Photo-biomodulation and soybean isoflavones on amyloid-beta peptide-induced oxidative stress and inflammation

2013 ◽  
Author(s):  
Biwen Tao
Keyword(s):  
Oxidative Stress ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Soybean Isoflavones ◽  
Beta Peptide

scholarly journals Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Pol Picón-Pagès ◽  
Daniela A. Gutiérrez ◽  
Alejandro Barranco-Almohalla ◽  
Giulia Crepin ◽  
Marta Tajes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Western Blot ◽  
Amyloid Beta ◽  
Initiation Factor ◽  
Amyloid Beta Peptide ◽  
Braak Stage ◽  
Eukaryotic Initiation Factor ◽  
Bace1 Expression ◽  
Beta Peptide

Alzheimer’s disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part mediated by free radicals. Interestingly, it has been reported that oxidative stress can also induce BACE1 transcription and expression. BACE1 is the key enzyme in the cleavage of the amyloid precursor protein to produce Aβ, and the expression of this enzyme has been previously shown to be enhanced in the brains of Alzheimer’s patients. Here, we have found that BACE1 expression is increased in the hippocampi from AD patients at both the early (Braak stage II) and late (Braak stage VI) stages of the disease as studied by immunohistochemistry and western blot. To address the role of Aβ and oxidative stress in the regulation of BACE1 expression, we have analyzed the effect of subtoxic concentrations of Aβ oligomers (0.25 μM) and H2O2 (10 mM) on a human neuroblastoma cell line. Firstly, our results show that Aβ oligomers and H2O2 induce an increase of BACE1 mRNA as we studied by qPCR. Regarding BACE1 translation, it is dependent on the phosphorylation of the eukaryotic initiation factor 2α (eIF2α), since BACE1 mRNA bears a 5′UTR that avoids its translation under basal conditions. BACE1 5′UTR contains four upstream initiating codons (uAUGs), and its translation is activated when eIF2α is phosphorylated. Consistently, we have obtained that Aβ oligomers and H2O2 increase the levels of BACE1 and p-eIF2α assayed by western blot and confocal microscopy. Our results suggest that Aβ oligomers increase BACE1 translation by phosphorylating eIF2α in a process that involves oxidative stress and conforms a pathophysiological loop, where the Aβ once aggregated favors its own production continuously by the increase in BACE1 expression as observed in AD patients.

scholarly journals Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Redox Biology ◽  
2018 ◽  
Vol 14 ◽  
pp. 450-464 ◽  
Author(s):  
C. Cheignon ◽  
M. Tomas ◽  
D. Bonnefont-Rousselot ◽  
P. Faller ◽  
C. Hureau ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Beta Peptide

Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons

2009 ◽  
Vol 29 (3) ◽  
pp. 455-464 ◽  
Author(s):  
Joana B. Melo ◽  
Carla Sousa ◽  
Pedro Garção ◽  
Catarina R. Oliveira ◽  
Paula Agostinho
Keyword(s):  
Oxidative Stress ◽  
Amyloid Beta ◽  
Cortical Neurons ◽  
Amyloid Beta Peptide ◽  
Beta Peptide

scholarly journals Neuroprotective Effect of ent-Kaur-15-en-17-al-18-oic Acid on Amyloid Beta Peptide-Induced Oxidative Apoptosis in Alzheimer’s Disease

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 142 ◽  
Author(s):  
Caiyun Zhang ◽  
Xingming Zhao ◽  
Shiqi Lin ◽  
Fangyuan Liu ◽  
Jiahui Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Neuroprotective Effect ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Amyloid Beta Peptide ◽  
Nuclear Factor ◽  
Beta Peptide

ent-Kaur-15-en-17-al-18-oic acid, extracted from the Chinese well known folk herb Leontopodium longifolium, performed a significantly neuroprotective effect on amyloid beta peptide 25-35 (Aβ25-35)-induced SH-SY5Y cells neurotoxicity in Alzheimer’s disease. The results demonstrated that this compound maintained oxidative stress balance, reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), and improved contents of glutathione (GSH) and superoxide dismutase (SOD) without obvious cytotoxicity. This compound also obviously relieved oxidative stress-induced apoptosis associated with p53 and nuclear factor κB (NF-κB) pathways accompanied by upregulating B-cell lymphoma-2 (bcl-2) and downregulating p53, nuclear factor κB (NF-κB), Bax, Cleaved-caspase 3, and Cytochrome C protein expressions further. Briefly, ent-kaur-15-en-17-al-18-oic acid protected cells from oxidative apoptosis associated with p53 and NF-κB pathways.

In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1–42-induced oxidative stress

2006 ◽  
Vol 84 (2) ◽  
pp. 418-426 ◽  
Author(s):  
Marzia Perluigi ◽  
Gururaj Joshi ◽  
Rukhsana Sultana ◽  
Vittorio Calabrese ◽  
Carlo De Marco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ferulic Acid ◽  
Ethyl Ester ◽  
Amyloid Beta ◽  
Acid Ethyl Ester ◽  
Amyloid Beta Peptide ◽  
Protective Effects ◽  
Beta Peptide ◽  
Ferulic Acid Ethyl Ester

Nanogold induces anti-inflammation against oxidative stress induced in human neural stem cells exposed to amyloid-beta peptide

2021 ◽  
Vol 145 ◽  
pp. 104992
Author(s):  
Ming-Chang Chiang ◽  
Christopher J.B. Nicol ◽  
Chien-Hung Lin ◽  
Shiang-Jiuun Chen ◽  
Chiahui Yen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Human Neural Stem Cells ◽  
Beta Peptide ◽  
Anti Inflammation
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