scholarly journals Effects of the ascorbic acid supplementation on NADH-diaphorase myenteric neurons in the duodenum of diabetic rats

BIOCELL ◽  
2006 ◽  
Vol 30 (2) ◽  
pp. 295-300 ◽  
Author(s):  
MARLI APARECIDA DOS SANTOS PEREIRA ◽  
MARIA CLA贒IA BAGATIN ◽  
JACQUELINE NELISIS ZANONI
2008 ◽  
Vol 14 (42) ◽  
pp. 6518 ◽  
Author(s):  
Priscila de Freitas ◽  
Maria Raquel Marçal Natali ◽  
Renata Virginia Fernandes Pereira ◽  
Marcilio Hubner Miranda Neto ◽  
Jacqueline Nelisis Zanoni

2003 ◽  
Vol 19 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Renata Cristina Onishi Zanardo ◽  
Jos� Walber Miranda Costa Cruz ◽  
Maria Aparecida de Oliveira ◽  
Zuleica Bruno Fortes

2009 ◽  
Vol 29 (4) ◽  
pp. 295-302
Author(s):  
Sonia M. Silverio ◽  
Renata de B. Mari ◽  
Naianne K. Clebis ◽  
Juliana R. Scoz ◽  
Ricardo de M. Germano ◽  
...  

The exacerbation of the oxidative stress and of the polyol pathway which impair damage myenteric plexus are metabolic characteristics of diabetes. The ascorbic acid (AA) is an antioxidant and an aldose reductase inhibitor, which may act as neuroprotector. The effects of AA supplementation on the density and cellular body profile area (CP) of myenteric neurons in STZ-induced diabetes in rats were assessed. Four groups with five animals each were formed: normoglycemic (C); diabetic (D); AA-treated diabetic (DS) and AA-treated normoglycemic (CS). Dosagen of 50mg of AA were given, three times a week, for each animal (group DS and CS). Ninety days later and after euthanasia, the ileum was collected and processed for the NADPH-diaphorase technique. There were no differences (P>0.05) in the neuronal density among the groups. The CP area was lower (P<0.05) in the DS and CS groups, with a higher incidence of neurons with a CP area exceeding 200µm² for groups C and D. The AA had no influence on the neuronal density in the ileum but had a neuroprotective effect, preventing the increase in the CP area and allowing a higher number of neurons with a CP area with less than 200µm².


Author(s):  
Piyawan Bunpo ◽  
Amonphat Chatarurk ◽  
Kodchaporn Intawong ◽  
Kananek Naosuk ◽  
Phennapha Klangsinsirikul

1973 ◽  
Vol 24 (2) ◽  
pp. 209-218 ◽  
Author(s):  
M. H. Sayers ◽  
S. R. Lynch ◽  
P. Jacobs ◽  
R. W. Charlton ◽  
T. H. Bothwell ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document