scholarly journals Near-infrared activated cyanine dyes as agents for photothermal therapy and diagnosis of tumors

Acta Naturae ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 102-113
Author(s):  
Elena I. Shramova ◽  
Aleksander B. Kotlyar ◽  
Ekaterina N. Lebedenko ◽  
Sergey M. Deyev ◽  
Galina M. Proshkina
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Therapeutic Index ◽  
Biological Tissues ◽  
Infrared Region ◽  
Deep Penetration ◽  
Photothermal Treatment ◽  
Diagnosis Of Cancer ◽  
Fluorescence Bioimaging ◽  
Therapy And Diagnosis

Today, it has become apparent that innovative treatment methods, including those involving simultaneous diagnosis and therapy, are particularly in demand in modern cancer medicine. The development of nanomedicine offers new ways of increasing the therapeutic index and minimizing side effects. The development of photoactivatable dyes that are effectively absorbed in the first transparency window of biological tissues (700900 nm) and are capable of fluorescence and heat generation has led to the emergence of phototheranostics, an approach that combines the bioimaging of deep tumors and metastases and their photothermal treatment. The creation of near-infrared (NIR) light-activated agents for sensitive fluorescence bioimaging and phototherapy is a priority in phototheranostics, because the excitation of drugs and/or diagnostic substances in the near-infrared region exhibits advantages such as deep penetration into tissues and a weak baseline level of autofluorescence. In this review, we focus on NIR-excited dyes and discuss prospects for their application in photothermal therapy and the diagnosis of cancer. Particular attention is focused on the consideration of new multifunctional nanoplatforms for phototheranostics which allow one to achieve a synergistic effect in combinatorial photothermal, photodynamic, and/or chemotherapy, with simultaneous fluorescence, acoustic, and/or magnetic resonance imaging.

scholarly journals CCCCC pentadentate chelates with planar Möbius aromaticity and unique properties

2016 ◽  
Vol 2 (8) ◽  
pp. e1601031 ◽  
Author(s):  
Congqing Zhu ◽  
Caixia Yang ◽  
Yongheng Wang ◽  
Gan Lin ◽  
Yuhui Yang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Density Functional ◽  
Near Infrared ◽  
Chelating Agent ◽  
Density Functional Theory Calculations ◽  
Infrared Region ◽  
Carbon Chain ◽  
Broad Absorption ◽  
Functional Theory ◽  
Potential Applications

The coordinating atoms in polydentate chelates are primarily heteroatoms. We present the first examples of pentadentate chelates with all binding atoms of the chelating agent being carbon atoms, denoted as CCCCC chelates. Having up to five metal-carbon bonds in the equatorial plane has not been previously observed in transition metal chemistry. Density functional theory calculations showed that the planar metallacycle has extended Craig-Möbius aromaticity arising from 12-center–12-electron dπ-pπ π-conjugation. These planar chelates have broad absorption in the ultraviolet-visible–near-infrared region and, thus, notable photothermal performance upon irradiation by an 808-nm laser, indicating that these chelates have potential applications in photothermal therapy. The combination of facile synthesis, high stability, and broad absorption of these complexes could make the polydentate carbon chain a novel building block in coordination chemistry.

scholarly journals Au–Silica Nanowire Nanohybrid as a Hyperthermia Agent for Photothermal Therapy in the Near-Infrared Region

Langmuir ◽  
2014 ◽  
Vol 30 (31) ◽  
pp. 9514-9523 ◽  
Author(s):  
Jiao Chen ◽  
Xuefeng Li ◽  
Xu Wu ◽  
Joshua T. Pierce ◽  
Nenny Fahruddin ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Region ◽  
Near Infrared Region

scholarly journals The short wave near-infrared fluorescence properties of two p-azaquinodimethane (p-AQM)-based conjugated polymers

2020 ◽  
Vol 13 (05) ◽  
pp. 2041003 ◽  
Author(s):  
Yaowei Zhu ◽  
Yawei Miao ◽  
Tingting Xue ◽  
Youchang Liu ◽  
Chunying Zheng ◽  
...  
Keyword(s):  
Conjugated Polymers ◽  
Near Infrared ◽  
Signal To Noise Ratio ◽  
Biological Tissues ◽  
Infrared Region ◽  
Short Wave ◽  
Quinone Structure ◽  
Living Tissues ◽  
Quinoid Structure

The absorption, scattering, and autofluorescence of biological tissues in short-wave infrared region (SWIR, 900–1700[Formula: see text]nm) are relatively low, so SWIR fluorescence usually has deeper penetration into living tissues, and can show a higher signal-to-noise ratio when used for imaging in vivo. However, there are few types of organic SWIR fluorescent materials currently. In this work, [Formula: see text]-azaquinodimethane ([Formula: see text]-AQM) with a quinoid structure is used as the acceptor unit, and carbazole or fluorene with sp3 hybridization are used as the donor units, two conjugated polymers were synthesized. The quinone structure is conducive to the redshift of absorption and fluorescence spectra, and the sp3 hybridization structure is conducive to weakening the aggregation quenching of polymer fluorescence. PF and PCz exhibited absorption peaks of 492[Formula: see text]nm and 508[Formula: see text]nm, respectively. The emission peaks of the two polymers are 920[Formula: see text]nm and 950[Formula: see text]nm, respectively, both in the short-wave near infrared region. The quantum yield (QY) of PF and PCz is 0.4% and 0.3%, respectively.

Functionalized 2D Nb2C nanosheets for primary and recurrent cancer photothermal/immune-therapy in NIR-II biowindow

Nanoscale ◽  
2021 ◽  
Author(s):  
Yao Lu ◽  
Xiaoge Zhang ◽  
Xiuqi Hou ◽  
Miao Feng ◽  
Zhong Cao ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Immune Therapy ◽  
Infrared Region ◽  
Recurrent Cancer ◽  
Anti Cancer ◽  
Near Infrared Region ◽  
Region Ii

Near-infrared region-II (NIR-II) cancer photothermal therapy (PTT) has become more and more attractive as NIR-II light shows higher tissue penetrating depth, which leads to better anti-cancer effects. Recently, the members...

Single-Walled Carbon Nanotubes Enhance Near-Infrared Region Photothermal Therapy

2009 ◽  
Vol 36 (10) ◽  
pp. 2676-2679 ◽  
Author(s):  
周非凡 Zhou Feifan ◽  
邢达 Xing Da ◽  
宋盛 Song Sheng ◽  
欧忠敏 Ou Zhongmin ◽  
陈伟 Chen Wei
Keyword(s):  
Carbon Nanotubes ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Single Walled Carbon Nanotubes ◽  
Infrared Region ◽  
Single Walled Carbon ◽  
Near Infrared Region ◽  
Walled Carbon Nanotubes

Photothermal therapy of acute leukemia cells in the near-infrared region using gold nanorods CD-33 conjugates

2011 ◽  
Author(s):  
Anton Liopo ◽  
André Conjusteau ◽  
Marina Konopleva ◽  
Michael Andreeff ◽  
Alexander Oraevsky
Keyword(s):  
Acute Leukemia ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Region ◽  
Leukemia Cells ◽  
Near Infrared Region

scholarly journals Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Peng Zhang ◽  
Lei Wang ◽  
Xiuying Chen ◽  
Xiang Li ◽  
Qinghai Yuan
Keyword(s):  
Photothermal Therapy ◽  
Room Temperature ◽  
Near Infrared ◽  
Infrared Region ◽  
Ct Imaging ◽  
Broad Absorption ◽  
Good Biocompatibility ◽  
Imaging Performance

Bi-based nanomaterials, such as Bi2Se3, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi2Se3 nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi2Se3 nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet–visible–near infrared region. Under irradiation at 808 nm, PEI-Bi2Se3 nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi2Se3 nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.

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