scholarly journals Toxicological Evaluation of Kenaf Seed Supercritical Carbon Dioxide-Oil in Male Sprague Dawley Rats

2021 ◽  
Vol 14 ◽  
pp. 1-7
Author(s):  
Siti Aisyah Abd Ghafar ◽  
Latifah Saiful Yazan ◽  
Sharida Fakhurazi ◽  
Maznah Ismail
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Plasma Cholesterol ◽  
Plasma Cholesterol Level ◽  
Sprague Dawley ◽  
Lower Plasma ◽  
Toxicological Evaluation ◽  
Sprague Dawley Rats ◽  
Kenaf Seed ◽  
Lower Plasma Cholesterol

Kenaf seed supercritical carbon dioxide oil (KSO-SFE) is known for its numerous health benefits such as high antioxidant activity, lower plasma cholesterol level, chemopreventive to cervical and colon cancer. As there has been no report of toxicological evaluation, present study was conducted to assess the toxicity effects of KSO-SFE at 500, 1000, 1500 mg/kg body weight/day on male Sprague Dawley rats for 90 days. Parameters measured were body and organs weight, hematology, serum biochemistry, and histopathology of liver and kidneys. Induction with KSO-SFE showed lower creatinine level at all doses when compared with control group. Whereas lower plasma cholesterol level has been observed at 1000 and 1500 mg/kg bw/day, respectively. These slight changes were considered no toxicological significance. No mortality or treatment-related adverse effects in any of the parameters measured throughout the administration period even at the highest dose (1500 mg/kg bw). Based on these results, the no-adverse-effect level (NOAEL) for KSO-SFE under the condition of this study corresponds to the highest dose (1500 mg/kg bw/day).

scholarly journals Beneficial Effect of Supercritical Carbon Dioxide Extracted (SC-CO2) Dabai (Canarium odontophyllum) Pulp Oil in Hypercholesterolemia-Induced SPF Sprague-Dawley Rats

2018 ◽  
Vol 13 (12) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Noor Atiqah Aizan Abdul Kadir ◽  
Azrina Azlan ◽  
Faridah Abas ◽  
Intan Safinar Ismail
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Total Cholesterol ◽  
Dose Group ◽  
Control Group ◽  
High Dose ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Canarium Odontophyllum ◽  
Supercritical Carbon

Production of dabai ( Canarium odontophyllum) pulp oil by supercritical carbon dioxide extraction is still relatively new and should be investigated. The objective of this study was to investigate the effects of supercritical carbon dioxide (SC-CO2) extracted dabai pulp oil (DPO) on rats induced with hypercholesterolemia. Male-specific pathogen free (SPF) Sprague-Dawley rats were fed with diets with high cholesterol contents for 4 weeks to induce hypercholesterolemia. Afterwards, the hypercholesterolemia rats were divided into groups namely: positive control group (PG), low dose group (LG), high dose group (HG), and statin group (SG). 0.5% and 2% of SC-CO2 DPO were administered to the LG and HG groups respectively for another 4 weeks. Changes in body weight and biochemistry profiles were measured. When compared with the normal rats that were fed with a normal basal diet, the hypercholesterolemia rats had elevated body weights and major increments in total cholesterol and LDL levels(NG) ( p<0.05). Paired-samples t-tests showed that the LG group exhibited a notable reduction in total cholesterol, triglyceride and LDL levels ( p<0.05) and an 8.26% increment in HDL level. Meanwhile, diminishing levels of total cholesterol, triglyceride and LDL levels were found in the HG group. Notable differences in AST and ALT levels were not detected in LG and HG groups when compared with the NG group. These results indicated that SC-CO2dabai pulp oil contains vital elements which contribute to cholesterol-loweringeffects and which can be used as special oils for health promotion and disease prevention.

Toxicological Evaluation of the ketogenic ester Bis Hexanoyl (R)-1,3-Butanediol: Subchronic Toxicity in Sprague Dawley Rats

2021 ◽  
pp. 112084
Author(s):  
Brianna J. Stubbs ◽  
Andrey I. Nikiforov ◽  
Marisa O. Rihner ◽  
Sari L. Weston ◽  
Nancy Higley ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Subchronic Toxicity ◽  
Toxicological Evaluation ◽  
Sprague Dawley Rats

Toxicological evaluation of an Allium-based commercial product in a 90-day feeding study in Sprague–Dawley rats

2016 ◽  
Vol 90 ◽  
pp. 18-29 ◽  
Author(s):  
P. Mellado-García ◽  
M. Puerto ◽  
S. Pichardo ◽  
M. Llana-Ruiz-Cabello ◽  
R. Moyano ◽  
...  
Keyword(s):  
Commercial Product ◽  
Sprague Dawley ◽  
Toxicological Evaluation ◽  
Feeding Study ◽  
Sprague Dawley Rats

scholarly journals Low Levels of Viscous Hydrocolloids Lower Plasma Cholesterol in Rats Primarily by Impairing Cholesterol Absorption

2000 ◽  
Vol 130 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Marie-Anne Levrat-Verny ◽  
Stephen Behr ◽  
Vikkie Mustad ◽  
Christian Rémésy ◽  
Christian Demigné
Keyword(s):  
Plasma Cholesterol ◽  
Cholesterol Absorption ◽  
Lower Plasma ◽  
Lower Plasma Cholesterol ◽  
Low Levels

scholarly journals Aversion to Desflurane and Isoflurane in Sprague-Dawley Rats (Rattus norvegicus)

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 950 ◽  
Author(s):  
Katrina Frost ◽  
Maaria Shah ◽  
Vivian S.Y. Leung ◽  
Daniel S.J. Pang
Keyword(s):  
Carbon Dioxide ◽  
Exposure Time ◽  
Washout Period ◽  
Rattus Norvegicus ◽  
Sprague Dawley ◽  
Initial Exposure ◽  
Treatment Groups ◽  
Avoidance Paradigm ◽  
Sprague Dawley Rats

Carbon dioxide and isoflurane are widely used for killing rats, yet may not truly achieve “euthanasia”, because they elicit aversion. The inhalant anesthetic desflurane is faster acting than isoflurane, representing a potential refinement. Using an aversion-avoidance paradigm, 24 rats were exposed to isoflurane or desflurane (n = 12 per group) at initial exposure. Fourteen rats were then re-exposed to isoflurane or desflurane (n = 7 per group), after a 7 days washout period. Initial exposure: time to recumbency was faster for desflurane than isoflurane (p = 0.0008, 95% CI [-12.9 to 32.6 s]), with 9/12 and 6/12 rats becoming recumbent, respectively. At initial exposure, there was no difference between groups in time to withdrawal (p = 0.714). At re-exposure, all rats withdrew and no rats became recumbent. Time to withdrawal at re-exposure did not differ between treatment groups (p = 0.083). Compared to initial exposure, time to withdrawal during re-exposure was similar for isoflurane (p = 0.228) and faster with desflurane (p = 0.012, 95% CI [19.1 to 49.5 s]). Isoflurane and desflurane are similarly aversive, with aversion increasing at re-exposure. The shorter time from exposure to recumbency with desflurane indicates that any distress is of a shorter duration when compared with isoflurane.

Daily rhythm of NaCl intake in rats fed low-Ca2+ diet: relation to plasma and urinary minerals and hormones

1996 ◽  
Vol 270 (3) ◽  
pp. R505-R517 ◽  
Author(s):  
M. G. Tordoff ◽  
A. Okiyama
Keyword(s):  
Dark Period ◽  
Plasma Concentrations ◽  
Salt Appetite ◽  
Sprague Dawley ◽  
Lower Plasma ◽  
Plasma Osmolarity ◽  
Dihydroxyvitamin D3 ◽  
Sprague Dawley Rats ◽  
The Difference ◽  
Plasma Phosphorus

To assess daily rhythms of salt appetite, we measured spontaneous 300 mM NaCl intake of male Sprague-Dawley rats fed a diet containing 150 or 25 mmol Ca2+/kg. Both groups drank most NaCl at night, but, as the dark period progressed, intakes of controls remained constant or diminished, whereas intakes of rats fed low-Ca2+ diet increased. During the late dark period, when the difference in NaCl intake between the two dietary groups was greatest, rats fed a low-Ca2+ diet lost more corticosterone and sodium in urine, had lower plasma osmolarity, and had higher plasma adrenocorticotropic hormone (ACTH) and corticosterone concentrations than did controls. Over the 24-h cycle, rats fed the low-Ca2+ diet excreted less Ca2+ and more corticosterone in urine than did controls. They also had consistently lower plasma concentrations of Ca2+ and renin activity and consistently higher plasma phosphorus, arginine vasopressin, parathyroid hormone, thyroxine, calcitonin, and 1,25-dihydroxyvitamin D3. These findings support the hypothesis that salt appetite induced by dietary Ca2+ deficiency involves a subtle dysfunction of the ACTH-corticosterone axis, but they also raise several other possibilities.

scholarly journals Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice1–3

2006 ◽  
Vol 84 (2) ◽  
pp. 312-321 ◽  
Author(s):  
Ilse Duivenvoorden ◽  
Peter J Voshol ◽  
Patrick CN Rensen ◽  
Wim van Duyvenvoorde ◽  
Johannes A Romijn ◽  
...  
Keyword(s):  
Plasma Cholesterol ◽  
Liver Steatosis ◽  
Lower Plasma ◽  
Lower Plasma Cholesterol

Chronic toxicological evaluation of dietary NovaSil Clay in Sprague-Dawley rats

2005 ◽  
Vol 22 (3) ◽  
pp. 259-269 ◽  
Author(s):  
Evans Afriyie-Gyawu ◽  
John Mackie ◽  
Bhagirathi Dash ◽  
Melinda Wiles ◽  
John Taylor ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Toxicological Evaluation ◽  
Sprague Dawley Rats ◽  
Novasil Clay
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