scholarly journals RIBAVIRIN INDUCED ANEMIA: A CROSS SECTIONAL STUDY AMONG PATIENTS WITH HEPATITIS C, VISITING OUT PATIENT DEPARTMENT OF A MAJOR PUBLIC SECTOR TERTIARY CARE HOSPITAL, KARACHI, PAKISTAN.

2018 ◽  
Vol 8 (3) ◽  
pp. 170-173
Author(s):  
Zulfiqar Ali Shaikh ◽  
Javeria Shamim ◽  
Kelash Nankani
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Hemoglobin Level ◽  
P Value ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Background: Hepatitis C is among one of the major global health issues; which may cause chronic liver disease, end stage liver disease, and hepatocellular carcinoma; subsequently requiring liver transplant. For HCV, standard treatment is a combination therapy of ribavirin and interferon for six months. Ribavirin fostered hemolysis is a major treatment-associated adverse effect. Our study aimed to assess ribavirin induced anemia among Hepatitis C patients visiting Civil Hospital, Karachi. Methods: A hospital-based cross-sectional study which included 106 Hepatitis C patients, of 15-60 years' age, visiting CHK, a public sector tertiary care hospital, from October 2017 to January 2018 by using non-probability convenient sampling technique. Results: Total 106 patients participated, 53 (50.0%) were males and 53 (50.0%) were females. Mean (±SD) age was 37.05 (±10.793). Mean (±SD) duration of ribavirin use was 3.03 (±1.523) months. Around 16.0% had ribavirin dose reduction. All of them experienced weakness, fatigue and light-headedness, 59.4% developed microcytic hypochromic anemia, 23.6% had severe anemia. Mean (±SD) hemoglobin level before the onset of treatment was 12.78 (±1.555). Mean hemoglobin level during treatment was 10.72g/dL. Mean reduction in hemoglobin levels was 2.07g/dL. The reduction in hemoglobin levels and the duration of therapy were correlated (p-value <0.05). The severity of anemia was related to age of the patients (p-value <0.05) but not with gender and RBC morphology. Conclusion: Ribavirin induces anemia. The duration of ribavirin therapy and initial hemoglobin levels were related to the severity of anemia, significant enough to cause dose modification and subsequently suboptimal levels affecting efficacy. In return hemoglobin reduction, dose modification and age of the patient were also related.

scholarly journals Comparative Study of Compliance between Sofosbuvir and Interferon in the Management of Viral Hepatitis at Tertiary Care Hospital of Gambat, Sindh, Pakistan

2021 ◽  
pp. 1-8
Author(s):  
Sajid Ali ◽  
Zuheeb Ahmed ◽  
Marvi Metlo ◽  
Tahseen Ahmed ◽  
Shahzad Ali ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Hepatitis C ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Duration Of Action ◽  
N 93

Introduction: Hepatitis can be defined as inflammation of the liver. Hepatitis may be acute or chronic. It is estimated that in 2017, approximately 15 million people suffered from Hepatitis in Pakistan suffering from hepatitis. 150–200 million people, or approximately ~3% of the world's population, are living with chronic Hepatitis C. Methodology: A descriptive cross-sectional study was conducted on 300 patients selected by purposive sampling who were reported with Hepatitis-C and co infection of Hepatitis-C + Hepatitis-B, at a tertiary care hospital Gambat. A series of questions were asked from reported patients regarding symptoms and compliance. Results: The results were analyzed by using SPSS-22. Among the 300 patients some were on sofosbuvir (n=150, 50%), which the others were on interferon (n=150, 50%). The findings showed that most of the patients on interferon were non-compliant (n=125,83.3%), and only (n=25, 16.7%) are compliant. Among non-compliant factors, fear from injection was reported in (n=42, 33.6), technique for injection (n=38, 30.4%), prolong duration of action (n=35, 28%), adverse drug reaction (n=26, 20.8%). Better compliance was observed with sofosbuvir (n=93, 62.8%) and non-compliant were (57, 38%). Conclusion: This study concluded that better compliance was achieved with sofosbuvir as compared to interferon, rate of ADR’S were also less with sofosbuvir.

scholarly journals Hyponatremia in Chronic Liver Disease among Patients Presenting to a Tertiary Care Hospital: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (244) ◽  
pp. 1225-1228
Author(s):  
Abashesh Bhandari ◽  
Ashlesha Chaudhary
Keyword(s):  
Liver Disease ◽  
Confidence Interval ◽  
Chronic Liver Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Chronic Liver ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Introduction: Hyponatremia is a frequent problem in chronic liver disease. To the best of our knowledge, no study of hyponatremia in chronic liver disease has been conducted in our setting. The aim of this study is to study the prevalence of hyponatremia in patients with chronic liver disease attending the outpatient department of a tertiary care hospital. Methods: This descriptive cross-sectional study was conducted in 114 patients with chronic liver disease attending the out-patient department of a tertiary care hospital in Kathmandu, Nepal between November 2020 and July 2021. Ethical approval was taken from the Institutional Review Committee of Nepal Medical College and Teaching Hospital (Reference number: 028-077/078). Convenience sampling was done. The collected data was entered and analyzed in Microsoft Excel. Calculation of point estimate at 95% confidence interval was done along with frequency and proportion for binary data. Results: Among 114 patients with chronic liver disease studied, 47 (41.22%) (32.18-50.25 at 95% Confidence Interval) patients had hyponatremia (≤130mmol/L) with mean age of 53.44±7.57 years. Thirty (63.8%) patients out of these were males and 17 (36.2%) patients were females. Conclusions: The prevalence of hyponatremia among patients with chronic liver disease was found to be higher when compared to other similar studies.

scholarly journals Spectrum of Mandibular Fractures in a Tertiary Care Hospital of Karachi

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Sana Iqbal ◽  
Ayesha Aslam ◽  
Sufyan Ahmed ◽  
Nabeel Khan ◽  
Mehwash Kashif ◽  
...  
Keyword(s):  
Road Traffic ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Mandibular Fractures ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Type Of Fracture

Objective: To evaluate the frequency, pattern, and etiology of mandibular fractures at a tertiary care hospital, in Karachi Study Design: Retrospective, cross-sectional study. Setting: Abbasi Shaheed Hospital, Karachi, Pakistan Methodology: The study was initiated in Outpatient Maxillofacial Surgery Department of Abbasi Shaheed Hospital Karachi. The duration of the study was 5 years and six months. Data of mandibular trauma was evaluated. In this retrospective, cross-sectional study the patients were recruited through convenience sampling and the inclusion criteria was patients from both genders suffered from mandibular trauma of mandibular region. Patients who suffered from the trauma of face other than mandible were excluded. The sample size of the study was 464.  A questionnaire was designed to enquire into the demographic details like age, sex, etiology, and site of fracture. The data was analyzed on SPSS version 17.0. Results: The majority of patients were males i.e. 384 (82.8%) while 80 (17.2%) were females. The most common type of fracture was combination fractures followed by parasymphysis i.e. 142 (30.6%) and 79 (17%) respectively. Road traffic accident was the major cause of trauma i.e. 332 (71.6%) followed by fall 96 (20.7%). Cross tabulation was done between different variables. Association of gender with etiology and type of fracture revealed non-significant p-value while the association of age with etiology revealed significant p-value. The highest number of mandibular fracture cases due to RTA were reported in the year 2019. Conclusion: It has been concluded that the frequency of mandibular trauma is quite high with male dominance. The most susceptible site of trauma is the combination and parasymphseal region and the most common etiology were road traffic accidents.

Confidence toward vaccination as reported by parents of children admitted to a tertiary care hospital in Riyadh, Saudi Arabia: A cross sectional study

Vacunas ◽  
2020 ◽  
Vol 21 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Y.M. AlGoraini ◽  
N.N. AlDujayn ◽  
M.A. AlRasheed ◽  
Y.E. Bashawri ◽  
S.S. Alsubaie ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

A Cross-sectional Study of Undiagnosed Fever in a Rural Population at a Tertiary Care Hospital of West Bengal

2018 ◽  
Vol 4 (3) ◽  
Author(s):  
Nandini Chatterjee ◽  
Supratick Chakraborty ◽  
Mainak Mukhopadhyay ◽  
Sinjon Ghosh ◽  
Bikramjit Barkandaj ◽  
...  
Keyword(s):  
Rural Population ◽  
West Bengal ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional
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