scholarly journals Surgical peripheral lymph node biopsies in Makurdi, Nigeria.

2019 ◽  
Vol 6 (3) ◽  
pp. 75-78
Author(s):  
Barnabas Eke ◽  
Babarinde Ojo ◽  
Rymond Vhriterhire ◽  
Issac Akper ◽  
Victor Ugwu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Teaching Hospital ◽  
Diagnostic Yield ◽  
Lymph Node Biopsy ◽  
University Teaching ◽  
Axillary Lymph ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
Lymph Node Enlargement ◽  
Common Causes

This study aims at determining the diagnostic value of peripheral lymph node biopsy and common causes of lymph node enlargement from biopsies obtained from patients with lymph-node enlargement at different sites in a teaching hospital in north central Nigeria town of Makurdi, Benue State. This is a retrospective study of surgical peripheral lymph node biopsies received in the department of Anatomic Pathology, Benue State University Teaching Hospital, Makurdi, Nigeria from February, 2012 to September, 2019. Total number of lymph node biopsies during the period was 47 representing 1.0% of surgical pathology specimens submitted to the department; 25 cases were females and 22 were males. Metastatic nodal involvement (57%), lymphoma (23%) and tuberculosis lymphadenitis (11%) were the most common causes of lymph node enlargement. All the studied nodes were localized. The most common sites of lymphadenopathy were axillary (21%), cervical (16%) and Inguinal (6%). While axillary lymph node enlargements were mostly associated with tumor metastasis, cervical and inguinal node enlargements were mostly associated with tuberculosis and lymphoma, respectively. Surgical excision of nodal enlargement for histological examination represents a simple, good diagnostic yield with lack of significant morbidity or mortality.

scholarly journals Peripheral Lymph Node Excisional Biopsy: Yield, Relevance, and Outcomes in a Remote Surgical Setup

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Ashish Lal Shrestha ◽  
Pradita Shrestha
Keyword(s):  
Lymph Node ◽  
Diagnostic Yield ◽  
Excisional Biopsy ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Histopathological Diagnosis ◽  
Peripheral Lymph Node ◽  
Less Invasive ◽  
Patient Profile ◽  
Peripheral Lymph

Objective. To study the patient profile for symptomatic peripheral lymphadenopathy in terms of histopathological findings and demography and evaluate the yield, relevance, and outcomes of peripheral lymph node biopsy (PLNB) as a diagnostic step in a remote setup in the absence of less invasive options like fine-needle aspiration cytology (FNAC) or ultrasonogram- (USG-) guided FNAC. Methods. A retrospective review of patients undergoing PLNB between 1 May 2011 and 30 April 2013 was done. Demographics, histopathological reports, and outcomes were studied. Results. Of 132 patients, 51 (38.63%) were male and 81 (61.36%) were female. There were 48 (36.3%) patients in the age group less than 16 years, and 84 (63.6%) were beyond 16 years. The commonest site of biopsy was the neck in 114 (86.36%) patients. The histopathological diagnosis was tuberculosis (TB) in 60 (45.45%) patients, reactive lymphadenitis in 29 (21.9%), nonspecific granuloma in 18 (13.6%), lymphoma in 7 (5.3%), acute lymphadenitis in 7 (5.3%), metastatic secondary in 3 (2.2%), and other benign causes in 8 (6.06%). Conclusions. PLNB is a procedure with good diagnostic yield in evaluation of peripheral lymphadenopathy. Its relevance is appreciable in a remote setup where less invasive options are unavailable. Its simplicity and lack of mortality/significant morbidity make it a valid option in rural surgical practice.

Whipple's disease: an unexpected finding in a peripheral lymph node biopsy

The Lancet ◽  
2014 ◽  
Vol 383 (9936) ◽  
pp. 2268 ◽  
Author(s):  
Sarah Walters ◽  
Talal Valliani ◽  
Robert Przemioslo ◽  
Nicholas Rooney
Keyword(s):  
Lymph Node ◽  
Lymph Node Biopsy ◽  
Unexpected Finding ◽  
Whipple’S Disease ◽  
Peripheral Lymph Node ◽  
Whipple's Disease ◽  
Node Biopsy ◽  
Peripheral Lymph

scholarly journals Diagnostic Value of Peripheral Lymph Node Biopsy in Sarcoidosis: A Report of 67 Cases

2007 ◽  
Vol 14 (4) ◽  
pp. 209-211 ◽  
Author(s):  
Halil Yanardag ◽  
Metin Caner ◽  
Irfan Papila ◽  
Sedat Uygun ◽  
Sabriye Demirci ◽  
...  
Keyword(s):  
Lymph Node ◽  
Low Cost ◽  
High Sensitivity ◽  
Practical Method ◽  
Diagnostic Value ◽  
Lymph Node Biopsy ◽  
Peripheral Lymph Node ◽  
Node Biopsy ◽  
Complication Risk ◽  
Peripheral Lymph

A peripheral lymph node (PLN) 1 cm or greater was found in 79 of 546 sarcoidosis patients (14.5%) between 1972 and 2005. Seventy-two of the 79 sarcoidosis patients had a lymph node biopsy performed. Sixty-seven of these biopsy specimens were histologically diagnosed as sarcoidosis, whereas five patients had a reactive adenopathy. For patients with histological diagnosis of sarcoidosis, localizations of the biopsies were as follows: cervical (n=21), supra-clavicular (n=20), inguinal (n=11), axillary (n=8), epitrochlear (n=5) and submandibular (n=2). At the time of biopsy, 12 patients had stage 0 disease, 37 patients had stage I disease, 14 patients had stage II disease and four patients had stage III disease. Skin involvement (16.4%) was the most frequently observed type of organ involvement in patients who had enlarged PLNs due to sarcoidosis. In the presence of an enlarged PLN in sarcoidosis, biopsy had a greater diagnostic value compared with other methods, as well as having a relatively low cost (approximately US$120) in Turkey. No procedure-related complications were observed. In conclusion, it is recommended that PLNs be thoroughly examined when sarcoidosis is suspected. If an enlarged PLN is found, biopsy should be routinely performed because it is an easy, convenient and practical method, with a low complication risk and a high sensitivity.

PERIPHERAL LYMPH NODE EXCISIONAL BIOPSY IN CHILDREN: YIELD IN A TERTIARY CARE CENTRE

2021 ◽  
pp. 67-70
Author(s):  
Dhvani Shah ◽  
Vishesh Dikshit ◽  
Apoorva Kulkarni ◽  
Abhaya Gupta ◽  
Paras Kothari ◽  
...  
Keyword(s):  
Lymph Node ◽  
Diagnostic Yield ◽  
Tertiary Care ◽  
Lymph Node Excision ◽  
Limited Resources ◽  
Excision Biopsy ◽  
Age Group ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
High Prevalence

AIM: To study the pediatric patients in a developing country undergoing peripheral lymph node excision biopsy in terms of demographics and histopathological ndings and evaluate the diagnostic yield of peripheral Lymph node excision biopsy in children. MATERIALS AND METHODS: A retrospective study of 402 patients was done of the children undergoing peripheral lymph node st st excision biopsy in a tertiary care center from 1 January 2013 to 31 December 2018 (6 years). Demographics, histopathological ndings and yields were studied. RESULTS: Out of the 402 patients, 218 (54.2%) were males and 184(45.8%) were females. Male to female ratio 1.18: 1. Maximum patients belonged to the age group of 4-6years (26.87%) followed by the age group of 2-4years of age (22.89%). Most common group of nodes excised were cervical (77.9%) followed by axillary and inguinal lymph nodes (9.2%) each. The most common etiology was reactive lymphoid hyperplasia (63.18%) in our study followed by tuberculous lymphadenitis(31.84%). Specic ndings were seen in 35.58% and non-specic ndings were seen in 64.42% patients. Malignancy was seen in 8 patients (2%). CONCLUSION: Peripheral Lymphadenopathy in pediatric population is always a diagnostic challenge. While FNAC tends to be investigation of choice for adults, in a developing country with limited resources and high prevalence of tuberculosis, peripheral lymph node biopsy is the gold standard with a good diagnostic yield and should always be considered for patients with persistent lymphadenopathy. Clinical significance: The study highlights the importance of excision biopsy in peripheral lymphadenopathy in children in a developing nation with limited resources and high prevalence of infectious diseases.

Orchidectomy and the immune response I. Effect of orchidectomy on lymphoid tissues of mice

1974 ◽  
Vol 185 (1081) ◽  
pp. 425-436 ◽  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Lymphoid Tissues ◽  
Spleen Size ◽  
Thymic Involution ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
Lymph Node Enlargement ◽  
Spleen Mass ◽  
Lymph Node Mass

The effects of pre- and postpuberal orchidectomy on the lymphoid tissues of mice have been studied. Prepuberal orchidectomy delayed the normal rate of thymic involution and caused relative hypertrophy of the thymus which was maximal 1 month after surgery. There was also enlargement of the peripheral lymph nodes to reach a sustained maximum by 6 weeks and also an increase of spleen size. Histological examination of the enlarged thymus showed widening of the cortex and medulla with increased cell density. The enlarged peripheral lymph nodes showed widening of the paracortical area which is thymus dependent. Synchronous thymectomy and orchidectomy prevented the lymph node enlargement that follows orchidectomy alone, but it did not affect the increase of spleen size until 3 months after surgery. After postpuberal orchidectomy thymic size increased to a maximum at 1 month and the increase of peripheral lymph node mass and spleen mass was less than the changes following prepuberal surgery ; only 3 months after operation was the lymph node mass of orchidectomized mice significantly greater than controls and changes in spleen mass were only apparent after correction for changes in body mass.

Diagnosis of Whipple's disease by peripheral lymph node biopsy

1959 ◽  
Vol 27 (2) ◽  
pp. 351-353 ◽  
Author(s):  
W.Crockett Chears ◽  
Albert G. Smith ◽  
Julian M. Ruffin
Keyword(s):  
Lymph Node ◽  
Lymph Node Biopsy ◽  
Whipple’S Disease ◽  
Peripheral Lymph Node ◽  
Whipple's Disease ◽  
Node Biopsy ◽  
Peripheral Lymph

Distinctive Peripheral Lymph Node Hyperplasia of Young Cats

1986 ◽  
Vol 23 (4) ◽  
pp. 386-391 ◽  
Author(s):  
F. M. Moore ◽  
W. E. Emerson ◽  
S. M. Cotter ◽  
R. A. DeLellis
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Plasma Cells ◽  
Leukemia Virus ◽  
Subsequent Development ◽  
Lymph Node Biopsy ◽  
Feline Leukemia Virus ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph ◽  
Lymph Node Hyperplasia

Peripheral lymph node enlargement was found in 14 of a series of 132 feline lymph node biopsy specimens. Six of nine cats tested had antibodies for feline leukemia virus (FeLV). Half of the cats were clinically normal while the remainder had fever, lethargy, anorexia, and hepatosplenomegaly. There was severe distortion of lymph nodal architecture with variable loss of discernible follicles and sinuses. Histiocytes, lymphocytes, immunoblasts, and plasma cells were present in expanded paracortical regions which encroached on, and occasionally effaced, lymphoid follicles. Postcapillary venules were numerous and prominent throughout the paracortex. The lymphadenopathy was most commonly transient (86% of cases) with subsequent development of lymphoma in one cat. Lymph nodes from seven kittens with experimental FeLV infection were compared with spontaneously enlarged lymph nodes; four of seven had B and T lymphocyte hyperplasia with normal nodal architecture. Three had partial loss of nodal architecture as a result of expanded paracortical regions populated largely by histiocytes and lymphocytes. Proliferation of postcapillary venules was not prominent in nodes from FeLV-infected cats. The cause of spontaneous lymph node hyperplasia of young cats was not determined. However, the similarity of lesions to those of kittens with experimental FeLV infection and the association with FeLV by serologic tests in six of nine cats suggest that this retrovirus may be involved in the pathogenesis of the lesion.

When Is Lymph Node Biopsy Indicated in Children with Enlarged Peripheral Nodes?

PEDIATRICS ◽  
1982 ◽  
Vol 69 (4) ◽  
pp. 391-396
Author(s):  
Philip J. Knight ◽  
Arlynne F. Mulne ◽  
Louis E. Vassy
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Disease Process ◽  
Lymph Node Biopsy ◽  
Specific Diagnosis ◽  
Node Biopsy ◽  
Peripheral Lymph ◽  
Lymph Node Enlargement ◽  
Diagnostic Biopsy ◽  
Reactive Hyperplasia

To better define the indications for diagnostic biopsy, 239 children who underwent peripheral lymph node biopsy were reviewed. The duration of the lymphadenopathy by history, the consistency of the lymph nodes, and the presence of more than one site of palpable adenopathy were not specific in differentiating serious diseases involving lymph nodes from reactive hyperplasia. The differential diagnosis of specific causes for lymph node enlargement is approached based on the child's age, the location of the adenopathy, and the presence or absence of lymph node fixation and tenderness. Most children with supraclavicular adenopathy, children sick with fever of one week's duration or with weight loss for which a specific diagnosis is not readily made, and some children with fixation of the lymph node to the overlying skin should undergo early biopsy. Excluding the above findings, when a specific diagnosis is not apparent, serial measurements with a ruler over several weeks appears to be the most reasonable method, at the present time, of discriminating hyperplastic lymph nodes from nodes that are involved by a progressive disease process.

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