scholarly journals Part I Cascade reaction : Mukaiyama-Aldol-Prins (MAP) and Mukaiyama-Aldol-Ene (MAE) Part II Synthetic studies towards the total synthesis of cytochalasans

2010 ◽  
Author(s):  
Hao Li
Keyword(s):  
Total Synthesis ◽  
Cascade Reaction ◽  
Mukaiyama Aldol ◽  
Synthetic Studies

First total synthesis of oteromycin utilizing one-pot four-step cascade reaction strategy

2013 ◽  
Vol 54 (6) ◽  
pp. 506-511 ◽  
Author(s):  
Hiromi Uchiro ◽  
Nobuhiro Shionozaki ◽  
Ryo Tanaka ◽  
Hiroyuki Kitano ◽  
Naoki Iwamura ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cascade Reaction ◽  
One Pot

Indole-Diterpene Synthetic Studies: Total Synthesis of (−)-21-Isopentenylpaxilline

2003 ◽  
Vol 86 (12) ◽  
pp. 3908-3938 ◽  
Author(s):  
Amos B. Smith ◽  
Haifeng Cui
Keyword(s):  
Total Synthesis ◽  
Synthetic Studies

scholarly journals Synthetic studies on the lycopodium alkaloids. IV. Total synthesis of dl-anhydrolycodoline and dl-lycopodine.

1978 ◽  
Vol 26 (10) ◽  
pp. 3150-3153 ◽  
Author(s):  
SANGWON KIM ◽  
YUKIHIDE BANDO ◽  
NOBUKO TAKAHASHI ◽  
ZENICHI HORII
Keyword(s):  
Total Synthesis ◽  
Lycopodium Alkaloids ◽  
Synthetic Studies

Synthetic Approaches Towards the Total synthesis of tubulysin and its fragments: A review

2021 ◽  
Vol 19 ◽  
Author(s):  
Nosheen Iqbal ◽  
Ameer Fawad Zahoor ◽  
Nasir Rasool ◽  
Samreen Gul Khan ◽  
Rabia Akhtar ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Claisen Rearrangement ◽  
Antitumor Agents ◽  
Aldol Reaction ◽  
Multidrug Resistant ◽  
Novel Drugs ◽  
Mukaiyama Aldol ◽  
Ic50 Values ◽  
Barbier Reaction ◽  
Synthetic Approaches

Background: Tubulysins, linear tetrapeptides show extraordinary cytotoxicity against various cancer cells, with IC50 values in nano or picomolar range. Due to their extremely vigorous anti-proliferative and antiangiogenic characteristics, tubulysins exhibit captivating prospects in the development of anticancer drugs. This review focuses on diverse routes for the total synthesis of natural and synthetic tubulysins as well as their fragments. Objective: The purpose of this review is to present the synthetic strategies for the development of antitumor agents, tubulysins. Conclusion: A range of synthetic pathways adopted for the total synthesis of tubulysins and their fragments have been described in this review. Synthesis of fragments, Tuv, Tup, and Tut can be accomplished by adopting appropriate strategies such as Manganese-mediated synthesis, Ireland-Claisen rearrangement, Mukaiyama aldol reaction, and Mannich process etc. Tubulysin B, D, U, V, and N14-desacetoxytubulysin H have been prepared through Mitsunobu reaction, tert-butanesulfinamide method, Tandem reaction, aza-Barbier reaction, Evans aldol reaction, and C-H activation strategies etc. The remarkable anticancer potential of tubulysins toward a substantiate target make them prominent leads for developing novel drugs against multidrug-resistant cancers.

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