scholarly journals Biosensors Technologies for Point-of-Care Testing – A Review

2020 ◽  
Vol 64 (4) ◽  
pp. 325-333
Author(s):  
Sylwia Baluta ◽  
Joanna Cabaj ◽  
Karol Malecha
Keyword(s):  
Continuous Monitoring ◽  
Point Of Care ◽  
Medical Intervention ◽  
Chronic Illnesses ◽  
In Situ Monitoring ◽  
Efficient Treatment ◽  
Physicochemical Changes ◽  
Wide Range ◽  
System Miniaturization ◽  
New Generation

Chronic illnesses require continuous monitoring and medical intervention for efficient treatment to be achieved. Therefore, designing a responsive system that will reciprocate to the physicochemical changes may offer superior therapeutic activity In this respect, biosensors development, which offers constant, fast, selective and sensitive in situ monitoring is extremely important. The ability of biosensors miniaturization opens new technological pathways for the development of innovative approaches, which will be able to detect a wide range of compounds in the "multi-mode" system. Miniaturization and integration of important components result in many advantages: reducing the time of analysis and laboratory processes, automatization of measurements, compactness, and portability. Biosensing instruments also represent a very promising scientific way for construction new generation of wearable, portable and implantable bioelectronic devices for Point-Of-Care (POC) testing application. Biosensors also offer a powerful opportunity in early diagnosis and treatment of illness, which is an essential value in the case of POC testing. POC is mostly focused on the patient with chronic illness, where the continuous monitoring of analytes, is required to allow changing of the dosage and treatment period. In this review, we present the application of biosensing platforms in one chip, which can be used in wireless, wearable and swallowable sensors for POC diagnostic.

scholarly journals Contagion Management at the Méditerranée Infection University Hospital Institute

2021 ◽  
Vol 10 (12) ◽  
pp. 2627
Author(s):  
Pierre-Edouard Fournier ◽  
Sophie Edouard ◽  
Nathalie Wurtz ◽  
Justine Raclot ◽  
Marion Bechet ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Early Diagnosis ◽  
Personal Protective Equipment ◽  
Early Stage ◽  
Point Of Care ◽  
University Hospital ◽  
Protective Equipment ◽  
Monitoring Point ◽  
Epidemiological Monitoring ◽  
Wide Range

The Méditerranée Infection University Hospital Institute (IHU) is located in a recent building, which includes experts on a wide range of infectious disease. The IHU strategy is to develop innovative tools, including epidemiological monitoring, point-of-care laboratories, and the ability to mass screen the population. In this study, we review the strategy and guidelines proposed by the IHU and its application to the COVID-19 pandemic and summarise the various challenges it raises. Early diagnosis enables contagious patients to be isolated and treatment to be initiated at an early stage to reduce the microbial load and contagiousness. In the context of the COVID-19 pandemic, we had to deal with a shortage of personal protective equipment and reagents and a massive influx of patients. Between 27 January 2020 and 5 January 2021, 434,925 nasopharyngeal samples were tested for the presence of SARS-CoV-2. Of them, 12,055 patients with COVID-19 were followed up in our out-patient clinic, and 1888 patients were hospitalised in the Institute. By constantly adapting our strategy to the ongoing situation, the IHU has succeeded in expanding and upgrading its equipment and improving circuits and flows to better manage infected patients.

scholarly journals The Impact of Initial Conditions in N-Body Simulations of Debris Discs

2015 ◽  
Vol 32 ◽  
Author(s):  
E. Thilliez ◽  
S. T. Maddison
Keyword(s):  
Numerical Simulations ◽  
Initial Conditions ◽  
Parent Body ◽  
Dust Trapping ◽  
Physical Context ◽  
Disc Width ◽  
Wide Range ◽  
Belt Width ◽  
New Generation ◽  
The Impact

AbstractNumerical simulations are a crucial tool to understand the relationship between debris discs and planetary companions. As debris disc observations are now reaching unprecedented levels of precision over a wide range of wavelengths, an appropriate level of accuracy and consistency is required in numerical simulations to confidently interpret this new generation of observations. However, simulations throughout the literature have been conducted with various initial conditions often with little or no justification. In this paper, we aim to study the dependence on the initial conditions of N-body simulations modelling the interaction between a massive and eccentric planet on an exterior debris disc. To achieve this, we first classify three broad approaches used in the literature and provide some physical context for when each category should be used. We then run a series of N-body simulations, that include radiation forces acting on small grains, with varying initial conditions across the three categories. We test the influence of the initial parent body belt width, eccentricity, and alignment with the planet on the resulting debris disc structure and compare the final peak emission location, disc width and offset of synthetic disc images produced with a radiative transfer code. We also track the evolution of the forced eccentricity of the dust grains induced by the planet, as well as resonance dust trapping. We find that an initially broad parent body belt always results in a broader debris disc than an initially narrow parent body belt. While simulations with a parent body belt with low initial eccentricity (e ~ 0) and high initial eccentricity (0 < e < 0.3) resulted in similar broad discs, we find that purely secular forced initial conditions, where the initial disc eccentricity is set to the forced value and the disc is aligned with the planet, always result in a narrower disc. We conclude that broad debris discs can be modelled by using either a dynamically cold or dynamically warm parent belt, while in contrast eccentric narrow debris rings are reproduced using a secularly forced parent body belt.

scholarly journals Review of Functional Treatments for Modified Wood

Coatings ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 327
Author(s):  
Morwenna J. Spear ◽  
Simon F. Curling ◽  
Athanasios Dimitriou ◽  
Graham A. Ormondroyd
Keyword(s):  
High Performance ◽  
Responsive Materials ◽  
Wood Modification ◽  
Wide Range ◽  
Natural Wood ◽  
Impregnation Modification ◽  
New Applications ◽  
New Generation ◽  
Dimensional Instability ◽  
Modified Wood

Wood modification is now widely recognized as offering enhanced properties of wood and overcoming issues such as dimensional instability and biodegradability which affect natural wood. Typical wood modification systems use chemical modification, impregnation modification or thermal modification, and these vary in the properties achieved. As control and understanding of the wood modification systems has progressed, further opportunities have arisen to add extra functionalities to the modified wood. These include UV stabilisation, fire retardancy, or enhanced suitability for paints and coatings. Thus, wood may become a multi-functional material through a series of modifications, treatments or reactions, to create a high-performance material with previously impossible properties. In this paper we review systems that combine the well-established wood modification procedures with secondary techniques or modifications to deliver emerging technologies with multi-functionality. The new applications targeted using this additional functionality are diverse and range from increased electrical conductivity, creation of sensors or responsive materials, improvement of wellbeing in the built environment, and enhanced fire and flame protection. We identified two parallel and connected themes: (1) the functionalisation of modified timber and (2) the modification of timber to provide (multi)-functionality. A wide range of nanotechnology concepts have been harnessed by this new generation of wood modifications and wood treatments. As this field is rapidly expanding, we also include within the review trends from current research in order to gauge the state of the art, and likely direction of travel of the industry.

Host-vector systems

1989 ◽  
Vol 324 (1224) ◽  
pp. 477-485 ◽  
Keyword(s):  
Genetic Manipulation ◽  
Pharmaceutical Products ◽  
Host Cells ◽  
Animal Cells ◽  
Vector Systems ◽  
Wide Range ◽  
Novel Host ◽  
Basic Concepts ◽  
Foreign Genes ◽  
New Generation

In 1980 it was only possible to express foreign genes in bacteria and a few easily cultured animal cells. During the subsequent eight years specialized vectors have been developed to allow the genetic manipulation of a wide range of both prokaryotes and eukaryotes. One of the major goals of biotechnology in 1980 was to use host cells as ‘factories’ for the production of proteins that were only available in minute quantities from natural sources. This has already lead to a new generation of pharmaceutical products. Advances in our understanding of host-vector systems have defined new goals. The basic concepts of expression vector design will be illustrated. Some of the new goals are discussed with particular reference to the exploitation of novel host-vector systems to develop vaccines and anti-viral agents against AIDS.

Abstract 120: Surpass Flow Diverter for Endovascular Treatment of Intracranial Aneurysms - A Multicenter Preliminary Clinical and Angiographic Experience in 161 Patients with 186 Aneurysms

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Ajay K Wakhloo ◽  
Pedro Lylyk ◽  
Joost de Vries ◽  
Matthew J Gounis ◽  
Alexandra Biondi ◽  
...  
Keyword(s):  
Intracranial Aneurysms ◽  
Experimental Studies ◽  
Flow Diverter ◽  
Posterior Circulation ◽  
Parent Artery ◽  
Anterior Circulation ◽  
Neck Size ◽  
Wide Range ◽  
New Generation

Objective: Validated through experimental studies a new generation of flow diverters (Surpass™ FD) was evaluated for treatment of intracranial aneurysms (IA). We present our multicenter preliminary clinical and angiographic experience. METHODS: To achieve the calculated flow disruption between the parent artery and aneurysm for thrombosis, single FDs were placed endovascularly in parent arteries. Implants measured 2.5-5.3mm in diameter with a length of 10-80mm. Patients were enrolled harboring a wide range large and giant wide-neck, fusiform and multiple small and blister-type aneurysm. Clinical and angiographic follow-up were performed at 1-3, 6, and 12 months. RESULTS: A total of 186 consecutive IA in 161 patients (mean age 57.1 years) were treated at 33 centers. Fifty-three aneurysms were smaller than 5 mm, 64 were 5-9.9mm in diameter, 47 were 10-20mm in diameter, and 22 were larger than 20mm (10.4±0.7mm, neck size 6.0±0.5mm [mean±SEM]) . The aneurysms originated in 63.4% from the internal carotid artery; 22% and 14.5% of the lesions were located in the anterior circulation distal to Circle of Willis and posterior circulation respectively. Technical success was achieved in 182 aneurysms (98%); average number of devices used per aneurysm was 1.05. Permanent morbidity and mortality during the follow-up period of mean 8.4months (range 1-24 months) including periprocedural complications for patients with aneurysms of the anterior circulation were encountered in 5 (3.7%) and 2 (1.5 %) patients respectively and 1 (3.7%) and 4 (14.8%) respectively for patients with aneurysms of the posterior circulation location. One-hundred-ten patients (70.5%) harboring 127 (70.2%) were available for clinical and angiographic follow-up and showed a complete or near complete aneurysm occlusion in 63 (81.8%) of the ICA. Aneurysms of the ICA≥10mm that were completely covered by FD and not previously stent-treated with a minimum of 6 months follow-up available in 16 patients showed a complete obliteration in 81.3% (n=13) and >90% occlusion in remaining 3 patients. CONCLUSION: Preliminary data demonstrate high safety and efficacy of a new generation of FD for a wide range of IA of the anterior and posterior circulation with a single implant.

Automation and Management of Design Process of the Main Drive for an Innovative Fruits and Vegetables Washer

2021 ◽  
Vol 27 (1) ◽  
pp. 9-17
Author(s):  
V. P. Bui ◽  
◽  
S. S. Gavruishin ◽  
V. B. Phung ◽  
H. M. Dang ◽  
...  
Keyword(s):  
Design Process ◽  
Rational Design ◽  
Fruits And Vegetables ◽  
Rational Solution ◽  
Quality Criteria ◽  
Pareto Optimal ◽  
Optimal Domain ◽  
Wide Range ◽  
A New Technique ◽  
New Generation

A new technique is described, used by the authors to automate the design process of the main drive of a new generation machine intended for industrial washing of fruits and vegetables. To solve the problem of multi-criteria design, the original approach is proposed that uses interconnected mathematical models describing the dynamic behavior, strength reliability and functional characteristics of the machine in a unified information space. The generalized mathematical model includes 12 controlled parameters, 16 functional constraints, and 3 quality criteria. A genetic algorithm was used to find the space of Pareto-optimal solutions. The situational approach was used to select the final rational solution from a set of solutions belonging to the Pareto-optimal domain. The rational design of option the washer found using the proposed approach is compared with the existing ones. The proposed design methodology can be recommended for the design of a wide range of similar mechanical structures.

The life and works of Domenico Mario Nuti, 1937–2020: An appreciation

2021 ◽  
Vol 71 (2) ◽  
pp. 181-194
Author(s):  
Saul Estrin ◽  
Milica Uvalic
Keyword(s):  
Economic Theory ◽  
Original Work ◽  
Policy Advice ◽  
Wide Range ◽  
New Generation ◽  
At Home

AbstractIt is challenging to provide an encompassing portrait of Mario Nuti's life and works: he was an exceptional man, who made significant intellectual contributions across a wide range of fields, as well as inspiring generations of students, colleagues and the profession in general, for more than fifty years. A brilliant debater and controversialist, he was equally at home in economic theory and in giving policy advice, and over the decades he had made significant contributions to many branches of the discipline. In this memorial article, we try to give a flavour of the man and his work, hopefully reminding the conoscenti of Mario's perceptive and original work, while introducing a new generation of scholars to his distinctive take on the field of economics.

scholarly journals A Review of Comparison of Complications of Vaginal Hysterectomy with and without Concomitant Surgery for SUI: A 5 Years’ Experience at a Tertiary Care Hospital of Pakistan

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Raheela Mohsin Rizvi ◽  
Munnazza Akhtar ◽  
Nadeem Faiyaz Zuberi
Keyword(s):  
Vaginal Hysterectomy ◽  
Tertiary Care ◽  
Length Of Hospital Stay ◽  
International Classification Of Diseases ◽  
Medical Intervention ◽  
Uterovaginal Prolapse ◽  
Care Hospital ◽  
Cross Sectional ◽  
Efficient Treatment ◽  
Concomitant Surgery

Objective. The study was performed to review the complications of surgery for POP with or without surgery for SUI. This included the need for second procedure two years after the primary surgery.Study Design. We conducted a retrospective cross-sectional comparative study at the Aga Khan University, Karachi, Pakistan. International Classification of Diseases, 9th revision, Clinical Modification (ICD-9-CM) was used to identify women who underwent vaginal hysterectomy with anterior/posterior repair alone and those with concomitant tension-free vaginal tape surgery for urodynamic stress incontinence.Results. The 28 cases of VH/repair combined with TVT were compared for complications with 430 cases of VH with repair alone. The basic characteristics like age, BMI, and degree of prolapse showed no statistical difference among two groups. The main comorbidities in both groups were hypertension, diabetes, and bronchial asthma. We observed no significant differences in intraoperative and postoperative complications except for cuff abscess, need for medical intervention, and readmission following discharge from hospital, which were higher in cases with vaginal hysterectomy with concomitant TVT.Conclusions. Vaginal hysterectomy is an efficient treatment for uterovaginal prolapse with a swift recovery, short length of hospital stay, and rare serious complications. The addition of surgery for USI does not appear to increase the morbidity.

Cryogenic Machining of Titanium Ti-5553 Alloy

2019 ◽  
Vol 141 (4) ◽  
Author(s):  
Yusuf Kaynak ◽  
Armin Gharibi
Keyword(s):  
Titanium Alloy ◽  
Tool Wear ◽  
Cutting Temperature ◽  
Cryogenic Cooling ◽  
Machining Process ◽  
Dry Machining ◽  
Cryogenic Machining ◽  
Machining Performance ◽  
Wide Range ◽  
New Generation

Titanium alloy Ti-5Al-5V-3Cr-0.5Fe (Ti-5553) is a new generation of near-beta titanium alloy that is commonly used in the aerospace industry. Machining is one of the manufacturing methods to produce parts that are made of this near-beta alloy. This study presents the machining performance of new generation near-beta alloys, namely, Ti-5553, by focusing on a high-speed cutting process under cryogenic cooling conditions and dry machining. The machining experiments were conducted under a wide range of cutting speeds, including high speeds that used liquid nitrogen (LN2) and carbon dioxide (CO2) as cryogenic coolants. The experimental data on the cutting temperature, tool wear, force components, chip breakability, dimensional accuracy, and surface integrity characteristics are presented and were analyzed to evaluate the machining process of this alloy and resulting surface characteristics. This study shows that cryogenic machining improved the machining performance of the Ti-5553 alloy by substantially reducing the tool wear, cutting temperature, and dimensional deviation of the machined parts. The cryogenic machining also produced shorter chips as compared to dry machining.

scholarly journals Preface. The XIV International Research and Practice Conference “Ukrainian School of Mining Engineering” (USME 2020)

2020 ◽  
Vol 201 ◽  
pp. 00001
Author(s):  
Gennadiy Pivnyak ◽  
Volodymyr Bondarenko ◽  
Iryna Kovalevska ◽  
Roman Lysenko ◽  
Olha Malova
Keyword(s):  
International Research ◽  
Mining Industry ◽  
Mining Engineering ◽  
Research And Practice ◽  
Wide Range ◽  
New Ideas ◽  
Science And Education ◽  
Labor Safety ◽  
Important Means ◽  
New Generation

The XIV International Research and Practice Conference “Ukrainian School of Mining Engineering” once again has made an important contribution to the mining industry, science and education. In the course of the conference, a wide range of problems was discussed: theoretical aspects of mining; domestic and foreign experience; personnel training in modern realities; problems of mineral deposits development; fundamental concepts of labor safety, etc. Fruitful dialogue and exchange of experience among conference participants contribute to the generation of new ideas, discoveries, technologies that will find their application in the nearest future. The formation of a new generation of scientists and engineers is taking place today, and therefore this representative conference is an important means of creating a new intellectual environment. The conference promotes the establishment of effective contacts between representatives of different scientific schools and directions, and the acquisition of invaluable experience and practice by researchers.

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