scholarly journals Effects of crocin on locomotor activity as well as novel object recognition and object location memories in chronic restraint stressed rats

2020 ◽  
pp. 123-132
Author(s):  
Maryam Radahmadi ◽  
Azadehalsadat Hosseini Dastgerdi ◽  
Ali Asghar Pourshanazari
Keyword(s):  
Object Recognition ◽  
Locomotor Activity ◽  
Object Location ◽  
Novel Object Recognition ◽  
Novel Object

scholarly journals Global brain volume reductions in a sub-chronic phencyclidine animal model for schizophrenia and their relationship to recognition memory

2019 ◽  
Vol 33 (10) ◽  
pp. 1274-1287 ◽  
Author(s):  
Nazanin Doostdar ◽  
Eugene Kim ◽  
Ben Grayson ◽  
Michael K Harte ◽  
Joanna C Neill ◽  
...  
Keyword(s):  
Object Recognition ◽  
Locomotor Activity ◽  
Brain Volume ◽  
Perirhinal Cortex ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Object Exploration ◽  
Brain Changes ◽  
Global Brain ◽  
Structural Brain

Background: Cognitive deficits and structural brain changes co-occur in patients with schizophrenia. Improving our understanding of the relationship between these is important to develop improved therapeutic strategies. Back-translation of these findings into rodent models for schizophrenia offers a potential means to achieve this goal. Aims: The purpose of this study was to determine the extent of structural brain changes and how these relate to cognitive behaviour in a sub-chronic phencyclidine rat model. Methods: Performance in the novel object recognition task was examined in female Lister Hooded rats at one and six weeks after sub-chronic phencyclidine (2 mg/kg intra-peritoneal, n=15) and saline controls (1 ml/kg intra-peritoneal, n=15). Locomotor activity following acute phencyclidine challenge was also measured. Brain volume changes were assessed in the same animals using ex vivo structural magnetic resonance imaging and computational neuroanatomical analysis at six weeks. Results: Female sub-chronic phencyclidine-treated Lister Hooded rats spent significantly less time exploring novel objects ( p<0.05) at both time-points and had significantly greater locomotor activity response to an acute phencyclidine challenge ( p<0.01) at 3–4 weeks of washout. At six weeks, sub-chronic phencyclidine-treated Lister Hooded rats displayed significant global brain volume reductions ( p<0.05; q<0.05), without apparent regional specificity. Relative volumes of the perirhinal cortex however were positively correlated with novel object exploration time only in sub-chronic phencyclidine rats at this time-point. Conclusion: A sustained sub-chronic phencyclidine-induced cognitive deficit in novel object recognition is accompanied by global brain volume reductions in female Lister Hooded rats. The relative volumes of the perirhinal cortex however are positively correlated with novel object exploration, indicating some functional relevance.

No effects of PCSK9-inhibitor treatment on spatial learning, locomotor activity, and novel object recognition in mice

2021 ◽  
Vol 396 ◽  
pp. 112875
Author(s):  
Frieder Schlunk ◽  
Paul Fischer ◽  
Hans M.G. Princen ◽  
Andre Rex ◽  
Vincent Prinz ◽  
...  
Keyword(s):  
Object Recognition ◽  
Locomotor Activity ◽  
Spatial Learning ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Pcsk9 Inhibitor ◽  
Inhibitor Treatment

Novel object recognition and object location tasks in zebrafish: Influence of habituation and NMDA receptor antagonism

2018 ◽  
Vol 155 ◽  
pp. 249-260 ◽  
Author(s):  
Karina Vidarte Gaspary ◽  
Gustavo Kellermann Reolon ◽  
Darlan Gusso ◽  
Carla Denise Bonan
Keyword(s):  
Object Recognition ◽  
Nmda Receptor ◽  
Object Location ◽  
Novel Object Recognition ◽  
Receptor Antagonism ◽  
Novel Object

scholarly journals Mice deficient in the NAAG synthetase II gene Rimkla are impaired in a novel object recognition task

2021 ◽  
Author(s):  
Ivonne Becker ◽  
Lihua Wang‐Eckhardt ◽  
Julia Lodder‐Gadaczek ◽  
Yong Wang ◽  
Agathe Grünewald ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Task ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Object Recognition Task ◽  
Novel Object Recognition Task

scholarly journals Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome

2021 ◽  
Vol 15 ◽  
Author(s):  
Cesar Sierra ◽  
Ilario De Toma ◽  
Lorenzo Lo Cascio ◽  
Esteban Vegas ◽  
Mara Dierssen
Keyword(s):  
Down Syndrome ◽  
Object Recognition ◽  
Environmental Factors ◽  
Mouse Models ◽  
Recognition Task ◽  
Novel Object Recognition ◽  
The Novel ◽  
Wild Type ◽  
Male And Female ◽  
Novel Object

The use of mouse models has revolutionized the field of Down syndrome (DS), increasing our knowledge about neuropathology and helping to propose new therapies for cognitive impairment. However, concerns about the reproducibility of results in mice and their translatability to humans have become a major issue, and controlling for moderators of behavior is essential. Social and environmental factors, the experience of the researcher, and the sex and strain of the animals can all have effects on behavior, and their impact on DS mouse models has not been explored. Here we analyzed the influence of a number of social and environmental factors, usually not taken into consideration, on the behavior of male and female wild-type and trisomic mice (the Ts65Dn model) in one of the most used tests for proving drug effects on memory, the novel object recognition (NOR) test. Using principal component analysis and correlation matrices, we show that the ratio of trisomic mice in the cage, the experience of the experimenter, and the timing of the test have a differential impact on male and female and on wild-type and trisomic behavior. We conclude that although the NOR test is quite robust and less susceptible to environmental influences than expected, to obtain useful results, the phenotype expression must be contrasted against the influences of social and environmental factors.

scholarly journals Cbsoverdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically withDyrk1a

2018 ◽  
Author(s):  
Damien Marechal ◽  
Véronique Brault ◽  
Alice Leon ◽  
Dehren Martin ◽  
Patricia Lopes Pereira ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Object Recognition ◽  
Synaptic Transmission ◽  
Actin Cytoskeleton ◽  
Epistatic Interaction ◽  
Novel Object Recognition ◽  
The Novel ◽  
Novel Object ◽  
Cystathionine Beta Synthase ◽  
Necessary And Sufficient

ABSTRACTIdentifying dosage sensitive genes is a key to understand the mechanisms underlying intellectual disability in Down syndrome (DS). The Dp(17Abcg1-Cbs)1Yah DS mouse model (Dp1Yah) show cognitive phenotype and needs to be investigated to identify the main genetic driver. Here, we report that, in the Dp1Yah mice, 3 copies of the Cystathionine-beta-synthase gene (Cbs)are necessary to observe a deficit in the novel object recognition (NOR) paradigm. Moreover, the overexpression ofCbsalone is sufficient to induce NOR deficit. Accordingly targeting the overexpression of human CBS, specifically in Camk2a-expressing neurons, leads to impaired objects discrimination. Altogether this shows thatCbsoverdosage is involved in DS learning and memory phenotypes. In order to go further, we identified compounds that interfere with the phenotypical consequence of CBS overdosage in yeast. Pharmacological intervention in the Tg(CBS) with one selected compound restored memory in the novel object recognition. In addition, using a genetic approach, we demonstrated an epistatic interaction betweenCbsandDyrk1a, another human chromosome 21 gene encoding the dual-specificity tyrosine phosphorylation-regulated kinase 1a and an already known target for DS therapeutic intervention. Further analysis using proteomic approaches highlighted several pathways, including synaptic transmission, cell projection morphogenesis, and actin cytoskeleton, that are affected by DYRK1A and CBS overexpression. Overall we demonstrated that CBS overdosage underpins the DS-related recognition memory deficit and that bothCBSandDYRK1Ainteract to control accurate memory processes in DS. In addition, our study establishes CBS as an intervention point for treating intellectual deficiencies linked to DS.SIGNIFICANT STATEMENTHere, we investigated a region homologous to Hsa21 and located on mouse chromosome 17. We demonstrated using three independent genetic approaches that the overdosage of the Cystathionine-beta-synthase gene (Cbs) gene, encoded in the segment, is necessary and sufficient to induce deficit in novel object recognition (NR).In addition, we identified compounds that interfere with the phenotypical consequence of CBS overdosage in yeast and in mouse transgenic lines. Then we analyzed the relation between Cbs overdosage and the consequence of DYRK1a overexpression, a main driver of another region homologous to Hsa21 and we demonstrated that an epistatic interaction exist betweenCbsandDyrk1aaffecting different pathways, including synaptic transmission, cell projection morphogenesis, and actin cytoskeleton.

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