scholarly journals Biodegradable poly (lactic acid) microspheres for drug delivery systems

2000 ◽  
Vol 41 (6) ◽  
pp. 720 ◽  
Author(s):  
Suong Hyn Hyon
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid ◽  
Biodegradable Poly

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

2014 ◽  
Vol 2 (20) ◽  
pp. 3133-3141 ◽  
Author(s):  
Claire Jouannin ◽  
Corine Tourné-Péteilh ◽  
Vincent Darcos ◽  
Tahmer Sharkawi ◽  
Jean-Marie Devoisselle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

Drug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen

2013 ◽  
Vol 33 (7) ◽  
pp. 4002-4008 ◽  
Author(s):  
Ana Paula Serafini Immich ◽  
Manuel Lis Arias ◽  
Núria Carreras ◽  
Rafael Luís Boemo ◽  
José Antonio Tornero
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid ◽  
Nanofiber Membranes

Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems

2013 ◽  
Vol 21 (4) ◽  
pp. 1064-1071 ◽  
Author(s):  
Nita Tudorachi ◽  
Rodica Lipsa ◽  
Cornelia Vasile ◽  
Fanica Mustata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Aspartic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

Biodegradable poly(lactide-co-glycolide-co-ε-caprolactone) block copolymers – evaluation as drug carriers for a localized and sustained delivery system

2015 ◽  
Vol 3 (41) ◽  
pp. 8143-8153 ◽  
Author(s):  
Ji Hoon Park ◽  
Hwi Ju Kang ◽  
Doo Yeon Kwon ◽  
Bo Keun Lee ◽  
Bong Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Poly Lactic Acid ◽  
Sustained Delivery ◽  
System P ◽  
Biodegradable Poly

To develop an appropriate drug carrier for drug delivery systems, we prepared random poly(lactide-co-glycolide-co-ε-caprolactone) (PLGC) copolymers in comparison to commercial poly(lactic acid-co-glycolic acid) (PLGA) grades.

scholarly journals Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core–shell nanoparticles as a stimuli-responsive drug delivery system

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Ayae Sugawara-Narutaki ◽  
Katsuya Kato ◽  
Fukue Nagata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Delivery Systems ◽  
Ph Sensitivity ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Shell Nanoparticles ◽  
The Core ◽  
Core Shell Nanoparticles

Biodegradable nanoparticles have been well studied as biocompatible delivery systems. Nanoparticles of less than 200 nm in size can facilitate the passive targeting of drugs to tumour tissues and their accumulation therein via the enhanced permeability and retention (EPR) effect. Recent studies have focused on stimuli-responsive drug delivery systems (DDS) for improving the effectiveness of chemotherapy; for example, pH-sensitive DDS depend on the weakly acidic and neutral extracellular pH of tumour and normal tissues, respectively. In our previous work, core–shell nanoparticles composed of the biodegradable polymer poly(lactic acid) (PLA) and the widely used inorganic biomaterial hydroxyapatite (HAp, which exhibits pH sensitivity) were prepared using a surfactant-free method. These PLA/HAp core–shell nanoparticles could load 750 wt% of a hydrophobic model drug. In this work, the properties of the PLA/HAp core–shell nanoparticles loaded with the anti-cancer drug paclitaxel (PTX) were thoroughly investigated in vitro . Because the PTX-containing nanoparticles were approximately 80 nm in size, they can be expected to facilitate efficient drug delivery via the EPR effect. The core–shell nanoparticles were cytotoxic towards cancer cells (4T1). This was due to the pH sensitivity of the HAp shell, which is stable in neutral conditions and dissolves in acidic conditions. The cytotoxic activity of the PTX-loaded nanoparticles was sustained for up to 48 h, which was suitable for tumour growth inhibition. These results suggest that the core–shell nanoparticles can be suitable drug carriers for various water-insoluble drugs.

New biodegradable polymers of L-lactic acid and aromatic hydroxy acids and their applications in drug delivery systems

1992 ◽  
Vol 81 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Kazumichi Imasaka ◽  
Masaru Yoshida ◽  
Hironobu Fukuzaki ◽  
Masaharu Asano ◽  
Minoru Kumakura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Biodegradable Polymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydroxy Acids

scholarly journals Nanosized Minicells Generated by Lactic Acid Bacteria for Drug Delivery

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Huu Ngoc Nguyen ◽  
Santa Romero Jovel ◽  
Tu Hoang Khue Nguyen
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
The Body ◽  
Inorganic Nanoparticles ◽  
Microbial Infection ◽  
Clinical Stages

Nanotechnology has the ability to target specific areas of the body, controlling the drug release and significantly increasing the bioavailability of active compounds. Organic and inorganic nanoparticles have been developed for drug delivery systems. Many delivery systems are through clinical stages for development and market. Minicell, a nanosized cell generated by bacteria, is a potential particle for drug delivery because of its size, safety, and biodegradability. Minicells produced by bacteria could drive therapeutic agents against cancer, microbial infection, and other diseases by targeting. In addition, minicells generated by lactic acid bacteria being probiotics are more interesting than others because of their benefits like safety, immunological improvement, and biodegradation. This review aims to highlight the stages of development of nanoparticle for drug delivery and discuss their advantages and limitations to clarify minicells as a new opportunity for the development of potential nanoparticle for drug delivery.

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