scholarly journals METABOLIC RISK FACTORS OF URINARY STONE DISEASE IN CHILDREN

2012 ◽  
Vol 19 (1) ◽  
Author(s):  
Dandy Tanuwidjaja ◽  
Safendra Siregar
Keyword(s):  
Uric Acid ◽  
Calcium Phosphate ◽  
Urinary Stone ◽  
Urinary Calcium ◽  
Stone Disease ◽  
Metabolic Risk ◽  
Creatinine Ratio ◽  
Stone Analysis ◽  
Urinary Stone Disease ◽  
Significant Difference

Objective: To evaluate metabolic risk factor of urinary stone disease in children. Material & method: In this hospital-based preliminary study, children with urinary stone disease who underwent stone removal in Hasan Sadikin Hospital were included. Control group consisted children with other diseases, matched for age and BMI. Blood evaluation (uric acid, calcium and phosphate) and 24-hour urine evaluation (calcium, phosphate, sodium, magnesium, uric acid, acidity, and urine volume) were measured before the stone removal. Stone analysis was performed later. Data was analyzed using Kruskal Wallis and Spearman correlation test. Results: Eight subjects with urinary tract stone and 8 normal subjects were included to the study. This study included 4 (50%) subjects with renal stone, 3 (37,5%) subjects with bladder stone, and 1 (12,5%) subject with distal urethral stone. Stone analysis revealed 6 (75%) calcium oxalate, 1 (12,5%) calcium phosphate, and 1 (12,5%) struvite stone. There was no significant difference in blood calcium, phosphate, and uric acid between groups. 24 hours urinary calcium level was higher in subjects with stone disease (40,8 mg vs 10,6 mg, p=0,027). Urinary calcium-to-creatinine ratio was also higher in stone disease (0,23 vs 0,02 mg/mg creatinine, p=0,002). There was no significant difference of other urinary electrolites and uric acid level between groups. Conclusion: Twenty four hours urinary calcium level and urinary calcium-to-creatinine ratio is higher in children with urinary stone disease. Keywords: Urinary stone disease, children, metabolic risk factors.

scholarly journals Assessment of Cardiac Functions and Subclinical Cardiovascular Risk In Children with Urolithiasis: An Initial Study

2021 ◽  
Author(s):  
Ahmet Midhat Elmacı ◽  
Hayrullah Alp ◽  
Muhammet İrfan Dönmez
Keyword(s):  
Cardiovascular Risk ◽  
Tissue Doppler ◽  
Urinary Stone ◽  
Stone Disease ◽  
Doppler Imaging ◽  
Control Group ◽  
Study Group ◽  
Fat Tissue ◽  
Urinary Stone Disease ◽  
Significant Difference

Abstract Information on cardiovascular problems related to childhood urinary stone disease is limited. The aim of this study is to assess the ventricular functions and subclinical cardiovascular risk in children with urolithiasis using echocardiographic measurements. Children readily diagnosed with urolithiasis were enrolled in the study as well as children with no urinary stone disease confirmed via urinary ultrasonography. Body mass index (BMI) and blood pressures were noted as well as basic serum parameters. Carotid intima media thickness (cIMT), epicardial fat tissue (EFT) thickness and periaortic fat tissue (PFT) thickness were measured via transthoracic echocardiography in addition to pulsed and tissue Doppler imaging. Myocardial performance indexes were also calculated and correlation analyses were made. A total of 17 patients (10 boys) were enrolled in the study with a mean age of 8.57 ± 2.62 years. There were 17 children (12 boys) in the control group and their mean age was 9.53 ± 1.72 years. There was no statistically significant difference between the two groups in terms of demographic and laboratory variables. Tissue Doppler echocardiography revealed that Tei indexes of left ventricle, right ventricle and septum were significantly higher in the study group than in the controls (p < 0.001 for all). The cIMT (0.041 ± 0.012 vs. 0.025 ± 0.002), EFT (0.432 ± 0.083 vs. 0.325 ± 0.032) and PFT thicknesses (0.138 ± 0.029 vs. 0.113 ± 0.008) of the study group were statistically higher than the control group (p < 0.001, p < 0.001 and p = 0.002, respectively) indicating a higher CVD risk.Conclusions: Children with urolithiasis presented not only biventricular early systolic and diastolic dysfunction but also subclinical atherosclerosis in early ages. Cardiovascular complications should be considered in the follow-up and treatment of these patients.

scholarly journals Urinary stone composition: Gender and age variations, and evolution in the last 7 years.

2017 ◽  
Vol 34 (3-4) ◽  
pp. 7-12
Author(s):  
Pedro Valente ◽  
Hélder Castro ◽  
Inês Pereira ◽  
Fernando Vila ◽  
Paulo Araújo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Calcium Phosphate ◽  
Calcium Oxalate ◽  
Urinary Stone ◽  
Stone Analysis ◽  
Stone Composition ◽  
Magnesium Ammonium Phosphate ◽  
Age Variations ◽  
Gender And Age ◽  
Ammonium Urate

Objectives: To evaluate urinary stone composition in our institution, its gender and age, including variations and the evolution in the last 7 years. Material and Methods: The authors reviewed all urinary stone analysis performed since January 2009 to September 2015 in our hospital – Centro Hospitalar do Tâmega e Sousa, Penafiel, Portugal. Patients were stratified by gender, age and stone composition analyzing the evolution of stone composition in different years. The stone analysis method was infrared spectroscopy. Results: From 302 valid stone analysis reports, 55,3% were female and 44,7% were male patients. Mean patient age was 51±14 years old. A total of 7 different mineral components were identified. 51,6% (n=156) of all the stones had Calcium Oxalate, 41% (n=124) had Calcium Phosphate (33% of Apatite form), 37,7% (n=114) had Uric Acid, 22,1% (n=67) had Ammonium Urate, 9,6% (n=29) had Magnesium Ammonium Phosphate, 6,3% (n=19) had Sodium Urate, and 1,3% (n=4) had Cystine in its composition. Only 30,4% of stones had a single chemical compound. Of these 56% were pure stones of Calcium Oxalate, and 31% were pure stone of Uric Acid. The most frequent mixed stone was Calcium Oxalate + Calcium Phosphate (Apatite) followed by Uric Acid + Ammonium Urate comprehending 45% and 27% of all mixed stones respectively. Related to the ethology we divided stones into 3 groups, pure non-infection, pure infection, and mixed with component of infection, and the prevalence was 37,7%, 4,3% and 57,9% respectively. The distribution between genders was similar and the highest difference was in the Ammonium Urate compound with 28% prevalence in male and 17% in women. (p=0,379)
Patients after 50 years old had more prevalence of Uric Acid component accounting for 49% of their stones.(p<0,001) . Along the 7 years of study we identified a significant reduction in the prevalence of mixed stones with component of infection, gradually decreasing from 89,6% in 2009 to 27% in 2015. Conclusions: Calcium Oxalate calculus were the most prevalent, but this difference was not as important as in other studies worldwide. This study highlights the importance of the development of National and European database to report all regional stone composition variations.

scholarly journals Cross-sectional and prospective data on urinary calcium and urinary stone disease

2003 ◽  
Vol 63 (6) ◽  
pp. 2200-2206 ◽  
Author(s):  
Massimo Cirillo ◽  
Davide Stellato ◽  
Paolo Panarelli ◽  
Martino Laurenzi ◽  
Natale G. De Santo ◽  
...  
Keyword(s):  
Urinary Stone ◽  
Urinary Calcium ◽  
Stone Disease ◽  
Cross Sectional ◽  
Prospective Data ◽  
Urinary Stone Disease

Effect of Indapamide on Urinary Calcium Excretion in Patients with and without Urinary Stone Disease

2005 ◽  
Vol 39 (6) ◽  
pp. 1034-1038 ◽  
Author(s):  
Kadir Ceylan ◽  
Cevat Topal ◽  
Reha Erkoc ◽  
Hayriye Sayarlioglu ◽  
Saban Can ◽  
...  
Keyword(s):  
Urinary Stone ◽  
Urinary Calcium ◽  
Stone Disease ◽  
Idiopathic Hypercalciuria ◽  
Calcium Excretion ◽  
Urinary Stone Disease ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

BACKGROUND: Indapamide is an antihypertensive agent similar to thiazides, but with some different effects. Thiazide and thiazide-like diuretics are useful in preventing recurrent urinary stone formation due to their hypocalciuric effects. OBJECTIVE: To determine the hypocalciuric and other effects on certain laboratory parameters of indapamide 1.5 mg in different patient groups. METHODS: Four groups of patients recruited from urology and nephrology outpatient departments were experiencing non-hypercalciuric urinary stone disease (group 1), idiopathic hypercalciuria (group 2), urinary stone disease with hypercalciuria (group 3), and essential hypertension (group 4). In all patients, fasting serum uric acid, calcium, sodium, potassium, cholesterol, triglyceride, parathyroid hormone (PTH) values, and morning second-spot urine calcium and creatinine levels were assessed before and 8 weeks after treatment with indapamide. RESULTS: Urinary calcium excretion was reduced significantly in all groups: group 1 from 0.10 ± 0.02 to 0.07 ± 0.03 (mean ± SD; 30% reduction; p < 0.001), group 2 from 0.30 ± 0.15 to 0.15 ± 0.10 (50% reduction; p < 0.001), group 3 from 0.35 ± 0.15 to 0.20 ± 0.10 (43% reduction; p < 0.001), and group 4 from 0.10 ± 0.03 to 0.08 ± 0.02 (20% reduction; p < 0.0010). These results should be interpreted with caution since no control group was included in this study. Mean serum uric acid and triglyceride levels were significantly increased, and mean PTH and potassium levels and diastolic and systolic blood pressure were significantly decreased in all groups. Few temporary adverse effects, such as dizziness and fatigue, were noticed and none of them caused discontinuation of treatment. CONCLUSIONS: Indapamide 1.5 mg/day is effective in decreasing calciuria in patients with non-hypercalciuric urinary stone disease, idiopathic hypercalciuria, urinary stone disease with hypercalciuria, and essential hypertension. This could be achieved with few adverse effects similar to those of thiazides and indapamide 2.5 mg. Indapamide decreased the PTH levels in all groups. Long-term clinical benefits of these effects should be evaluated prospectively with further randomized studies.

scholarly journals The impact of metabolic risk management on recurrence of urinary stones

2012 ◽  
Vol 2 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Yigit Akin ◽  
Selcuk Yucel ◽  
Ahmet Danisman ◽  
Tibet Erdogru ◽  
Mehmet Baykara
Keyword(s):  
Risk Management ◽  
Risk Analysis ◽  
Stone Formation ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Metabolic Risk ◽  
Metabolic Abnormalities ◽  
Urinary Stone Disease ◽  
The Impact

Introduction: Urinary stone disease is a common urologic problem and recurrence in stone formation is a very familiar issue to urologists. Although recurrence in stone formation has been linked to metabolic abnormalities, it can be accessible by metabolic risk analysis studies.Methods: Herein, we present our experience in metabolic risk management on recurrence of urinary stones for 10 years in Akdeniz University School of Medicine department of Urology. We retrospectively analyzed Akdeniz University Urinary Stone Database between dates of January 2000 and December 2010. We found over 3500 patients who were managed by SWL (shock wave lithotripsy) or PCNL (percutaneus nephrolithotripsy) or URS (Ureterorenoscopic lithotripsy) or open surgery.Results: 525 patients’ metabolic risk analysis was ordered due to recurrent urinary stone disease. Only 134 (25.5 %) current metabolic analysis were returned. Mean patient age was 32.2 years (range: 19-82 years).Patients were 103 male and 31 female. Stone analysis results were CaOx monohydrate in 48 (35.8 %), CaOx dihydrate in 8 (5.9 %), CaOx mono and dihydrate in 70 (52.2 %), uric acid in 3, CaOx monohydrate and uricacid in 2, cystine in 2, and struvite in 1 patient, respectively. The  metabolic risk analysis showed some abnormality in 54 (40.2 %) patients.Conclusion: Although compliance to metabolic risk analysis studies is low among recurrent urinary stone formers, some significant metabolic abnormalities could be detected in those who are effectively screened.Recurrence of urinary stones in patients who are started on appropriate metabolic management can be prevented.

Urinary Stone Disease in Pregnancy: Current Management Practices in a Large National Cohort

Urology ◽  
2020 ◽  
Vol 142 ◽  
pp. 60-64
Author(s):  
Kyle Spradling ◽  
Ericka M. Sohlberg ◽  
Shufeng Li ◽  
Chiyuan Amy Zhang ◽  
William D. Brubaker ◽  
...  
Keyword(s):  
Management Practices ◽  
Urinary Stone ◽  
Stone Disease ◽  
Current Management ◽  
Urinary Stone Disease ◽  
National Cohort ◽  
In Pregnancy

scholarly journals Short-Term Tolvaptan Increases Water Intake and Effectively Decreases Urinary Calcium Oxalate, Calcium Phosphate and Uric Acid Supersaturations

2016 ◽  
Vol 195 (5) ◽  
pp. 1476-1481 ◽  
Author(s):  
Wisit Cheungpasitporn ◽  
Stephen B. Erickson ◽  
Andrew D. Rule ◽  
Felicity Enders ◽  
John C. Lieske
Keyword(s):  
Uric Acid ◽  
Calcium Phosphate ◽  
Calcium Oxalate ◽  
Water Intake ◽  
Urinary Calcium ◽  
Short Term

Risk of Postpartum Urinary Stone Disease in Women with History of Urinary Stone Disease During Pregnancy

2021 ◽  
Author(s):  
Kyle Spradling ◽  
Chiyuan A Zhang ◽  
Alan C Pao ◽  
Joseph C Liao ◽  
John T Leppert ◽  
...  
Keyword(s):  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stone Disease ◽  
History Of
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