The role of spontaneous bursts of muscle sympathetic nerve activity in mediating peripheral vascular responses and cardiovascular hemodynamics in resting man

2013 ◽  
Author(s):  
Seth T. Fairfax
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Peripheral Vascular ◽  
Nerve Activity ◽  
Vascular Responses ◽  
Cardiovascular Hemodynamics ◽  
Spontaneous Bursts

Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia

1995 ◽  
Vol 79 (2) ◽  
pp. 581-588 ◽  
Author(s):  
U. Leuenberger ◽  
E. Jacob ◽  
L. Sweer ◽  
N. Waravdekar ◽  
C. Zwillich ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Matched Control ◽  
Sleep Stage ◽  
Muscle Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Obstructive Apnea ◽  
Arterial Blood ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is associated with oscillations of arterial blood pressure (BP) that occur in phase with irregularities of respiration. To explore the role of the sympathetic nervous system in these responses, we studied muscle sympathetic nerve activity (MSNA; peroneal microneurography), an index of vasoconstrictor nerve traffic, and BP during awake regular breathing and during spontaneous apneas in patients with OSA. To determine the role of the arterial chemoreflex, we also examined the effects of 100% O2 (hyperoxia) on MSNA and BP. In awake regularly breathing patients with OSA (n = 12), resting MSNA was markedly higher than in an age-matched control population (n = 15) [41 +/- 23 (SD) vs. 24 +/- 17 bursts/min; P < 0.05] and was unchanged during hyperoxia (n = 9). Apneas during sleep (n = 8) were associated with surges in MSNA followed by transient rises in BP when breathing resumed. In contrast to room air apneas, hyperoxic apneas of similar duration were associated with attenuated MSNA responses (+82 +/- 84% vs. +5 +/- 25% compared with awake baseline; P < 0.05; n = 6), even though O2 did not affect sleep stage and the occurrence of arousal. Thus the BP oscillations that occur with apnea during sleep may in part be mediated by intermittent surges of sympathetic activity resulting in vasoconstriction. Because the MSNA responses to obstructive apnea are blunted during O2 administration, they appear to be linked to intermittent arterial hypoxemia and stimulation of arterial chemoreceptors.

scholarly journals Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men

Hypertension ◽  
2018 ◽  
Vol 71 (1) ◽  
pp. 192-198 ◽  
Author(s):  
Jennifer R. Vranish ◽  
Seth W. Holwerda ◽  
Benjamin E. Young ◽  
Daniel P. Credeur ◽  
Jordan C. Patik ◽  
...  
Keyword(s):  
Black Men ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Spontaneous Bursts

scholarly journals Influence of multiparity on sympathetic nerve activity during normal pregnancy

2020 ◽  
Vol 318 (4) ◽  
pp. H816-H819 ◽  
Author(s):  
Mark B. Badrov ◽  
Jeung-Ki Yoo ◽  
Craig D. Steinback ◽  
Margie H. Davenport ◽  
Qi Fu
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Sympathetic Nerve ◽  
Baroreflex Sensitivity ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Disease Development ◽  
Neural Regulation ◽  
Nerve Activity

Recent evidence suggests an elevated risk of cardiovascular disease development in multiparous women. Therefore, we investigated the effects of multiparity on within-pregnancy sympathetic neural regulation in normotensive, pregnant women. We retrospectively analyzed heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA; n = 8) data from 10 women whom participated in microneurographic research studies during two sequential pregnancies (i.e., PREG1 and PREG2). There was no difference in resting BP between pregnancies ( P > 0.05), whereas HR trended higher in PREG2 versus PREG1 ( P = 0.06). MSNA burst frequency was greater in PREG2 versus PREG1 after adjusting for age (32 ± 12 vs. 22 ± 12 bursts/min; P = 0.049), whereas burst incidence did not differ (40 ± 16 vs. 34 ± 17 bursts/100 heartbeats; P = 0.21). Sympathetic baroreflex sensitivity was not different between PREG1 and PREG2 ( P > 0.05). Our results may highlight a possible role of altered within-pregnancy sympathetic neural regulation in the observed relationship in women between parity and future cardiovascular disease risk. NEW & NOTEWORTHY To our knowledge, this is the first study to investigate the effects of multiparity on within-pregnancy sympathetic neural regulation. We observed augmented muscle sympathetic nerve activity in women’s second studied pregnancy versus their first. Conversely, blood pressure and sympathetic baroreflex sensitivity did not differ, whereas a trend for increased heart rate was observed. Our results highlight a possible role of altered within-pregnancy sympathetic neural regulation in the relationship between increased parity and cardiovascular disease development.

scholarly journals Role of Respiratory Motor Output in Within-Breath Modulation of Muscle Sympathetic Nerve Activity in Humans

1999 ◽  
Vol 85 (5) ◽  
pp. 457-469 ◽  
Author(s):  
Claudette M. St. Croix ◽  
Makoto Satoh ◽  
Barbara J. Morgan ◽  
James B. Skatrud ◽  
Jerome A. Dempsey
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Motor Output ◽  
Nerve Activity
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