scholarly journals Exercise programme to improve quality of life for patients with end-stage kidney disease receiving haemodialysis: the PEDAL RCT

2021 ◽  
Vol 25 (40) ◽  
pp. 1-52
Author(s):  
Sharlene A Greenwood ◽  
Pelagia Koufaki ◽  
Jamie H Macdonald ◽  
Catherine Bulley ◽  
Sunil Bhandari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Usual Care ◽  
Physical Component Summary ◽  
Short Form ◽  
Physical Component Summary Score ◽  
Improve Quality ◽  
Maintenance Haemodialysis ◽  
Intradialytic Exercise

Background Whether or not clinically implementable exercise interventions in haemodialysis patients improve quality of life remains unknown. Objectives The PEDAL (PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease) trial evaluated the clinical effectiveness and cost-effectiveness of a 6-month intradialytic exercise programme on quality of life compared with usual care for haemodialysis patients. Design We conducted a prospective, multicentre randomised controlled trial of haemodialysis patients from five haemodialysis centres in the UK and randomly assigned them (1 : 1) using a web-based system to (1) intradialytic exercise training plus usual-care maintenance haemodialysis or (2) usual-care maintenance haemodialysis. Setting The setting was five dialysis units across the UK from 2015 to 2019. Participants The participants were adult patients with end-stage kidney disease who had been receiving haemodialysis therapy for > 1 year. Interventions Participants were randomised to receive usual-care maintenance haemodialysis or usual-care maintenance haemodialysis plus intradialytic exercise training. Main outcome measures The primary outcome of the study was change in Kidney Disease Quality of Life Short Form, version 1.3, physical component summary score (from baseline to 6 months). Cost-effectiveness was determined using health economic analysis and the EuroQol-5 Dimensions, five-level version. Additional secondary outcomes included quality of life (Kidney Disease Quality of Life Short Form, version 1.3, generic multi-item and burden of kidney disease scales), functional capacity (sit-to-stand 60 and 10-metre Timed Up and Go tests), physiological measures (peak oxygen uptake and arterial stiffness), habitual physical activity levels (measured by the International Physical Activity Questionnaire and Duke Activity Status Index), fear of falling (measured by the Tinetti Falls Efficacy Scale), anthropometric measures (body mass index and waist circumference), clinical measures (including medication use, resting blood pressure, routine biochemistry, hospitalisations) and harms associated with intervention. A nested qualitative study was conducted. Results We randomised 379 participants; 335 patients completed baseline assessments and 243 patients (intervention, n = 127; control, n = 116) completed 6-month assessments. The mean difference in change in physical component summary score from baseline to 6 months between the intervention group and control group was 2.4 arbitrary units (95% confidence interval –0.1 to 4.8 arbitrary units; p = 0.055). Participants in the intervention group had poor compliance (49%) and very poor adherence (18%) to the exercise prescription. The cost of delivering the intervention ranged from £463 to £848 per participant per year. The number of participants with harms was similar in the intervention (n = 69) and control (n = 56) groups. Limitations Participants could not be blinded to the intervention; however, outcome assessors were blinded to group allocation. Conclusions On trial completion the primary outcome (Kidney Disease Quality of Life Short Form, version 1.3, physical component summary score) was not statistically improved compared with usual care. The findings suggest that implementation of an intradialytic cycling programme is not an effective intervention to enhance health-related quality of life, as delivered to this cohort of deconditioned patients receiving haemodialysis. Future work The benefits of longer interventions, including progressive resistance training, should be confirmed even if extradialytic delivery is required. Future studies also need to evaluate whether or not there are subgroups of patients who may benefit from this type of intervention, and whether or not there is scope to optimise the exercise intervention to improve compliance and clinical effectiveness. Trial registration Current Controlled Trials ISRCTN83508514. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 25, No. 40. See the NIHR Journals Library website for further project information.

scholarly journals The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial

2020 ◽  
Author(s):  
Sharlene A Greenwood ◽  
Pelagia Koufaki ◽  
Jamie Macdonald ◽  
Sunil Bhandari ◽  
James Burton ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Usual Care ◽  
Controlled Trial ◽  
Improve Quality ◽  
Exercise Interventions ◽  
Randomized Controlled ◽  
The Uk ◽  
Intradialytic Exercise

Abstract Background Exercise interventions designed to improve physical function and reduce sedentary behaviour in haemodialysis (HD) patients might improve exercise capacity, reduce fatigue and lead to improved quality of life (QOL). The PrEscription of intraDialytic exercise to improve quAlity of Life study aimed to evaluate the effectiveness of a 6-month intradialytic exercise programme on QOL and physical function, compared with usual care for patients on HD in the UK. Methods We conducted a prospective, pragmatic multicentre randomized controlled trial in 335 HD patients and randomly (1:1) assigned them to either (i) intradialytic exercise training plus usual care maintenance HD or (ii) usual care maintenance HD. The primary outcome of the study was the change in Kidney Disease Quality of Life Short Form (KDQOL-SF 1.3) Physical Component Score between baseline and 6 months. Additional secondary outcomes included changes in peak aerobic capacity, physical fitness, habitual physical activity levels and falls (International Physical Activity Questionnaire, Duke’s Activity Status Index and Tinetti Falls Efficacy Scale), QOL and symptom burden assessments (EQ5D), arterial stiffness (pulse wave velocity), anthropometric measures, resting blood pressure, clinical chemistry, safety and harms associated with the intervention, hospitalizations and cost-effectiveness. A nested qualitative study investigated the experience and acceptability of the intervention for both participants and members of the renal health care team. Results At baseline assessment, 62.4% of the randomized cohort were male, the median age was 59.3 years and 50.4% were white. Prior cerebrovascular events and myocardial infarction were present in 8 and 12% of the cohort, respectively, 77.9% of patients had hypertension and 39.4% had diabetes. Baseline clinical characteristics and laboratory data for the randomized cohort were generally concordant with data from the UK Renal Registry. Conclusion The results from this study will address a significant knowledge gap in the prescription of exercise interventions for patients receiving maintenance HD therapy and inform the development of intradialytic exercise programmes both nationally and internationally. Trial Registration ISRCTN N83508514; registered on 17 December 2014.

scholarly journals Qualidade de vida de clientes em hemodiálise e necessidades de orientação de enfermagem para o autocuidado

2011 ◽  
Vol 15 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Iraci dos Santos ◽  
Renata de Paula Faria Rocha ◽  
Lina Márcia Miguéis Berardinelli
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Rio De Janeiro ◽  
Short Form

Este trabalho relaciona necessidades de orientação de enfermagem com a qualidade de vida de clientes com doença renal crônica, em hemodiálise, considerando conceitos de Autocuidado de Orem. Método descritivo, mediante entrevista com 43 clientes de um Hospital Universitário do Rio de Janeiro, de 2008 a 2009. Os sujeitos de pesquisa têm hipertensão arterial, encontrando-se 83,72% em hemodiálise há menos de um ano. Aplicando o Kidney Disease Quality of Life Short Form, obtiveram-se os menores escores nas dimensões: física; emocional; condição de trabalho; capacidade funcional. Esses resultados foram relacionados aos obtidos com as necessidades de orientação de enfermagem para nutrição, ingestão de líquidos, complicações da hemodiálise, anticoagulação, atividade física, de lazer e associação a grupos, concluindo-se que esses clientes encontram-se no Sistema de Autocuidado totalmente compensatório. Sugere-se o desenvolvimento da orientação de enfermagem para o autocuidado, em consulta de enfermagem, visando promover a qualidade de vida dos clientes.

scholarly journals Adultos e idosos em hemodiálise: avaliação da qualidade de vida relacionada à saúde

2008 ◽  
Vol 21 (spe) ◽  
pp. 152-159 ◽  
Author(s):  
Luciana Kusumoto ◽  
Sueli Marques ◽  
Vanderlei José Haas ◽  
Rosalina Aparecida Paterzani Rodrigues
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form

OBJETIVOS: Caracterizar os adultos e idosos em hemodiálise residentes em Ribeirão Preto-SP. Avaliar e descrever as diferenças na Qualidade de Vida Relacionada à Saúde (QVRS) desses pacientes. MÉTODOS: Estudo seccional e populacional com 194 pacientes em hemodiálise em quatro serviços de diálise do município. Os instrumentos utilizados foram: para caracterização da população, Mini Exame do Estado Mental e Kidney Disease and Quality of Life-Short Form (KDQOL-SF TM). RESULTADOS: Dos pacientes, 132 eram adultos e 62 idosos. Foram encontradas diferenças entre os escores médios dos dois grupos, com significância estatística nas dimensões do KDQOL-SF TM: Funcionamento físico, Função física, emocional, Sobrecarga da doença renal e Estímulo da equipe de diálise. CONCLUSÃO: A insuficiência renal crônica terminal e a hemodiálise se relacionaram com a QVRS dos adultos e idosos. Os resultados podem subsidiar a atuação dos profissionais da saúde para atender as necessidades iminentes, prevenir complicações, enfim almejar uma melhor QVRS.

scholarly journals Trabalho e qualidade de vida relacionada à saúde de pacientes em diálise peritoneal

2012 ◽  
Vol 25 (3) ◽  
pp. 352-357 ◽  
Author(s):  
Marília Pilotto de Oliveira ◽  
Luciana Kusumota ◽  
Sueli Marques ◽  
Rita de Cássia Helú Mendonça Ribeiro ◽  
Rosalina Aparecida Partezani Rodrigues ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form

OBJETIVO: Descrever e comparar a Qualidade de Vida Relacionada à Saúde (QVRS) de pacientes em Diálise Peritoneal (DP) que tinham ou não trabalho remunerado. MÉTODOS: Estudo seccional e populacional com 82 pacientes dos dois serviços de DP de Ribeirão Preto, (SP). A coleta de dados foi realizada por entrevistas entre dezembro/2009 e março/2010. Os questionário para caracterização dos pacientes, o Miniexame do Estado Mental e o Kidney Disease and Quality of Life-Short Form foram usados. Foram feitas as análises estatística exploratória uni e bivariada e a confirmatória bivariada entre variáveis independentes e as dimensões de QVRS. RESULTADOS: os pacientes com trabalho remunerado apresentavam maiores escores médios refletindo melhor QVRS para a maioria das dimensões do instrumento utilizado. CONCLUSÃO: o trabalho é uma faceta importante da vida desses pacientes e merece a atenção dos profissionais da saúde na busca de estratégias que favoreçam e incentivem sua manutenção e reinserção no mercado de trabalho.

scholarly journals Ativação de pacientes em hemodiálise: fatores associados e qualidade de vida relacionada à saúde

2021 ◽  
Author(s):  
◽  
Denise Rocha Raimundo Leone
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form ◽  
Patient Activation ◽  
Minas Gerais ◽  
Patient Activation Measure

Introdução: o tratamento hemodialítico impõe modificações no cotidiano do indivíduo e demanda autogerenciamento eficaz da saúde para que se alcancem as metas terapêuticas e consequentemente uma melhor qualidade de vida relacionada à saúde. Há evidências de que pessoas com altos níveis de ativação apresentam comportamentos mais saudáveis e melhores desfechos clínicos quando comparadas a pessoas com baixa ativação. Dessa forma, mensurar a ativação dos pacientes em hemodiálise possibilita a identificação do grau de autogerenciamento destes e viabiliza intervenções de saúde direcionadas ao indivíduo, considerando suas crenças, habilidades e motivações. Objetivo: avaliar o nível de ativação de pacientes em hemodiálise e seus fatores associados. Metodologia: estudo com abordagem quantitativa e corte transversal, realizado com 162 pessoas em tratamento hemodialítico de uma unidade de terapia renal substitutiva, sediada no município de Juiz de Fora, Minas Gerais. Os participantes responderam a dois questionários, um para avaliação sociodemográfica e clínica e outro para classificação econômica, e também a duas escalas, uma para mensurar o nível de ativação (Patient Activation Measure-13) e outra para avaliação da qualidade de vida (Kidney Disease Quality of life short form). Foram coletados dados secundários, referentes aos resultados de exames laboratoriais e valores de ultrafiltração, para avaliação dos resultados em saúde. Foi realizada a análise descritiva dos dados para caracterização da população, regressão de Poisson com variância robusta para verificar associação entre o escore de ativação e os dados sociodemográficos, socioeconômicos e clínicos e regressão Logística com a finalidade de estabelecer o relacionamento entre os níveis de ativação com a qualidade de vida relacionada à saúde. Utilizou-se o software SPSS versão 23.0 e o STATA. Resultados: foram construídos dois artigos intitulados “Fatores associados à ativação de pacientes em hemodiálise “e “Nível de ativação e qualidade de vida relacionada à saúde de pessoas em hemodiálise”. Ressalta-se que dos participantes, 63% eram homens, a idade média foi de 59,23+ 15 anos e 74,1% realizavam tratamento há menos de cinco anos. O escore médio da ativação do paciente foi de 60,85 +15,57, sendo a mediana de 53,2 (intervalo de confiança: 58,4 – 63,3). Associou-se à maior prevalência de alta ativação possuir nível superior de ensino e não necessitar de cuidador e à menor prevalência de alta ativação ter o domicílio classificado como B2 ou D-E e não ter realizado previamente outra terapia renal substitutiva. Em relação a ativação e qualidade de vida, o nível de ativação foi associado aos domínios sintomas, funcionamento físico, saúde geral, bem-estar emocional, energia/fadiga e o componente mental da qualidade de vida relacionada à saúde. Conclusão: a maior parte de pessoas em hemodiálise não possuem habilidades, conhecimentos e motivações o suficiente para serem responsáveis pelo autogerenciamento de sua saúde, o que reforça a relevância da atuação profissional em realizar intervenções de saúde que visem melhorar os níveis de ativação dessa população.

scholarly journals New Model for Couple Therapy for Patients with Chronic Pain and their Caregivers: An Attempt to Improve Quality of Life and Reduce Pain

2020 ◽  
Vol 16 (1) ◽  
pp. 53-58
Author(s):  
Shima Rouhi ◽  
Payman Dadkhah ◽  
Manijeh Firoozi ◽  
Masoud Hashemi
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Interpersonal Relationships ◽  
Couple Therapy ◽  
Short Form ◽  
Control Group ◽  
Improve Quality ◽  
Innovative Therapy ◽  
Quasi Experimental

Background: Several psychological interventions have been implemented to manage chronic pain. In this study, in addition to the patients, his/her spouses have participated in the program. Besides, this innovative therapy integrates several practical approaches into one comprehensive protocol. Objective: This study aimed to analyze the effectiveness of couple therapy (patient/caregiver-oriented) on improving the quality of life and reducing pain among patients with chronic pain. Methods: The present study is a quasi-experimental and clinical trial with a control group with pretest and posttest. The authors conducted this study at LABAFINEJAD Hospital in Tehran on 30 patients with chronic pain and their spouses by having a short form of a questionnaire for quality of life and chronic pain score questionnaire to measure the effectiveness of the treatment. Results: The results indicated that this treatment increased two aspects of quality of life remarkably, social function and strength for continuing the performance; that help boosts interpersonal relationships as well. Regarding the results, although the couple-based treatment could improve all aspects of pain, the two primary subscales, physical health and mental health, both enhanced. Besides, the treatment reduced the intensity of pain. Conclusion: Couple-based intervention through increasing social support, improving the quality of sex, decentralizing of pain, and paying attention to the neglected needs of caregivers and patients with chronic pain can improve quality of life and reduce pain in patients.

Ποιότητα ζωής ασθενών με χρόνια νεφρική ανεπάρκεια που υποβλήθηκαν σε επιτυχή μεταμόσχευση νεφρού

2019 ◽  
Author(s):  
Αικατερίνη Μπαλάσκα
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form

Η αξιολόγηση της ποιότητας ζωής των ασθενών που βρίσκονταν σε αιμοκάθαρση και υποβλήθηκαν σε επιτυχή μεταμόσχευση νεφρού διατηρώντας το μόσχευμα πέντε χρόνια μετά την μεταμόσχευση, καθώς και η διερεύνηση των παραγόντων που την επηρεάζουν.Υλικό- Μέθοδος: Η έρευνα έγινε σε μια ομάδα ασθενών Ν 120 ξεκινώντας από το 2009. Πραγματοποιήθηκε μία προ-μέτρηση (πριν την μεταμόσχευση) και δύο μετά-μετρήσεις (24 και 60 μήνες μετά την μεταμόσχευση)]. Η συλλογή των δεδομένων έγινε με συνέντευξη και χρησιμοποιήθηκε το ερωτηματολόγιο KDQOL-SF (Kidney Disease Quality of Life Short Form). Αποτελέσματα: Η μέση ηλικία των νεφροπαθών ήταν 51,2 έτη, το 71% ήταν άντρες και το 29% ήταν γυναίκες. Το 54,2% των νεφροπαθών διέμεναν μόνιμα στην Αθήνα, ενώ το 45,8% στην επαρχία. Το 79,4% ήταν έγγαμοι και το 20,6% ήταν άγαμοι/διαζευγμένοι/χήροι, ενώ το 76,6% είχαν παιδιά και το 23,4% δεν είχαν παιδιά. Το 29% ήταν απόφοιτοι γυμνασίου, το 29% ήταν απόφοιτοι δημοτικού, το 24,3% ήταν απόφοιτοι λυκείου, το 13,1% ήταν απόφοιτοι ΑΕΙ/ΤΕΙ και το 4,7% ήταν αγράμματοι. Το 59,8% των νεφροπαθών δεν ήταν συνταξιούχοι, ενώ το 40,2% ήταν συνταξιούχοι.Ο μέσος αριθμός ετών αιμοκάθαρσης ήταν 4,8. Το 91,6% των νεφροπαθών έλαβαν μόσχευμα από πτωματικό δότη, ενώ το 8,4% έλαβαν μόσχευμα από ζωντανό δότη. Το 92.5 % των νεφροπαθών επεβίωσαν έπειτα από τα πέντε χρόνια διεξαγωγής της μελέτης και 9 ασθενείς έχουν αποβιώσει ποσοστό 7,5 % Η συνολική ποιότητα ζωής (SF) μετά την επιτυχή μεταμόσχευση νεφρού παρουσίασε θεαματική βελτίωση. Ιδιαίτερα οι πιο θεαματικές μεταβολές παρατηρήθηκαν στην φυσική κατάσταση καθώς και στο συναισθηματικό επίπεδο. Στο ειδικό για τη νόσο ερωτηματολόγιο KDQOL στατιστικά σημαντική βρέθηκε να είναι η βελτίωση στην ποιότητα της ζωής ένα χρόνο μετά τη μεταμόσχευση και ιδιαίτερα θεαματικές μεταβολές παρατηρήθηκαν στην επιβάρυνση από την ίδια τη νόσο, στην γενετήσια λειτουργικότητα, στα συμπτώματα και στον ύπνο.Οι ασθενείς που έλαβαν μόσχευμα από ζωντανό δότη είχαν ελαφρά υψηλότερο σκορ στην ποιότητα της ζωής τους σε σχέση με αυτούς που είχαν λάβει πτωματικό μόσχευμα. Επίσης καλύτερη ποιότητα ζωής φάνηκαν να έχουν οι ασθενείς που είχαν παιδιά σε σχέση με αυτούς που δεν είχαν.Τέλος όσο περισσότερο χρόνο βρίσκονταν οι ασθενείς στην αιμοκάθαρση τόσο καλύτερη και η ποιότητα ζωής τους μετά την μεταμόσχευση.Συμπέρασμα: Το τελικό στάδιο της νεφρικής ανεπάρκειας είναι μια χρόνια κατάσταση η οποία μειώνει σημαντικά την ποιότητα ζωής των θυμάτων της. Η μεταμόσχευση νεφρού είναι η θεραπεία εκλογής για πολλούς απ΄ αυτούς τους αρρώστους. Όπως φάνηκε μέσα από την παρούσα μελέτη, η επιτυχημένη μεταμόσχευση νεφρού προάγει σημαντικά την ποιότητα ζωής των ασθενών σε σχέση με την αιμοκάθαρση.

scholarly journals Quality of Life and Symptom Burden among Chronic Kidney Disease of Uncertain Etiology (CKDu) Patients in Girandurukotte, Sri Lanka

2020 ◽  
Vol 17 (11) ◽  
pp. 4041 ◽  
Author(s):  
Hansani Madushika Abeywickrama ◽  
Swarna Wimalasiri ◽  
Yu Koyama ◽  
Mieko Uchiyama ◽  
Utako Shimizu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Short Form ◽  
Symptom Burden ◽  
Symptom Index ◽  
The Mean ◽  
Uncertain Etiology

Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients’ lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. The instruments applied were the Kidney Disease Quality of Life—Short Form (KDQOL-SFTM) version 1.3 and CKD Symptom Index—Sri Lanka. Socio-demographic, disease-related, and anthropometric variables were also investigated. The mean age of patients was 61.87 (SD 11.31), while 69.2% were male. The mean glomerular filtration rate was 28.17 (SD 14.03) mL/min/1.73 min2, and 70.8% were anemic. Bone/joint pain was the most experienced symptom while the median number of symptoms reported by patients was 5 (IQR 3–7). The mean symptom burden, physical component summary, mental component summary, and kidney-disease-specific component scores were 12.71 (SD 10.45), 68.63 (SD 19.58), 78.53 (SD 18.78), and 81.57 (SD 5.86), respectively. Age was found to be a significant predictor of HRQOL, while hemoglobin level and being a farmer were significant predictors of symptom burden. Our data indicate that CKDu patients in all stages experience at least one symptom affecting all aspects of HRQOL.

scholarly journals Impact of Medium Cut-Off Dialyzers on Patient-Reported Outcomes: COREXH Registry

2020 ◽  
pp. 1-9
Author(s):  
Juan Carlos Alarcon ◽  
Alfonso Bunch ◽  
Freddy Ardila ◽  
Eduardo Zuñiga ◽  
Jasmin I. Vesga ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Repeated Measures ◽  
Patient Reported Outcomes ◽  
Short Form ◽  
High Flux ◽  
Middle Molecules ◽  
Patient Reported ◽  
The Impact

<b><i>Introduction:</i></b> A new generation of hemodialysis (HD) membranes called medium cut-off (MCO) membranes possesses enhanced capacities for middle molecule clearance, which have been associated with adverse outcomes in this population. These improvements could potentially positively impact patient-reported outcomes (PROs). <b><i>Objective:</i></b> The objective of this study was to evaluate the impact of MCO membranes on PROs in a cohort of HD patients in Colombia. <b><i>Methods:</i></b> This was a prospective, multicenter, observational cohort study of 992 patients from 12 renal clinics in Colombia who were switched from high-flux HD to MCO therapy and observed for 12 months. Changes in Kidney Disease Quality of Life 36-Item Short Form Survey (KDQoL-SF36) domains, Dialysis Symptom Index (DSI), and restless legs syndrome (RLS) 12 months after switching to MCO membranes were compared with time on high-flux membranes. Repeated measures of ANOVA were used to evaluate changes in KDQoL-SF36 scores; severity scoring was used to assess DSI changes over time; Cochran’s Q test was used to evaluate changes in frequency of diagnostic criteria of RLS. <b><i>Results:</i></b> During 12 months of follow-up, 3 of 5 KDQoL-SF36 domains improved compared with baseline: symptoms (<i>p</i> &#x3c; 0.0001), effects of kidney disease (<i>p</i> &#x3c; 0.0001), and burden of kidney disease (<i>p</i> &#x3c; 0.001). The proportion of patients diagnosed with RLS significantly decreased from 22.1% at baseline to 10% at 12 months (<i>p</i> &#x3c; 0.0001). No significant differences in the number of symptoms (DSI, <i>p =</i> 0.1) were observed, although their severity decreased (<i>p</i> = 0.009). <b><i>Conclusions:</i></b> In conventional HD patients, the expanded clearance of large middle molecules with MCO-HD membranes was associated with higher health-related quality of life scores and a decrease in the prevalence of RLS.

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