scholarly journals Invasive cystic hypersecretory carcinoma of breast associated with papillary pattern: a rare and poorly recognised variant of ductal carcinoma of the breast

2014 ◽  
Vol 8 ◽  
Author(s):  
Parul Gupta
Keyword(s):  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Cystic Hypersecretory Carcinoma ◽  
Papillary Pattern

Invasive Cystic Hypersecretory Ductal Carcinoma of Breast

1999 ◽  
Vol 123 (11) ◽  
pp. 1108-1110 ◽  
Author(s):  
Marille E. Herrmann ◽  
Kenneth D. McClatchey ◽  
Kalliopi P. Siziopikou
Keyword(s):  
Ductal Carcinoma ◽  
Breast Disease ◽  
Invasive Disease ◽  
Carcinoma Of The Breast ◽  
Current Case ◽  
Long Term Follow Up ◽  
Lobular Breast Carcinoma ◽  
Cystic Hypersecretory Carcinoma

Abstract Few individual cases of invasive cystic hypersecretory ductal carcinoma of the breast have been described. Review of 33 cases of cystic hypersecretory carcinoma, including the current case, indicate that only 6 cases presented with invasive disease. Two of these cases had positive nodes and 2 had distal metastases. The case presented here is unique in an additional aspect: the contralateral breast harbored lobular breast carcinoma 10 years after mastectomy of the first malignancy. Bilateral breast disease resulting in bilateral mastectomies over long-term follow-up, as in the case presented here, was reported in 3 of 33 cases.

Acinic Cell Carcinoma of the Breast: Report of a Case With Immunohistochemical and Next-Generation Sequencing Studies

2021 ◽  
pp. 106689692110085
Author(s):  
Kaitlin D. Weaver ◽  
James Isom ◽  
Ashwini Esnakula ◽  
Karen Daily ◽  
Jaya R. Asirvatham
Keyword(s):  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Left Breast ◽  
Acinic Cell Carcinoma ◽  
Next Generation ◽  
Carcinoma Of The Breast ◽  
Acinic Cell ◽  
Generation Sequencing

Acinic cell carcinoma of the breast is a rare subtype of triple-negative breast cancer that recapitulates the appearance of tumors seen in salivary glands. We present the case of a 42-year-old woman with an irregular, nontender mass above the left nipple during routine obstetric appointment at 24 weeks gestation. She was subsequently diagnosed with triple-negative invasive ductal carcinoma of the left breast, Nottingham grade 3, via core needle biopsy. She was treated with neoadjuvant therapy (doxorubucin and cyclophosphamide) antenatally and paclitaxel in the postpartum period followed by left mastectomy with sentinel node biopsy. The carcinoma in the mastectomy specimen showed a spectrum of morphologic patterns with immunohistochemistry revealing strong positivity for alpha-1-antichymotrypsin, epithelial membrane antigen (EMA), lysozyme, and S100. The histomorphology paired with the immunoprofile led us to the diagnosis of acinic cell carcinoma. We retrospectively performed immunostains in the core biopsy specimen, which demonstrated GATA-3 and DOG-1 positivity. Next-generation sequencing of the postneoadjuvant specimen using a 70-gene panel revealed 2 single-nucleotide variant (SNV) mutations: tumor protein 53 (TP53) (c.747G>T) SNV mutation and rearranged during transfection (RET) (c.2899G>A) SNV mutation.

High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast

PROTEOMICS ◽  
2003 ◽  
Vol 3 (10) ◽  
pp. 1863-1873 ◽  
Author(s):  
Richard I. Somiari ◽  
Anthony Sullivan ◽  
Stephen Russell ◽  
Stella Somiari ◽  
Hai Hu ◽  
...  
Keyword(s):  
High Throughput ◽  
Proteomic Analysis ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Infiltrating Ductal Carcinoma

Coexistent adenomyoepithelioma and invasive ductal carcinoma of the breast: presentation as separate tumors

2008 ◽  
Vol 41 (4) ◽  
pp. 238-242 ◽  
Author(s):  
Naoto Kuroda ◽  
Nokiaki Fujishima ◽  
Masahiko Ohara ◽  
Takashi Hirouchi ◽  
Keiko Mizuno ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast
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