scholarly journals The Role of P53 in Transdifferentiation of EPCs into Smooth Muscle Cells Induced by Oscillatory Shear Stress

2019 ◽  
Vol 16 (s1) ◽  
pp. 93-93
Author(s):  
Yu Gao ◽  
Meiyue Wang ◽  
Yanting He ◽  
Lanlan Li ◽  
Xiaodong Cui ◽  
...  
Keyword(s):  
Shear Stress ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Oscillatory Shear ◽  
Oscillatory Shear Stress

MODULATION OF HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS BY SHEAR STRESS: THE ROLE OF TGF BETA1

2004 ◽  
Vol 13 (3) ◽  
pp. 190
Author(s):  
Jonathan Ghosh ◽  
David Murray ◽  
Cay Kielty ◽  
Michael Walker
Keyword(s):  
Shear Stress ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Human Coronary Artery

Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration, and NO production responses

2011 ◽  
Vol 300 (1) ◽  
pp. H76-H83 ◽  
Author(s):  
Hongyan Kang ◽  
Yubo Fan ◽  
Xiaoyan Deng
Keyword(s):  
Shear Stress ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Heparan Sulfate ◽  
Muscle Cells ◽  
Flow Chamber ◽  
No Production ◽  
Physiological Level

The endothelial cell glycocalyx, a structure coating the luminal surface of the vascular endothelium, and its related mechanotransduction have been studied by many over the last decade. However, the role of vascular smooth muscle cells (SMCs) glycocalyx in cell mechanotransduction has triggered little attention. This study addressed the role of heparan sulfate proteoglycans (HSPGs), a major component of the glycocalyx, in the shear-induced proliferation, migration, and nitric oxide (NO) production of the rat aortic smooth muscle cells (RASMCs). A parallel plate flow chamber and a peristaltic pump were employed to expose RASMC monolayers to a physiological level of shear stress (12 dyn/cm2). Heparinase III (Hep.III) was applied to selectively degrade heparan sulfate on the SMC surface. Cell proliferation, migration, and NO production rates were determined and compared among the following four groups of cells: 1) untreated with no flow, 2) Hep.III treatment with no flow, 3) untreated with flow of 12 dyn/cm2 exposure, and 4) Hep.III treatment with flow of 12 dyn/cm2 exposure. It was observed that flow-induced shear stress significantly suppressed SMC proliferation and migration, whereas cells preferred to aligning along the direction of flow and NO production were enhanced substantially. However, those responses were not found in the cells with Hep.III treatment. Under flow condition, the heparinase III-treated cells remained randomly oriented and proliferated as if there were no flow presence. Disruption of HSPG also enhanced wound closure and inhibited shear-induced NO production significantly. This study suggests that HSPG may play a pivotal role in mechanotransduction of SMCs.

The role of WNT/b-catenin signaling in smooth muscle cells during lung development and repair

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
A Moiseenko ◽  
E El Agha ◽  
B MacKenzie ◽  
S De Langhe ◽  
S Bellusci
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Lung Development ◽  
Muscle Cells
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