scholarly journals Review on Hot Melt Extrusion Technology and it's Application

2019 ◽  
pp. 253-260
Author(s):  
Mali A. S. ◽  
Gavali K. V. ◽  
Choudhari R. G. ◽  
Anekar V. P. ◽  
Gavhane Y. N.
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Hot Melt Extrusion ◽  
Delivery Systems ◽  
Taste Masking ◽  
Melt Extrusion ◽  
Pharmaceutical Ingredients ◽  
Pharmaceutical Industries ◽  
Extrusion Technology ◽  
Hot Melt

The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to proven its ability to efficiently manufacture novel products. With the use of HME we can increase solubility and bioavailability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems. resulting improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). Hot-melt extrusion techniques are pragmatic in the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. In This paper we review about the types of Extruder, solid dispersion and Application of the HME to the pharmaceutical industries.

FDM 3D printing of modified drug-delivery systems using hot melt extrusion: a new approach for individualized therapy

2017 ◽  
Vol 8 (11) ◽  
pp. 957-966 ◽  
Author(s):  
Marcilio Cunha-Filho ◽  
Maísa RP Araújo ◽  
Guilherme M Gelfuso ◽  
Tais Gratieri
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery Systems ◽  
Hot Melt Extrusion ◽  
Delivery Systems ◽  
Individualized Therapy ◽  
Melt Extrusion ◽  
New Approach ◽  
Hot Melt

scholarly journals Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1424
Author(s):  
Juliana dos Santos ◽  
Guilherme Silveira da Silva ◽  
Maiara Callegaro Velho ◽  
Ruy Carlos Ruver Beck
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery Systems ◽  
Hot Melt Extrusion ◽  
Delivery Systems ◽  
Melt Extrusion ◽  
Swelling Properties ◽  
Fused Deposition ◽  
Hot Melt ◽  
Printing Techniques

Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

scholarly journals Bioadhesive Drug Delivery System for Enhancing the Permeability of a BCS Class III Drug via Hot-Melt Extrusion Technology

2017 ◽  
Vol 18 (7) ◽  
pp. 2639-2647 ◽  
Author(s):  
Nicole S. Mendonsa ◽  
Priyanka Thipsay ◽  
Dong Wuk Kim ◽  
Scott T. Martin ◽  
Michael A. Repka
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hot Melt Extrusion ◽  
Class Iii ◽  
Melt Extrusion ◽  
Extrusion Technology ◽  
Hot Melt

scholarly journals A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Mohammed Maniruzzaman ◽  
Joshua S. Boateng ◽  
Martin J. Snowden ◽  
Dennis Douroumis
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Hot Melt Extrusion ◽  
Pharmaceutical Products ◽  
Taste Masking ◽  
Oral Drug ◽  
Melt Extrusion ◽  
Process Technology ◽  
Processing Technologies ◽  
Hot Melt

Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.

scholarly journals An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part II

2019 ◽  
Vol 16 (6) ◽  
pp. 567-582 ◽  
Author(s):  
Sandeep Sarabu ◽  
Suresh Bandari ◽  
Venkata Raman Kallakunta ◽  
Roshan Tiwari ◽  
Hemlata Patil ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hot Melt Extrusion ◽  
First Century ◽  
Melt Extrusion ◽  
Twenty First Century ◽  
Extrusion Technology ◽  
Novel Drug ◽  
Hot Melt
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