scholarly journals Early detection of Prostate Cancer with Prostate Specific Antigen > 4 ng/ml : A Multivariate Logistic Regression

2015 ◽  
Vol 22 (1) ◽  
Author(s):  
Prahara Yuri ◽  
Sungsang Rochadi
Keyword(s):  
Prostate Cancer ◽  
Logistic Regression ◽  
Family History ◽  
Early Detection ◽  
Receiver Operating Characteristic ◽  
Prostate Specific Antigen ◽  
Operating Characteristic ◽  
Prostate Volume ◽  
Specific Antigen ◽  
The Relationship

Background:Early detection of prostate cancer is a possible means of decreasing the mortality and increasing the quality of life. Objective :To determine whether the prostate specific antigen (PSA), abnormal DRE, family history, age, and prostate volume could increase the specificity and sensitivity of screening for prostate cancer. Methods :We included 92 patients with PSA > 4 ng/ml between January and December 2011 in Sardjito Hospital. Patients received prostate biopsy due to having abnormal serum prostate specific antigen (PSA) level. The relationship between the possibility of prostate cancer and the following variables were evaluated including: age; PSA level, prostate volume, DRE finding and family history. By using chi-square analysis, multiple logistic regression and receiver operating characteristic (ROC) curve were drawn based on the predictive scoring equation to predict the possibility of prostate cancer. All analyses were performed with SPSS, version 18.0. Results:We analyzed 92 patients with PSA > 4 ng/ml. It showed the relationship between the possibility of prostate cancer and the following variables, including : age (p < 0.001), PSA level (p < 0,001), DRE finding (p < 0.001) family history (p < 0,001) except prostate volume (p = 0.398). Using a predictive equation, P = 1/(1-e-X), where X= -3,821 +1.846 (if DRE positive) + 2,488 ( if family history positive ) + 1.718 ( when PSA > 10 ) + 1.414 ( when age > 68), followed by receiver-operating characteristic curve analysis, it showed the sensitivity 90,4% and specificity 85 % in predicting the possibility of prostate cancer. Conclusion:  Age,  DRE  finding,  PSA  and  family  history  are  factors  associated prostate cancer. They can be used as independent predictor to predict prostate cancer. Key words: Logistic regression, early detection,prostate cancer

scholarly journals Role of Prostate Volume in the Early Detection of Prostate Cancer in a Cohort with Slowly Increasing Prostate Specific Antigen

2013 ◽  
Vol 54 (5) ◽  
pp. 1202 ◽  
Author(s):  
Young Min Kim ◽  
Sungchan Park ◽  
June Kim ◽  
Seonghun Park ◽  
Ji Ho Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Early Detection ◽  
Prostate Specific Antigen ◽  
Prostate Volume ◽  
Specific Antigen

scholarly journals epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer

2019 ◽  
pp. 1-18 ◽  
Author(s):  
Eve O’Reilly ◽  
Alexandra V. Tuzova ◽  
Anna L. Walsh ◽  
Niamh M. Russell ◽  
Odharnaith O’Brien ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Methylation ◽  
High Risk ◽  
Early Detection ◽  
Receiver Operating Characteristic ◽  
Prostate Biopsy ◽  
Operating Characteristic ◽  
Specific Antigen ◽  
High Grade ◽  
Cancer Of The Prostate

Purpose Liquid biopsies that noninvasively detect molecular correlates of aggressive prostate cancer (PCa) could be used to triage patients, reducing the burdens of unnecessary invasive prostate biopsy and enabling early detection of high-risk disease. DNA hypermethylation is among the earliest and most frequent aberrations in PCa. We investigated the accuracy of a six-gene DNA methylation panel (Epigenetic Cancer of the Prostate Test in Urine [epiCaPture]) at detecting PCa, high-grade (Gleason score greater than or equal to 8) and high-risk (D’Amico and Cancer of the Prostate Risk Assessment] PCa from urine. Patients and Methods Prognostic utility of epiCaPture genes was first validated in two independent prostate tissue cohorts. epiCaPture was assessed in a multicenter prospective study of 463 men undergoing prostate biopsy. epiCaPture was performed by quantitative methylation-specific polymerase chain reaction in DNA isolated from prebiopsy urine sediments and evaluated by receiver operating characteristic and decision curves (clinical benefit). The epiCaPture score was developed and validated on a two thirds training set to one third test set. Results Higher methylation of epiCaPture genes was significantly associated with increasing aggressiveness in PCa tissues. In urine, area under the receiver operating characteristic curve was 0.64, 0.86, and 0.83 for detecting PCa, high-grade PCa, and high-risk PCa, respectively. Decision curves revealed a net benefit across relevant threshold probabilities. Independent analysis of two epiCaPture genes in the same clinical cohort provided analytical validation. Parallel epiCaPture analysis in urine and matched biopsy cores showed added value of a liquid biopsy. Conclusion epiCaPture is a urine DNA methylation test for high-risk PCa. Its tumor specificity out-performs that of prostate-specific antigen (greater than 3 ng/mL). Used as an adjunct to prostate-specific antigen, epiCaPture could aid patient stratification to determine need for biopsy.

Prostate volume and prostate-specific antigen in the absence of prostate cancer: A review of the relationship and prediction of long-term outcomes

The Prostate ◽  
2001 ◽  
Vol 49 (3) ◽  
pp. 208-212 ◽  
Author(s):  
Michael M. Lieber ◽  
Steven J. Jacobsen ◽  
Rosebud O. Roberts ◽  
Thomas Rhodes ◽  
Cynthia J. Girman
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Prostate Volume ◽  
Specific Antigen ◽  
Long Term Outcomes ◽  
The Relationship
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