scholarly journals 1-hydroxymethyl Harmine-TGFβSF Inhibitor: Inovasi Terapi Diabetes Melitus Terbaru Melalui Inisiasi Proses Regenerasi Sel β Pankreas pada Penderita DM Tipe 1 dan 2

2021 ◽  
Vol 2 (2) ◽  
pp. 104-15
Author(s):  
Ghea Mangkuliguna ◽  
Glenardi ◽  
Rexel Kuatama
Keyword(s):  
Diabetes Mellitus ◽  
Cell Proliferation ◽  
Google Scholar ◽  
First Year ◽  
Literature Study ◽  
Β Cells ◽  
Novel Therapy ◽  
Hydroxymethyl Group ◽  
Diabetes Melitus

Background: Type 1 and 2 diabetes mellitus (DM) is a chronic metabolic disease most commonly affects millions of people worldwide. Despite the differences in pathogenesis, both share one thing in common - that is the drastic depletion in the number of pancreatic β cells. Unfortunately, physiological proliferation of β cells has come to a halt starting from the first year of neonatal. To overcome this problem, researchers have been searching for molecules with the ability to induce β cells proliferation. Upon extensive screening, only harmine was proven to be the most potent β cells proliferation inducer. Furthermore, combination of harmine with TGFβSF inhibitor was found to boost harmine’s effectivity even more. Another development was also made to improve harmine’s selectivity by incorporating 1-hydroxymethyl group. Objective: Evaluate the potency of 1-hydroxymethyl harmine-TGFβSF inhibitor as a novel therapy for DM. Method: A systematic literature study was conducted with the database from Pubmed, Google Scholar, ScienceDirect, and Proquest for articles published within 2015-2019. Discussion: This literature review yields result that harmine-TGFβSF inhibitor is proven to induce β cells proliferation up to 18%/day or equal to 18 times the normal cell proliferation rate during embryogenesis. Moreover, incorporating 1-hydroxymethyl group into harmine is proven not only to improve selectivity but also lessen the toxicity, making 1-hydroxymethyl harmine safe as a novel therapy for diabetes. Conclusion: 1-hydroxymethyl harmine-TGFβSF inhibitor display promising potential as a novel therapy for all type of diabetes patients. Keywords: diabetes mellitus, harmine, TGFβSF inhibitor, β cell proliferation   Latar Belakang: Diabetes Melitus (DM) tipe 1 maupun tipe 2 merupakan penyakit metabolik kronis yang paling banyak ditemukan di seluruh dunia. Walaupun memiliki proses patogenesis yang berbeda, namun kedua tipe DM ini ternyata memiliki kesamaan, yaitu terjadinya penurunan kuantitas sel β pankreas. Sayangnya, kemampuan regenerasi sel β pankreas manusia telah terhenti semenjak tahun pertama masa neonatal. Untuk menangani permasalahan tersebut, para peneliti menemukan sebuah molekul bernama harmine yang terbukti efektif menginisiasi proses regenerasi sel β pankreas. Selanjutnya, untuk meningkatkan efektifitas dari harmine agar lebih baik lagi, peneliti kemudian mengkombinasikan harmine dengan TGFβSF inhibitor. Sedangkan, untuk meningkatkan selektivitas dari harmine, peneliti menambahkan gugus 1-hidroksimetil pada molekul tersebut. Tujuan: Evaluasi potensi 1-hydroxymethyl harmine-TGFβSF inhibitor sebagai terapi utama bagi semua penderita DM. Metode: Penelitian dilakukan dengan melakukan tinjauan pustaka dari beberapa database jurnal, yakni PubMed, Google Scholar, ScienceDirect dan ProQuest dengan kriteria literatur dipublikasikan dalam kurun waktu 2015-2019. Pembahasan: Studi literatur ini menunjukan bahwa harmine-TGFβSF inhibitor telah terbukti mampu meningkatkan proliferasi sel β pankreas manusia hingga mencapai 18%/hari atau setara dengan 18 kali kecepatan embriogenesis pada sel normal. Selain itu, penambahan gugus 1-hidroksimetil pada harmine juga telah terbukti tidak hanya mampu meningkatkan selektivitas dari molekul tersebut, tetapi juga mampu menurunkan efek toksisitasnya, sehingga aman digunakan sebagai terapi anti-diabetes terbaru. Kesimpulan: 1-hydroxymethyl harmine-TGFβSF inhibitor memiliki potensi yang menjanjikan untuk menjadi terapi baru bagi semua tipe penderita DM. Kata Kunci: diabetes mellitus, harmine, proliferasi sel β, TGFβSF inhibitor

scholarly journals Pelaksanaan discharge planning pada pasien diabetes melitus: Studi literatur

2020 ◽  
Vol 14 (4) ◽  
pp. 503-521
Author(s):  
Linda Yulia ◽  
Tuti Pahria ◽  
Sandra Pebrianti
Keyword(s):  
Diabetes Mellitus ◽  
Full Text ◽  
Discharge Planning ◽  
Narrative Review ◽  
Google Scholar ◽  
Literature Study ◽  
Planning Stage ◽  
Patients With Diabetes ◽  
Diabetes Melitus ◽  
Quasi Experiment

Discharge planning from hospital to home among patients with diabetes mellitus: A literature studyBackground: Several studies have stated that patients with diabetes mellitus who do not get proper management when discharge after hospitalization are very at risk to readmission because of complications. Properly discharge planning programme is very essentials to reduce the number of readmission and following by controlled on patient's conditions. However, the fruitfulness level of discharge planning program in each hospital was different. planning in DM patients is still not optimal and does not explain in detail the discharge planning stages.  Purpose: To determine several studies of discharge planning programme among patients with diabetes mellitus in several hospitalMethod: Literature study method with narrative review approach. Search for articles using databases by Science Direct, Pubmed and Google Scholar by entering keywords "discharge planning or return planning, Stages or steps, Diabetes or glycemic." From the search results, there were 13,743 articles that matched the keywords, then an examination carried out based on inclusion criteria (published year 2011-2020, articles in Indonesian and English, using the retrospect cohort method, RCT, and Quasi Experiment, full-text articles, discuss discharge planning stages) and exclusion criteria (articles on systematic reviews, proceedings, editorials and books). An examination carried out based on the title, sample, research method, and getting 10 articles.Results: Analyzing result of 10 articles found that the discharge planning stage was the first stage starting from the time when admitting to hospital by conducting an assessment, diagnosis, planning, implementation and evaluation. The second stage was for the patient treated by providing education and training. Providing education included information about disease, signs and symptoms of disease, things that must avoid from experienced health problems and complications, and information about health service sources in the community. While training included the use of drugs, insulin, diet, physical activity, management of hypo and hyperglycemia, foot care, and blood glucose control. The third stage was after the patient discharged from the hospital by following up in form of telephone counseling and visits to the patient's home. The result of this literature study can be used as learning material for further research and material in providing nursing care. Keywords: Discharge planning; Hospital; Patients; Diabetes mellitus; Literature studyPendahuluan: Pasien DM yang tidak mendapatkan penatalaksanaan yang tepat sangat beresiko mengalami berbagai komplikasi. Beberapa penelitian menyebutkan pasien DM cenderung kembali menjalani rawat ulang setelah pulang dari rumah sakit akibat dari komplikasi. Discharge planning terbukti dapat mengurangi jumlah kunjungan ulang ke rumah sakit dengan keluhan yang sama dan bahkan dapat mengurangi tingkat komplikasi. Namun, untuk saat ini, pelaksanaan discharge planning pada pasien DM masih kurang optimal dan tidak secara rinci menjelaskan tentang tahapan discharge planning.Tujuan: Untuk mengetahui tahapan dalam pemberian discharge planning pada pasien diabetes melitus.Metode: Penelitian ini menggunakan metode studi literatur dengan pendekatan narrative review. Pencarian artikel menggunakan database yaitu Science Direct, Pubmed dan Google Scholar dengan memasukkan kata kunci yaitu “discharge planning or perencanaan pulang, Stages or tahapan, Diabetes or glycemic. Dari hasil pencarian ditemukan sebanyak 13,743 artikel yang sesuai dengan kata kunci, kemudian dilakukan pemeriksaan berdasarkan kriteria inklusi (terbit tahun 2011-2020, artikel dalam Bahasa Indonesia dan Bahasa Inggris, menggunakan metode kohort retrospekti, RCT, dan Quasi Experiment, artikel tersedia full text, membahas tahapan discharge planning) serta kriteria eksklusi (Artikel systematic review, proceeding, editorial dan buku). Selanjutnya dilakukan pemeriksaan berdasarkan judul, sampel, metode penelitian, dan isi sehingga didapatkan 10 artikel.Hasil: Dari 10 artikel ditemukan tahapan discharge planning tahap pertama dimulai sejak pasien masuk ke rumah sakit dengan melakukan pengkajian, diagnosa, perencanaan, implementasi, dan evaluasi. Tahap kedua selama pasien di rawat dengan memberikan pendidikan dan pelatihan. Pemberian pendidikan meliputi informasi tentang penyakit, tanda dan gejala penyakit, hal-hal yang harus dihindarkan dari gangguan kesehatan yang dialami dan komplikasi, serta informasi tentang sumber-sumber pelayanan kesehatan dimasyarakat. Sedangkan pelatihan meliputi penggunaan obat dan insulin, diet, aktivitas fisik, manajemen hipo dan hiperglikemia, perawatan kaki, dan kontrol glukosa darah. Tahap ketiga yaitu setelah pasien keluar dari rumah sakit dengan melakukan tindak lanjut berupa konseling telepon dan kunjungan ke rumah pasien. Hasil studi literatur ini dapat dijadikan sebagai bahan pembelajaran untuk penelitian selanjutnya dan bahan dalam memberikan asuhan keperawatan oleh perawat pada pasien diabetes melitus.

scholarly journals Review: Interaksi Antara Obat Konvensional dan Herbal untuk Diabetes Mellitus

2021 ◽  
Vol 8 (1) ◽  
pp. 56-70
Author(s):  
Izzah Al Mukminah ◽  
Raden Bayu Indradi
Keyword(s):  
Diabetes Mellitus ◽  
Aloe Vera ◽  
Google Scholar ◽  
Diabetes Melitus

Pendahuluan: Prevalensi Diabetes Melitus (DM) di Indonesia tinggi dan bahkan mengalami fluktuasi dari 422 juta jiwa menjadi 463 juta jiwa dalam 5 tahun. Pada tatalaksana penyakit DM, salah satunya ialah terapi farmakologi menggunakan Obat Antihiperglikemik (OAH). Saat ini selain OAH, masyarakat juga menggunakan herbal untuk mengatasi DM. Senyawa aktif herbal yang telah terbukti berkontribusi dalam pengobatan beragam dan multikomponen, namun tidak semua komponen tersebut diketahui memberikan efek terapeutik pada DM. Maka, tujuan dari tinjauan pustaka ini untuk mengetahui interaksi yang terjadi antara obat konvensional dan herbal untuk DM. Metode: Pencarian literatur dilakukan pada bulan Mei 2020. Situs yang digunakan adalah Google Scholar, Elsevier dan NCBI.  Kata kunci yang digunakan untuk menemukan sumber jurnal ialah “interaksi obat DM dan herbal”, “interaction of diabetic drugs and herbs”, “herbal untuk diabetes”, dan “herbs for diabetes”. Jurnal yang digunakan sebagai sumber berjumlah 15 jurnal dengan fokus penelitian secara in vivo  dan klinis. Hasil: Multikomponen pada herbal tersebut jika digunakan bersamaan dengan OAH berpotensi untuk menimbulkan interaksi, beberapa studi melaporkan bahwa OAH dan herbal untuk antidiabetes memiliki interaksi sinergis atau antagonis. Berdasarkan pustaka beberapa penelitian interaksi obat dan herbal bisa terjadi, seperti Metformin, Glibenklamid dan Pioglitazon dengan Aloe vera berinteraksi sinergis. Kesimpulan: Potensi interaksi antagonis dan sinergis muncul pada beberapa hasil penelitian interaksi herbal dengan OAH.

scholarly journals Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 973
Author(s):  
Adrian Vlad ◽  
Viorel Serban ◽  
Romulus Timar ◽  
Alexandra Sima ◽  
Veronica Botea ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Background Information ◽  
First Year ◽  
Age Group ◽  
Newly Diagnosed ◽  
Β Cells ◽  
Specific Antibodies ◽  
Autoimmune Destruction ◽  
Geographical Regions

Background and Objective: It is known that several viruses are involved in the pathogenesis of type 1 diabetes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new worldwide spread virus that may act as a trigger for the autoimmune destruction of the β-cells, as well, and thus lead to an increase in the incidence of type 1 diabetes. Material and Methods: The Romanian National Organization for the Protection of Children and Adolescents with Diabetes (ONROCAD) has collected information regarding new cases of type 1 diabetes in children aged 0 to 14 years from all over the country since 1996 and has computed the incidence of type 1 diabetes in this age group. Results: We observed a marked increase in the incidence of type 1 diabetes in the first year of the COVID-19 pandemic, with 16.9%, from 11.4/100,000 in 2019 to 13.3/100,000 in 2020, much higher compared to previous years (mean yearly increase was 5.1% in the period 1996–2015 and 0.8% in the interval 2015–2019). The proportion of newly diagnosed cases was significantly higher in the second half of 2020 compared to the second half of the previous years (57.8 vs. 51%, p < 0.0001). Conclusions: All these aspects suggest the role that SARS-CoV-2 could have in triggering pancreatic autoimmunity. To confirm this, however, collecting information from larger populations from different geographical regions, monitoring the incidence curves over a period of several years, and gathering background information on COVID-19 and/or data on COVID-19 specific antibodies are needed.

scholarly journals Pemberian Ekstrak Biji Jintan Hitam pada Diabetes Melitus Tipe 2 sebagai Terapi

2019 ◽  
Vol 8 (2) ◽  
pp. 67-74
Author(s):  
Asri Pandiangan ◽  
Kristian Pieri Ginting
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Google Scholar ◽  
Pharmacological Intervention ◽  
Black Seed ◽  
Bioactive Component ◽  
Diabetes Melitus

Diabetes melitus  atau DM merupakan kelompok penyakit metabolic dengan karakteristik hiperglikemia yang terjadi akibat kelainan sekresi insulin, kelainan kerja insulin atau kedua-duanya. Prevalensi diabetes melitus pada penduduk usia>15 tahun sebesar 6,9%, Toleransi Glukosa Terganggu atau TGT sebesar 29,9% dan Gula Darah Puasa Terganggu atau GDPT sebesar 36,6%. Diabetes mellitus merupakan silent killer. Adapun gejala-gejala klasik pada diabetes adalah polifagi, polidipsi dan poliuri. Penanganan pasien diabetes terbagi atas terapi farmakologi dan non farmakologi. Literatur review ini bertujuan mengetahui efek pemberian ekstrak biji jintan hitam terhadap pasien diabetes mellitus tipe 2 sebagai terapi alternatif yang sudah dilakukan oleh peneliti sebelumnya. Metode yang digunakan dalam artikel ini adalah penelusuran artikel melalui database NCBI dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2001 sampai 2019 dengan 32 sumber pustaka. Berbagai penelitian eksperimental yang dilakukan menunjukkan bahwa kandungan bioaktif pada biji jintan hitam bermanfaat sebagai anti diabetes. Kandungan biji jintan hitam sebagai antioksidan dapat meningkatkan sekresi insulin dengan meningkatkan metabolism energi di mitokondria, meningkatkan jalur intraseluler pada reseptor dan menurunkan glukoneogenesis dengan menekan sintesis enzim glukoneogenik.   Kata kunci: diabetes melitus, thymoquine, anti diabetes   EFFECT OF BLACK SEED EXTRACT FOR DIABETES MELLITUS TYPE 2 AS ALTERNATIVE THERAPY   ABSTRACT Diabetes mellitus or DM  is an group metabolic disease with the hyperglycemia characteristic because of insulin secretion disorder, insulin activity or both of them. The prevalence of diabetes mellitus at the age > 15 years old, is 6.9 percent, 29.9 percent ImpairedGlucoseTolerance or IGT and 36.6 percent ImpairedFastingGlycaemia or IFG.. Diabetes mellitus is a silent killer. As for classic symptoms of diabetes are polyphagia, polydipsia and polyuria. Intervention for patient diabetes divided by pharmacological and non pharmacological intervention. This literature review aims to find out which effect of Black Seed for patient of diabetes mellitus type 2 as alternative therapythat have been done by previous researchers. The method used in this article is the search of articles through the NCBI and Google Scholar databases. The year of publication of library sources is from 2009 to 2018 with 29 library sources.Various experimental research conducted showed part bioactive component useful as antidiabetic. Bioactive component as antioxidant can increase insulin secretion by increasing energy metabolism at mitochondria and increasing intraceluler pathway on insulin receptor and reduce gluconeogenesis by reduce synthesis gluconeogenic enzyme.   Keywords: diabetes mellitus, thymoquinone, anti diabetic

scholarly journals Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4381
Author(s):  
Zakiyatul Faizah ◽  
Bella Amanda ◽  
Faisal Yusuf Ashari ◽  
Efta Triastuti ◽  
Rebecca Oxtoby ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Diabetic Mice ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
In Vivo Models ◽  
Type 2 Dm ◽  
Type 1 Dm

Diabetes mellitus (DM) is one of the major causes of death in the world. There are two types of DM—type 1 DM and type 2 DM. Type 1 DM can only be treated by insulin injection whereas type 2 DM is commonly treated using anti-hyperglycemic agents. Despite its effectiveness in controlling blood glucose level, this therapeutic approach is not able to reduce the decline in the number of functional pancreatic β cells. MST1 is a strong pro-apoptotic kinase that is expressed in pancreatic β cells. It induces β cell death and impairs insulin secretion. Recently, a potent and specific inhibitor for MST1, called XMU-MP-1, was identified and characterized. We hypothesized that treatment with XMU-MP-1 would produce beneficial effects by improving the survival and function of the pancreatic β cells. We used INS-1 cells and STZ-induced diabetic mice as in vitro and in vivo models to test the effect of XMU-MP-1 treatment. We found that XMU-MP-1 inhibited MST1/2 activity in INS-1 cells. Moreover, treatment with XMU-MP-1 produced a beneficial effect in improving glucose tolerance in the STZ-induced diabetic mouse model. Histological analysis indicated that XMU-MP-1 increased the number of pancreatic β cells and enhanced Langerhans islet area in the severe diabetic mice. Overall, this study showed that MST1 could become a promising therapeutic target for diabetes mellitus.

scholarly journals The structural and functional recovery of pancreatic β-cells in type 1 diabetes mellitus induced mesenchymal stem cell-conditioned medium

2016 ◽  
Vol 9 (5) ◽  
pp. 535-539 ◽  
Author(s):  
Widagdo Sri Nugroho ◽  
Dwi Liliek Kusindarta ◽  
Heru Susetya ◽  
Ida Fitriana ◽  
Guntari Titik Mulyani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Type 1 Diabetes Mellitus ◽  
Functional Recovery ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Cell Conditioned Medium

Teplizumab for Treatment of Type 1 Diabetes Mellitus

2012 ◽  
Vol 46 (10) ◽  
pp. 1405-1412 ◽  
Author(s):  
Jessica W Skelley ◽  
Lindsey K Elmore ◽  
Jeffrey A Kyle
Keyword(s):  
Diabetes Mellitus ◽  
Monoclonal Antibody ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Human Monoclonal Antibody ◽  
Clinical Trial Data ◽  
Data Sources ◽  
Β Cells ◽  
Phase 3

Objective: To review the pharmacology, pharmacokinetics, safety, and efficacy of teplizumab and evaluate relevant clinical trial data. Data Sources: Searches of MEDLINE, International Pharmaceutical Abstracts, ClinicalTrials.gov, American Diabetes Association scientific posters, and Google Scholar (1966-May 2012) were conducted using the key words teplizumab. anti-CD3 monoclonal antibody, MGA031, and hOKT3γ1 (Ala-Ala). Searches were limited to articles published in English. Study Selection and Data Extraction: Clinical trials evaluating teplizumab for type 1 diabetes mellitus (T1DM) published in English were selected from the data sources. All published relevant abstracts were included. References cited in identified articles were used for additional citations. Data Synthesis: T1DM accounts for up to 10% of all cases of diabetes mellitus, T1DM is characterized as a chronic and progressive autoimmune disease leading to the destruction of insulin-producing β-cells of the pancreas. Teplizumab is a humanized Fc-mutated anti-CD3 monoclonal antibody that alters the function of the T-lymphocytes that mediate the destruction of the insulin-producing β-cells. While clinical data are limited, both Phase 2 and Phase 3 studies have demonstrated preserved C-peptide response as a measure of insulin production, decreased exogenous insulin use, and improved grycemic control following a 12- to 14-day teplizumab infusion in patients diagnosed with T1DM within the previous 6 weeks. However, 1 Phase 3 trial tailed to find the same benefits in those diagnosed with T1DM within the previous 12 weeks when a lower cumulative teplizumab dose was used. Initial studies indicated that teplizumab is well tolerated, with a self-limiting rash as the most commonly reported adverse effect. Conclusions: Teplizumab is an anti-CD3 human monoclonal antibody with promising activity in treatment of patients with T1DM, Results from Phase 3 trials are needed to further determine safety, efficacy, and dosing frequency.

scholarly journals KONSEP, MODEL ATAU TEORI YANG EFEKTIF SEBAGAI PENDEKATAN EDUKASI DALAM MERUBAH PERILAKU PASIEN DIABETES MELITUS : LITERATUR REVIEW.

2021 ◽  
Vol 12 (1) ◽  
pp. 1
Author(s):  
Anita Rosman ◽  
Saldy Yusuf ◽  
Takdir Tahir
Keyword(s):  
Diabetes Mellitus ◽  
Health Education ◽  
Literature Review ◽  
Theory Model ◽  
Google Scholar ◽  
Concept Model ◽  
Mesh Terms ◽  
Research Questions ◽  
Provide Health Education ◽  
Diabetes Melitus

ABSTRAKPenderita Diabetes Melitus (DM) tiap tahunnya mengalami peningkatan, apabila tidak tertangani dengan baik maka akan menimbulkan berbagai macam komplikasi. Komplikasi dan resiko dapat dicegah apabila perilaku terhadap pola hidup dan kebiasan pasien DM dapat berubah. Terdapat beberapa teori perubahan perilaku yang dapat di gunakan dalam melakukan edukasi kesehatan pada pasien DM. Meskipun demikian evaluasi terhadap konsep, model atau teori sebagai media edukasi dalam perubahan perilaku pasien DM belum diketahui. Tujuan dari literature review ini adalah untuk mengetahui konsep, model atau teori yang efektif digunakan untuk memberikan edukasi kesehatan kepada pasien DM dalam merubah perilaku mereka. Metode yang digunakan dengan cara melakukan pencarian beberapa studi yang diterbitkan melalui database PubMed, Science Direct, Wiley dan Google Scholar. Strategi pencarian menggunakan kombinasi istilah MeSH Terms. Pertanyaan penelitian dirancang dengan menggunakan prinsip PICO. Studi yang dipilih diterbitkan dari tahun 2015-2019. Setelah dilakukan pencarian artikel dengan kata kunci tersebut maka total artikel yang di review dalam tinjauan literatur ini sebanyak delapan artikel. Konsep, model atau teori PRECEDE PROCEED paling banyak digunakan dalam pencarian literatur ini dibandingkan dengan model yang lain dan salah satu penelitian mengatakan bahwa peningkatan yang signifikan sudah terjadi sejak bulan pertama setelah dilakukannya intervensi.Kata Kunci :  diabetes mellitus, theory, model, behaviorABSTRACTPatients with Diabetes Mellitus (DM) have increased every year, if not handled properly it will cause various kinds of complications. Complications and risks can be prevented if behavior towards the lifestyle and habits of DM patients can change. There are several theories of behavior change that can be used in health education for DM patients. However the evaluation of concepts, models or theories as educational media in changing the behavior of DM patients is unknown. The purpose of this literature review is to find out the concepts, models or theories that are effectively used to provide health education to DM patients in changing their behavior. The method used by searching several studies published through the PubMed, Science Direct, Wiley and Google Scholar databases. The search strategy uses a combination of MeSH Terms. Research questions were designed using PICO principles. Selected studies were published from 2015-2019. After searching for articles with these keywords, the total articles reviewed in this literature review were eight articles. The concept, model or theory of PRECEDE PROCEED is the most widely used in this literature search compared to other models and one of the studies says that a significant increase has occurred since the first month after the intervention.Keywords : diabetes mellitus, theory, model, behavior

scholarly journals Etlingera Elatior sebagai Antihperglikemi pada Penderita Diabetes Mellitus

2021 ◽  
Vol 3 (1) ◽  
pp. 189-198
Author(s):  
Hanifah Sapto Putri
Keyword(s):  
Diabetes Mellitus ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Google Scholar ◽  
Etlingera Elatior ◽  
Diabetes Melitus

Etlingera elatior atau kecombrang merupakan salah satu tanaman yang memiliki berbagai efek farmakologis diantaranya yaitu sebagai antihiperglikemi pada penyakit diabetes mellitus. Tujuan literature review ini yaitu untuk mengetahui efek tanaman kecombrang dalam menurunkan kadar gula darah pada penderita diabetes melitus. Sumber yang digunakan terdiri dari dua puluh delapan sumber yang berasal dari Google Scholar, Pubmed, NCBI, Elsevier, dan situs-situs lainnya dengan rentang waktu 2010-2020. Artikel tersebut kemudian dianalisis dengan metode systematic literature review yaitu mengumpulkan, mengevaluasi dan mengembangkan penelitian pada fokus topik tertentu. Dari beberapa penelitian yang dilakukan didapatkan hasil bahwa tanaman kecombrang memiliki manfaat sebagai antihiperglikemi. Di mana senyawa aktif seperti flavonoid, fenolik dan saponin yang ada pada tanaman kecombrang memiliki kemampuan menghambat enzim amilase dan glukosidase, menetralkan radikal bebas, serta sebagai proteksi terhadap kerusakan sel beta pankreas dalam aktivitas antihiperglikemi pada pasien diabetes melitus.

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