scholarly journals Growth Inhibitory Effect of Palatine Tonsil-derived Mesenchymal Stem Cells on Head and Neck Squamous Cell Carcinoma Cells

2012 ◽  
Vol 5 (2) ◽  
pp. 86 ◽  
Author(s):  
Yun-Sung Lim ◽  
Jin-Choon Lee ◽  
Yoon Se Lee ◽  
Byung-Joo Lee ◽  
Soo-Geun Wang
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Mesenchymal Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Inhibitory Effect ◽  
Carcinoma Cells ◽  
Growth Inhibitory Effect ◽  
Growth Inhibitory

scholarly journals Interaction of head and neck squamous cell carcinoma cells and mesenchymal stem cells under hypoxia and normoxia

2020 ◽  
Vol 20 (5) ◽  
pp. 1-1
Author(s):  
Christian Wilhelm ◽  
Agmal Scherzad ◽  
Maximilian Bregenzer ◽  
Till Meyer ◽  
Thomas Gehrke ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Mesenchymal Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma

scholarly journals Resident and bone marrow-derived mesenchymal stem cells in head and neck squamous cell carcinoma

Oral Oncology ◽  
2010 ◽  
Vol 46 (5) ◽  
pp. 336-342 ◽  
Author(s):  
Astrid De Boeck ◽  
Kishan Narine ◽  
Wilfried De Neve ◽  
Marc Mareel ◽  
Marc Bracke ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Squamous Cell Carcinoma ◽  
Mesenchymal Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

scholarly journals Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Oncotarget ◽  
2017 ◽  
Vol 8 (13) ◽  
pp. 20961-20973 ◽  
Author(s):  
Muzafar A. Macha ◽  
Satyanarayana Rachagani ◽  
Asif Khurshid Qazi ◽  
Rahat Jahan ◽  
Suprit Gupta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma

Different Aspects of Head and Neck Squamous Cell Carcinoma: Cancer Stem Cells, Their Niche and Targeted Therapy

2020 ◽  
Vol 15 ◽  
Author(s):  
Meriç Bilgiç Küçükgüven ◽  
Betül Çelebi-Saltik
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Targeted Therapy ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Crucial Role ◽  
Tumor Therapy ◽  
Neck Squamous Cell Carcinoma

: Head and Neck Squamous Cell Carcinoma (HNSCC) is categorized as the sixth most common cancer worldwide, with an incidence of more than 830,000 cases per year and a mortality rate of 50%. Tobacco use, alcohol consumption, and Human Papillomavirus infection are the prominent risks for HNSCC. Despite significant developments in the treatment of HNSCC, a high rate of recurrences makes the clinical situation worse and results in poor survival rates. Recent perspectives demonstrate that whereas epithelial transformation plays a crucial role in cancer development, tumor surrounding microenvironment takes part in progression of cancer as well. Cancer Stem Cells (CSCs), which harbor unlimited self-renewal capacity, have a crucial role in the growth of HNSCC and this cell population is responsible for tumor recurrence unless eliminated by targeted therapy. CSCs are not only a promising target for tumor therapy, but also a crucial biomarker to determine the patients at high risk for undetermined results and disease development. Just as the bone marrow which is the niche of hematopoietic and mesenchymal stem cells, is important for stem cells maintenance. Similarly, the concept of microenvironment is also important for the maintenance of CSCs. Apart from the cell-cell interactions, there are many parameters in the cancer microenvironment that affect the development of cancer, such as extracellular regulation, vascularization, microbial flora, pH and oxygenation. The purpose of this review is to introduce HNSCC, explain the role of CSCs and their microenvironment and refer to the conventional and novel targeted therapy for HNSCC and CSCs.

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