scholarly journals Hepatitis C in Poland in 2018

2020 ◽  
pp. 209-222
Author(s):  
Karolina Zakrzewska ◽  
Małgorzata Stępień ◽  
Magdalena Rosińska
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Epidemiological Surveillance ◽  
Acute Hepatitis C ◽  
Medical Procedures ◽  
Route Of Transmission ◽  
Central Statistical ◽  
Diagnosis Rate ◽  
Central Statistical Office ◽  
Demographic Surveys

OBJECTIVE. Analysis of data on hepatitis C, collected as part of epidemiological surveillance in 2018, compared to previous years. MATERIAL AND METHODS. Analysis of: 1) individual data from surveillance in 2018 2) diagnosis rate from bulletins “Infectious diseases and poisonings in Poland” for the years 2012-2018 and 3) data about deaths due to hepatitis C from the Demographic Surveys and Labour Market Department of the Central Statistical Office. RESULTS. In 2018, there was a decrease in the number of reported hepatitis C cases (3,442 cases) and the diagnosis rate (8.96 per 100,000; taking into account the territorial distribution: from 3.29 per 100,000 in the Podkarpackie voivodeship to 13.69 per 100,00 in the Lubuskie voivodeship). The disproportion of the rates between the sexes returned (in men 9.34 per 100,000 vs. women: 8.61 per 100,000). The disproportion of the diagnosis rate depending on the place of residence was still evident (urban: 10.84 per 100,000 vs. rural: 6.12 per 100,000). There are differences in the values of the diagnosis rates, analyzed in terms of gender, age groups and the place of residence. Based on the EU definition, 14 acute hepatitis C were reported, while according to the PL definition, 88 cases (0.4% and 2.6% of all reported cases, respectively). HCV infections due to medical procedures are still the main route of transmission, also in cases of acute hepatitis C - which indicates the current route of transmission. According to the Demographic Surveys and Labour Market Department of the Central Statistical Office, 119 deaths related to hepatitis C were reported. CONCLUSIONS. For years, the general picture of hepatitis C in Poland, observed through epidemiological surveillance, is determined by the availability of testing for HCV infections. The analysis identified subpopulations in which primary prevention activities (e.g. safer medical procedures, intensifying activities in the area of harm reduction for people who inject drugs) as well as secondary prevention (access to testing and quick inclusion in treatment) should be particularly strengthened. According to the micro-elimination strategy, the improvement of testing in particularly affected groups, including marginalized populations, is necessary to achieve the WHO goal of eliminating HCV by 2030.

scholarly journals Hepatitis C in Poland in 2017

2019 ◽  
pp. 167-178
Author(s):  
Karolina Zakrzewska ◽  
Małgorzata Stępień ◽  
Magdalena Rosińska
Keyword(s):  
Hepatitis C ◽  
Hcv Infection ◽  
Epidemiological Surveillance ◽  
Central Statistical ◽  
Diagnosis Rate ◽  
Urban Rural ◽  
Central Statistical Office ◽  
Demographic Surveys ◽  
High Level ◽  
Epidemiological Situation

OBJECTIVE. The aim of this article was to analyze the epidemiological situation of HCV in Poland in 2017, based on data collected as part of epidemiological surveillance. MATERIAL AND METHODS. The analysis was carried out based on: 1) individual data collected as part of epidemiological interviews with persons diagnosed with HCV infection in 2017, 2) diagnosis rate from bulletins “Infectious diseases and poisonings in Poland” for the years 2011-2017 and 3) data about deaths due to hepatitis C from the Demographic Surveys and Labour Market Department of the Central Statistical Office. RESULTS. In 2017, the diagnosis rate of HCV infection stayed on high level: 10.44 per 100,000 (4010 cases were reported). Stabilization of hepatitis C epidemiological situation was observed in the following issues: 1) diagnosis rate reported in men and women remained at a similar level (10.55 vs. 10.33 per 100,000); 2) diagnosis rate still showed variation depending on the voivodship (from 4.09 to 18.48 per 100,000) and the location of residence (urban/rural, 12.7 vs. 7.0 per 100,000); 3) the percentage of hospitalization accompanying the new cases of HCV infection has shown downward trend (36% in 2017); 4) the decreasing hepatitis C mortality trend was continued (175 cases of death in 2017); 5) the most common possible transmission route were still medical procedures. In 2017, the outbreak of HCV infection in the Lubelskie was registered. (8 patients, 291 exposed persons, with whom computer tomography with a contrast from multi-dose packaging was conducted, using an automatic injection device). CONCLUSIONS. Epidemiological situation of hepatitis C since 2015 is stable. The role of medical care in the transmission of HCV infections in Poland is worrying.

scholarly journals Epidemiological characteristics and medical follow-up of 61 patients with acute hepatitis C identified through the hepatitis C surveillance system in France

2007 ◽  
Vol 136 (7) ◽  
pp. 988-996 ◽  
Author(s):  
C. BROUARD ◽  
P. PRADAT ◽  
E. DELAROCQUE-ASTAGNEAU ◽  
C. SILVAIN
Keyword(s):  
Hepatitis C ◽  
Drug Use ◽  
Acute Hepatitis ◽  
Surveillance System ◽  
Spontaneous Clearance ◽  
Acute Hepatitis C ◽  
Medical Procedures ◽  
Invasive Medical Procedures

SUMMARYThis study aimed to describe current epidemiological and clinical characteristics, medical follow-up and outcome in the real practice of acute hepatitis C (AHC) patients. AHC cases were retrospectively identified through the French Hepatology Reference Centres Surveillance system and additional data were collected. Sixty-one patients with AHC were identified (sex ratio: M/F 1·7/1; mean age 39 years). Forty-four (72%) had documented seroconversion within a 6-month period. Main reported risk exposures were intravenous or nasal drug use (35%), invasive medical procedures (25%) and sexual contact with a HCV-positive partner (20%). Spontaneous clearance of HCV RNA was observed in seven out of 16 patients followed without therapy. This study confirms the major role of drug use in HCV transmission and highlights the role of invasive medical procedures and occupational exposure.

Treatment of acute hepatitis C infection with interferon-alfa 2b monotherapy prevents development of chronic HCV infection

2001 ◽  
Vol 120 (5) ◽  
pp. A567-A567 ◽  
Author(s):  
E JAECKEL ◽  
M CORNBERG ◽  
T SANTANTONIO ◽  
J MAYER ◽  
H WEDEMEYER ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Interferon Alfa ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Acute Hepatitis C in Haemophiliacs Due to “Virus-Inactivated” Clotting Factor Concentrates

1992 ◽  
Vol 68 (06) ◽  
pp. 781-781 ◽  
Author(s):  
A Gerritzen ◽  
B Scholt ◽  
R Kaiser ◽  
K E Schneweis ◽  
H-H Brackmann ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Clotting Factor ◽  
Acute Hepatitis C ◽  
Clotting Factor Concentrates

Long-lasting Imprint in the Soluble Inflammatory Milieu despite Early Treatment of Acute Symptomatic Hepatitis C

2021 ◽  
Author(s):  
Tanvi Khera ◽  
Yanqin Du ◽  
Daniel Todt ◽  
Katja Deterding ◽  
Benedikt Strunz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Partial Restoration ◽  
Acute Hcv ◽  
Direct Acting ◽  
Inflammatory Milieu

Abstract Background Treatment with direct acting antivirals (DAAs) in patients with chronic hepatitis C infection leads to partial restoration of soluble inflammatory mediators (SIMs). In contrast, we hypothesized that early DAA treatment of acute hepatitis C with DAAs may normalize most SIMs. Methods In this study, we made use of a unique cohort of acute symptomatic hepatitis C who cleared HCV with a 6-week course of ledipasvir/sofosbuvir. Plasma samples were used for proximity extension assay (PEA) measuring 92 proteins. Results Profound SIM alterations were observed in acute HCV patients, with marked upregulation of IL-6 and CXCL10 while certain mediators were down-regulated (e.g. MCP-4, IL-7). During treatment and follow-up, the majority of SIMs decreased but not all normalized (e.g. CDCP1, IL-18). Of note, SIMs that were down-regulated before DAA treatment remained suppressed while others that were initially unchanged, declined to lower values during treatment and follow-up (e.g.CD244). Conclusions Acute hepatitis C was associated with marked changes in the soluble inflammatory milieu as compared to both chronic hepatitis patients and healthy controls. Whereas early DAA treatment partly normalized this altered signature, long-lasting imprints of HCV remained. Thus, acute HCV-induced changes in the immune system may persist even after a short duration of viremia.

Surveillance of acute hepatitis C in Cairo, Egypt

2005 ◽  
Vol 76 (4) ◽  
pp. 520-525 ◽  
Author(s):  
Maha M. El Gaafary ◽  
Claire Rekacewicz ◽  
Amira Gamal Abdel-Rahman ◽  
Mohamed Farouk Allam ◽  
Mostafa El Hosseiny ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C

Treatment of acute hepatitis C with alpha interferon in hypogammaglobulinaemia - the UK gammagard outbreak

1995 ◽  
Vol 108 (4) ◽  
pp. A1082 ◽  
Author(s):  
CJ Healey ◽  
J Watson ◽  
M. Durridge ◽  
N Snowdon ◽  
J Christie ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Alpha Interferon ◽  
Acute Hepatitis C ◽  
The Uk

scholarly journals Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies

Hepatology ◽  
2002 ◽  
Vol 36 (4) ◽  
pp. 993-1000 ◽  
Author(s):  
Alberto Larghi ◽  
Massimo Zuin ◽  
Andrea Crosignani ◽  
Maria Lisa Ribero ◽  
Cristina Pipia ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Healthy Volunteers ◽  
Acute Hepatitis C
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