scholarly journals Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration

2001 ◽  
Vol 4 (21) ◽  
Author(s):  
S O'Meara ◽  
N Cullum ◽  
M Majid ◽  
T Sheldon
Keyword(s):  
Systematic Reviews ◽  
Diabetic Foot ◽  
Care Management ◽  
Antimicrobial Agents ◽  
Chronic Wounds ◽  
Wound Care ◽  
Foot Ulceration

scholarly journals New Antibacterial Paper Made of Silver Phosphate Cellulose Fibers: A Preliminary Study on the Elimination of Staphylococcus aureus Involved in Diabetic Foot Ulceration

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Virginie Blanchette ◽  
Dan Belosinschi ◽  
Thanh Tung Lai ◽  
Lyne Cloutier ◽  
Simon Barnabé
Keyword(s):  
Staphylococcus Aureus ◽  
Growth Inhibition ◽  
Diabetic Foot ◽  
Wound Care ◽  
Cellulose Fibers ◽  
Cell Counting ◽  
Commercial Products ◽  
Foot Ulceration ◽  
Silver Phosphate ◽  
Significant Difference

Aim. To evaluate in vitro the antibacterial effect of a paper made of silver phosphate cellulose fibers (SPCF) on Staphylococcus aureus, the most common diabetic foot ulceration (DFU) pathogen when compared with other common commercial products. Methods. The antibacterial activity of SPCF samples was evaluated through time with cell counting on agar plates. SPCF samples were then compared with commercial wound care products currently in use in DFU treatments (Silvercel™, Acticoat 7, and Aquacel Ag ExtraTM) through time on agar plates (growth inhibition zones). Results. After 6 hours, there was no viable bacterial cell detected on either plate (p<0.05). There was a net growth inhibition zone for SPCF samples but no significant difference between the two silver concentrations. Compared with common commercial products, SPCF paper provides results equal to Acticoat 7 (p<0.05) and superior to Aquacel AG ExtraTM and Silvercel™ at lower silver concentrations (p<0.001). Conclusions. These results have shown the efficiency of SPCF paper to eliminate Staphylococcus aureus in these conditions. SPCF papers are effective when compared with other common commercial products and could have an industrial potential in wound care. Infected DFU could benefit from the antibacterial effectiveness of SPCF, but more relevant experimentations related to foot ulcers are needed.

scholarly journals Bioactive Antimicrobial Peptides as Therapeutic Agents for Infected Diabetic Foot Ulcers

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1894
Author(s):  
Jessica Da Silva ◽  
Ermelindo C. Leal ◽  
Eugénia Carvalho
Keyword(s):  
Wound Healing ◽  
Antimicrobial Peptides ◽  
Broad Spectrum ◽  
Diabetic Foot ◽  
Molecular Mechanisms ◽  
Antimicrobial Agents ◽  
Chronic Wounds ◽  
Foot Ulcer ◽  
Wound Management ◽  
Diabetic Patients

Diabetic foot ulcer (DFU) is a devastating complication, affecting around 15% of diabetic patients and representing a leading cause of non-traumatic amputations. Notably, the risk of mixed bacterial–fungal infection is elevated and highly associated with wound necrosis and poor clinical outcomes. However, it is often underestimated in the literature. Therefore, polymicrobial infection control must be considered for effective management of DFU. It is noteworthy that antimicrobial resistance is constantly rising overtime, therefore increasing the need for new alternatives to antibiotics and antifungals. Antimicrobial peptides (AMPs) are endogenous peptides that are naturally abundant in several organisms, such as bacteria, amphibians and mammals, particularly in the skin. These molecules have shown broad-spectrum antimicrobial activity and some of them even have wound-healing activity, establishing themselves as ideal candidates for treating multi-kingdom infected wounds. Furthermore, the role of AMPs with antifungal activity in wound management is poorly described and deserves further investigation in association with antibacterial agents, such as antibiotics and AMPs with antibacterial activity, or alternatively the application of broad-spectrum antimicrobial agents that target both aerobic and anaerobic bacteria, as well as fungi. Accordingly, the aim of this review is to unravel the molecular mechanisms by which AMPs achieve their dual antimicrobial and wound-healing properties, and to discuss how these are currently being applied as promising therapies against polymicrobial-infected chronic wounds such as DFUs.

scholarly journals The Visualization of Biofilms in Chronic Diabetic Foot Wounds Using Routine Diagnostic Microscopy Methods

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Angela Oates ◽  
Frank L. Bowling ◽  
Andrew J. M. Boulton ◽  
Philip G. Bowler ◽  
Daniel G. Metcalf ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Antimicrobial Agents ◽  
Chronic Wounds ◽  
Environmental Scanning Electron Microscopy ◽  
Environmental Scanning ◽  
Diabetic Patients ◽  
Gram Stain ◽  
Bright Field ◽  
Planktonic Bacteria ◽  
Biofilm Matrix

Diabetic foot wounds are commonly colonised by taxonomically diverse microbial communities and may additionally be infected with specific pathogens. Since biofilms are demonstrably less susceptible to antimicrobial agents than are planktonic bacteria, and may be present in chronic wounds, there is increasing interest in their aetiological role. In the current investigation, the presence of structured microbial assemblages in chronic diabetic foot wounds is demonstrated using several visualization methods. Debridement samples, collected from the foot wounds of diabetic patients, were histologically sectioned and examined using bright-field, fluorescence, and environmental scanning electron microscopy and assessed by quantitative differential viable counting. All samples (n= 26) harboured bioburdens in excess of 5 log10CFU/g. Microcolonies were identified in 4/4 samples by all three microscopy methods, although bright-field and fluorescence microscopy were more effective at highlighting putative biofilm morphology than ESEM. Results in this pilot study indicate that bacterial microcolonies and putative biofilm matrix can be visualized in chronic wounds using florescence microscopy and ESEM, but also using the simple Gram stain.

scholarly journals Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care

2021 ◽  
Vol 11 (3) ◽  
pp. 1230
Author(s):  
Inês Guimarães ◽  
Sara Baptista-Silva ◽  
Manuela Pintado ◽  
Ana L. Oliveira
Keyword(s):  
Antimicrobial Agents ◽  
Chronic Wounds ◽  
Wound Care ◽  
Release Kinetics ◽  
Wound Dressings ◽  
Wound Site ◽  
Biological Potential ◽  
Efficient Alternative ◽  
Biological Performance ◽  
Complex Wounds

In chronic wounds, the regeneration process is compromised, which brings complexity to the therapeutic approaches that need to be adopted, while representing an enormous loss in the patients’ quality of life with consequent economical costs. Chronic wounds are highly prone to infection, which can ultimately lead to septicemia and morbidity. Classic therapies are increasing antibiotic resistance, which is becoming a critical problem beyond complex wounds. Therefore, it is essential to study new antimicrobial polymeric systems and compounds that can be effective alternatives to reduce infection, even at lower concentrations. The biological potential of polyphenols allows them to be an efficient alternative to commercial antibiotics, responding to the need to find new options for chronic wound care. Nonetheless, phenolic compounds may have some drawbacks when targeting wound applications, such as low stability and consequent decreased biological performance at the wound site. To overcome these limitations, polymeric-based systems have been developed as carriers of polyphenols for wound healing, improving its stability, controlling the release kinetics, and therefore increasing the performance and effectiveness. This review aims to highlight possible smart and bio-based wound dressings, providing an overview of the biological potential of polyphenolic agents as natural antimicrobial agents and strategies to stabilize and deliver them in the treatment of complex wounds. Polymer-based particulate systems are highlighted here due to their impact as carriers to increase polyphenols bioavailability at the wound site in different types of formulations.

scholarly journals Bovine Based Collagen Dressings in Wound Care Management

2020 ◽  
pp. 48-63
Author(s):  
Rameshkumar Santhanam ◽  
Mohd Adha P. Rameli ◽  
Azleena Al Jeffri ◽  
Wan Iryani Wan Ismail
Keyword(s):  
Clinical Utility ◽  
Care Management ◽  
Chronic Wounds ◽  
Biomedical Application ◽  
Wound Care ◽  
Wound Dressings ◽  
Fundamental Information ◽  
Negative Impacts ◽  
Essential Knowledge ◽  
Treatment Procedures

Collagen plays a significant role in treating acute and chronic wounds such as cuts, burns, ulcers associated with other illness via enhancing the debridement of infected tissues, angiogenesis and promoting natural growth. There are several types of collagen, which can be obtained from various animal sources such as chicken, bovine, porcine, fish etc. Among that bovine based collagen contributed many shares towards biomedical application. Nowadays using bovine based collagen biomaterials for wound care is in trend to minimize the negative impacts such as infection, pain and other side effects. However, its applicable and effectiveness are not fully revealed. At the same time, clinicians and researchers are exploring and implementing advanced techniques and treatment procedures to reduce the wound healing burden effectively. In this review, we aimed to focus on the fundamental information about types of wound dressings, collagen dressings and the clinical utility of bovine based collagen dressings in providing essential knowledge in advanced wound care management.

The Evidence for Antimicrobial and Hard to Infect Regenerative Matrices

2021 ◽  
Author(s):  
Keval Ray ◽  
◽  
Nazanin Khajoueinejad ◽  
So Park ◽  
Mabel Chan ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Basic Science ◽  
Antimicrobial Agents ◽  
Chronic Wounds ◽  
Wound Care ◽  
Antimicrobial Properties ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Full Understanding ◽  
Wound Bed Preparation

Preparation of the wound bed is a key step in the use of cell- and tissue-based therapy (CTP). In particular, good pre-application debridement is an essential component of CTP. However, there are many situations in which the wound bed is not adequately debrided, including trauma, burn, and in cases of chronic wounds with significant biofilm. In the setting of inadequate wound bed preparation, the use of a CTP that has either added or intrinsic antimicrobial properties is attractive. Some CTPs include added antimicrobial agents such as PHMB or silver, while others have intrinsic antimicrobial components, such as Omega 3 fatty acids. In addition, some wound-covering dressings are completely synthetic, and therefore simply do not become infected. A full understanding of the basic science and clinical data supporting the use of these therapies is important for the advanced wound care practitioner.

Diabetic foot syndrome

2011 ◽  
Vol 152 (29) ◽  
pp. 1171-1177 ◽  
Author(s):  
Gábor Szabad
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Wound Care ◽  
Diabetic Foot Syndrome ◽  
Foot Ulceration ◽  
Complications Of Diabetes ◽  
Treatment Regimes ◽  
Increased Risk ◽  
Multi Level

Diabetes mellitus contributes to a number of disorders that can affect the quality of life. Amongst this diabetic foot syndrome and diabetic foot ulceration are serious secondary complications of diabetes mellitus. Persons with diabetic foot ulceration have an increased risk of amputation. In the first part of this review the author focuses on the pathophysiology of diabetic foot ulceration. The second part covers the topics of current and future therapies. The reader will understand the need and modes for preventive measures, the importance of multi level education in this topic, and the need for specialized wound care centers. As emphasized by the author, diabetic foot syndrome and ulceration are serious complications of diabetes mellitus, which can lead to devastating lower-extremity amputations and possible death. Specialized wound care centers, multi level education and proper adherence to standard treatment regimes can potentially prevent the need for amputation. Orv. Hetil., 2011, 152, 1171–1177.[Formula: see text]

scholarly journals Tratamientos innovadores utilizados en el manejo de las heridas crónicas

2017 ◽  
Vol 14 (2) ◽  
pp. 80
Author(s):  
Natalia Rodríguez-Gil ◽  
Lorena Martínez-Delgado ◽  
Nelson Rolando Campos-Guzman
Keyword(s):  
Diabetic Foot ◽  
Chronic Wounds ◽  
Wound Care ◽  
Scientific Evidence ◽  
Foot Pressure ◽  
Calidad De Vida ◽  
Palabras Clave ◽  
The Individual ◽  
New Treatments ◽  
Type Of Injury

RESUMENIntroducción: Del tipo de tratamiento y la eficacia del mismo depende la evolución y la mejora en la calidad de vida del paciente con heridas crónicas; existen diversos tratamientos para las heridas crónicas de acuerdo con el tipo de lesión, la duración del tratamiento y los factores individuales del paciente. Los diversos tratamientos innovadores demuestran resultados favorables en cuanto a la reducción del tiempo y el tamaño de las heridas crónicas. Este artículo tiene como objetivo describir los tratamientos innovadores utilizados en el manejo de las heridas crónicas, de uso poco frecuente en las clínicas de heridas. Metodología: revisión de la literatura estructurada en tres fases: recolección de artículos en bases de datos como Scopus, Pubmed, Dialnet, Ebscohots, y Elsevier; uso de palabras clave como pie diabético, herida crónica y úlcera por presión; revisión y clasificación de 50 artículos en idioma español, inglés y portugués. Resultados: se registraron 12 tratamientos innovadores para el manejo de las heridas cónicas, cada uno con evidencia científica de su utilidad en los distintos tipos de heridas crónicas. Conclusión: conocer nuevos tratamientos ayuda al enfermero a ampliar las opciones de intervención, presentar alternativas de tratamiento de menor costo, o más rápida dependiendo del tipo de herida y la condición del paciente.PALABRAS CLAVE: Úlcera de la Pierna, pie diabético, úlcera por presión.INNOVATIVE TREATMENTS USED IN THE HANDLING OF CHRONIC WOUNDSABSTRACTIntroduction: The type of treatment and its efficacy depends on the evolution and the improvement of the quality of life of the patient with chronic wounds; diverse treatments exist for chronic wounds according to the type of injury, duration of the treatment, and the individual factors of the patient. The diverse innovative treatments demonstrate favorable results in terms of reduction of time and size of chronic wounds. This article has as its objective to describe the innovative treatments used in the handling of chronic wounds, of infrequent use in wound care centers. Methodology: review of the structured literature in three phases: recollection of articles in databases such as Scopus, Pubmed, Dialnet, Ebscohots, and Elsevier; use of keywords such as diabetic foot, chronic wound, and pressure ulcer; review and classification of 50 articles in Spanish, English, and Portuguese. Results: 12 innovative treatments were registered for the handling of chronic wounds, each one with scientific evidence of their utility in the different types of chronic wounds. Conclusion: determine new treatments helps the nurse to extent the intervention options, and present treatment alternatives of lower cost or faster treatment depending on the type of wound and the condition of the patient.KEYWORDS: Leg ulcer, diabetic foot, pressure ulcerTRATAMENTOS INOVADORES UTILIZADOS NO MANEJO DAS FERIDAS CRÓNICASRESUMO Introdução: Do tipo de tratamento e da eficácia do mesmo depende a evolução e a melhora na qualidade de vida do paciente com feridas crónicas; existem   diversos tratamentos para as feridas crónicas de acordo ao tipo de lesão, à duração do tratamento, e aos fatores individuais do paciente. Os diversos tratamentos inovadores demostram resultados favoráveis em quanto à redução do tempo e o tamanho das feridas crónicas. Este artigo tem como objetivo descrever os tratamentos inovadores utilizados no manejo das feridas crónicas, de uso pouco frequente nas clínicas de feridas. Metodologia: revisão da literatura estruturada em três fases: recolecção de artigos em bases de dados como Scopus, Pubmed, Dialnet, Ebscohots e Elsevier; uso de palavras chave como pé diabético, ferida crónica e úlcera por pressão; revisão e classificação de 50 artigos em idioma Espanhol, Inglês e Português. Resultados: registraram-se 12 tratamentos inovadores para o manejo das feridas cónicas, cada um com evidencia científica de sua utilidade nos diferentes tipos de feridas crónicas. Conclusão: o conhecimento de novos tratamentos ajuda ao enfermeiro a ampliar as opções de intervenção, apresentando alternativas de tratamento mais rápidas ou de menor custo, dependendo do tipo de ferida e da condição do paciente.Palavras-chave: Pé diabético, Úlcera da Perna, Úlcera por pressão 

scholarly journals Treatment of Non-Healing Diabetic Foot Wounds with Vaporous Hyperoxia Therapy in Conjunction with Standard Wound Care

2021 ◽  
Author(s):  
Dustin Kruse ◽  
Kenneth Morgan ◽  
Jeremy Christensen ◽  
Brian Derner ◽  
Brett Sachs
Keyword(s):  
Diabetic Foot ◽  
Oxygen Therapy ◽  
Chronic Wounds ◽  
Wound Care ◽  
Historical Analysis ◽  
Low Frequency ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Closure Rate ◽  
Wound Debridement

Vaporous Hyperoxia Therapy (VHTTM), a patented FDA-510 (k) cleared technology, is an adjunct therapy used in conjunction with standard wound care (SWC). VHT is said to improve the health of wounded tissue by administering a low-frequency, non-contact, non-thermal ionic anti-microbial hydrating mist alternating with concentrated topical oxygen therapy (TOT). VHT was used to treat 36 subjects with chronic diabetic foot ulcers (DFUs) that were previously treated unsuccessfully with SWC. The average age of DFU in the study was 11 months old and the average size was over 3 cm2. Wounds were either Wagner Grade 2 or 3 and most commonly on the plantar surface around the midfoot. Treatment consisted of twice weekly applications of VHT and wound debridement. Subjects were followed to wound closure, 20 weeks, or 40 treatments, whichever came first. The combination of SWC and VHT in the group that met and maintained compliance throughout the study period achieved an 83% DFU closure rate within a 20-week time period. The average time for DFU closure in this study was 9.4 weeks. Historical analysis of SWC shows a 30.9% healing rate of all wounds, not differentiating chronic wounds. Accordingly, SWC/VHT increases chronic diabetic foot ulcer healing rates by 2.85 times compared with SWC alone. The purpose of this study was two-fold: first, to observe the effect of VHT on healing rates and time to healing in previously nonhealing DFUs and second, to compare VHT with SWC, TOT and hyperbaric oxygen therapy (HBOT) and ultrasound therapies.

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