scholarly journals Central Corneal Thickness and Corneal Endothelial Cell Changes Caused by Contact Lens Use in Diabetic Patients

2011 ◽  
Vol 52 (2) ◽  
pp. 322 ◽  
Author(s):  
Hyun Sung Leem ◽  
Koon Ja Lee ◽  
Ki Cheul Shin
Keyword(s):  
Endothelial Cell ◽  
Contact Lens ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Diabetic Patients ◽  
Cell Changes

scholarly journals The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness

2020 ◽  
Author(s):  
Tae Gi Kim ◽  
Yoo Jin Kim
Keyword(s):  
Type 2 Diabetes ◽  
Endothelial Cell ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Control Group ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
Significant Difference

Abstract Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 type 2 diabetes patients (1022 eyes) and 900 (1799 eyes) non-diabetic patients. The endothelial cell density (ECD), variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness (CCT) were analyzed using a noncontact specular microscope and a Pentacam Scheimpflug camera. We also examined the correlation between the corneal parameters and the duration of diabetes. Blood HbA1c results in DM patients were used within 2 months of ophthalmic examination. The controls had no diabetes confirmed by blood tests. For all ages, the subjects with type 2 diabetes showed significantly lower ECD, hexagonality, higher CV, and thicker CCT than the control group. This difference was more pronounced in patients with long-standing DM (≥10 years) and high HbA1c (≥7 %). When stratified by age group, from the 60s group, corneal endothelial cell parameters showed a statistically significant difference between DM and control groups. The duration of diabetes was inversely correlated with ECD (r=-0.167; P=0.000), but HbA1c was not correlated with ECD. These findings suggest that diabetes affects corneal endothelial cell in older age and those with long-standing DM and higher HbA1c. Regular corneal endothelial examinations are required in diabetic patients.

scholarly journals The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoo Jin Kim ◽  
Tae Gi Kim
Keyword(s):  
Type 2 Diabetes ◽  
Endothelial Cell ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Control Group ◽  
Diabetic Patients ◽  
Duration Of Diabetes ◽  
Significant Difference

AbstractAim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 (1022 eyes) type 2 diabetes patients and 900 (1799 eyes) non-diabetic patients. The endothelial cell density (ECD), variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness (CCT) were analyzed using a noncontact specular microscope and a Pentacam Scheimpflug camera. We also examined the correlation between the corneal parameters and the duration of diabetes. For total ages, the subjects with type 2 diabetes showed significantly lower ECD, hexagonality, higher CV, and thicker CCT than the control group. This difference was more pronounced in patients with long-standing DM (≥ 10 years) and high HbA1c (≥ 7%). When stratified by age group, from the 60 s group, corneal endothelial cell parameters showed a statistically significant difference between DM and control groups. The duration of diabetes was inversely correlated with ECD (r =  − 0.167; p = 0.000). These findings suggest that diabetes affects corneal endothelial cell in older age and those with long-standing DM and higher HbA1c. Regular corneal endothelial examinations are required in diabetic patients.

scholarly journals Panretinal photocoagulation laser in diabetic retinopathy patients

2021 ◽  
Vol 15 (6) ◽  
pp. 1820-1823
Author(s):  
Farshad Ostadian ◽  
Fereydoun Farrahi ◽  
Bahman Cheraghian
Keyword(s):  
Diabetic Retinopathy ◽  
Endothelial Cell ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Diabetic Patients ◽  
Panretinal Photocoagulation ◽  
Double Frequency ◽  
Frequency Laser ◽  
Photocoagulation Laser

Background: It was reported that corneal endothelial cell depletion is a complication of the retinal laser. In this study, the effect of panretinal laser on corneal endothelium was investigated. Method: A group consisting of 47 eyes of 47 Diabetic patients who need a panretinal photocoagulation laser was compared with another group of 47 diabetic patients who did not require a laser. The patient's age was chosen in the range of 50-70 and the tools included Ellex double frequency LASER, Specular microscopy, Pachymetry, and Condense Lens 90. Time course of coefficient of variation, endothelial cell density, hexagonal cells and central corneal thickness were evaluated. ANOVA, Dennett's, and Mann-Whitney test was used to compare the data. P-value of <0.05 was considered statistically significant. Results: We found no significant differences in age, gender between the two groups. There was no significant differences in hexagonal cells, coefficient of variation, endothelial cell density and central corneal thickness between the two groups at any time points. Conclusion: This study suggests that the "panretinal photocoagulation laser" conserves corneal endothelial cells of subsequent damage in diabetic retinopathy patients Keywords: photocoagulation laser, corneal, endothelial cell, argon laser, double frequency laser.

scholarly journals ROLE OF VITAMIN D IN ENDOTHELIAL CELL OF RETINA

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Dr. Sonpal Jindal ◽  
Dr. Mukesh Kumar Taneja
Keyword(s):  
Vitamin D ◽  
Endothelial Cell ◽  
Vitamin D Deficiency ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Control Group ◽  
Study Group ◽  
Vitamin D Levels ◽  
Corneal Endothelial Cell Density

Vitamin D deficiency is a common health problem worldwide. Many parts of the human eye, including the epithelium of the cornea, lens, ciliary body, and retinal pigment epithelium, as well as the corneal endothelium, ganglion cell layer, and retinal photoreceptors, contain vitamin D receptor. Physiological effects of vitamin D From an ocular point of view, the role in macular and retinal health had been advanced, as well as the involvement in corneal inflammatory response, wound healing, and dry eye disease. The most important effect of vitamin D is on, phosphorus, calcium metabolism and on bone mineralization. Recently, it was observed that vitamin D deficiency and insufficiency are related with common cancers, cardiovascular diseases, metabolic syndromes, infectious, and many chronic diseases including autoimmune disease. Benefits of vitamin D may be amplified through synergistic interaction with topical corticosteroids which accelerates improvement in corneal shape and optics, substantially benefiting the control of ocular surface disease and dry eye symptoms. Aqueous humour is the primary source responsible for the feeding of corneal endothelial layer hence endothelial abnormalities can be expected due to accumulated inflammatory cytokines and multiple toxic products in the aqueous humour of the patients with vitamin D deficiency. MATERIAL AND METHODS: Subjects were selected with vitamin D deficiency in the age group of 20–55 years. 50 patients having serum vitamin D levels <15 ng/ml were included in the study. Serum vitamin D levels of <15 ng/ml were included in the control group. Vitamin D levels in tear fluid were measured by direct competitive chemiluminescent enzyme linked immunoassay. A complete ophthalmic evaluation was performed in all participants which includes assessment of visual acuity, anterior segment evaluation and posterior segment evaluation. Specular microscopy was performed on the eyes of the patients with vitamin D deficiency and healthy control group individuals. Corneal endothelial cell density (CD) and central corneal thickness (CCT) values were calculated automatically using the software of the specular microscope.  RESULTS: The study group included 23 male and 27 female subjects while study group included 24 male and 26 female. Mean age of male in study group was 46.4 ± 12.56 and female was 45.6 ± 11.77. In control group mean male age was 48.5 ± 9.25 and female age was 49.56 ± 12.55. In study group Mean Corneal endothelial cell density (CD)  was observed as 2632.89 ± 189.25 cells/mm 2  and Mean central corneal thickness (CCT) was 587.2 ± 25.89 μ. In control group Mean Corneal endothelial cell density (CD) was observed as 2954.97 ± 116.89 cells/mm 2  and Mean central corneal thickness (CCT) was 546.0 ± 36.22 μ. Vitamin D levels of Tears in study group was 8.4 ± 1.7 ng/ml  and in control group it was 16.2 ± 2.3 ng/ml. CONCLUSION: It has been observed that there is statistically significant difference in the corneal endothelial cell density (CD) and central corneal thickness (CCT) in patients with vitamin D deficiency. It was observed that Vitamin D is present in tear fluid and there is significant difference in the levels of vitamin D in study and control group.

scholarly journals Corneal thickness and endothelial cell density in diabetic and non- diabetic patients: a hospital based comparative study

2018 ◽  
Vol 5 (3) ◽  
pp. 694 ◽  
Author(s):  
Nagaraj G. ◽  
Anasuya Sangaraj Desai ◽  
Nagesh Jayaram
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Endothelial Cell Density ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Specular Microscopy ◽  
The Mean

Background: Diabetes mellitus is associated with structural changes in corneal endothelial cells and their thickness. The present study was done to compare the endothelial cell density (ECD), central corneal thickness (CCT) and morphology in diabetic and non-diabetic patients.Methods: A cross-sectional study was conducted at Minto Ophthalmic hospital, BMC and RI Bangalore for a period of 20 months (October 2013 - May 2015). A total of 200 study subjects, 100 diabetics and 100 non-diabetic age matched controls were selected, and complete timed ophthalmic evaluation was performed. Specular microscopy was performed on all patients for endothelial cell count assessment and corneal thickness was measured by Pachymeter. The data was analyzed and represented using descriptive statistics. ‘t’ test was used for comparing the two groups.Results: The mean endothelial cell density in diabetic group was significantly lower (2438.73±250.23cells/mm2) compared to non-diabetic group (2599.88±168.16cells/mm2) (p<0.0001). The mean Central corneal thickness in diabetic group was significantly higher (518.40±28.13 μm) compared to control group (490.14±24.31 μm) (p<0.001). The Co-efficient of variation percentage of the diabetics was higher than the non-diabetics but this difference was not statistically significant (P>0.05). The hexagonality percentage was significantly lower in diabetic group compared to the controls suggesting less pleomorphism in the diabetic group.Conclusions: The study concludes that the endothelial cell density was lower and central corneal thickness was higher in diabetic patients compared with the non-diabetics. The altered endothelial morphology was significantly seen in the form of pleomorphism (hexagonality) but polymegathism was not significantly altered.

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