GUANIDINE: A SIMPLE MOLECULE WITH GREAT POTENTIAL: FROM CATALYSTS TO BIOCIDES AND MOLECULAR GLUES

INEOS OPEN ◽  
2021 ◽  
Author(s):  
F. V. Drozdov ◽  
◽  
V. M. Kotov ◽  
Keyword(s):  
Smart Materials ◽  
Crucial Role ◽  
Chemical Properties ◽  
Structural Features ◽  
The Other ◽  
Synthetic Drugs ◽  
Guanidine Derivatives ◽  
Living Organisms ◽  
The One ◽  
Related Compounds

This review is devoted to the general methods for obtaining guanidine derivatives and related compounds, their chemical properties, and structural features. On the one hand, guanidine and its derivatives play a crucial role in the metabolism of living organisms. On the other hand, owing to their unique properties and simple synthesis, the guanidine derivatives are used as synthetic drugs and biocidal agents, catalysts, ligands, and sweeteners. Furthermore, the guanidine derivatives serve as a basis for the creation of modern smart materials.

Role Inversion and Its Function in the Iphigeneia at Aulis

Ramus ◽  
1986 ◽  
Vol 15 (2) ◽  
pp. 83-92
Author(s):  
Dale Chant
Keyword(s):  
Everyday Life ◽  
Crucial Role ◽  
Final Analysis ◽  
The Other ◽  
The Subject ◽  
The One ◽  
Pyrrhic Victory

In the Iphigeneia at Aulis role and role inversion are paramount concerns. Indeed it could be contended that in this play we find Euripides' clearest and best defined account of human (and divine) variability. Agamemnon, Menelaos, Achilleus, Iphigeneia, and even, in the final analysis, Artemis, all take positions and attitudes diametrically opposed to those initially adopted. Moreover, the basic thrust behind these movements in position and attitude is the same for each of these characters. All are concerned, in one way or another, with the saving or destruction of Iphigeneia, a situation which most emphatically includes Iphigeneia herself. For on the one hand she wildly supplicates to be saved, while on the other she gladly offers her body to the blade. In addition, Iphigeneia plays a crucial role in greater destructions. If she is destroyed by Agamemnon's and the army's actions, then Greece is destroyed in turn by her (Agamemnon's and the Greeks' final triumph is a ‘Pyrrhic’ victory at best), a situation made all the more ironic by her affected stance of saviour to the fatherland. In Iphigeneia's case, however, the discrepancy between intention and the consequences of action is innocent enough. The play gives no hint that she is at all aware of the irony implicit in her actions. But such lack of awareness is not postulated with regard to Agamemnon, Menelaos and Achilleus. The duplicities and hypocrisies of these three have been the subject of much analysis, and it is at least a critical commonplace to observe that they are characterised in a way more reminiscent of the sour end of everyday life than of the due proprieties associated with heroic, or Homeric, behaviour.

“Every Act of Preservation is an Act of Creation”: Paul Schrader’s Eco-theology in First Reformed

2020 ◽  
pp. 171-188
Author(s):  
Tatiana Prorokova
Keyword(s):  
Climate Change ◽  
Global Warming ◽  
The Other ◽  
Complex Relationship ◽  
Health Issues ◽  
Current State ◽  
Other Hand ◽  
Living Organisms ◽  
The One

This chapter scrutinizes the complex relationship between climate change and theology, as represented in First Reformed, as well as Paul Schrader’s understanding of humanity’s major problems today. Analyzing the issue of ecological decline through the prism of religion, Schrader outlines the ideology that presumably might help humanity survive at the age of global warming. Through the complex discussions of such issues as despair, anxiety, and hope, Schrader deduces the formula of survival in which preservation is the key component. Equating humans to God, Schrader, on the one hand, censures those actions that led to progress but destroyed the environment, yet, on the other hand, he foregrounds the fact that humans can also save the planet now. Schrader portrays both humans and Earth as living organisms created by God. He draws explicit parallels between the current state of our planet and the problems that we experience – from political ones, including war, to more personal ones like health issues.

Some Observations on the Phenomena of Life and Mind

1868 ◽  
Vol 13 (64) ◽  
pp. 437-449
Author(s):  
Robert Dunn
Keyword(s):  
Nervous System ◽  
Present State ◽  
The Other ◽  
Mental Life ◽  
States Of Consciousness ◽  
Physical Forces ◽  
Material Conditions ◽  
Living Organisms ◽  
The One

Life and mind, in their abstract nature or essence alike inscrutable to us, are problems which belong to the same category; for, in this world, we know nothing of life apart from an organism, and we have no manifestations of mind independently of a brain and nervous system. Here living organisms are required for the display of the vital phenomena, and a brain and nervous system for the manifestations of mind. Life has accordingly been defined as “the collective expression for a series of phenomena which take place exclusively in bodies that are organized,” and “mind as the functional manifestations of the living brain.” But then, and at the outset, it is to be remembered that in affirming sensation, emotion, thought, and volition to be functions of the nervous system, what is really maintained is this, that the vesicular matter of the encephalic ganglia furnishes the material conditions—the medium through which these mental phenomena are made manifest in this life. It may indeed be asked, Are not the physical forces of external nature, which underlie all vital phenomena, and the changing states of consciousness which constitute our mental life, as inscrutable to us in their nature or essence as are life and mind ? and it must be conceded that they are. Matter and force are coexistent, and are correlative. Nor can we conceive of the one but in association with, by, and through the other, any more than we can conceive of life, in our present state of existence, apart from an organism, or of thought independently of a living brain.

1-[2-(2-Hydroxymethylphenylthio)benzyl]-4-methylpiperzine and related compounds as potential antidepressants: Synthesis and pharmacological acreening

1984 ◽  
Vol 49 (4) ◽  
pp. 1009-1020 ◽  
Author(s):  
Irena Červená ◽  
Miroslav Protiva
Keyword(s):  
Potassium Carbonate ◽  
Secondary Alcohol ◽  
The Other ◽  
Lithium Aluminium Hydride ◽  
Keto Acid ◽  
Open Model ◽  
Lithium Aluminium ◽  
Neuroleptic Agent ◽  
The One ◽  
Related Compounds

Heating of 1-(2-iodobenzoyl)-4-methylpiperazine (II) with thiophenol and its 2-methyl, 4-methyl, 4-chloro and 2-hydroxymethyl derivatives in dimethylformamide in the presence of potassium carbonate, copper and cuprous iodide gave the piperazides IV-VIII; compound VIII was transformed by reduction with lithium aluminium hydride to the title compound I. The acid IX, obtained by a reaction of 5-chloro-2-iodobenzoic acid with 2-methylthiophenol, was reduced to the alcohol X, which was transformed via the chloride XI to 1-[5-chloro-2-(2-methylphenylthio)-benzyl]-4-methylpiperazine (XII), an open model of the neuroleptic agent clorothepin. Heating of 2,5-dichloroacetophenone with thiosalicylic acid afforded the keto acid XIII whose reaction with 1-methylpiperazine was carried out with the help of N,N"-carbonyldiimidazole. The piperazide XIV obtained was reduced on the one hand with sodium borohydride to the secondary alcohol XV, and with lithium aluminium hydride to 1-(2-[4-chloro-2-(1-hydroxyethyl)phenylthio]benzyl)-4-methylpiperazine (XVI) on the other. None of the dibasic piperazines (I, XII, XVI) did show antireserpine activity. In the general screening, some of the piperazides displayed a mild hypotensive (II, VIII, XIV, XV), adrenolytic (VIII), mild stimulating and antitussic (V), and spasmolytic, antiinflammatory and negatively ino- and chronotropic (XIV) activities.

COMMENTS ON THE STRUCTURAL FEATURES OF THE PAIS–UHLENBECK OSCILLATOR

2013 ◽  
Vol 28 (14) ◽  
pp. 1375001 ◽  
Author(s):  
B. BAGCHI ◽  
A. GHOSE CHOUDHURY ◽  
PARTHA GUHA
Keyword(s):  
Differential Equation ◽  
Fourth Order ◽  
Order Differential Equation ◽  
Structural Features ◽  
The Other ◽  
Alternative Derivation ◽  
The One ◽  
Fourth Order Differential Equation

We explore the Jacobi last multiplier (JLM) as a means for deriving the Lagrangian of a fourth-order differential equation. In particular, we consider the classical Pais–Uhlenbeck problem and write down the accompanying Hamiltonian. We then compare such an expression with our alternative derivation of the Hamiltonian that makes use of the Ostrogradski's method and show how a mapping from the one to the other is achievable by variable transformations.

I.—The Primitive Spindle as a Fundamental Feature in the Embryology of Plants

1924 ◽  
Vol 43 ◽  
pp. 1-36 ◽  
Author(s):  
F.O. Bower
Keyword(s):  
The Other ◽  
Fundamental Feature ◽  
Living Organisms ◽  
The One ◽  
Two Kingdoms

The analogies between the two Kingdoms of Living Organisms are so numerous that in many ways the study of the one may be rightly held to illuminate that of the other. Provided the lines of comparison be broad enough, good may come from following out such analogies. But whenever the comparisons are more closely drawn they should be examined critically: and in any case nothing more than analogy can be postulated for any comparison relating to their advanced types.

scholarly journals The Influence of Pragmatic Norms on the English Proverbs

2021 ◽  
Vol 11 (3) ◽  
Author(s):  
Dr.Hamid Suleiman Khalaf Kadhim
Keyword(s):  
Language Use ◽  
Structural Features ◽  
Point Of View ◽  
The Other ◽  
Cooperative Principle ◽  
Scientific Investigations ◽  
Illocutionary Acts ◽  
The Subject ◽  
Maxim Of Quality ◽  
The One

In human languages proverbs constitute a very important aspect of language use. Thus, they have been a subject of varying attention from different specialists: linguists and language users in general. Shakespeare is described as the most adroit user of proverbs in literature; therefore, his plays have been the subject of numerous scientific investigations, whereby from a linguistic point of view the focus has primarily been aimed at vocabulary and grammar. On the one hand, attention has been paid regularly to lexical items because Shakespeare is supposed to have been a great innovator of words due to his coinage of new lexemes and his usage of several unknown expressions. Linguistic studies have also been concerned with grammatical constructions which are typical of the English at Shakespeare’s time. Many writers employ proverbs in their works but Shakespeare is different in the way he employs proverbs which are used to serve different functions and to achieve different illocutionary acts. These proverbs are embedded in the flow of conversations and they may flout one or more than one of Grice‘s maxims. The present study aims at analyzing proverbs and explaining how far Grice’s cooperative principles (maxims) are abided by in Shakespeare’s proverbs as specified in the data. Proverbs are sometimes said to mean something else in addition to what is explicitly stated. Words may mean something beyond those intended by the speaker or the writer. These extra meanings might achieve or refer to different illocutionary acts. The study explores whether or not these illocutionary acts share certain structural features. In order to achieve the aims of the research, the following hypotheses have been proposed: Grice’s cooperative principle is frequently flouted in Shakespeare’s proverbs. The maxim of Quality seems to be flouted more than the other maxims. This maxim is mainly flouted by the use of metaphor. Shakespeare’s proverbs are also characterized by the use of the speech

scholarly journals Muzyka jako teofania? Pytania do George’a Steinera

Principia ◽  
2019 ◽  
Vol 66 ◽  
Author(s):  
Marcin Trzęsiok
Keyword(s):  
Crucial Role ◽  
The Other ◽  
Critical Reading ◽  
Musical Aesthetics ◽  
Philosophy Of Music ◽  
Rhetorical Question ◽  
Other Hand ◽  
Special Place ◽  
The One ◽  
Name Of God

Music occupies a special place in George Steiner’s thinking: “Three areas: the essence and name of God, higher mathematics and music (what is the connection between them?) are located at the limits of language” (Steiner, Errata). The seemingly rhetorical question in parentheses turns out to be a source of deep controversy, the essence of which is revealed in historical-genealogical reflection. Steiner attempts to incorporate Romantic metaphysics within the traditional scholastic symbiosis of Biblical creationism and Pythagoreanism, which reveals his philosophy of music to be entangled in a range of contradictions. On the one hand, a critical reading of Steiner's works uncovers the difficulties posed by the attempt to reconcile pre- and post-Enlightenment culture; on the other hand, the still unused opportunities offered by Romanticism and its modernist continuations are clearly visible. Musical aesthetics, rooted in the idea of infinity, plays a crucial role in these divagations.

scholarly journals Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2

2020 ◽  
Vol 11 ◽  
Author(s):  
Yue Zhu ◽  
De-Yu Xie
Keyword(s):  
Hydrogen Bonds ◽  
Inhibitory Activity ◽  
Docking Simulation ◽  
Binding Pocket ◽  
Structural Features ◽  
The Other ◽  
Main Protease ◽  
Inhibitory Activities ◽  
The One

We report to use the main protease (Mpro) of SARS-Cov-2 to screen plant flavan-3-ols and proanthocyanidins. Twelve compounds, (–)-afzelechin (AF), (–)-epiafzelechin (EAF), (+)-catechin (CA), (–)-epicatechin (EC), (+)-gallocatechin (GC), (–)-epigallocatechin (EGC), (+)-catechin-3-O-gallate (CAG), (–)-epicatechin-3-O-gallate (ECG), (–)-gallocatechin-3-O-gallate (GCG), (–)-epigallocatechin-3-O-gallate (EGCG), procyanidin A2 (PA2), and procyanidin B2 (PB2), were selected for docking simulation. The resulting data predicted that all 12 metabolites could bind to Mpro. The affinity scores of PA2 and PB2 were predicted to be −9.2, followed by ECG, GCG, EGCG, and CAG, −8.3 to −8.7, and then six flavan-3-ol aglycones, −7.0 to −7.7. Docking characterization predicted that these compounds bound to three or four subsites (S1, S1′, S2, and S4) in the binding pocket of Mpro via different spatial ways and various formation of one to four hydrogen bonds. In vitro analysis with 10 available compounds showed that CAG, ECG, GCG, EGCG, and PB2 inhibited the Mpro activity with an IC50 value, 2.98 ± 0.21, 5.21 ± 0.5, 6.38 ± 0.5, 7.51 ± 0.21, and 75.3 ± 1.29 μM, respectively, while CA, EC, EGC, GC, and PA2 did not have inhibitory activities. To further substantiate the inhibitory activities, extracts prepared from green tea (GT), two muscadine grapes (MG), cacao, and dark chocolate (DC), which are rich in CAG, ECG, GAG, EGCG, or/and PB2, were used for inhibitory assay. The resulting data showed that GT, two MG, cacao, and DC extracts inhibited the Mpro activity with an IC50 value, 2.84 ± 0.25, 29.54 ± 0.41, 29.93 ± 0.83, 153.3 ± 47.3, and 256.39 ± 66.3 μg/ml, respectively. These findings indicate that on the one hand, the structural features of flavan-3-ols are closely associated with the affinity scores; on the other hand, the galloylation and oligomeric types of flavan-3-ols are critical in creating the inhibitory activity against the Mpro activity.

scholarly journals Marine-Derived Collagen as Biomaterials for Human Health

2021 ◽  
Vol 8 ◽  
Author(s):  
Ning Xu ◽  
Xue-Liang Peng ◽  
Hao-Ru Li ◽  
Jia-Xuan Liu ◽  
Ji-Si-Yu Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Properties ◽  
Extraction Methods ◽  
Marine Organisms ◽  
The Other ◽  
Physical And Chemical Properties ◽  
Fish Scales ◽  
The One ◽  
Physical And Chemical ◽  
And Chemical Properties

Collagen is a kind of biocompatible protein material, which is widely used in medical tissue engineering, drug delivery, cosmetics, food and other fields. Because of its wide source, low extraction cost and good physical and chemical properties, it has attracted the attention of many researchers in recent years. However, the application of collagen derived from terrestrial organisms is limited due to the existence of diseases, religious beliefs and other problems. Therefore, exploring a wider range of sources of collagen has become one of the main topics for researchers. Marine-derived collagen (MDC) stands out because it comes from a variety of sources and avoids issues such as religion. On the one hand, this paper summarized the sources, extraction methods and characteristics of MDC, and on the other hand, it summarized the application of MDC in the above fields. And on the basis of the review, we found that MDC can not only be extracted from marine organisms, but also from the wastes of some marine organisms, such as fish scales. This makes further use of seafood resources and increases the application prospect of MDC.

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