scholarly journals Chemical modification of temperature-sensitive pluronic block copolymers and their aggregation properties

2005 ◽  
Author(s):  
Xiangyuan Xiong
Keyword(s):  
Block Copolymers ◽  
Chemical Modification ◽  
Temperature Sensitive ◽  
Pluronic Block Copolymers

Temperature-sensitive behaviour of poly(glycidol)-b-poly(N-isopropylacrylamide) block copolymers

2010 ◽  
Vol 288 (7) ◽  
pp. 777-786 ◽  
Author(s):  
Sebastian Mendrek ◽  
Aleksandra Mendrek ◽  
Hans-Juergen Adler ◽  
Andrzej Dworak ◽  
Dirk Kuckling
Keyword(s):  
Block Copolymers ◽  
Temperature Sensitive

Enhancement of carboplatin toxicity by Pluronic block copolymers

2005 ◽  
Vol 106 (1-2) ◽  
pp. 188-197 ◽  
Author(s):  
Agata A. Exner ◽  
Tianyi M. Krupka ◽  
Katherine Scherrer ◽  
J. Maxwell Teets
Keyword(s):  
Block Copolymers ◽  
Pluronic Block Copolymers

scholarly journals Sulfonation and Characterization of Tert-Butyl Styrene/Styrene/Isoprene Copolymer and Polypropylene Blends for Blood Compatibility Applications

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1351
Author(s):  
Bin-Hong Tsai ◽  
Yung-Han Chuang ◽  
Chi-Hui Cheng ◽  
Jui-Che Lin
Keyword(s):  
Block Copolymers ◽  
Chemical Modification ◽  
Blood Compatibility ◽  
Blood Platelet ◽  
Mineral Oil ◽  
Tert Butyl ◽  
Hydrophobic Nature ◽  
Polypropylene Blends ◽  
Uv Ozone

Hydrogenated styrenic block copolymers (HSBCs) have been used in medical tubing for many years due to their high clarity, flexibility, kink resistance, and toughness. However, when it comes to blood storage applications, HSBC compounds’ market has been limited because of their high hydrophobicity, which may trigger platelet adhesion when contacting with blood. HSBC needs to be physically or chemically modified in advance to make it blood compatible; however, HSBC has strong UV/ozone resistance, thermooxidative stability, and excellent processing capability, which increases the difficulty of the chemical modification process as unsaturated dienes has been converted to saturated stable midblocks. Moreover, medical HSBC-containing compounds primarily make up with the non-polar, hydrophobic nature and benign characteristics of other common ingredients (U.S. Pharmacopeia (USP) grades of mineral oil and polypropylene), which complicates the realization of using HSBC-containing compounds in blood-contacting applications, and this explains why few studies had disclosed chemical modification for biocompatibility improvement on HSBC-containing compounds. Sulfonation has been reported as an effective way to improve the material’s blood/platelet compatibility. In this study, hydrogenated tert-butyl styrene (tBS)-styrene-isoprene block copolymers were synthesized and its blends with polypropylene and USP grades of mineral oil were selectively sulfonated by reaction with acetyl sulfate. By controlling the ratio of the hydrogenated tBS-styrene-isoprene block copolymer in the blend, sulfonated films were optimized to demonstrate sufficient physical integrity in water as well as thermal stability, hydrophilicity, and platelet compatibility.

scholarly journals Self-Assembly of Temperature Sensitive Unilamellar Vesicles by a Blend of Block Copolymers in Aqueous Solution

Polymers ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 63 ◽  
Author(s):  
Jong Dae Jang ◽  
Changwoo Do ◽  
Joona Bang ◽  
Young Soo Han ◽  
Tae-Hwan Kim
Keyword(s):  
Block Copolymers ◽  
Hydrophobic Interaction ◽  
Self Assembly ◽  
Small Angle Neutron Scattering ◽  
Mass Fraction ◽  
Temperature Sensitive ◽  
Vesicular Structure ◽  
Wide Range ◽  
Scattering Measurements ◽  
Potential Applications

A self-assembled unilamellar vesicle, which can be used as a drug delivery system, was easily and simply fabricated using a blended system of Pluronic block copolymers. Controlling the hydrophilic mass fraction of block copolymers (by blending the block copolymer with a different hydrophilic mass fraction) and temperature (i.e., the hydrophobic interaction is controlled), a vesicular structure was formed. Small angle neutron scattering measurements showed that the vesicular structure had diameters of empty cores from 13.6 nm to 79.6 nm, and thicknesses of the bilayers from 2.2 nm to 8.7 nm when the hydrophobic interaction was changed. Therefore, considering that the temperature of the vesicle formation is controllable by the concentration of the blended block copolymers, it is possible for them to be applied in a wide range of potential applications, for example, as nanoreactors and nanovehicles.

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