scholarly journals Establishing a Central Registry of State Assets: third time lucky?

2018 ◽  
pp. 1-3
Author(s):  
Anto Bajo ◽  
◽  
Marko Ignjatović
Keyword(s):  
Central Registry

Initial Reports on Child Abuse and Neglect from the U. S. Army Central Registry (1975-1995)

1996 ◽  
Author(s):  
J. E. McCarroll ◽  
◽  
R. J. Ursano ◽  
A. E. Norwood ◽  
C. S. Fullerton ◽  
...  
Keyword(s):  
Child Abuse ◽  
Child Abuse And Neglect ◽  
Central Registry ◽  
Abuse And Neglect

scholarly journals Laminopathies’ Treatments Systematic Review: A Contribution Towards a ‘Treatabolome’

2021 ◽  
pp. 1-21
Author(s):  
Antonio Atalaia ◽  
Rabah Ben Yaou ◽  
Karim Wahbi ◽  
Annachiara De Sandre-Giovannoli ◽  
Corinne Vigouroux ◽  
...  
Keyword(s):  
Rare Diseases ◽  
Case Reports ◽  
Phenotypic Expression ◽  
Genetic Diagnosis ◽  
Specific Treatment ◽  
Case Series ◽  
Treatment Recommendations ◽  
Scientific Data ◽  
Bibliographic Databases ◽  
Central Registry

Background: Variants in the LMNA gene, encoding lamins A/C, are responsible for a growing number of diseases, all of which complying with the definition of rare diseases. LMNA-related disorders have a varied phenotypic expression with more than 15 syndromes described, belonging to five phenotypic groups: Muscular Dystrophies, Neuropathies, Cardiomyopathies, Lipodystrophies and Progeroid Syndromes. Overlapping phenotypes are also reported. Linking gene and variants with phenotypic expression, disease mechanisms, and corresponding treatments is particularly challenging in laminopathies. Treatment recommendations are limited, and very few are variant-based. Objective: The Treatabolome initiative aims to provide a shareable dataset of existing variant-specific treatment for rare diseases within the Solve-RD EU project. As part of this project, we gathered evidence of specific treatments for laminopathies via a systematic literature review adopting the FAIR (Findable, Accessible, Interoperable, and Reusable) guidelines for scientific data production. Methods: Treatments for LMNA-related conditions were systematically collected from MEDLINE and Embase bibliographic databases and clinical trial registries (Cochrane Central Registry of Controlled Trials, clinicaltrial.gov and EudraCT). Two investigators extracted and analyzed the literature data independently. The included papers were assessed using the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. Results: From the 4783 selected articles by a systematic approach, we identified 78 papers for our final analysis that corresponded to the profile of data defined in the inclusion and exclusion criteria. These papers include 2 guidelines/consensus papers, 4 meta-analyses, 14 single-arm trials, 15 case series, 13 cohort studies, 21 case reports, 8 expert reviews and 1 expert opinion. The treatments were summarized electronically according to significant phenome-genome associations. The specificity of treatments according to the different laminopathic phenotypical presentations is variable. Conclusions: We have extracted Treatabolome-worthy treatment recommendations for patients with different forms of laminopathies based on significant phenome-genome parings. This dataset will be available on the Treatabolome website and, through interoperability, on genetic diagnosis and treatment support tools like the RD-Connect’s Genome Phenome Analysis Platform.

scholarly journals Impact of the Level of Adherence to Mediterranean Diet on the Parameters of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1514
Author(s):  
Dimitra Rafailia Bakaloudi ◽  
Lydia Chrysoula ◽  
Evangelia Kotzakioulafi ◽  
Xenophon Theodoridis ◽  
Michail Chourdakis
Keyword(s):  
Metabolic Syndrome ◽  
Mediterranean Diet ◽  
Observational Studies ◽  
Positive Impact ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Central Registry ◽  
High Adherence ◽  
The Impact

High adherence to the Mediterranean diet (MD) has been associated with a lower prevalence of Metabolic Syndrome (MetS). The present study aimed to investigate the impact of MD adherence on parameters of MetS. A systematic literature search was performed in PubMed, Cochrane Central Registry of Clinical Trials (CENTRAL), Scopus, EMBASE, Web of Science and Google Scholar databases. Observational studies that recorded adherence to MD and components/measures of the MetS, such as waist circumference (WC), blood pressure (BP), fasting blood glucose (FBG), high-density lipoprotein (HDL) cholesterol and triglycerides (TG), were included in this study. A total of 58 studies were included in our study. WC and TG were significantly lower in the high adherence MD group (SMD: −0.20, (95%CI: −0.40, −0.01), SMD: −0.27 (95%CI: −0.27, −0.11), respectively), while HDL cholesterol was significantly higher in the same group (SMD: −0.28 (95%CI: 0.07, 0.50). There was no difference in FBG and SBP among the two groups (SMD: −0.21 (95%CI: −0.54, 0.12) & SMD: −0.15 (95%CI: −0.38, 0.07), respectively). MD may have a positive impact on all parameters of MetS. However, further research is needed in this field.

A STUDY OF THE ACCURACY OF CANCER RISK FACTOR INFORMATION REPORTED TO A CENTRAL REGISTRY COMPARED WITH THAT OBTAINED BY INTERVIEW

1989 ◽  
Vol 129 (3) ◽  
pp. 616-624 ◽  
Author(s):  
ROSS C. BROWNSON ◽  
JAMES R DAVIS ◽  
JIAN C. CHANG ◽  
THOMAS M. DILORENZO ◽  
THOMAS J. KEEFE ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cancer Risk ◽  
Cancer Risk Factor ◽  
Central Registry ◽  
Risk Factor Information

scholarly journals 1178 High coronary wall shear strain developed more vulnerable plaque compared to low shear strain: a systematic review and meta-analysis

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
A B Bajraktari ◽  
I B Bytyci ◽  
S E Elezi ◽  
M Y H Henein
Keyword(s):  
Shear Strain ◽  
Vulnerable Plaque ◽  
Meta Analysis ◽  
Necrotic Core ◽  
Core Area ◽  
Plaque Area ◽  
Central Registry ◽  
Wall Shear ◽  
The Impact

Abstract Background and Aim Arterial wall strain has been proposed to impact the features of developed plaques. The aim of this meta-analysis is to assess the impact of different types of wall shear strain (WSS) on the changes of vulnerable plaque in coronary artery disease (CAD). Methods We systematically searched PubMed-Medline, EMBASE, Scopus, Google Scholar and the Cochrane Central Registry, from 1989 up to May 2019 in order to select clinical trials and observational studies, which assessed the relationship between WSS measured by intravascular ultrasound (IVUS) and morphology of plaque in CAD. Results In 7 studies, a total of 724 patients with 32,083 segments were recruited, with mean follow up 8.4 months. The pooled analysis showed that low WSS was associated with larger baseline lumen area WMD 2.55 [1.34 to 3.76, p < 0.001], smaller plaque area WMD -1.16 [-0.1.84 to -0.49, p = 0007] and necrotic core area WMD -0.45 [-0.78 to 0.14, p = 0.004], dense calcium score WMD -0.18 [-0.46 to 0.10, p = 0.01], and fibrous area WMD -0.79 [-1.84 to 0.30, p = 0.02] as well as smaller fibro-fatty area WMD -0.22 [-0.57 to 0.13, p = 0.02] compared to high WSS. At follow-up, the high WSS had regression of fibrous area, WMD -0.12 [-0.22 to -0.02, p = 0.02] and fibro-fatty area WMD -0.11 [-0.23 to -0.01, p = 0.04], reduction of plaque area WMD -0.09 [-0.17 to -0.02, p = 0.01] and increased dense calcium WMD 0.08 [0.02 to 0.14, p = 0.006] and necrotic core area WMD 0.07 [0.01 to 0.13, p = 0.03] compared to low WSS (Figure 1). The high WSS developed more profound remodeling compared to low WSS (40 vs. 18%, p < 0.05) with more constructive remodelling with low WSS (78%vs. 40 %, p < 0.01). Conclusions. Baseline high WSS is associated with higher necrotic core, calcium, fibrous and fibro-fatty area compared with low WSS, and during follow up the high WSS resulted in the development of more profound remodeling compared with low WSS. These findings highlighted the role of IVUS in detecting the vulnerable plaque in CAD. Abstract 1178 Figure 1. Mean change of plaque morpholo

Clinical Utility of Hyperglycosylated hCG in Serum Taken before Hydatidiform Mole Evacuation to Predict Persistent Trophoblastic Disease

2006 ◽  
Vol 21 (1) ◽  
pp. 45-49 ◽  
Author(s):  
H. Ngo Duc ◽  
N.E. van Trommel ◽  
F.C.G.J. Sweep ◽  
L.F.A.G. Massuger ◽  
C.M.G. Thomas
Keyword(s):  
Diagnostic Accuracy ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hydatidiform Mole ◽  
Subsequent Development ◽  
Serum Samples ◽  
Roc Curve Analysis ◽  
Trophoblastic Disease ◽  
Central Registry ◽  
Hydatidiform Moles

Objective Human chorionic gonadotropin (hCG) is widely used in the management of hydatidiform mole and persistent trophoblastic disease (PTD). Studies on hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen, ITA) in PTD are limited. In serum samples taken before evacuation of molar pregnancies we measured the concentrations of free hCG β-subunit (free hCGβ), “total” hCG (hCG+hCGβ) and ITA, and determined whether ITA, the two other hCG analytes, or the calculated ratios of hCGβ/hCG+hCGβ, hCGβ/ITA and hCG+hCGβ/ITA could predict the later development of PTD. Design A retrospective study based on blood specimens collected in the Dutch Central Registry for Hydatidiform Moles. The study group comprised 97 patients with hydatidiform moles who did not develop PTD after mole evacuation and 33 patients who did develop PTD. Methods Serum samples from 130 patients with hydatidiform mole with or without PTD were assayed using specific (radio)immunoassays for free hCGβ, total hCG, and ITA. From these analytes we also calculated the ratios hCGβ/hCG+hCGβ, hCGβ/ITA, and hCG+hCGβ/ITA. To predict the development of PTD from these analytes and parameters we performed receiver-operating characteristic (ROC) curve analysis, resulting in areas under the curve (AUCs) that represented the diagnostic accuracy which was rated in a range from excellent (AUC >0.9 or <0.1) to poor (AUC 0.4–0.6). Results The diagnostic accuracy of ITA was moderate (0.618) and not different from that of free hCGβ (0.610) and hCG+hCGβ (0.622). Conclusions ITA as well as the other analytes and parameters in serum taken prior to evacuation from patients with molar pregnancies cannot be used to predict the subsequent development of persistent trophoblastic disease.

scholarly journals The Effect of Perinatal Fish Oil Supplement on Perinatal Depression: A Systemic Review and Meta- Analysis of Randomized Clinical Trials

2019 ◽  
pp. 262-271
Author(s):  
Helman S ◽  
Baker RB ◽  
Hassan M ◽  
Nafee T ◽  
Yang J ◽  
...  
Keyword(s):  
Fish Oil ◽  
Odds Ratio ◽  
Randomized Clinical Trials ◽  
Perinatal Depression ◽  
Meta Analysis ◽  
Systemic Review ◽  
Effect Measure ◽  
Central Registry ◽  
Fish Oil Supplementation ◽  
Reduced Risk

Background: Perinatal depression is a common complication of pregnancy and can have severe and long-termadverse effects on both mother and infant. Randomized controlled trials (RCT) assessing the effect of fish oilsupplements on perinatal depression have shown mixed results.Objectives: We performed a systematic review and meta-analysis to assess the effects of fish oil supplementation during pregnancy on perinatal depression.Methods: A comprehensive search of MEDLINE (PubMed), EMBASE, and Cochrane Central Registry were conducted in adherence with the PRISMA guideline. Only RCTs published in English from January 2000 to date were included. The participants were pregnant women receiving fish oil supplementation or placebo. Summary effect measure of each study was converted to a common effect measure (log odds ratio) and its variance was calculated to estimate the pooled odds ratio and its 95% confidence Interval using random Effects model. Heterogeneity was assessed used restricted maximum likelihood method.Results: Nine trials were included in our analysis (2,979 women). Prevention Cohort (n = 5): Fish oil supplementation during pregnancy was associated with reduced risk of developing perinatal depression (OR: 0.87; CI: 0.076 to 0.99; p = 0.03). Treatment Cohort (n = 4) Fish oil supplementation during pregnancy was associated with reduced risk of persistent perinatal depression during postpartum period but did not reach statistical significance.Conclusion: In conclusion, a meta-analysis of included RCTs data shows a significant reduction in incidences of perinatal depression in women who received fish oil supplements during pregnancy. However, there was no evidence for a similar effect among women diagnosed with perinatal depression or women with major depressive disorder.

scholarly journals STUDY OF EMBARGO’S AFFECT ON CANCER IN IRAQ

2004 ◽  
Vol 1 (1) ◽  
pp. 93-101
Author(s):  
Baghdad Science Journal
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Respiratory System ◽  
Soft Tissues ◽  
Lymphatic System ◽  
Descriptive Statistics ◽  
Ministry Of Health ◽  
Central Registry ◽  
Productive System

different ?? ? injury ? This study aims to knowing the affect of embargo on cancer tutors in Iraq according to different body systems , In addition, this '?0 kinds study aims at knowing t^e categories ages that can be mostly injured by the cancer Egression analysis and descriptive statistics( median and frequency tables). ^?^???? have been used to achieve these two aims .This study includes ah the seventy cancer s Iraq from 1980-1998 and the data have been from the Ministry of Health / ?? tumors Iraqicancer board administration / central registry. The results of this study are emale productive? : Embargo has affected the ten different body systems as .? central nervous system and opthamamology , Hematology ,Respiratory ? system system , male productive system , lymphatic system, connective and other soft tissues

A randomized trial of nicardipine in subarachnoid hemorrhage: angiographic and transcranial Doppler ultrasound results

1993 ◽  
Vol 78 (4) ◽  
pp. 548-553 ◽  
Author(s):  
E. Clarke Haley ◽  
Neal F. Kassell ◽  
James C. Torner ◽  
_ _
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Doppler Ultrasound ◽  
Transcranial Doppler ◽  
Transcranial Doppler Ultrasound ◽  
High Dose ◽  
Content Type ◽  
Central Registry ◽  
Significant Difference ◽  
Fine Print ◽  
Flow Velocities

✓ Calcium antagonist drugs were proposed for use in patients with recent aneurysmal subarachnoid hemorrhage (SAH) because of their ability to block the effects of a wide variety of vasoconstrictor substances on cerebral arteries in vitro. It was suggested that these agents might, therefore, be useful in ameliorating cerebral vasospasm and its ischemic consequences which frequently complicate SAH. This hypothesis was tested in an arm of a randomized double-blind placebo-controlled trial of high-dose intravenous nicardipine in patients with recently ruptured aneurysms. Participating investigators were required to send selected copies of all admission and follow-up angiograms obtained between Days 7 and 11 following hemorrhage (the peak period of risk for vasospasm) to the Central Registry of the Cooperative Aneurysm Study for blinded interpretation and review for the presence and severity of angiographic vasospasm. In centers with transcranial Doppler ultrasound (TCD) capabilities, middle cerebral artery (MCA) mean flow velocities were measured and recorded. Angiograms obtained between Days 7 and 11 were available for 103 (23%) of 449 patients receiving nicardipine and 121 (26%) of 457 receiving placebo. There was a balance of prognostic factors for vasospasm between the groups. Fifty-one percent of placebo-treated patients had moderate or severe vasospasm on “Day 7–11 angiograms” compared to 33% of nicardipine-treated patients. This difference is statistically significant (p < 0.01). Sixty-seven (49%) of 137 placebo-treated patients examined with TCD between Days 7 and 11 had mean MCA flow velocities exceeding 120 cm/sec compared to 26 (23%) of 112 nicardipine-treated patients (significant difference, p < 0.001). These data suggest that high-dose intravenous nicardipine reduces the incidence and severity of delayed cerebral arterial narrowing in patients following aneurysmal SAH.

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