scholarly journals Endothelial Tight Junction Protein ZO-1 Response to Multiple-Mechanical Stimulations After Stent Implamtation

2019 ◽  
Vol 16 (S2) ◽  
pp. 140-141
Author(s):  
Yang Wang ◽  
Shuang Ge ◽  
Junyang Huang ◽  
Ruolin Du ◽  
Tieying Yin ◽  
...  
Keyword(s):  
Tight Junction ◽  
Tight Junction Protein ◽  
Junction Protein ◽  
Endothelial Tight Junction

scholarly journals Expression of Endothelial Tight Junction Protein Occludin under Mechanical Factors after Stent Implantation

2019 ◽  
Vol 16 (S2) ◽  
pp. 138-139
Author(s):  
Junyang Huang ◽  
Shuang Ge ◽  
Yang Wang ◽  
Ruolin Du ◽  
Yazhou Wang ◽  
...  
Keyword(s):  
Tight Junction ◽  
Stent Implantation ◽  
Tight Junction Protein ◽  
Junction Protein ◽  
Mechanical Factors ◽  
Endothelial Tight Junction

scholarly journals Impact of the Endothelial Tight Junction Protein Claudin-5 on Clinical Profiles of Patients With COPD

2018 ◽  
Vol 10 (5) ◽  
pp. 533
Author(s):  
Byeong-Gon Kim ◽  
Pureun-Haneul Lee ◽  
Sun-Hye Lee ◽  
Ae-Rin Baek ◽  
Jong-Sook Park ◽  
...  
Keyword(s):  
Tight Junction ◽  
Tight Junction Protein ◽  
Junction Protein ◽  
Clinical Profiles ◽  
Endothelial Tight Junction

scholarly journals Polycystin-2 Activity Is Controlled by Transcriptional Coactivator with PDZ Binding Motif and PALS1-associated Tight Junction Protein

2010 ◽  
Vol 285 (44) ◽  
pp. 33584-33588 ◽  
Author(s):  
Kerstin Duning ◽  
Deike Rosenbusch ◽  
Marc A. Schlüter ◽  
Yuemin Tian ◽  
Karl Kunzelmann ◽  
...  
Keyword(s):  
Tight Junction ◽  
Tight Junction Protein ◽  
Binding Motif ◽  
Transcriptional Coactivator ◽  
Junction Protein

scholarly journals Endothelial-specific insulin receptor substrate-1 overexpression worsens neonatal hypoxic-ischemic brain injury via mTOR-mediated tight junction disassembly

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yi-Fang Tu ◽  
Si-Tse Jiang ◽  
Chi-Wu Chiang ◽  
Li-Ching Chen ◽  
Chao-Ching Huang
Keyword(s):  
Endothelial Cells ◽  
Brain Injury ◽  
Tight Junction ◽  
Insulin Receptor ◽  
Vascular Endothelial Cells ◽  
Tight Junction Protein ◽  
Insulin Receptor Substrate ◽  
Vascular Endothelial ◽  
Transgenic Rats ◽  
Junction Protein

AbstractHypoxic-ischemic (HI) encephalopathy is the major cause of mortality and disability in newborns. The neurovascular unit is a major target of acute and chronic brain injury, and therapies that protect simultaneously both neurons and vascular endothelial cells from neonatal HI injury are in demand. Insulin receptors and its key downstream molecule-insulin receptor substrate −1 (IRS-1) are potential neuroprotective targets and expressed both in neuron and endothelial cells. To investigate whether IRS-1 can act similarly in neurons and vascular endothelial cells in protecting neurovascular units and brain form HI injury, we found that neuron-specific IRS-1 transgenic rats showed reduced neurovascular injury and infarct volumes, whereas endothelial-specific IRS-1 transgenic rats showed increased blood-brain barrier (BBB) disruption and exaggerated neurovascular injury after neonatal HI brain injury. Endothelial-specific IRS-1 overexpression increased vascular permeability and disassembled the tight junction protein (zonula occludens-1) complex. Inhibition of mammalian target of rapamycin (mTOR) by rapamycin preserved tight junction proteins and attenuated BBB leakage and neuronal apoptosis after HI in the endothelial-specific IRS-1 transgenic pups. Together, our findings suggested that neuronal and endothelial IRS-1 had opposite effects on the neurovascular integrity and damage after neonatal HI brain injury and that endothelial IRS-1 worsens neurovascular integrity after HI via mTOR-mediated tight junction protein disassembly.

The Tight Junction Protein Cingulin Regulates Gene Expression and RhoA Signaling

2009 ◽  
Vol 1165 (1) ◽  
pp. 88-98 ◽  
Author(s):  
Sandra Citi ◽  
Serge Paschoud ◽  
Pamela Pulimeno ◽  
Francesco Timolati ◽  
Fabrizio De Robertis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tight Junction ◽  
Tight Junction Protein ◽  
Junction Protein ◽  
Rhoa Signaling
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