scholarly journals A systematic review of the clinical, public health and cost-effectiveness of rapid diagnostic tests for the detection and identification of bacterial intestinal pathogens in faeces and food

2007 ◽  
Vol 11 (36) ◽  
Author(s):  
I Abubakar ◽  
L Irvine ◽  
C Aldus ◽  
G Wyatt ◽  
R Fordham ◽  
...  
2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Deisy Cristina Restrepo-Posada ◽  
Jaime Carmona-Fonseca ◽  
Jaiberth Antonio Cardona-Arias

An amendment to this paper has been published and can be accessed via the original article.


2019 ◽  
Vol 25 (6) ◽  
pp. 659-666 ◽  
Author(s):  
R. Luo ◽  
N. Fongwen ◽  
C. Kelly-Cirino ◽  
E. Harris ◽  
A. Wilder-Smith ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wenjun Zhu ◽  
XiaoXiao Ling ◽  
Wenru Shang ◽  
Yanqiu Du ◽  
Jinyu Liu ◽  
...  

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Alinune N. Kabaghe ◽  
Benjamin J. Visser ◽  
Rene Spijker ◽  
Kamija S. Phiri ◽  
Martin P. Grobusch ◽  
...  

2018 ◽  
Vol 5 (6) ◽  
pp. e277-e290 ◽  
Author(s):  
Carmen Figueroa ◽  
Cheryl Johnson ◽  
Nathan Ford ◽  
Anita Sands ◽  
Shona Dalal ◽  
...  

2021 ◽  
Author(s):  
Loveness Mukuka ◽  
Andros Theo ◽  
Mowa Zambwe ◽  
Peter J Chipimo

Objective: To investigate the performance of the HIV RDTs used in Zambia. Method: 2,564 participants aged between 15 and 95 years from two sites in Lusaka province years were tested on OraQuick ADVANCE, Abbot Determine, and then confirmed on Uni-Gold Recombigen. The data from the participants were analyzed using SPSS version 25.0. Results: The 3 RDTs when compared to the 4th generation Abbot Architect results had the following results: OraQuick ADVANCE, Alere Determine and Uni-Gold Ultra, at 95% CI had Sensitivities of: 91.8%, 93.3% and 92.5% respectively. The specificities of OraQuick ADVANCE and Uni-Gold were the same (100.0%; 95% CI: 98.8 -100.0) but slightly different from Alere Determine (99.8%). Positive predictive values at 95% CI were 100% for OraQuick ADVANCE and Uni-Gold and 98.4% for Alere Determine. Negative predictive values (at 95% CIs) were 99.1, 99.2 and 99.1 for OraQuick ADVANCE, Alere Determine, and Uni-Gold Ultra respectively. The results showed that these RDTs could only detect 12 out of every 13 HIV positive results. Conclusion: Third generation RDTs are not effective in detecting acute positive cases. Fourth generation Rapid Tests are required to capture the positive cases being missed out.


Author(s):  
Usha Adiga ◽  
Tirthal Rai

Objective: The objective of the study is to compare three techniques, routinely used rapid diagnostic tests (lateral flow immune chromatography) versus nucleic acid amplification test (NAT)  versus Paper-based microfluidics for DNA diagnostics of Malaria, in terms of their sensitivity and specificity as diagnostic tests in detecting malarial infection among febrile illnesses, suspected of malaria, as well as to compare their cost-effectiveness. Methodology: Three seventy febrile cases suspected of malaria with negative results with RDT will be screened by real-time PCR and DNA microfluidics techniques, sensitivity and specificity of these as screening tests will be compared. The number of extra positive cases detected by NAT gives us the yield. Cost-effectiveness analysis will be done by calculating the incremental cost-effectiveness ratio (ICER) and average cost-effectiveness ratio (ACER) for the tests. Statistical Analysis: Statistical analysis will be done using SPSS version 21. Sensitivity, specificity, Positive predictive values will be computed. Comparison of sensitivity and specificity of NAT, a paper microfluidic technique for DNA diagnostics and RDT will be carried out using McNemar’s test. Receiver operating curves will be generated separately to assess the utility of the NAT. Conclusion: The Implications of this study from the patient's perspective would mean early diagnosis which forms the tenet of control of the disease by increasing the yield. Early diagnosis at the community level would translate into the application of efficient prevention mechanisms to spread the infection. The cost-effectiveness analysis would provide a scientific basis for the adoption of the best test for the diagnosis, given the economic feasibility of the study.


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