Among them, 40 were clinically diagnosed with oral leukoplakia, 40 were diagnosed with oral lichen planus, 40 were diagnosed with oral submucous fibrosis, and 40 were in the control group. The prepared smears were subjected to Papanicolaou stain and analyzed microscopically for the evaluation of the cytomorphological features.Results and Discussion. When analyzed microscopically, 36 (90%) out of the 40 oral leukoplakic lesions showed Class II cytological features whereas 4 (10%) revealed Class I features. Among 40 patients with oral lichen planus, 26 (65%) showed Class II features while the remaining 14 (35%) revealed Class I features. In 40 subjects with oral submucous fibrosis, 32 (80%) showed Class II features while the other 8 (20%) showed Class I features. All the 40 control subjects showed Class I features. Thus, OEC can be widely advocated as an addition to clinical conclusion and an adjunct to biopsy.

scholarly journals Complete Blood Count as a Diagnostic Marker in Oral Lichen Planus

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1766-1771
Author(s):  
Indra G ◽  
Maragathavalli G ◽  
Deepika Rajendran
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Blood Count ◽  
Diagnostic Marker ◽  
Complete Blood Count ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Oral Precancerous Lesions ◽  
Oral Lichen

Oral precancerous lesions and conditions like oral lichen planus, leukoplakia, or oral submucous fibrosis have the potential to develop into oral cancer. Oral cancer accounts for approximately 3 % of all malignancies. Oral lichen planus is a premalignant condition occurring in the oral cavity due to various factors. Blood investigations are routinely done minimally invasive procedures carried out for various diagnostic purposes. The study aims to identify if the complete blood count (CBC) can be used as a pathologic diagnostic marker in an oral premalignant disorder like oral lichen planus. A total of 64 patients (38 female, 26 male) were taken into the study between the period July 2019 - March 2020. Each patient is exposed to blood investigations, and their results are studied. The results of the study show a minimal variation in the blood results. In conclusion, to determine if it can be used as a pathological diagnostic marker in premalignant disorders like oral lichen planus, further studies must be carried out in larger populations.

scholarly journals A clinical study on precancerous lesions of oral cavity in patients attending dental hospital, Telangana

2019 ◽  
Vol 6 (11) ◽  
pp. 4739
Author(s):  
Soundarya Hanumakonda ◽  
Marri Swetha ◽  
Mallela Bhashitha ◽  
Harsha Mudigonda
Keyword(s):  
Oral Cavity ◽  
Oral Lichen Planus ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Age Distribution ◽  
Precancerous Lesion ◽  
Number Of Patients ◽  
Dental Hospital ◽  
Submucous Fibrosis ◽  
Oral Lichen

Background: Aim of the retrospective study is to determine the type and frequency of the precancerous lesions of the oral cavity and to assess their sex, age distribution among the patients.Methods: Study was conducted based on year-wise data collected during 2015 to 2018 of all the patients with precancerous lesions of oral cavity.Results: The total number of patients was 1247, out of which 803 (64.39%) were males and 444 (35.60%) were females. Most common precancerous lesion is oral submucous fibrosis (70.24%) followed by oral lichen planus (19.08%), leukoplakia (8.98%), erythroplakia (1.68%).Conclusions: We observed marked geographical variation in the incidences of various precancerous lesions. Mostly males are affected by precancerous lesions than females.

scholarly journals Evaluation of polymorphism of P53 protein codon 72 in oral lichen planus by PCR technique

2018 ◽  
Vol 12 (4) ◽  
pp. 245-251 ◽  
Author(s):  
Seyed Hosein Tabatabaei ◽  
Mohammad Hasan Sheikhha ◽  
Mahammad Hasan Akhavan Karbasi ◽  
sedighe zarmehi ◽  
Mehdi Hoseini
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
P53 Protein ◽  
Positive Control ◽  
Negative Control ◽  
Predisposing Factor ◽  
Tissue Samples ◽  
Codon 72 ◽  
Chi Squared ◽  
Oral Lichen

Background. Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control. Methods. Seventy paraffin-embedded tissue samples (30 OLP, 20 OSCC and 20 IFH) were studied. DNA was purified and amplified using allele-specific polymerase chain reaction to detect polymorphism. The final amplified products were identified using gel electrophoresis. Data were analyzed using chi-squared test and odds ratio. Results. The mean ages in the OLP, OSCC and IFH groups were 43.28, 58.2 and 53.47 years, respectively, with significant differences. There were no significant differences in gender between the three groups (P=0.413); however, the differences in genotypes and alleles were significant between the three groups (P=0.021 and P=0.030, respectively). By considering IFH as a reference, the frequency of proline allele in OLP and OSCC was significantly higher than that of arginine allele (P=0.015 and P=0.028, respectively). In addition, by considering OSCC as a reference and at P=1, there were no significant differences in the frequencies of alleles between OSCC and OLP. Conclusion. The results might indicate the premalignant potential of OLP, and such polymorphism might be a genetic predisposing factor for conversion of OLP to OSCC. In addition, in the subjects evaluated the proline allele was considered a risk factor.

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