346. Occupational Exposures to Metalworking Fluids in Machine Shops

391. A Model for Occupational Exposure to Metalworking Fluids in Small-Sized Machine Shops

10.3320/1.2763744 ◽

2000 ◽

Author(s):

K. Sieber ◽

G. Piacitelli

Keyword(s):

Occupational Exposure ◽

Metalworking Fluids ◽

Machine Shops

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Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories

Occupational and Environmental Medicine ◽

10.1136/oemed-2017-104666 ◽

2018 ◽

Vol 75 (5) ◽

pp. 328-336 ◽

Cited By ~ 5

Author(s):

Régis Colin ◽

Michel Grzebyk ◽

Pascal Wild ◽

Guy Hédelin ◽

Ève Bourgkard

Keyword(s):

Bladder Cancer ◽

Occupational Exposure ◽

Case Control Study ◽

Occupational Exposures ◽

Case Control ◽

Metalworking Fluids ◽

Cumulative Exposure ◽

Cancer Case ◽

Increased Risk ◽

Control Study

ObjectivesTo assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence.MethodsA nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident bladder cancer case diagnosed from 2006 to 2012. Controls were matched to cases on age at diagnosis and counter-matched on a surrogate measure of exposure to MWFs derived from a job-exposure matrix. Cases (n=84) and controls (n=251) were face-to-face interviewed. Experts assessed occupational exposure to MWFs (straight, soluble and synthetic) using questionnaires and reports from factory visits. Occupational exposures were based on three metrics: duration, frequency-weighted duration and cumulative exposure index. Conditional multiple logistic regressions were used to determine ORs and 95% CIs, taking non-occupational and occupational exposure into account.ResultsIn the 25 years before diagnosis, ORs increased significantly with duration of exposure to straight MWFs (OR=1.13 (1.02–1.25)) and increased with frequency-weighted duration of exposure to straight MWFs (OR=1.44 (0.97–2.14)). These results remained valid after adjusting for duration of smoking, average number of cigarettes smoked per day, time since smoking cessation and exposure to polycyclic aromatic hydrocarbons (PAHs). ORs also increased with soluble MWFs but not significantly. No significant association was found with older exposures to MWFs or with exposure to synthetic MWFs.ConclusionThe increased risk of bladder cancer observed among workers exposed to straight MWFs and to a lesser extent to soluble MWFs may be explained by the presence of carcinogens (such as PAH) in mineral oils component of straight and soluble oils. Prevention therefore remains necessary in sectors using MWFs.

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An Evaluation of Short-Term Exposures to Metalworking Fluids in Small Machine Shops

AIHAJ - American Industrial Hygiene Association ◽

10.1080/15298660108984636 ◽

2001 ◽

Vol 62 (3) ◽

pp. 342-348 ◽

Cited By ~ 8

Author(s):

Dennis M. O'Brien ◽

Greg M. Piacitelli ◽

W. Karl Sieber ◽

Robert T. Hughes ◽

James D. Catalano

Keyword(s):

Metalworking Fluids ◽

Short Term ◽

Small Machine ◽

Machine Shops

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End-stage renal disease and metalworking fluid exposure

Occupational and Environmental Medicine ◽

10.1136/oemed-2020-106715 ◽

2021 ◽

pp. oemed-2020-106715

Author(s):

Deepika Shrestha ◽

Sally Picciotto ◽

Michael P LaValley ◽

Sa Liu ◽

S Katharine Hammond ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Renal Disease ◽

End Stage Renal Disease ◽

Occupational Exposures ◽

Metalworking Fluids ◽

Cumulative Exposure ◽

Subdistribution Hazard ◽

Risk Of Death ◽

Stage Renal Disease ◽

End Stage

ObjectiveDespite increasing prevalence of end-stage renal disease (ESRD), little attention has been directed to how occupational exposures may contribute to risk. Our objective was to investigate the relationship between metalworking fluids (MWF) and ESRD in a cohort of 36 703 male autoworkers.MethodsWe accounted for competing risk of death, using the subdistribution hazard approach to estimate subhazard ratios (sHRs) and 95% CIs in models with cubic splines for cumulative exposure to MWF (straight, soluble or synthetic).ResultsBased on 501 ESRD cases and 13 434 deaths, we did not observe an association between MWF and ESRD overall. We observed modest associations between MWF and ESRD classification of glomerulonephritis and diabetic nephropathy. For glomerulonephritis, the 60th percentile of straight MWF was associated with an 18% increased subhazard (sHR=1.18, 95% CI: 0.99 to 1.41). For diabetic nephropathy, the subhazard increased 28% at the 60th percentile of soluble MWF (sHR=1.28, 95% CI: 1.00 to 1.64). Differences by race suggest that black males may have higher disease rates following MWF exposure.ConclusionsExposure to straight and soluble MWF may be related to ESRD classification, though this relationship should be further examined.

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