scholarly journals Prolonged in vivo gene silencing using multilayered nanoparticles as a sirna delivery system

2018 ◽  
Author(s):  
◽  
Yang Fei Tan
Keyword(s):  
Gene Silencing ◽  
Delivery System ◽  
Sirna Delivery ◽  
Sirna Delivery System

Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

2014 ◽  
Vol 50 (58) ◽  
pp. 7806-7809 ◽  
Author(s):  
Hangxiang Wang ◽  
Wei Chen ◽  
Haiyang Xie ◽  
Xuyong Wei ◽  
Shengyong Yin ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Gene Silencing ◽  
Delivery System ◽  
Self Assembly ◽  
Sirna Delivery ◽  
Single Step ◽  
Chimeric Peptide ◽  
Supramolecular Nanoparticles ◽  
Sirna Delivery System

A practical and tumor cell-specific siRNA delivery system was developedviasingle-step self-assembly of an arginine-rich chimeric peptide with siRNA.

scholarly journals Novel siRNA Delivery System to Target Podocytes In Vivo

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9463 ◽  
Author(s):  
Peter V. Hauser ◽  
Jeffrey W. Pippin ◽  
Cora Kaiser ◽  
Ronald D. Krofft ◽  
Paul T. Brinkkoetter ◽  
...  
Keyword(s):  
Delivery System ◽  
Sirna Delivery ◽  
Sirna Delivery System

scholarly journals Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Jiangyu Wu ◽  
Weizhe Huang ◽  
Ziying He
Keyword(s):  
Gene Silencing ◽  
Delivery System ◽  
Sirna Delivery ◽  
Dna Delivery ◽  
Small Interfering Rnas ◽  
Dna And Rna ◽  
Promising Tool ◽  
Knowing That ◽  
Delivery Efficiency ◽  
Sirna Delivery System

RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small interfering RNAs (siRNA) are used to specifically downregulate the expression of the targeted gene, known as the term “gene silencing.” One key point for successful gene silencing is to employ a safe and efficient siRNA delivery system. In this context, dendrimers are emerging as potential nonviral vectors to deliver siRNA for RNAi purpose. Dendrimers have attracted intense interest since their emanating research in the 1980s and are extensively studied as efficient DNA delivery vectors in gene transfer applications, due to their unique features based on the well-defined and multivalent structures. Knowing that DNA and RNA possess a similar structure in terms of nucleic acid framework and the electronegative nature, one can also use the excellent DNA delivery properties of dendrimers to develop effective siRNA delivery systems. In this review, the development of dendrimer-based siRNA delivery vectors is summarized, focusing on the vector features (siRNA delivery efficiency, cytotoxicity, etc.) of different types of dendrimers and the related investigations on structure-activity relationship to promote safe and efficient siRNA delivery system.

Development of an siRNA delivery system targeting macrophage function in-vivo

2012 ◽  
Vol 215 (3) ◽  
pp. S74 ◽  
Author(s):  
Felix C. Blanco ◽  
Priya Srinivasan ◽  
Ryan M. Walk ◽  
Jason A. Snyder ◽  
Mark Behlke ◽  
...  
Keyword(s):  
Delivery System ◽  
Sirna Delivery ◽  
Macrophage Function ◽  
Sirna Delivery System

scholarly journals Gene Silencing via RNAi and siRNA Quantification in Tumor Tissue Using MEND, a Liposomal siRNA Delivery System

2013 ◽  
Vol 21 (6) ◽  
pp. 1195-1203 ◽  
Author(s):  
Yu Sakurai ◽  
Hiroto Hatakeyama ◽  
Yusuke Sato ◽  
Mamoru Hyodo ◽  
Hidetaka Akita ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Delivery System ◽  
Tumor Tissue ◽  
Sirna Delivery ◽  
Sirna Delivery System

scholarly journals A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

2018 ◽  
Vol 140 (47) ◽  
pp. 16264-16274 ◽  
Author(s):  
Yiwen Dong ◽  
Tianzhu Yu ◽  
Ling Ding ◽  
Erik Laurini ◽  
Yuanyu Huang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gene Silencing ◽  
Delivery System ◽  
Sirna Delivery ◽  
Dual Targeting ◽  
Sirna Delivery System

scholarly journals A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44138 ◽  
Author(s):  
Nan Jiang ◽  
Xusheng Zhang ◽  
Xiufen Zheng ◽  
Di Chen ◽  
Kingsun Siu ◽  
...  
Keyword(s):  
Delivery System ◽  
Fulminant Hepatitis ◽  
Sirna Delivery ◽  
Liver Cells ◽  
Sirna Delivery System

Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery

2016 ◽  
Vol 52 (6) ◽  
pp. 1194-1197 ◽  
Author(s):  
Yong Wang ◽  
Hong Xiao ◽  
Jing Fang ◽  
Xingsu Yu ◽  
Zhenwei Su ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gene Silencing ◽  
Delivery System ◽  
Target Gene ◽  
Sirna Delivery ◽  
Sirna Delivery System

A siRNA delivery system with pH and reduction dual-sensitivity was developed for efficient target gene silencing in cancer therapy.

scholarly journals In vivo siRNA delivery system for targeting to the liver by poly-l-glutamic acid-coated lipoplex

2014 ◽  
Vol 4 ◽  
pp. 1-7 ◽  
Author(s):  
Yoshiyuki Hattori ◽  
Ayako Nakamura ◽  
Shohei Arai ◽  
Mayu Nishigaki ◽  
Hiroyuki Ohkura ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Delivery System ◽  
Sirna Delivery ◽  
Sirna Delivery System
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